Gene

KWMTBOMO08289

Pre Gene Modal

BGIBMGA009540

Annotation

PREDICTED:_tetratricopeptide_repeat_protein_5-like_[Papilio_xuthus]

Location

Bomo_Chr14(-):4418926-4424974      View in EpiBrowser

Full name

Tetratricopeptide repeat protein 5      

Alternative Name

Stress-responsive activator of p300

Location in the cell

Cytoplasmic   Reliability : 2.757

CDS

ATGTCGGAATCAGAAGTGGAAGCTGATATAATAGAAAATGTTGCAGAAGTCCTGGATAATCTATCGAAAGAACTAGAAGAATTGTATAGGTTTCGAAACTTGTTTTTTGAAAATCAACCAATTAGTATGGCTGCAGAAAAAAATAAGCAAGTTGAGGAAAAGAAAAATCTACTCCTAGAAAAGTTTGAATCCATAGATGATGCACAAATACCATCAGCATCGAGAGCCCAGTTCTTGTACCTTAAAGGACGTTGCTATAATATTAGTCCAACATATGATGCAAGAGCTACACATTGTCTCAGCAAAGCAGTAAAGTGGAATCCTCACATGGTGGATGCTTGGAATGAACTTGGCGAATGTTATTGGAAGAATATGAATGTTAAAGAGGCTAAAGCCAGCTTCGAAGCTGCTTTGAAACATGAAAGGAATCGACTCTCACTACGTTGTCTGTCAATCATTTTGAGACAAGAAGGTGGTGACAGAAAACGTCCTGATTCCACCAATGCGATTGGCACAAGTGTTGAACTTGCAAAAGAGGCTGTATCTCAGGACACAAAAGACGGTATCTCATGGACAGTATTAGGGAATGCTTTATTATGCCAGTTCTTTATGGTCTCCCAAGATCCAGCAATTCTGAAATTATGCATGACAGCATATAGGCAAGCCTGGGCTGATCCTGTTGCTAAGGGGCAGCCGGATTTATACTACAATAAGGCTATTGCCTTGAAATATGACGAAATATACGATGAAGCATTAGAAAACTTTGAATATGCGTGTCGTTTGGATCCCCCGTGGGAACCACCGCAGTTGGAACTCCAAAAGTTAAAACAATATTTAAACGAAACAAATGAATTAGTACGAACTAAAGGAAAGATTAAAGTTAAGAAACTGACACAGATGGTACAGTCGATAGACGAGAAGATGCTAGGAATATACAGCCCAGAAGGTTTGCACACATTCGGTGGTCGTCGCAACGTGACCCTAGAGCTGTGTCGGTTGGAAGATTTGCACGAGGGACTCAATGAAGGAAAAGTCATATTAGGAAGAGTCGTTGGCTCCATTCACAATGAAAATGCTGTGCCTTTTTCGTTCGCAATCGTTGGTCAGGGCATGCAGTGCGCCTGCGTCACCGTCTACAACTGGGCCTCGGGTCGGGGAGCCATCATTGGAGACTGCGTGACTATACCGGAACCACTACTGACCGTACACAAACACGCATCCGAATTGGCCAGCTACGAGTTCAAGTCGATCCGCGTCAACAACCCGACGCTGCTGCTGGTGAACGGCAGGCGCGTCGGCCGCGAGCAGTACGCGAGCACGCGCGTCACCAGCACCTACGAGCTGCACTGA

Protein

MSESEVEADIIENVAEVLDNLSKELEELYRFRNLFFENQPISMAAEKNKQVEEKKNLLLEKFESIDDAQIPSASRAQFLYLKGRCYNISPTYDARATHCLSKAVKWNPHMVDAWNELGECYWKNMNVKEAKASFEAALKHERNRLSLRCLSIILRQEGGDRKRPDSTNAIGTSVELAKEAVSQDTKDGISWTVLGNALLCQFFMVSQDPAILKLCMTAYRQAWADPVAKGQPDLYYNKAIALKYDEIYDEALENFEYACRLDPPWEPPQLELQKLKQYLNETNELVRTKGKIKVKKLTQMVQSIDEKMLGIYSPEGLHTFGGRRNVTLELCRLEDLHEGLNEGKVILGRVVGSIHNENAVPFSFAIVGQGMQCACVTVYNWASGRGAIIGDCVTIPEPLLTVHKHASELASYEFKSIRVNNPTLLLVNGRRVGREQYASTRVTSTYELH

Description

Adapter protein involved in p53/TP53 response that acts by regulating and mediating the assembly of multi-protein complexes. Required to facilitate the interaction between JMY and p300/EP300 and increase p53/TP53-dependent transcription and apoptosis. Prevents p53/TP53 degradation by MDM2 (By similarity).

