Gene

KWMTBOMO08264  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA009442

Annotation

hypothetical_protein_KGM_12367_[Danaus_plexippus]

Location

Bomo_Chr14(-):3103436-3112534      View in EpiBrowser

Full name

Hemicentin-1      

Alternative Name

Fibulin-6

Location in the cell

Nuclear   Reliability : 1.259 PlasmaMembrane   Reliability : 1.451

CDS

ATGTTCCGAATAGAACCGAAACAAGGGAAATATTGTATGTTCATTCGGACTCACGAGGTAGTTTCAGTAACGCTGTACATAAAAAGTGATTTGGTCTTCTGTTTCGGATTCTCACCTAAATACCCTAAATCATTGGAGGAGACCAGCACTAGGCCTATGGCAGGTCGTTCGAACTACATACTAATAAGCGTAGTGGACACAAAGATACGATTGGTTTCGTTGGAAATGAAATGTGGTAATATGACGACTGTCATAAGCTTTGAATATACCACTAACGAAAGGTATTACACGAGCAGAGCATTTGTGGATCCCAACAGATTATGTCGCATCACGGCAATAGGAGAGGATGAGAATTCTCAAGGATTTATAGGTGCTACAAAGTTACTCAAGCCACAAGAACAAGTGTCAAATATTTCGGCGCTAAAACCAACTGTAGTGATTATTGATCCAGAATATACGCTGTTCGACTTTGGCACCGATGTTTCATTGACGTGCAAAATAAAAGGACATCCAGAGCCTGTTGTGAAATGGGAAGATGATGACGGCCACTTACATCCTTCCGAGCTGATCCTGCTCGAATTACCCTCGACTTACATCAGTTACGTTACGATAACGAACATAACACGGAACATGACCATTTCCTGCAAAGCTGAGAACACAGAAGGTTCATCTGAAACCAGTCTCCATGTTTATATTAACAAGACATTTACTTTTGACATTGTGCAAACGCCGTCAGATATAACAATAGAATACGGCGAAGAAGATACAGTATTTTGTGAGGTGTCTGCTTACCCCGAAGCCACCACAAAATGGTATCACAACAACTCCGAAATAGTCTCCTCCCAGAATCTCCAGCTGATACCAGACGACAATGCCATGGTTATTAAAAACATGACTTTAGATTACACGGGCGATTATAAATGTGTCGTCGAGAACGTCGCTAATAAAAAAGAATTTGATTTTGTCATCAGTATATCCGGCTTGGAATCCCCTCAGATTGAAATCAATACACGAGAAATCGTATTGAGACCAGGTGATTCAGCGGAACTCAATTGCAGGATCTTGAAAGGAAATCCTGCCCCTCTTATCACTTGGCAACACAAATCTGCAGACGAATTCGCTTCTGACGAACTACCCGAATATTCTATTATAGTTGGAAATAAGCTTAGGATTTTATCTATTAAAAAGGAACATGAAGGAATATACCGATGCACAGCTGTAAATCTCATGGGCGAAAGCTCAGCGGAAGTAACGTTGAAAGTTCAATTTGCTCCTGTCATTAAAGATGATGTTATATATCCCCAAACTGTGCCGGTGAAGGAGGGAGATAATGTGGAACTACCTTGTGACGTCACAGCATCACCGGAAGCTGTAGTTAGATGGGAAATGTCACAAGATGATGTTATAATCCCACTGGATCAAAGACACGTTACAGATGACCAGAATACACATAGATTTACTGCCTTGTGGAGAGATTCCGGTCATTATCACTGTATTGCCGAAAATGCCCTGGGAACAGCAAAGAAAACCATTCTAGTAAATGTCTTAGTGGCCCCATACATCGAAACACCACAGTCAAAAACATTGACAGTTCGTTCAGGCTCAACTGTCAAACTAGCGTGCAACGTTCTATACGGTAATCCGGCTCCATCTTTGAAATGGAAATTCATAAATAAGGATTCCACGTCTAGGATACTCAGAAACAACAGGACGAGTTCGTTAACCTTGAACAATGTCAACAAATTAAATGAAGGTTCCTATATGTGCATCGTGGACAATGCACTAGGCTCTGACAGGATTAAATATCAATTAAAAGTTGAATAA

