SGID Silkworm Genome Informatics Database
Gene
KWMTBOMO08283
Pre Gene Modal
BGIBMGA009432
Annotation
PREDICTED:_paired_box_protein_Pax-6?_partial_[Amyelois_transitella]
Full name
Paired box protein Pax-6      
Alternative Name
Oculorhombin
Aniridia type II protein
Transcription factor
Location in the cell
Nuclear   Reliability : 4.736
 

Sequence

CDS
ATGCACAGCGCGGCTATGGGTGGTGGAGGCCTCTTCGGATGCTCGTCGGCTGGTCACAGCGGCATCAATCAGCTGGGCGGGGTCTACGTCAACGGACGACCGCTGCCGGACTCGACTCGGCAAAAGATCGTGGAACTAGCCCACTCCGGAGCTAGACCCTGCGACATCAGCCGCATCCTGCAGGTCTCCAACGGCTGTGTCTCCAAAATACTAGGCAGCTTCACACGCAGATATTACGAGACGGGGTCGATAAAGCCACGCGCGATTGGTGGGTCCAAGCCCCGGGTGGCGACCACTCCAGTTGTCCAGAAGATAGCCGACTACAAGCGGGAGTGCCCCTCGATCTTCGCCTGGGAGATCAGGGACCGCCTGCTCAGCGAAAACGTGTGCAATAACGACAACATACCCAGTGTGTCATCAATAAACCGAGTACTACGGAACCTGGCCTCGCAGAAGGAGCAAGCGGCATCAGCGCAGAACGATAGCGTGTATGAGAAACTGAGGATGTTCAATGGTCAAGCGGCGACTGGATGGTGGTATCCAGGGCTACCCACCGCGCCGACCGCACCGGCGATACCAGCCCCACTGCCCCCTCAACTCAGGACCACAACAGAAGAGCAGAAACGAGATACAATTCAGTCGGAAGCGGGTTCAGACGGGAACAGTGAACATGCGTCATCAGGCGACGAGGACTCGCAGATGAGACTCCGATTGAAGAGGAAACTCCAGAGGAACAGGACCAGTTTCACAAATGACCAAATAGATAGTCTCGAGAAGGAATTCGAGAGGACCCACTACCCGGACGTGTTCGCCCGGGAGAGACTCGCTGAAAAGATTGGATTGCCTGAGGCACGTATCCAGGTATGGTTCTCAAATCGTCGTGCAAAATGGCGTCGCGAAGAGAAACTCCGGAGCCAGCGTCGCGACGCGCCGGCCGCGTCTCCTCCCGCACCCCCCGCGCCGCGACTCCCCCTCAATGGAGGCTTCAATTCCATGTACAGCCCCATACCGCAACCCATTGCCACAATGGCTGATTCTTACAGCTCGATGTCTGGTGGGCTCTCCTCATCGTGTCTCCAGCAGCGAGACGGCGGCTACCCCTACATGTTCGGGGACGTCCTCGCCAGCGGAGGGTACTCCAGAGCCCCGGCAGCGCATCAGCAGCACCCGGCTTACTCACAGCCACAGCCCGCTGGCAGTACGGGTGTGATATCGGCGGGCGTGAGCGTACCCGTGCAGATACCGTCGCAGGGGCCCGACCTCGCGTCCAACTACTGGGGCCGGCTCCAGTGA
Protein
MHSAAMGGGGLFGCSSAGHSGINQLGGVYVNGRPLPDSTRQKIVELAHSGARPCDISRILQVSNGCVSKILGSFTRRYYETGSIKPRAIGGSKPRVATTPVVQKIADYKRECPSIFAWEIRDRLLSENVCNNDNIPSVSSINRVLRNLASQKEQAASAQNDSVYEKLRMFNGQAATGWWYPGLPTAPTAPAIPAPLPPQLRTTTEEQKRDTIQSEAGSDGNSEHASSGDEDSQMRLRLKRKLQRNRTSFTNDQIDSLEKEFERTHYPDVFARERLAEKIGLPEARIQVWFSNRRAKWRREEKLRSQRRDAPAASPPAPPAPRLPLNGGFNSMYSPIPQPIATMADSYSSMSGGLSSSCLQQRDGGYPYMFGDVLASGGYSRAPAAHQQHPAYSQPQPAGSTGVISAGVSVPVQIPSQGPDLASNYWGRLQ

