Gene

KWMTBOMO08283

Pre Gene Modal

BGIBMGA009432

Annotation

PREDICTED:_paired_box_protein_Pax-6?_partial_[Amyelois_transitella]

Location

Bomo_Chr14(-):4164139-4238744      View in EpiBrowser

Full name

Paired box protein Pax-6      

Alternative Name

Oculorhombin
Aniridia type II protein

Transcription factor

PAX

Location in the cell

Nuclear   Reliability : 4.736

CDS

ATGCACAGCGCGGCTATGGGTGGTGGAGGCCTCTTCGGATGCTCGTCGGCTGGTCACAGCGGCATCAATCAGCTGGGCGGGGTCTACGTCAACGGACGACCGCTGCCGGACTCGACTCGGCAAAAGATCGTGGAACTAGCCCACTCCGGAGCTAGACCCTGCGACATCAGCCGCATCCTGCAGGTCTCCAACGGCTGTGTCTCCAAAATACTAGGCAGCTTCACACGCAGATATTACGAGACGGGGTCGATAAAGCCACGCGCGATTGGTGGGTCCAAGCCCCGGGTGGCGACCACTCCAGTTGTCCAGAAGATAGCCGACTACAAGCGGGAGTGCCCCTCGATCTTCGCCTGGGAGATCAGGGACCGCCTGCTCAGCGAAAACGTGTGCAATAACGACAACATACCCAGTGTGTCATCAATAAACCGAGTACTACGGAACCTGGCCTCGCAGAAGGAGCAAGCGGCATCAGCGCAGAACGATAGCGTGTATGAGAAACTGAGGATGTTCAATGGTCAAGCGGCGACTGGATGGTGGTATCCAGGGCTACCCACCGCGCCGACCGCACCGGCGATACCAGCCCCACTGCCCCCTCAACTCAGGACCACAACAGAAGAGCAGAAACGAGATACAATTCAGTCGGAAGCGGGTTCAGACGGGAACAGTGAACATGCGTCATCAGGCGACGAGGACTCGCAGATGAGACTCCGATTGAAGAGGAAACTCCAGAGGAACAGGACCAGTTTCACAAATGACCAAATAGATAGTCTCGAGAAGGAATTCGAGAGGACCCACTACCCGGACGTGTTCGCCCGGGAGAGACTCGCTGAAAAGATTGGATTGCCTGAGGCACGTATCCAGGTATGGTTCTCAAATCGTCGTGCAAAATGGCGTCGCGAAGAGAAACTCCGGAGCCAGCGTCGCGACGCGCCGGCCGCGTCTCCTCCCGCACCCCCCGCGCCGCGACTCCCCCTCAATGGAGGCTTCAATTCCATGTACAGCCCCATACCGCAACCCATTGCCACAATGGCTGATTCTTACAGCTCGATGTCTGGTGGGCTCTCCTCATCGTGTCTCCAGCAGCGAGACGGCGGCTACCCCTACATGTTCGGGGACGTCCTCGCCAGCGGAGGGTACTCCAGAGCCCCGGCAGCGCATCAGCAGCACCCGGCTTACTCACAGCCACAGCCCGCTGGCAGTACGGGTGTGATATCGGCGGGCGTGAGCGTACCCGTGCAGATACCGTCGCAGGGGCCCGACCTCGCGTCCAACTACTGGGGCCGGCTCCAGTGA