Protein

MFRIEPKQGKYCMFIRTHEVVSVTLYIKSDLVFCFGFSPKYPKSLEETSTRPMAGRSNYILISVVDTKIRLVSLEMKCGNMTTVISFEYTTNERYYTSRAFVDPNRLCRITAIGEDENSQGFIGATKLLKPQEQVSNISALKPTVVIIDPEYTLFDFGTDVSLTCKIKGHPEPVVKWEDDDGHLHPSELILLELPSTYISYVTITNITRNMTISCKAENTEGSSETSLHVYINKTFTFDIVQTPSDITIEYGEEDTVFCEVSAYPEATTKWYHNNSEIVSSQNLQLIPDDNAMVIKNMTLDYTGDYKCVVENVANKKEFDFVISISGLESPQIEINTREIVLRPGDSAELNCRILKGNPAPLITWQHKSADEFASDELPEYSIIVGNKLRILSIKKEHEGIYRCTAVNLMGESSAEVTLKVQFAPVIKDDVIYPQTVPVKEGDNVELPCDVTASPEAVVRWEMSQDDVIIPLDQRHVTDDQNTHRFTALWRDSGHYHCIAENALGTAKKTILVNVLVAPYIETPQSKTLTVRSGSTVKLACNVLYGNPAPSLKWKFINKDSTSRILRNNRTSSLTLNNVNKLNEGSYMCIVDNALGSDRIKYQLKVE

Description

Promotes cleavage furrow maturation during cytokinesis in preimplantation embryos. May play a role in the architecture of adhesive and flexible epithelial cell junctions. May play a role during myocardial remodeling by imparting an effect on cardiac fibroblast migration.

Catalytic Activity

H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate

Keywords

Age-related macular degeneration   Alternative splicing   Basement membrane   Calcium   Cell cycle   Cell division   Cell junction   Complete proteome   Cytoplasm   Disease mutation   Disulfide bond   EGF-like domain   Extracellular matrix   Glycoprotein   Immunoglobulin domain   Polymorphism   Reference proteome   Repeat   Secreted   Sensory transduction   Signal   Vision  

Feature

chain  Hemicentin-1
splice variant  In isoform 3.
sequence variant  In dbSNP:rs7539719.

Uniprot

H9JIU1   A0A2H1VT69   A0A0N1PJI5   A0A0L7L9E3   A0A194PZJ6   A0A212F378   + More
A0A2A4IXE1   A0A437BRF1   A0A437B1H8   A0A212F6F9   A0A0N1IPC9   A0A2A4J8M3   A0A0N1I874   A0A2H1V2M3   A0A3S2LTX9   A0A3S2L5P2   H9JIJ3   A0A194PYQ7   A0A158R5T7   A0A2W1BAW8   G3NWN1   A0A3B4WM49   A0A194Q7A1   A0A3B4UEA3   G3H9S6   A0A2D0T6P7   A0A2U9C6G6   A0A3N0YC56   A0A0S7H0Q2   A0A0S7GZK4   A0A3P8WNL8   A0A087Y670   A0A210QUZ9   A0A1I7ZUY9   A0A2B4RR01   A0A1I7ZTZ0   W4Y7I7   A0A3Q2CT39   A0A158QVI2   A0A3S2N4W0   A0A2G9Q1G3   A0A1D5PQF5   A0A3Q3AIK5   A0A1D5PWR7   A0A0R3T0Q4   A0A1D5NYH4   A0A1D5PY27   A0A1D5PMN5   A0A2I4B518   A0A3B4E5X1   A0A0S7LGL7   A0A3B4G3M3   A0A2A4JKA5   A0A3Q1B6M5   A0A401SMA0   G1T5K0   A0A0K0EUT2   A0A146YJH4   M3YKJ2   I3JUM9   A0A2Y9DEM0   A0A147AWT0   A0A068XX77   A0A3P9NWC9   E4XJ18   A0A146YJD2   A0A146YJL7   A0A0N4ZRH6   H3ADQ7   A0A3Q2V180   A0A3Q7PIR6   A0A2Y9JST8   A0A091GDU5   Q96RW7-2   Q96RW7   A0A226NXN6   A0A146YLE1   A0A1U7UYH7   A0A146YKT7   A0A158REM4   E0VC72   A0A1S3KK60   A0A1S3KKA0   A0A1W5AAI4   F6R9N9   A0A3M0K585   A0A0P7X0M9   M3X1M2   A0A3Q7T881   A0A194PFK9   A0A1I7RWJ4   A0A1A7ZB19   A0A1I7U000   A0A1I7U001   A0A1A8AP34   M3ZJI9   A0A158Q3H3   A0A3B4Z1V9   G7MF24  