Summary

Description
Transcription factor with important functions in the development of the eye, nose, central nervous system and pancreas. Required for the differentiation of pancreatic islet alpha cells. Competes with PAX4 in binding to a common element in the glucagon, insulin and somatostatin promoters. Regulates specification of the ventral neuron subtypes by establishing the correct progenitor domains (By similarity).
Transcription factor with important functions in the development of the eye, nose, central nervous system and pancreas. Required for the differentiation of pancreatic islet alpha cells (By similarity). Competes with PAX4 in binding to a common element in the glucagon, insulin and somatostatin promoters. Regulates specification of the ventral neuron subtypes by establishing the correct progenitor domains (By similarity). Isoform 5a appears to function as a molecular switch that specifies target genes.
Transcription factor with important functions in the development of the eye, nose, central nervous system and pancreas. Required for the differentiation of pancreatic islet alpha cells. Competes with PAX4 in binding to a common element in the glucagon, insulin and somatostatin promoters (By similarity). Regulates specification of the ventral neuron subtypes by establishing the correct progenitor domains.
Subunit
Interacts with MAF and MAFB. Interacts with TRIM11; this interaction leads to ubiquitination and proteasomal degradation, as well as inhibition of transactivation, possibly in part by preventing PAX6 binding to consensus DNA sequences.
Similarity
Belongs to the paired homeobox family.
Keywords
Alternative splicing   Complete proteome   Developmental protein   Differentiation   Direct protein sequencing   Disease mutation   DNA-binding   Homeobox   Nucleus   Paired box   Reference proteome   Transcription   Transcription regulation   Ubl conjugation   3D-structure   Peters anomaly   Repressor  
Feature
chain  Paired box protein Pax-6
splice variant  In isoform 3.
sequence variant  In AN1.
EMBL
KQ459585    KPI98175.1    KQ460627    KPJ13446.1    RSAL01000016    RVE53029.1    + More
AGBW02007765    OWR54587.1    KQ971338    EFA02830.2    KYB27953.1    NEVH01020341    PNF21538.1    GEDC01015648    JAS21650.1    GECU01029138    JAS78568.1    UFQS01001062    UFQT01001062    SSX08780.1    SSX28692.1    UFQT01000002    SSX17089.1    DS235063    EEB11187.1    CVRI01000005    CRK87764.1    GL446691    EFN87393.1    GDHC01013583    JAQ05046.1    LJIJ01000173    ODN01076.1    AAZX01005026    AAZX01014109    AAZX01018084    AAZX01021306    KQ977622    KYN01346.1    KK852485    KDR22799.1    LNIX01000006    OXA52716.1    JH431363    GDIQ01020228    JAN74509.1    GAMC01003100    JAC03456.1    GAMC01003098    JAC03458.1    LN624822    CEH19758.1    OUUW01000017    SPP88948.1    CH475404    EDY70832.1    CH479285    EDW25268.1    CH916380    EDV90908.1    CH964272    EDW83579.2    CM000831    CH940665    ACY70471.1    EDW71088.1    CH933813    EDW10927.1    JRES01000552    KNC30268.1    CH480855    EDW52643.1    AE014135    AY051487    AAF59395.4    AAK92911.1    AF134350    AAD31712.1    CM002916    KMZ07347.1    CH954184    EDV45217.1    EU169112    ABW23132.1    KRT05135.1    SPP88947.1    CH902659    EDV33930.1    AAKN02048405    DQ217589    ABA90484.1    AAGW02037526    AAGW02037527    AAGW02037528    AGTP01048264    AAPE02023618    CABD030078140    AEMK02000009    AJFE02107122    AJFE02107123    AAQR03002365    JU334738    AFE78491.1    NDHI03003391    PNJ68803.1    PNJ68805.1    PNJ68816.1    PNJ68817.1    PNJ68824.1    PNJ68831.1    PNJ68838.1    AQIA01020593    AB171050    BAE88113.1    AACZ04016470    NBAG03000219    PNI78767.1    PNI78769.1    PNI78780.1    PNI78781.1    PNI78788.1    PNI78795.1    PNI78802.1    GAMS01006506    GAMR01007056    JAB16630.1    JAB26876.1    AY707088    KT580798    KT580799    AAU12168.1    ALU11231.1    X63963    Y19196    Y19199    AK028059    AK139054    BC011272    BC036957    M77842    M77844    M93650    AY047583    BX640762    Z83307    Z95332    BC011953    KRF85331.1    AK074881    BAG52023.1    U69644    AJ627631    AY540905    AY540906    BC128741    S74393    AMGL01032799    AMGL01032800    AMGL01032801    AMGL01032802    BC116038    KRG07295.1    AGCU01126135    AGCU01126136    AGCU01126137    LSYS01006880    OPJ73971.1    DQ870843    ABI98848.1    ACTA01025499    ACTA01033499    ACTA01041498    ACTA01049498    CH471064    EAW68234.1    BEZZ01000593    GCC34394.1    BFAA01002958    GCB66691.1    AGB96570.1    AF154555    AF154556    AAF73272.1    KMZ07346.1   
Pfam
PF00292   PAX        + More
PF00046   Homeodomain
Interpro
IPR001356   Homeobox_dom        + More
IPR036388   WH-like_DNA-bd_sf       
IPR009057   Homeobox-like_sf       
IPR017970   Homeobox_CS       
IPR001523   Paired_dom       
SUPFAM
SSF46689   SSF46689       
Gene 3D
PDB
6PAX     E-value=2.43752e-60,     Score=589

