Gene

KWMTBOMO08301  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA009533

Annotation

PREDICTED:_cytoskeleton-associated_protein_5_[Bombyx_mori]

Location

Bomo_Chr14(-):4661160-4672348      View in EpiBrowser

Full name

Protein mini spindles      

Location in the cell

Cytoplasmic   Reliability : 3.555

CDS

ATGACACAAACTGTTCACAATATGGAAGATGAATACAAGAAGTTACCAACAGAAGAAAAATGTGTTCACAAGCTCTGGAAGGCCAGAGTGGCAGGCTATGAGGAGACAATCAAACTCTTCAATCAGATTGACGACGAGAAGTCACCGGAATGGAACAAGTATTTGGGATTAATCAAGAAGTTTGTGACTGACAGCAATGCTGCCGCTCAGGAAAAAGGATTGGAAGCTACTCTTGTATTTGTTGAGAACTGCGGCCATGCTGGTAAGACCACTGGAGAGGTCATGTCCGGGATTATTGCCAAGTGCTTTTCCGCACCCAAGACTAAAACTAAAGATTTGGCCTTACAGATAACCCTAATGTATATAGAAATAGAGAAACACGAAATTGTTGAAGAAGAATTATTGAAAGGCATGGAGCAGAAGAATCCTAAAGTGGTAGCAGCCTGTGTCGCGACTTTGAATACTGCCCTCAAACAGTTCGGCAATAAAGTTATAGCCATCAAACCTATGGTCAAGAAAATACCTGTACTACTCGCTGACCGAGATAAAACTGTCAGGGACGAGATGAAAGCCTTAGTTGTGGAAATGCACAGATGGATAGGCCCCGCGATAGAGCCGCACATCGCGTCCCTGCAGGCGGTGGTGCAGCAAGAGCTGCGGGAGGCGTTCACCAGCGGCGGTGGCGGCGCGCAGCCCACGCGCTACCTGCGATCCCAACAACACAAGACAAGGGATGCCCCCACCGCTGATACCACAGACGGCGGTGCCGAAGACGAGGATGCAGATACTGGAGGTGGAGACTGCACAGATGTGGATCCATTCGATCTATTGGATCCTGTCGAGATTCTATCCAAACTACCTAAAGACTTCTATGATAAATTGGAAGCCAAGAAATGGAAAGATAGAAAAGAAGCACTTGATGCTCTAGAGGCATTGCTGAAAACTGCTCCCAAGTTGGAGCCTGGGGATTATGCTGATCTTGTCAGAGCACTCAAGAAGGTATTTATATCGCACTGGGACAGAAAGTTTGGTTTCGCTATTTACTCTCATAGAAAGTAG

Protein

MTQTVHNMEDEYKKLPTEEKCVHKLWKARVAGYEETIKLFNQIDDEKSPEWNKYLGLIKKFVTDSNAAAQEKGLEATLVFVENCGHAGKTTGEVMSGIIAKCFSAPKTKTKDLALQITLMYIEIEKHEIVEEELLKGMEQKNPKVVAACVATLNTALKQFGNKVIAIKPMVKKIPVLLADRDKTVRDEMKALVVEMHRWIGPAIEPHIASLQAVVQQELREAFTSGGGGAQPTRYLRSQQHKTRDAPTADTTDGGAEDEDADTGGGDCTDVDPFDLLDPVEILSKLPKDFYDKLEAKKWKDRKEALDALEALLKTAPKLEPGDYADLVRALKKVFISHWDRKFGFAIYSHRK

Description

Binds to the plus end of microtubules and regulates microtubule dynamics and microtubule organization. Promotes cytoplasmic microtubule nucleation and elongation. May act as a microtubule antipause factor that rapidly catalyzes the transition from pause to either growth or shrinkage. Involved in mitotic spindle elongation. Involved in the establishment of cell polarity and mitotic spindle orientation in neuroblasts. Required for maintaining the bipolarity of acentrosomal meiotic spindles; the function is dependent on tacc and involves ncd. Involved in oocyte microtubule cytoskeleton organization and bicoid mRNA localization. Seems to be involved in elongation of kinetochore-derived microtubule fibers.

Subunit

Interacts with tacc, dgt6.

Similarity

Belongs to the TOG/XMAP215 family.