Protein

MHSAAMGGGGLFGCSSAGHSGINQLGGVYVNGRPLPDSTRQKIVELAHSGARPCDISRILQVSNGCVSKILGSFTRRYYETGSIKPRAIGGSKPRVATTPVVQKIADYKRECPSIFAWEIRDRLLSENVCNNDNIPSVSSINRVLRNLASQKEQAASAQNDSVYEKLRMFNGQAATGWWYPGLPTAPTAPAIPAPLPPQLRTTTEEQKRDTIQSEAGSDGNSEHASSGDEDSQMRLRLKRKLQRNRTSFTNDQIDSLEKEFERTHYPDVFARERLAEKIGLPEARIQVWFSNRRAKWRREEKLRSQRRDAPAASPPAPPAPRLPLNGGFNSMYSPIPQPIATMADSYSSMSGGLSSSCLQQRDGGYPYMFGDVLASGGYSRAPAAHQQHPAYSQPQPAGSTGVISAGVSVPVQIPSQGPDLASNYWGRLQ

Description

Transcription factor with important functions in the development of the eye, nose, central nervous system and pancreas. Required for the differentiation of pancreatic islet alpha cells. Competes with PAX4 in binding to a common element in the glucagon, insulin and somatostatin promoters. Regulates specification of the ventral neuron subtypes by establishing the correct progenitor domains (By similarity).
Transcription factor with important functions in the development of the eye, nose, central nervous system and pancreas. Required for the differentiation of pancreatic islet alpha cells (By similarity). Competes with PAX4 in binding to a common element in the glucagon, insulin and somatostatin promoters. Regulates specification of the ventral neuron subtypes by establishing the correct progenitor domains (By similarity). Isoform 5a appears to function as a molecular switch that specifies target genes.
Transcription factor with important functions in the development of the eye, nose, central nervous system and pancreas. Required for the differentiation of pancreatic islet alpha cells. Competes with PAX4 in binding to a common element in the glucagon, insulin and somatostatin promoters (By similarity). Regulates specification of the ventral neuron subtypes by establishing the correct progenitor domains.

Subunit

Interacts with MAF and MAFB. Interacts with TRIM11; this interaction leads to ubiquitination and proteasomal degradation, as well as inhibition of transactivation, possibly in part by preventing PAX6 binding to consensus DNA sequences.

Similarity

Belongs to the paired homeobox family.

Keywords

Alternative splicing   Complete proteome   Developmental protein   Differentiation   Direct protein sequencing   Disease mutation   DNA-binding   Homeobox   Nucleus   Paired box   Reference proteome   Transcription   Transcription regulation   Ubl conjugation   3D-structure   Peters anomaly   Repressor  

Feature

chain  Paired box protein Pax-6
splice variant  In isoform 3.
sequence variant  In AN1.

Uniprot

A0A194Q439   A0A194RC13   A0A3S2LG24   A0A212FLI3   D1ZZR4   A0A139WJ10   + More
A0A2J7PYX8   A0A1B6D7L7   A0A1B6HV64   A0A336L552   A0A336LKB8   E0VCT1   A0A1J1HK27   E2BA95   A0A146LD26   A0A1D2N7X8   K7J6S2   A0A195CKV0   A0A067RSK7   A0A226E7T7   T1JIT2   A0A0N8EJN0   W8BQD7   W8BW79   A0A0F7TDH4   A0A3B0KXY6   B5DRZ9   B4HC93   B4JZP2   B4NHL0   B4MEY7   B4L7D3   A0A0L0CCV2   B4IKQ3   Q9V490   Q9XZC2   A0A0J9S132   A0A1W4VHQ6   B3P9Q4   A8VFE9   A0A0R3P0G3   A0A3B0K3Y7   B3N1J5   A0A286XBI8   Q38L56   G1T0K0   A0A287D9N3   A0A2K6CL21   A0A2K6L4C8   G1P774   A0A2I2ZFV9   A0A287AAF3   A0A2K5Y8D0   A0A2R9CK82   A0A2K5MMA0   H0XKU3   A0A2K5JGR6   H9FV32   A0A2K6S284   A0A2K6GSJ3   A0A3Q7XWK9   A0A2Y9D899   A0A2J8WG99   A0A2U3WCG5   I7G9J6   A0A2J8P422   F6S4R0   Q66SS1   P63015   P26367   A0A0Q9WKW4   B3KQG1   A0A1S3FEX4   P63016   G3TZY7   A0A2K5QU00   A0A3Q7U5D5   W5Q3U9   Q1LZF1   A0A341C1H6   A0A2Y9F604   A0A340XHU6   A0A384A1M6   A0A3Q0D361   H0WX77   A0A1U7S5R9   A0A0Q9XFH6   K7G268   A0A1V4JP70   A4GG27   G1LK37   D3DQZ8   A0A401SVE9   G1KAP0   A0A401P0Q4   A0A2K5Y8E0   L0MPR7   Q9I877   A0A0J9USS3  

