Gene

KWMTBOMO08271

Pre Gene Modal

BGIBMGA009524

Annotation

Hermansky-Pudlak_syndrome_5_[Bombyx_mori]

Location

Bomo_Chr14(+):3162035-3172309      View in EpiBrowser

Full name

Hermansky-Pudlak syndrome 5 protein homolog      

Alternative Name

Protein pink
dHPS5

Location in the cell

Nuclear   Reliability : 2.524

CDS

ATGCCTCCTCCTTATATATTGCAGGAACTTCCAAATGTTACAGAATGCATTAATTACCCAATCAAAAATGTACAACGTATAAAGTACACGTGCTTTGATGTTTCAAAATCGCTGTTAGCATTTGGAGCTACGAGTGGTGGTATTTACATATTCAACAAGAATCCGTGTGAATTTGTGCAACTGATTCCAAATAAGGATGGCGCTATCACGCGTCTTTCAATATCGGCTGACGAGAAGCACGTTGGCTTCGCGAATGGGCGCGGTGTTATCACGGTGTCAGGGTGCGAACAGGGTCCCAACGCCCTGCATTCGGTAGTCACGTCCAAGGAGCACCAGGGCAACGAGGTCACCGCGCTGGCCTGGAGCGGCAACATGCTCTTTAGCGGCGATGACGTAGGCAAGATAGCGGTCCTGCAGCTGCAGAGTTTCATCGCAAAAACAATGTTCCAGAGTTCGTCGCAAACGATCATGAATTTGGATTCTCGTGTATGTCAAATTGACGTAAAATCGTATATGCTATTGGTATCGACGTTGACCCGGTGTTATCTATGCGACACGACCGAAGAACAATACAGGCAGATAGGCCAGAAACTAAGGGACGGCGAATTCGGTGCTTGTTTCGTTAACAAAGAGAACGCCGTCGAGATTAACATTAAGAACAAAGTTAAGGATTATTCGGAAGTCAGGAAATACAGTATTATCAACGAGGACAGCAGCTTCGCCGTCGGTAGGGGATTGGATAACACATTGGTCTTCGCCGCCAGACCCTCGTCTCGGCTGTGGGAAGCCGCCGTCGATGGGACAGTCAAAAGGACGCACCAGTTCAAACAGATTTTAGGAAGGAGTCCCATGAATATTCTAACAGTAGACGCTTATGAACACGAAAGACATAGTTTCGATGAAATGGCCACTATTAACGCTGACGGCCTATCGGTCAATTTTCCGAGGATCTTCAATCTCAATGGCGTCATATTTTCGTACAAGAAAGACGCTCTTTTCTTTCTCAACTTGGATAATGTTGACCACACGATTTGGTGCGCTCGTTACAAAAGCATAGCCGACTGTAAGGTCTACGGTGATGCGATATACGTTTGGCTAAATAACGGATCGTTAATCAATTTGAAGTTCATGAAAATAGACAAATTCCTGATCAAATGTTACGTCGATGACAAGCATCGTTTGTGTGCGAATTTGTGTGCTCAATACAAAGATTATTTACTGGCCAACGAGATGTCAACGAGGCTGCACATCCTCGCCGGGCTGAAAGAGAAAATTGACGATAAAGAACTGCTGGAAACTATCCATACTCTGTTAGTGAAGTTCGAAAGATTGAAAGAGAACGAAGCCAAGAAAGTGAAATCTGGGATATACGTGGTTGACAATACGTATAACGCACAAACTTCATTGATGAGTGAAATGGATAAAACAATCGACAATAACGAAGAATATAGTTTCGGTAACATACCACCGGAGGCCATGCAGACGCTGAAAGACTTCAGTGTGTCGGTCACGGACAGATTGAATACGAGTAAAAAGATTTTAAAAGAGAAATGGGACGACTTCGAAGGGAAAATGAAGCACCTCAGTGTCGAGAAACCGCAAGAGAAACTAATTATGCCCCCCGCCCAAACTCCCAAAATAATATCAAGAGATGAACCTTTAGCTCTTGATCAAACGCCTGTATTGGAACGCGATATAGTCTTCAAACAACCTAGTCAAAAAGCCATAGAAATAGAAAATAATATTAGCTCAGACAAAGACGATATCTGTAAATCTCTCTATCAATATTTTAGGTTAAGCCTCGTCGGTAAGGAAGATGAAAAATCGAATTTAATTTCTATTATAGAAAGCTTCGCCTGTGATATTAGGTCAGTTTACGAATTGATGAGACTGTTGGAGGATTATTGCGCGTCCGTCGGCTCGCCGGAGGAATCTAAATACGTACCGAACAATATATTCTTGAAGTATTTAAGCGAGACGACGAAACGGGCCCAGTTCTTGGACTGCATCATAAGTGATGAGGTTCTGTACAAATACTTTGTCGACTCCTGCATATCGGTTAATCTGAAGGGTCAGAAACATACGGACTTTGGTTGCGAGTGCGGCTACCCGCTTCCTTACGCCAGGACCAAGCAAAACCCGATCTTCTTCGAGCTGATCGACGAATTCATCGAGAGACAGTGGTCTAGTCCGACGAAAGAGCAATGCTACGACACGTGCAAACGGATGCCGTATTTATGGAGGAAAATTTTATATTTGAGACGAAACGAAGATCTCGTGAATATCTTGAGGATATTAATGCAGATGCTGGATGAGAGTTTGCTGCACAACTTCCTGCCGCAGTTCACTTTGGACAGCTGGAGTAGAGCGGTCCAGCTGTACGCCACGTTGCACGCGAACGTTTGTCTGAACTGCTCGAAGAAGTTCAGCAACGTTTCCGTCAAGGACACGCTGTGCTGGGACGATCTGGGGGCGCTGATGATCAAAAGCGTCGGCGGAAGGAACTCGCTTAGGATAATGGAGGAGCATTCACGTCTGATAGAGCCGGGCGAGGTGACCGTCAAGTTCTATCACACATGCCTGATGGTTACCATGTTCGAGAAGTATGATTCGACGGTGACAGCGCAACTAGTCGACGCTCTATACACCAGCTATAGATATGAAGATTCTAAACATGAGATATGCAATCTTCTTCGAAACACAACAGGAGGACAACTGAAGAACACTTCCTTGCCGATATCGGTGGCAGCGAAGTCCCGGCACTGGGGCCTGAAGCCGTTAGCTTCGAACGATAAAAACGATTTCACCGATATTTTAGATAACATAGCCGACATTAACAACGGGGTATCCGATTGCGCTCTGTGCGGGCTGCCGTTACGAAATGACGTTTTGATCAAAGATGGCGGACTCTGGGTTTTTAAATGCGGCCACACTTTCCACGGTGCGTGTTTGGATTTAAACAAACTGAAACTGTGCCCGCACGCTTGTGCGTGTAAAAGCGTCGATGTTAAATGA