Subunit

Interacts with JMY and p300/EP300.

Keywords

3D-structure   Complete proteome   Cytoplasm   DNA damage   DNA repair   Nucleus   Phosphoprotein   Polymorphism   Reference proteome   Repeat   TPR repeat  

Feature

chain  Tetratricopeptide repeat protein 5
sequence variant  In dbSNP:rs34675160.

Uniprot

H9JJ39   A0A194PXX8   A0A194RC17   A0A2A4J8R8   A0A3S2P5N7   A0A0C9RYX1   + More
A0A1Y1M5P0   E9J0S8   A0A232ESW6   K7J6R9   A0A151WPS4   A0A151JXG6   A0A195ECV5   A0A158NXR6   A0A154PE41   A0A195AZQ6   A0A026WKS7   F4WTH1   E2BAA0   A0A2J7R321   A0A087ZRS6   E1ZYT4   A0A0L7R5W3   D1ZZR8   A0A195CKV9   A0A1B6HXA3   A0A1Y1MB57   A0A0M9A450   E0VHW1   A0A1B6F4K9   A0A2J7R335   A0A1B6DEG0   A0A2A3EP51   A0A067RBV7   A0A310SWV8   A7RRB4   A0A1B6KVA8   A0A3L8E224   A0A0B7AF55   A0A2P8ZDS4   K1PNB1   A0A3M6U3G2   C3XU94   V4B2K3   T1J2A1   A0A3Q0JKL5   A0A1S3JSL4   A0A1S3JT74   A0A0B7AEN7   A0A1Y1M944   A0A3Q0E0Q4   G1LG62   A0A1W2W544   A0A3Q7VBL8   A0A3Q0K5Y5   A0A384BH51   A0A452RHI0   A0A2K6U289   F6Q337   U6CTX2   G3SQJ0   U3C0A8   F7D0C6   A0A2R9BP76   Q8N0Z6   G3QDN9   M3W130   A0A2I3RW55   G3WGM9   H2NKH1   A0A2K5QJJ6   A0A0B7AE47   S7PHZ4   G1PS04   G5B5Q3   A0A0D9RW71   A0A2K5F1G4   A0A2I3H703   A0JMT7   Q6NRA9   A0A383ZZM7   I3MEN8   A0A2Y9EAG2   A0A2U3WUI0   L5MB24   A0A3S1BJB2   A0A2K5YA58   A0A3Q7RI40   A0A250YIA0   L5K6D8   A0A091CWR2   K9IJW8   M3Z354   A0A2K5M0H4   M7BDF6   H0VDM7   F6WBF3  

Pubmed

19121390    26354079    28004739    21282665    28648823    20075255    + More
21347285    24508170    21719571    20798317    18362917    19820115    20566863    24845553    17615350    30249741    29403074    22992520    30382153    18563158    23254933    20010809    19892987    25243066    22722832    14702039    12508121    15489334    21269460    22362889    22398555    17975172    16136131    21709235    21993624    21993625    26763976    27762356    28087693    23258410    23624526    17495919   