Keywords

3D-structure   Cell cycle   Cell division   Complete proteome   Cytoplasm   Cytoskeleton   Meiosis   Mitosis   Reference proteome   Repeat  

Feature

chain  Protein mini spindles

Uniprot

H9JJ32   A0A2A4JMM8   A0A2A4JNE8   A0A3S2NK60   A0A2H1V9Y1   A0A212EPW6   + More
A0A194PXY3   A0A182GZY0   A0A1S4FBN3   Q0IFD6   A0A182KL40   A0A182MWU9   Q7QHF0   A0A1Y9J0Y2   A0A182WDI5   A0A1S4H6S3   A0A182U972   A0A182VKB9   A0A2C9GRE7   A0A182RTD3   W5J5U5   A0A1Q3F0V9   A0A1Q3F0Z5   A0A1Q3F0T5   A0A1Q3F0R6   A0A182NZM0   B0WL70   A0A2M4CKY5   A0A2M4CKP4   A0A182QHS5   A0A182FKK5   A0A084VHT8   A0A182JNC0   A0A182SXJ2   A0A1Y1K5P3   A0A034VK16   A0A182YB26   A0A1B6LMD6   A0A2P8XIM0   A0A240PP00   A0A1J1IJA6   A0A1I8P7C8   A0A1I8P7A2   A0A1I8P7I4   A0A0A1WXY4   A0A0L0BP62   A0A1W4X2D8   A0A1I8NBI3   A0A1I8NBJ1   A0A1I8NBI5   A0A1I8NBI9   A0A1B6CWX2   A0A1A9XWB6   A0A1B6DJ97   A0A0K8UJZ7   A0A1B6C9W5   A0A1B0BL53   A0A1B6CVQ0   T1PMG3   T1PA08   T1PKC6   A0A1B0CAC3   A0A1A9VFM3   A0A1B0A8N6   A0A2M4CL34   A0A0K8VLG4   A0A0K8WJE2   A0A1B0FPK5   W4VRR1   A0A1A9W8C3   A0A0M4F2L5   B4JGA2   A0A3B0JN84   A0A3B0JN73   A0A3B0JRN5   A0A1Y1JZC9   A0A1Y1K4W3   A0A1Y1JZU4   D6WD03   A0A2J7R1U2   A0A2J7R1T6   A0A2J7R1U0   W8APC2   W8B9B2   W8APC6   A0A0R1E7Q6   A0A0R1E3L8   A0A0Q9XD54   A0A0Q9WLZ6   A0A0Q9X1B7   A0A0Q9X968   B4KAF5   A0A0Q9WFV8   A0A0B4K700   B4LY15   A0A0Q9WQR7   A0A0B4K664   Q9VEZ3   Q9U5W6  

Pubmed

19121390    22118469    26354079    26483478    17510324    20966253    + More
12364791    20920257    23761445    24438588    28004739    25348373    25244985    29403074    25830018    26108605    25315136    17994087    18362917    19820115    24495485    17550304    10731132    12537568    12537572    12537573    12537574    16110336    17569856    17569867    12537569    10477755    11433295    15530399    16303556    15775959    19836241    21965297    26953351    17889670    24966168    25720490   