Protein

MPPPYILQELPNVTECINYPIKNVQRIKYTCFDVSKSLLAFGATSGGIYIFNKNPCEFVQLIPNKDGAITRLSISADEKHVGFANGRGVITVSGCEQGPNALHSVVTSKEHQGNEVTALAWSGNMLFSGDDVGKIAVLQLQSFIAKTMFQSSSQTIMNLDSRVCQIDVKSYMLLVSTLTRCYLCDTTEEQYRQIGQKLRDGEFGACFVNKENAVEINIKNKVKDYSEVRKYSIINEDSSFAVGRGLDNTLVFAARPSSRLWEAAVDGTVKRTHQFKQILGRSPMNILTVDAYEHERHSFDEMATINADGLSVNFPRIFNLNGVIFSYKKDALFFLNLDNVDHTIWCARYKSIADCKVYGDAIYVWLNNGSLINLKFMKIDKFLIKCYVDDKHRLCANLCAQYKDYLLANEMSTRLHILAGLKEKIDDKELLETIHTLLVKFERLKENEAKKVKSGIYVVDNTYNAQTSLMSEMDKTIDNNEEYSFGNIPPEAMQTLKDFSVSVTDRLNTSKKILKEKWDDFEGKMKHLSVEKPQEKLIMPPAQTPKIISRDEPLALDQTPVLERDIVFKQPSQKAIEIENNISSDKDDICKSLYQYFRLSLVGKEDEKSNLISIIESFACDIRSVYELMRLLEDYCASVGSPEESKYVPNNIFLKYLSETTKRAQFLDCIISDEVLYKYFVDSCISVNLKGQKHTDFGCECGYPLPYARTKQNPIFFELIDEFIERQWSSPTKEQCYDTCKRMPYLWRKILYLRRNEDLVNILRILMQMLDESLLHNFLPQFTLDSWSRAVQLYATLHANVCLNCSKKFSNVSVKDTLCWDDLGALMIKSVGGRNSLRIMEEHSRLIEPGEVTVKFYHTCLMVTMFEKYDSTVTAQLVDALYTSYRYEDSKHEICNLLRNTTGGQLKNTSLPISVAAKSRHWGLKPLASNDKNDFTDILDNIADINNGVSDCALCGLPLRNDVLIKDGGLWVFKCGHTFHGACLDLNKLKLCPHACACKSVDVK