EMBL

BABH01040265    KQ459585    KPI98182.1    KQ460627    KPJ13451.1    NWSH01002456    + More
PCG68259.1    RSAL01000016    RVE53033.1    GBYB01014560    GBYB01014561    GBYB01014562    GBYB01014563    JAG84327.1    JAG84328.1    JAG84329.1    JAG84330.1    GEZM01039899    JAV81102.1    GL767538    EFZ13486.1    NNAY01002367    OXU21450.1    AAZX01000213    KQ982851    KYQ49830.1    KQ981567    KYN39802.1    KQ979074    KYN23050.1    ADTU01003356    KQ434886    KZC10113.1    KQ976692    KYM77686.1    KK107159    EZA56647.1    GL888336    EGI62489.1    GL446691    EFN87398.1    NEVH01007823    PNF35238.1    GL435242    EFN73624.1    KQ414648    KOC66156.1    KQ971338    EFA01806.1    KQ977622    KYN01343.1    GECU01037618    GECU01028402    JAS70088.1    JAS79304.1    GEZM01039897    JAV81106.1    KQ435740    KOX76845.1    DS235172    EEB12967.1    GECZ01024577    JAS45192.1    PNF35240.1    GEDC01013215    JAS24083.1    KZ288202    PBC33497.1    KK852567    KDR21227.1    KQ759874    OAD62374.1    DS469531    EDO45981.1    GEBQ01024646    JAT15331.1    QOIP01000001    RLU26717.1    HACG01032407    CEK79272.1    PYGN01000086    PSN54645.1    JH818965    EKC17980.1    RCHS01002309    RMX48136.1    GG666464    EEN68468.1    KB203854    ESO82669.1    JH431796    HACG01032403    CEK79268.1    GEZM01039900    GEZM01039898    JAV81100.1    ACTA01148253    ACTA01156252    HAAF01001938    CCP73764.1    GAMT01007352    GAMS01010919    GAMR01003050    GAMQ01002820    GAMP01002666    JAB04509.1    JAB12217.1    JAB30882.1    JAB39031.1    JAB50089.1    AJFE02037282    AJFE02037283    AK074553    AL356019    BC008647    BC030822    BC053538    CABD030091995    CABD030091996    CABD030091997    AANG04001761    AACZ04052400    GABC01010837    GABF01002296    GABD01010185    GABE01004007    NBAG03000456    JAA00501.1    JAA19849.1    JAA22915.1    JAA40732.1    PNI22209.1    AEFK01008730    AEFK01008731    AEFK01008732    ABGA01395405    NDHI03003485    PNJ36182.1    HACG01032409    CEK79274.1    KE162312    EPQ07737.1    AAPE02015125    KM486791    JH168595    AIZ09076.1    EHB04614.1    AQIB01128679    ADFV01127204    BC126001    CM004466    AAI26002.1    OCU01550.1    BC070853    AAH70853.1    AGTP01114621    AGTP01114622    AGTP01114623    AGTP01114624    KB102338    ELK35507.1    RQTK01000186    RUS84991.1    GFFW01001512    JAV43276.1    KB030984    ELK07090.1    KN124097    KFO22260.1    GABZ01006145    JAA47380.1    AEYP01102348    AEYP01102349    KB535354    EMP33620.1    AAKN02019211    AAKN02019212   

Proteomes

UP000005204    UP000053268    UP000053240    UP000218220    UP000283053    UP000215335    + More
UP000002358    UP000075809    UP000078541    UP000078492    UP000005205    UP000076502    UP000078540    UP000053097    UP000007755    UP000008237    UP000235965    UP000005203    UP000000311    UP000053825    UP000007266    UP000078542    UP000053105    UP000009046    UP000242457    UP000027135    UP000001593    UP000279307    UP000245037    UP000005408    UP000275408    UP000001554    UP000030746    UP000079169    UP000085678    UP000189704    UP000008912    UP000286642    UP000261680    UP000291022    UP000233220    UP000002281    UP000007646    UP000008225    UP000240080    UP000005640    UP000001519    UP000011712    UP000002277    UP000007648    UP000001595    UP000233040    UP000001074    UP000006813    UP000029965    UP000233020    UP000001073    UP000186698    UP000261681    UP000005215    UP000248480    UP000245340    UP000271974    UP000233140    UP000286641    UP000010552    UP000028990    UP000000715    UP000233060    UP000031443    UP000005447    UP000002280   

PRIDE

H9JJ39    Q8N0Z6   

Pfam

PF16669   TTC5_OB        + More
PF13181   TPR_8
PF07719   TPR_2
PF01562   Pep_M12B_propep
PF00090   TSP_1
PF05986   ADAM_spacer1
PF17771   ADAM_CR_2
PF01421   Reprolysin