Pubmed

26354079    22118469    18362917    19820115    20566863    20798317    + More
26823975    27289101    20075255    24845553    24495485    15632085    17994087    18057021    20479145    26108605    10731132    12537568    12537572    12537573    12537574    16110336    17569856    17569867    26109357    26109356    10198632    22936249    21993624    19347868    22722832    25319552    17194215    16136131    25243066    1687460    11779807    16141072    15489334    1685142    1612585    1684639    9163426    17901057    18628401    21084637    1684738    1345175    17974005    16554811    7958875    7668281    18669648    19414065    20068231    24290376    10346815    9482572    8364574    8162071    8640214    9147640    9281415    9792406    9538891    9856761    10441571    10234503    9931324    10955655    10737978    11553050    11309364    11826019    12721955    12634864    12552561    16493447    17595013    21850189    24033328    16303743    24952136    7981749    11880342    24114637    20809919    17381049    17525177    20010809    11181995    30297745   

EMBL

KQ459585    KPI98175.1    KQ460627    KPJ13446.1    RSAL01000016    RVE53029.1    + More
AGBW02007765    OWR54587.1    KQ971338    EFA02830.2    KYB27953.1    NEVH01020341    PNF21538.1    GEDC01015648    JAS21650.1    GECU01029138    JAS78568.1    UFQS01001062    UFQT01001062    SSX08780.1    SSX28692.1    UFQT01000002    SSX17089.1    DS235063    EEB11187.1    CVRI01000005    CRK87764.1    GL446691    EFN87393.1    GDHC01013583    JAQ05046.1    LJIJ01000173    ODN01076.1    AAZX01005026    AAZX01014109    AAZX01018084    AAZX01021306    KQ977622    KYN01346.1    KK852485    KDR22799.1    LNIX01000006    OXA52716.1    JH431363    GDIQ01020228    JAN74509.1    GAMC01003100    JAC03456.1    GAMC01003098    JAC03458.1    LN624822    CEH19758.1    OUUW01000017    SPP88948.1    CH475404    EDY70832.1    CH479285    EDW25268.1    CH916380    EDV90908.1    CH964272    EDW83579.2    CM000831    CH940665    ACY70471.1    EDW71088.1    CH933813    EDW10927.1    JRES01000552    KNC30268.1    CH480855    EDW52643.1    AE014135    AY051487    AAF59395.4    AAK92911.1    AF134350    AAD31712.1    CM002916    KMZ07347.1    CH954184    EDV45217.1    EU169112    ABW23132.1    KRT05135.1    SPP88947.1    CH902659    EDV33930.1    AAKN02048405    DQ217589    ABA90484.1    AAGW02037526    AAGW02037527    AAGW02037528    AGTP01048264    AAPE02023618    CABD030078140    AEMK02000009    AJFE02107122    AJFE02107123    AAQR03002365    JU334738    AFE78491.1    NDHI03003391    PNJ68803.1    PNJ68805.1    PNJ68816.1    PNJ68817.1    PNJ68824.1    PNJ68831.1    PNJ68838.1    AQIA01020593    AB171050    BAE88113.1    AACZ04016470    NBAG03000219    PNI78767.1    PNI78769.1    PNI78780.1    PNI78781.1    PNI78788.1    PNI78795.1    PNI78802.1    GAMS01006506    GAMR01007056    JAB16630.1    JAB26876.1    AY707088    KT580798    KT580799    AAU12168.1    ALU11231.1    X63963    Y19196    Y19199    AK028059    AK139054    BC011272    BC036957    M77842    M77844    M93650    AY047583    BX640762    Z83307    Z95332    BC011953    KRF85331.1    AK074881    BAG52023.1    U69644    AJ627631    AY540905    AY540906    BC128741    S74393    AMGL01032799    AMGL01032800    AMGL01032801    AMGL01032802    BC116038    KRG07295.1    AGCU01126135    AGCU01126136    AGCU01126137    LSYS01006880    OPJ73971.1    DQ870843    ABI98848.1    ACTA01025499    ACTA01033499    ACTA01041498    ACTA01049498    CH471064    EAW68234.1    BEZZ01000593    GCC34394.1    BFAA01002958    GCB66691.1    AGB96570.1    AF154555    AF154556    AAF73272.1    KMZ07346.1   