EMBL

BABH01040279    BABH01040280    NWSH01000976    PCG73307.1    PCG73306.1    RSAL01000016    + More
RVE53041.1    ODYU01001448    SOQ37660.1    AGBW02013389    OWR43501.1    KQ459585    KPI98192.1    JXUM01100352    JXUM01100353    KQ564562    KXJ72084.1    CH477356    EAT42779.1    AXCM01001359    AAAB01008816    EAA05144.4    APCN01001484    ADMH02002090    ETN59361.1    GFDL01013871    JAV21174.1    GFDL01013887    JAV21158.1    GFDL01013883    JAV21162.1    GFDL01013892    JAV21153.1    DS231980    EDS30243.1    GGFL01001741    MBW65919.1    GGFL01001742    MBW65920.1    AXCN02001729    ATLV01013235    KE524847    KFB37532.1    GEZM01096670    JAV54686.1    GAKP01015321    JAC43631.1    GEBQ01015124    JAT24853.1    PYGN01002013    PSN31814.1    CVRI01000049    CRK99142.1    GBXI01010580    JAD03712.1    JRES01001582    KNC21768.1    GEDC01019384    GEDC01013928    JAS17914.1    JAS23370.1    GEDC01014783    GEDC01011593    JAS22515.1    JAS25705.1    GDHF01025471    JAI26843.1    GEDC01027020    GEDC01016294    JAS10278.1    JAS21004.1    JXJN01016224    GEDC01019893    GEDC01015728    JAS17405.1    JAS21570.1    KA649285    AFP63914.1    KA645519    AFP60148.1    KA649247    AFP63876.1    AJWK01003648    AJWK01003649    GGFL01001791    MBW65969.1    GDHF01012904    JAI39410.1    GDHF01001061    JAI51253.1    CCAG010010888    GANO01000598    JAB59273.1    CP012526    ALC45345.1    CH916369    EDV92571.1    OUUW01000008    SPP83675.1    SPP83674.1    SPP83673.1    GEZM01096672    JAV54684.1    GEZM01096671    JAV54685.1    GEZM01096673    JAV54683.1    KQ971311    EEZ99362.1    NEVH01008202    PNF34801.1    PNF34800.1    PNF34799.1    GAMC01020197    JAB86358.1    GAMC01020196    JAB86359.1    GAMC01020192    JAB86363.1    CM000160    KRK03690.1    KRK03689.1    CH933806    KRG01667.1    CH940650    KRF82967.1    KRG01669.1    KRG01668.1    EDW15668.1    KRF82966.1    AE014297    AFH06447.1    EDW66881.1    KRF82971.1    AFH06448.1    BT023496    AJ249115    CAB55772.1   

Proteomes

UP000005204    UP000218220    UP000283053    UP000007151    UP000053268    UP000069940    + More
UP000249989    UP000008820    UP000075882    UP000075883    UP000007062    UP000076407    UP000075920    UP000075902    UP000075903    UP000075840    UP000075900    UP000000673    UP000075885    UP000002320    UP000075886    UP000069272    UP000030765    UP000075881    UP000075901    UP000076408    UP000245037    UP000075880    UP000183832    UP000095300    UP000037069    UP000192223    UP000095301    UP000092443    UP000092460    UP000092461    UP000078200    UP000092445    UP000092444    UP000091820    UP000092553    UP000001070    UP000268350    UP000007266    UP000235965    UP000002282    UP000009192    UP000008792    UP000000803   

PRIDE

H9JJ32    Q9VEZ3    Q9U5W6   

Pfam

PF12348   CLASP_N        + More
PF11640   TAN
PF02780   Transketolase_C
PF02779   Transket_pyr
PF00456   Transketolase_N

Interpro

IPR016024   ARM-type_fold        + More
IPR034085   TOG       
IPR024395   CLASP_N_dom       
IPR011989   ARM-like       
IPR021133   HEAT_type_2       
IPR021668   TAN       
IPR009014   Transketo_C/PFOR_II       
IPR005475   Transketolase-like_Pyr-bd       
IPR029061   THDP-binding       
IPR033248   Transketolase_C       
IPR020826   Transketolase_BS       
IPR005474   Transketolase_N       