Interpro

IPR011990   TPR-like_helical_dom_sf        + More
IPR032076   TTC5_OB       
IPR019734   TPR_repeat       
IPR038645   TTC5_OB_sf       
IPR013026   TPR-contain_dom       
IPR013105   TPR_2       
IPR002870   Peptidase_M12B_N       
IPR041645   ADAM_CR_2       
IPR024079   MetalloPept_cat_dom_sf       
IPR013273   ADAMTS/ADAMTS-like       
IPR000884   TSP1_rpt       
IPR036383   TSP1_rpt_sf       
IPR010294   ADAM_spacer1       
IPR001590   Peptidase_M12B       

SUPFAM

SSF48452   SSF48452        + More
SSF82895   SSF82895       

Gene 3D

1.25.40.10     2.40.50.550     2.20.100.10     3.40.390.10    

ProteinModelPortal

H9JJ39   A0A194PXX8   A0A194RC17   A0A2A4J8R8   A0A3S2P5N7   A0A0C9RYX1   + More
A0A1Y1M5P0   E9J0S8   A0A232ESW6   K7J6R9   A0A151WPS4   A0A151JXG6   A0A195ECV5   A0A158NXR6   A0A154PE41   A0A195AZQ6   A0A026WKS7   F4WTH1   E2BAA0   A0A2J7R321   A0A087ZRS6   E1ZYT4   A0A0L7R5W3   D1ZZR8   A0A195CKV9   A0A1B6HXA3   A0A1Y1MB57   A0A0M9A450   E0VHW1   A0A1B6F4K9   A0A2J7R335   A0A1B6DEG0   A0A2A3EP51   A0A067RBV7   A0A310SWV8   A7RRB4   A0A1B6KVA8   A0A3L8E224   A0A0B7AF55   A0A2P8ZDS4   K1PNB1   A0A3M6U3G2   C3XU94   V4B2K3   T1J2A1   A0A3Q0JKL5   A0A1S3JSL4   A0A1S3JT74   A0A0B7AEN7   A0A1Y1M944   A0A3Q0E0Q4   G1LG62   A0A1W2W544   A0A3Q7VBL8   A0A3Q0K5Y5   A0A384BH51   A0A452RHI0   A0A2K6U289   F6Q337   U6CTX2   G3SQJ0   U3C0A8   F7D0C6   A0A2R9BP76   Q8N0Z6   G3QDN9   M3W130   A0A2I3RW55   G3WGM9   H2NKH1   A0A2K5QJJ6   A0A0B7AE47   S7PHZ4   G1PS04   G5B5Q3   A0A0D9RW71   A0A2K5F1G4   A0A2I3H703   A0JMT7   Q6NRA9   A0A383ZZM7   I3MEN8   A0A2Y9EAG2   A0A2U3WUI0   L5MB24   A0A3S1BJB2   A0A2K5YA58   A0A3Q7RI40   A0A250YIA0   L5K6D8   A0A091CWR2   K9IJW8   M3Z354   A0A2K5M0H4   M7BDF6   H0VDM7   F6WBF3  

PDB

4ABN     E-value=4.03503e-69,     Score=665

KEGG

101744898    no KO assigned | (RefSeq) tetratricopeptide repeat protein 5-like

GO

GO:0005654   GO:0045944   GO:0003682   GO:0005737   GO:0003677   GO:0006281   GO:1901796   GO:0016740   GO:0005515   GO:0032780   GO:0042030   GO:0003917   GO:0016887   GO:0005634   GO:0030145   GO:0006412   GO:0016876   GO:0043039  

Subcellular location

Nucleus   Phosphorylation at Ser-203 results in nuclear localization, while unphosphorylated protein localizes to the cytoplasm.   With evidence from 2 publications.
Cytoplasm   Phosphorylation at Ser-203 results in nuclear localization, while unphosphorylated protein localizes to the cytoplasm.   With evidence from 2 publications.

Length:

449

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.10117

Exp number, first 60 AAs:

0

Total prob of N-in:

0.00491

outside

1  -  449

 

 

Pi

288.889787

Theta

196.956525

Tajima's D

1.805276

CLR

0.010904

CSRT

0.850007499625019

Interpretation

Uncertain