Proteomes

UP000053268    UP000053240    UP000283053    UP000007151    UP000007266    UP000235965    + More
UP000009046    UP000183832    UP000008237    UP000094527    UP000002358    UP000078542    UP000027135    UP000198287    UP000268350    UP000001819    UP000008744    UP000001070    UP000007798    UP000008792    UP000009192    UP000037069    UP000001292    UP000000803    UP000192221    UP000008711    UP000007801    UP000005447    UP000001811    UP000005215    UP000233120    UP000233180    UP000001074    UP000001519    UP000008227    UP000233140    UP000240080    UP000233060    UP000005225    UP000233080    UP000233220    UP000233160    UP000286642    UP000248480    UP000245340    UP000233100    UP000002277    UP000008225    UP000000589    UP000005640    UP000081671    UP000002494    UP000007646    UP000233040    UP000286640    UP000002356    UP000009136    UP000252040    UP000248484    UP000265300    UP000261681    UP000189706    UP000189705    UP000007267    UP000190648    UP000008912    UP000287033    UP000001646    UP000288216   

PRIDE

Q9V490    Q9XZC2    P63015    P26367    P63016    Q1LZF1    + More

Pfam

PF00292   PAX        + More
PF00046   Homeodomain

Interpro

IPR001356   Homeobox_dom        + More
IPR036388   WH-like_DNA-bd_sf       
IPR009057   Homeobox-like_sf       
IPR017970   Homeobox_CS       
IPR001523   Paired_dom       

SUPFAM

SSF46689   SSF46689       

Gene 3D

1.10.10.10    

CDD

cd00086  homeodomain
cd00131  PAX

ProteinModelPortal

A0A194Q439   A0A194RC13   A0A3S2LG24   A0A212FLI3   D1ZZR4   A0A139WJ10   + More
A0A2J7PYX8   A0A1B6D7L7   A0A1B6HV64   A0A336L552   A0A336LKB8   E0VCT1   A0A1J1HK27   E2BA95   A0A146LD26   A0A1D2N7X8   K7J6S2   A0A195CKV0   A0A067RSK7   A0A226E7T7   T1JIT2   A0A0N8EJN0   W8BQD7   W8BW79   A0A0F7TDH4   A0A3B0KXY6   B5DRZ9   B4HC93   B4JZP2   B4NHL0   B4MEY7   B4L7D3   A0A0L0CCV2   B4IKQ3   Q9V490   Q9XZC2   A0A0J9S132   A0A1W4VHQ6   B3P9Q4   A8VFE9   A0A0R3P0G3   A0A3B0K3Y7   B3N1J5   A0A286XBI8   Q38L56   G1T0K0   A0A287D9N3   A0A2K6CL21   A0A2K6L4C8   G1P774   A0A2I2ZFV9   A0A287AAF3   A0A2K5Y8D0   A0A2R9CK82   A0A2K5MMA0   H0XKU3   A0A2K5JGR6   H9FV32   A0A2K6S284   A0A2K6GSJ3   A0A3Q7XWK9   A0A2Y9D899   A0A2J8WG99   A0A2U3WCG5   I7G9J6   A0A2J8P422   F6S4R0   Q66SS1   P63015   P26367   A0A0Q9WKW4   B3KQG1   A0A1S3FEX4   P63016   G3TZY7   A0A2K5QU00   A0A3Q7U5D5   W5Q3U9   Q1LZF1   A0A341C1H6   A0A2Y9F604   A0A340XHU6   A0A384A1M6   A0A3Q0D361   H0WX77   A0A1U7S5R9   A0A0Q9XFH6   K7G268   A0A1V4JP70   A4GG27   G1LK37   D3DQZ8   A0A401SVE9   G1KAP0   A0A401P0Q4   A0A2K5Y8E0   L0MPR7   Q9I877   A0A0J9USS3  