SUPFAM

SSF48371   SSF48371        + More
SSF52518   SSF52518       
SSF52922   SSF52922       

Gene 3D

1.25.10.10     3.40.50.920    

CDD

cd02012  TPP_TK

ProteinModelPortal

H9JJ32   A0A2A4JMM8   A0A2A4JNE8   A0A3S2NK60   A0A2H1V9Y1   A0A212EPW6   + More
A0A194PXY3   A0A182GZY0   A0A1S4FBN3   Q0IFD6   A0A182KL40   A0A182MWU9   Q7QHF0   A0A1Y9J0Y2   A0A182WDI5   A0A1S4H6S3   A0A182U972   A0A182VKB9   A0A2C9GRE7   A0A182RTD3   W5J5U5   A0A1Q3F0V9   A0A1Q3F0Z5   A0A1Q3F0T5   A0A1Q3F0R6   A0A182NZM0   B0WL70   A0A2M4CKY5   A0A2M4CKP4   A0A182QHS5   A0A182FKK5   A0A084VHT8   A0A182JNC0   A0A182SXJ2   A0A1Y1K5P3   A0A034VK16   A0A182YB26   A0A1B6LMD6   A0A2P8XIM0   A0A240PP00   A0A1J1IJA6   A0A1I8P7C8   A0A1I8P7A2   A0A1I8P7I4   A0A0A1WXY4   A0A0L0BP62   A0A1W4X2D8   A0A1I8NBI3   A0A1I8NBJ1   A0A1I8NBI5   A0A1I8NBI9   A0A1B6CWX2   A0A1A9XWB6   A0A1B6DJ97   A0A0K8UJZ7   A0A1B6C9W5   A0A1B0BL53   A0A1B6CVQ0   T1PMG3   T1PA08   T1PKC6   A0A1B0CAC3   A0A1A9VFM3   A0A1B0A8N6   A0A2M4CL34   A0A0K8VLG4   A0A0K8WJE2   A0A1B0FPK5   W4VRR1   A0A1A9W8C3   A0A0M4F2L5   B4JGA2   A0A3B0JN84   A0A3B0JN73   A0A3B0JRN5   A0A1Y1JZC9   A0A1Y1K4W3   A0A1Y1JZU4   D6WD03   A0A2J7R1U2   A0A2J7R1T6   A0A2J7R1U0   W8APC2   W8B9B2   W8APC6   A0A0R1E7Q6   A0A0R1E3L8   A0A0Q9XD54   A0A0Q9WLZ6   A0A0Q9X1B7   A0A0Q9X968   B4KAF5   A0A0Q9WFV8   A0A0B4K700   B4LY15   A0A0Q9WQR7   A0A0B4K664   Q9VEZ3   Q9U5W6  

PDB

6MZE     E-value=4.00481e-19,     Score=232

KEGG

101745477    K16803 cytoskeleton-associated protein 5 | (RefSeq) cytoskeleton-associated protein 5

GO

GO:0004674   GO:0030951   GO:0000776   GO:0051298   GO:0005813   GO:0007051   GO:0051010   GO:0046785   GO:0000922   GO:0003824   GO:0045450   GO:0035371   GO:0007029   GO:0005737   GO:0007143   GO:0000132   GO:0015631   GO:0000022   GO:0090063   GO:0016325   GO:0008017   GO:0000278   GO:0031122   GO:0007344   GO:0007017   GO:0048477   GO:0005875   GO:0045196   GO:0007411   GO:0005488   GO:0006355   GO:0043565   GO:0003917   GO:0016887   GO:0005634   GO:0030145   GO:0006412   GO:0016876   GO:0043039  

Subcellular location

Cytoplasm   Localizes to the plus ends of growing microtubules in the cell interior in a Eb1-depenedent manner. Localizes to the lattice of growing and shrinking microtubule in a discontinuous pattern in the peripheral regions of interphase cells. Localized at acentrosomal poles of female meiotic spindle.   With evidence from 8 publications.
Cytoskeleton   Localizes to the plus ends of growing microtubules in the cell interior in a Eb1-depenedent manner. Localizes to the lattice of growing and shrinking microtubule in a discontinuous pattern in the peripheral regions of interphase cells. Localized at acentrosomal poles of female meiotic spindle.   With evidence from 8 publications.
Microtubule organizing center   Localizes to the plus ends of growing microtubules in the cell interior in a Eb1-depenedent manner. Localizes to the lattice of growing and shrinking microtubule in a discontinuous pattern in the peripheral regions of interphase cells. Localized at acentrosomal poles of female meiotic spindle.   With evidence from 8 publications.
Centrosome   Localizes to the plus ends of growing microtubules in the cell interior in a Eb1-depenedent manner. Localizes to the lattice of growing and shrinking microtubule in a discontinuous pattern in the peripheral regions of interphase cells. Localized at acentrosomal poles of female meiotic spindle.   With evidence from 8 publications.
Spindle   Localizes to the plus ends of growing microtubules in the cell interior in a Eb1-depenedent manner. Localizes to the lattice of growing and shrinking microtubule in a discontinuous pattern in the peripheral regions of interphase cells. Localized at acentrosomal poles of female meiotic spindle.   With evidence from 8 publications.

Length:

352

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.01764

Exp number, first 60 AAs:

0

Total prob of N-in:

0.06014

outside

1  -  352

 

 

Pi

15.052226

Theta

25.658812

Tajima's D

-1.476214

CLR

480.830108

CSRT

0.064296785160742

Interpretation

Uncertain