Description

Has a role in the biogenesis of eye pigment granules. Eye pigment granules are specialized forms of late endosomes or lysosomes. Biogenesis of pigment granules in the eye requires molecular components required for protein delivery to lysosomes.
Has a role in the biogenesis of eye pigment granules. Eye pigment granules are specialized forms of late endosomes or lysosomes. Biogenesis of pigment granules in the eye requires molecular components required for protein delivery to lysosomes (By similarity).

Miscellaneous

Pink was the second eye color gene identified by Morgan and colleagues, mutant flies were isolated in June 1910 just 2 months after isolation of the first white mutant allele. Another mutant allele of pink, peach, was isolated by Bridges in 1913, and according to a review published by Bridges and Morgan 10 years later, these alleles represented the first case of multiple allelomorphs described for an autosomal gene in Drosophila.

Similarity

Belongs to the HPS5 family.

Keywords

Complete proteome   Pigment   Reference proteome   Repeat   Sensory transduction   Vision   WD repeat  

Feature

chain  Hermansky-Pudlak syndrome 5 protein homolog

Uniprot

M0QVX1   H9JJ23   M0QVX4   M0QVX3   A0A2A4J728   A0A1E1WP95   + More
A0A3S2M7U0   A0A0N1IPK8   A0A212F378   A0A194Q429   A0A0L7L948   A0A2H1VJK2   A0A1W4XJV3   A0A1Y1KQG5   E2AFK3   A0A3L8DG63   A0A151IJ12   A0A195ED85   A0A0C9S1Q5   K7J2Q9   A0A088A459   A0A232EUT4   A0A034W1R3   A0A0K8VNK4   B3LWX4   A0A026WVL8   A0A1W4VQJ3   W8AUU0   A0A0A1XQ96   A0A0L0CKQ8   B3P4V2   U3PV63   Q9VHN9   A0A1A9VSL3   A0A1B0GDM7   B4PT82   A0A1A9Z4Y8   B4G456   B4M503   A0A1B0ATY2   Q297N8   A0A1I8PZ20   A0A1A9YAE0   B4HL38   A0A1A9W483   A0A1I8N8S9   B4KCP4   A0A336MFQ0   A0A1B0CBV7  

Pubmed

19121390    26354079    22118469    26227816    28004739    20798317    + More
30249741    20075255    28648823    25348373    17994087    24508170    24495485    25830018    26108605    10731132    12537568    12537572    12537573    12537574    16110336    17569856    17569867    26109357    26109356    12537569    9714595    17632576    17156100    17550304    15632085    25315136   