Ontologies

GO
GO:0007275   GO:0043565   GO:0006355   GO:0005634   GO:0003677   GO:0000977   GO:0000981   GO:0048854   GO:0045944   GO:0016319   GO:0008056   GO:0006357   GO:0048749   GO:0010628   GO:0035214   GO:0021778   GO:0019901   GO:0005654   GO:0030858   GO:0060041   GO:0021902   GO:0007435   GO:0005829   GO:0070410   GO:0070412   GO:0002052   GO:0035035   GO:0000790   GO:2000178   GO:0021986   GO:0048708   GO:0031625   GO:0030334   GO:0001764   GO:0006366   GO:0021912   GO:0021983   GO:0033365   GO:0000978   GO:0001228   GO:0000132   GO:0050680   GO:0021918   GO:0061303   GO:0042593   GO:0001227   GO:0023019   GO:1904798   GO:0021913   GO:0007224   GO:0001568   GO:0003309   GO:0071837   GO:0048505   GO:0001933   GO:0021796   GO:0009611   GO:0000979   GO:0008134   GO:0003322   GO:0001709   GO:1990830   GO:0045665   GO:0007411   GO:0021798   GO:0048596   GO:0030216   GO:0009786   GO:0009950   GO:0032808   GO:0021905   GO:0003682   GO:0042462   GO:0061072   GO:0002088   GO:0045893   GO:0009953   GO:0009952   GO:0022027   GO:0044212   GO:1901142   GO:0070094   GO:0021978   GO:0005737   GO:0021772   GO:0042660   GO:0002064   GO:0061034   GO:0007420   GO:2001224   GO:0045664   GO:0021543   GO:0030900   GO:0098598   GO:0043010   GO:0050767   GO:0120008   GO:0030154   GO:0010942   GO:0008285   GO:0001755   GO:0045165   GO:1904937   GO:0021593   GO:0061351   GO:0003310   GO:0010468   GO:0005667   GO:0007409   GO:0003700   GO:0003680   GO:0003690   GO:0030902   GO:0010975   GO:0003002   GO:0001654   GO:0048663   GO:0009887   GO:0007601   GO:0050768   GO:0007417   GO:0071333   GO:0021510   GO:0021549   GO:0071380   GO:0032869   GO:0044344   GO:0045471   GO:0035690   GO:0004842   GO:0016021   GO:0003917   GO:0016887   GO:0030145   GO:0006412   GO:0016876   GO:0043039  

Topology

Subcellular location
Nucleus  
Length:
430
Number of predicted TMHs:
0
Exp number of AAs in TMHs:
0.0475600000000001
Exp number, first 60 AAs:
0.04327
Total prob of N-in:
0.00385
outside
1  -  430
 
 

Population Genetic Test Statistics

Pi
223.859866
Theta
171.907535
Tajima's D
0.805001
CLR
0.179202
CSRT
0.605119744012799
Interpretation
Uncertain

Multiple alignment of Orthologues

 
 

Gene Tree

 
 
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