Pubmed

19121390    26354079    26227816    22118469    28756777    21804562    + More
24487278    28812685    26392177    15592404    30297745    21993624    25186727    23485966    21097902    9215903    14702039    16710414    14570714    24621616    20566863    18464734    17975172    21909270    23542700    22002653   

EMBL

BABH01023203    ODYU01004310    SOQ44045.1    KQ460426    KPJ14782.1    JTDY01002146    + More
KOB72005.1    KQ459585    KPI98164.1    AGBW02010618    OWR48173.1    NWSH01005792    PCG63944.1    RSAL01000016    RVE53022.1    RSAL01000206    RVE44350.1    AGBW02010045    OWR49308.1    KPJ14781.1    NWSH01002649    PCG67762.1    KPJ14779.1    ODYU01000391    SOQ35095.1    RVE44349.1    RSAL01000133    RVE46324.1    BABH01027071    BABH01027072    BABH01027073    BABH01027074    BABH01027075    BABH01027076    BABH01027077    BABH01027078    BABH01027079    BABH01027080    KPI98163.1    KZ150210    PZC72208.1    KQ459337    KPJ01408.1    JH000237    EGV94970.1    CP026254    AWP10692.1    RJVU01048406    ROL43461.1    GBYX01448277    JAO33197.1    GBYX01448276    JAO33198.1    AYCK01004151    AYCK01004152    AYCK01004153    NEDP02001728    OWF52578.1    LSMT01000353    PFX19596.1    AAGJ04172486    AAGJ04172487    AAGJ04172488    AAGJ04172489    AAGJ04172490    UXSR01005435    VDD81984.1    CM012440    RVE73540.1    KV922518    PIO09001.1    AADN05000650    UZAE01000104    VDN96274.1    GBYX01170112    JAO88629.1    NWSH01001280    PCG71863.1    BEZZ01000368    GCC31496.1    AAGW02054358    AAGW02054359    AAGW02054360    AAGW02054361    AAGW02054362    AAGW02054363    GCES01032044    JAR54279.1    AEYP01068968    AEYP01068969    AEYP01068970    AEYP01068971    AEYP01068972    AEYP01068973    AEYP01068974    AEYP01068975    AEYP01068976    AEYP01068977    AERX01012991    AERX01012992    AERX01012993    AERX01012994    AERX01012995    GCES01003303    JAR83020.1    LN902843    CDS36997.1    FN653057    CBY10461.1    GCES01032043    JAR54280.1    GCES01032047    JAR54276.1    AFYH01199621    AFYH01199622    AFYH01199623    AFYH01199624    AFYH01199625    AFYH01199626    AFYH01199627    AFYH01199628    AFYH01199629    AFYH01199630    KL448046    KFO79531.1    AF156100    AK056336    AK056557    AL118512    AL121996    AL133515    AL133553    AL135796    AL135797    AL391824    BX928748    AJ306906    AWGT02000278    OXB72513.1    GCES01032046    JAR54277.1    GCES01032048    JAR54275.1    UYWX01020384    VDM31969.1    DS235048    EEB10978.1    QRBI01000117    RMC08359.1    JARO02003647    KPP70078.1    AANG04001043    KQ459604    KPI92161.1    HADY01001021    SBP39506.1    HADY01018309    SBP56794.1    UYYG01001157    VDN56791.1    CM001253    EHH15721.1   

Proteomes

UP000005204    UP000053240    UP000037510    UP000053268    UP000007151    UP000218220    + More
UP000283053    UP000046393    UP000007635    UP000261360    UP000261420    UP000001075    UP000221080    UP000246464    UP000265120    UP000028760    UP000242188    UP000095287    UP000225706    UP000007110    UP000265020    UP000046399    UP000267029    UP000000539    UP000046398    UP000278807    UP000192220    UP000261440    UP000261460    UP000257160    UP000287033    UP000001811    UP000035680    UP000000715    UP000005207    UP000248480    UP000017246    UP000242638    UP000038045    UP000008672    UP000264840    UP000286641    UP000248482    UP000053760    UP000005640    UP000198419    UP000189704    UP000046396    UP000274429    UP000009046    UP000087266    UP000192224    UP000002279    UP000269221    UP000034805    UP000011712    UP000286640    UP000095284    UP000095282    UP000002852    UP000038040    UP000274756    UP000261400   