EMBL

AB542958    BAK95882.1    BABH01023206    BABH01023207    AB542961    BAK95885.1    + More
AB542960    BAK95884.1    NWSH01002649    PCG67761.1    GDQN01002250    JAT88804.1    RSAL01000016    RVE53023.1    KQ460426    KPJ14783.1    AGBW02010618    OWR48173.1    KQ459585    KPI98165.1    JTDY01002141    KOB72017.1    ODYU01002901    SOQ40971.1    GEZM01076787    JAV63653.1    GL439118    EFN67754.1    QOIP01000008    RLU19435.1    KQ977417    KYN02848.1    KQ979074    KYN22782.1    GBYB01014716    JAG84483.1    NNAY01002089    OXU22111.1    GAKP01010318    JAC48634.1    GDHF01012174    JAI40140.1    CH902617    EDV43813.1    KK107085    EZA60038.1    GAMC01013920    GAMC01013919    JAB92635.1    GBXI01002941    GBXI01000793    JAD11351.1    JAD13499.1    JRES01000344    KNC32049.1    CH954181    EDV49896.1    BT150357    AE014297    AGW52166.1    ALI30542.1    AY089625    AAF54263.1    AAL90363.1    CCAG010011968    CM000160    EDW96543.1    CH479179    EDW25094.1    CH940652    EDW59714.1    JXJN01003465    CM000070    EAL28167.1    CH480815    EDW43002.1    CH933806    EDW15893.1    UFQS01001167    UFQT01001167    SSX09330.1    SSX29232.1    AJWK01005874   

Proteomes

UP000005204    UP000218220    UP000283053    UP000053240    UP000007151    UP000053268    + More
UP000037510    UP000192223    UP000000311    UP000279307    UP000078542    UP000078492    UP000002358    UP000005203    UP000215335    UP000007801    UP000053097    UP000192221    UP000037069    UP000008711    UP000000803    UP000078200    UP000092444    UP000002282    UP000092445    UP000008744    UP000008792    UP000092460    UP000001819    UP000095300    UP000092443    UP000001292    UP000091820    UP000095301    UP000009192    UP000092461   

PRIDE

M0QVX1    H9JJ23    M0QVX4    M0QVX3    Q9VHN9    Q297N8    + More

Pfam

PF07679   I-set

Interpro

IPR015943   WD40/YVTN_repeat-like_dom_sf        + More
IPR036322   WD40_repeat_dom_sf       
IPR001841   Znf_RING       
IPR036179   Ig-like_dom_sf       
IPR003598   Ig_sub2       
IPR013098   Ig_I-set       
IPR036465   vWFA_dom_sf       
IPR013783   Ig-like_fold       
IPR003599   Ig_sub       
IPR007110   Ig-like_dom       
IPR035431   HPS5       

SUPFAM

SSF50978   SSF50978        + More
SSF53300   SSF53300       
SSF48726   SSF48726       

Gene 3D

2.130.10.10     2.60.40.10    

ProteinModelPortal

M0QVX1   H9JJ23   M0QVX4   M0QVX3   A0A2A4J728   A0A1E1WP95   + More
A0A3S2M7U0   A0A0N1IPK8   A0A212F378   A0A194Q429   A0A0L7L948   A0A2H1VJK2   A0A1W4XJV3   A0A1Y1KQG5   E2AFK3   A0A3L8DG63   A0A151IJ12   A0A195ED85   A0A0C9S1Q5   K7J2Q9   A0A088A459   A0A232EUT4   A0A034W1R3   A0A0K8VNK4   B3LWX4   A0A026WVL8   A0A1W4VQJ3   W8AUU0   A0A0A1XQ96   A0A0L0CKQ8   B3P4V2   U3PV63   Q9VHN9   A0A1A9VSL3   A0A1B0GDM7   B4PT82   A0A1A9Z4Y8   B4G456   B4M503   A0A1B0ATY2   Q297N8   A0A1I8PZ20   A0A1A9YAE0   B4HL38   A0A1A9W483   A0A1I8N8S9   B4KCP4   A0A336MFQ0   A0A1B0CBV7  

KEGG

100739997    K20191 Hermansky-Pudlak syndrome 5 protein | (RefSeq) BmHPS5; Hermansky-Pudlak syndrome 5

GO

GO:0031409   GO:0007601   GO:0050896   GO:0005737   GO:0006622   GO:0060967   GO:0048072   GO:0006727   GO:0006726   GO:0031084   GO:0005515   GO:0016787   GO:0046872   GO:0003917   GO:0016887   GO:0005634   GO:0030145   GO:0006412   GO:0016876   GO:0043039  

Length:

1004

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.0794199999999998

Exp number, first 60 AAs:

0.07883

Total prob of N-in:

0.00391

outside

1  -  1004

 

 

Pi

201.62102

Theta

168.58235

Tajima's D

1.053327

CLR

0.210932

CSRT

0.673116344182791

Interpretation

Uncertain