PDB

6PAX     E-value=2.43752e-60,     Score=589

KEGG

100529217    K08031 paired box protein 6 | (RefSeq) toy; twin of eyeless

GO

GO:0007275   GO:0043565   GO:0006355   GO:0005634   GO:0003677   GO:0000977   GO:0000981   GO:0048854   GO:0045944   GO:0016319   GO:0008056   GO:0006357   GO:0048749   GO:0010628   GO:0035214   GO:0021778   GO:0019901   GO:0005654   GO:0030858   GO:0060041   GO:0021902   GO:0007435   GO:0005829   GO:0070410   GO:0070412   GO:0002052   GO:0035035   GO:0000790   GO:2000178   GO:0021986   GO:0048708   GO:0031625   GO:0030334   GO:0001764   GO:0006366   GO:0021912   GO:0021983   GO:0033365   GO:0000978   GO:0001228   GO:0000132   GO:0050680   GO:0021918   GO:0061303   GO:0042593   GO:0001227   GO:0023019   GO:1904798   GO:0021913   GO:0007224   GO:0001568   GO:0003309   GO:0071837   GO:0048505   GO:0001933   GO:0021796   GO:0009611   GO:0000979   GO:0008134   GO:0003322   GO:0001709   GO:1990830   GO:0045665   GO:0007411   GO:0021798   GO:0048596   GO:0030216   GO:0009786   GO:0009950   GO:0032808   GO:0021905   GO:0003682   GO:0042462   GO:0061072   GO:0002088   GO:0045893   GO:0009953   GO:0009952   GO:0022027   GO:0044212   GO:1901142   GO:0070094   GO:0021978   GO:0005737   GO:0021772   GO:0042660   GO:0002064   GO:0061034   GO:0007420   GO:2001224   GO:0045664   GO:0021543   GO:0030900   GO:0098598   GO:0043010   GO:0050767   GO:0120008   GO:0030154   GO:0010942   GO:0008285   GO:0001755   GO:0045165   GO:1904937   GO:0021593   GO:0061351   GO:0003310   GO:0010468   GO:0005667   GO:0007409   GO:0003700   GO:0003680   GO:0003690   GO:0030902   GO:0010975   GO:0003002   GO:0001654   GO:0048663   GO:0009887   GO:0007601   GO:0050768   GO:0007417   GO:0071333   GO:0021510   GO:0021549   GO:0071380   GO:0032869   GO:0044344   GO:0045471   GO:0035690   GO:0004842   GO:0016021   GO:0003917   GO:0016887   GO:0030145   GO:0006412   GO:0016876   GO:0043039  

Subcellular location

Nucleus  

Length:

430

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.0475600000000001

Exp number, first 60 AAs:

0.04327

Total prob of N-in:

0.00385

outside

1  -  430

 

 

Pi

223.859866

Theta

171.907535

Tajima's D

0.805001

CLR

0.179202

CSRT

0.605119744012799

Interpretation

Uncertain