PRIDE

H9JIU1    H9JIJ3    G3H9S6    A0A1D5PWR7    Q96RW7   

Pfam

PF07679   I-set        + More
PF01223   Endonuclease_NS
PF14719   PID_2
PF13519   VWA_2
PF13895   Ig_2
PF00090   TSP_1
PF07645   EGF_CA
PF00047   ig
PF12662   cEGF
PF07474   G2F
PF00102   Y_phosphatase
PF00041   fn3
PF00052   Laminin_B
PF00008   EGF
PF00054   Laminin_G_1
PF00053   Laminin_EGF
PF02210   Laminin_G_2

Interpro

IPR013783   Ig-like_fold        + More
IPR007110   Ig-like_dom       
IPR003599   Ig_sub       
IPR013098   Ig_I-set       
IPR036179   Ig-like_dom_sf       
IPR003598   Ig_sub2       
IPR015943   WD40/YVTN_repeat-like_dom_sf       
IPR036322   WD40_repeat_dom_sf       
IPR036465   vWFA_dom_sf       
IPR001841   Znf_RING       
IPR001604   DNA/RNA_non-sp_Endonuclease       
IPR011993   PH-like_dom_sf       
IPR006020   PTB/PI_dom       
IPR033930   FAM43A/B_PTB       
IPR002035   VWF_A       
IPR000152   EGF-type_Asp/Asn_hydroxyl_site       
IPR000884   TSP1_rpt       
IPR036383   TSP1_rpt_sf       
IPR018097   EGF_Ca-bd_CS       
IPR013032   EGF-like_CS       
IPR000742   EGF-like_dom       
IPR009030   Growth_fac_rcpt_cys_sf       
IPR001881   EGF-like_Ca-bd_dom       
IPR013151   Immunoglobulin       
IPR013106   Ig_V-set       
IPR026823   cEGF       
IPR006605   G2_nidogen/fibulin_G2F       
IPR009017   GFP       
IPR006612   THAP_Znf       
IPR000387   TYR_PHOSPHATASE_dom       
IPR003961   FN3_dom       
IPR036116   FN3_sf       
IPR000242   PTPase_domain       
IPR029021   Prot-tyrosine_phosphatase-like       
IPR003595   Tyr_Pase_cat       
IPR016130   Tyr_Pase_AS       
IPR032984   Hemicentin-2       
IPR003006   Ig/MHC_CS       
IPR013320   ConA-like_dom_sf       
IPR002049   Laminin_EGF       
IPR000034   Laminin_IV       
IPR001791   Laminin_G       

SUPFAM

SSF48726   SSF48726        + More
SSF50978   SSF50978       
SSF53300   SSF53300       
SSF57184   SSF57184       
SSF82895   SSF82895       
SSF54511   SSF54511       
SSF52799   SSF52799       
SSF49265   SSF49265       
SSF49899   SSF49899       

Gene 3D

2.60.40.10     2.130.10.10     3.40.50.410     2.30.29.30     2.20.100.10     3.90.190.10    

CDD

cd01214  PTB_FAM43A
cd00255  nidG2
cd00063  FN3

ProteinModelPortal

H9JIU1   A0A2H1VT69   A0A0N1PJI5   A0A0L7L9E3   A0A194PZJ6   A0A212F378   + More
A0A2A4IXE1   A0A437BRF1   A0A437B1H8   A0A212F6F9   A0A0N1IPC9   A0A2A4J8M3   A0A0N1I874   A0A2H1V2M3   A0A3S2LTX9   A0A3S2L5P2   H9JIJ3   A0A194PYQ7   A0A158R5T7   A0A2W1BAW8   G3NWN1   A0A3B4WM49   A0A194Q7A1   A0A3B4UEA3   G3H9S6   A0A2D0T6P7   A0A2U9C6G6   A0A3N0YC56   A0A0S7H0Q2   A0A0S7GZK4   A0A3P8WNL8   A0A087Y670   A0A210QUZ9   A0A1I7ZUY9   A0A2B4RR01   A0A1I7ZTZ0   W4Y7I7   A0A3Q2CT39   A0A158QVI2   A0A3S2N4W0   A0A2G9Q1G3   A0A1D5PQF5   A0A3Q3AIK5   A0A1D5PWR7   A0A0R3T0Q4   A0A1D5NYH4   A0A1D5PY27   A0A1D5PMN5   A0A2I4B518   A0A3B4E5X1   A0A0S7LGL7   A0A3B4G3M3   A0A2A4JKA5   A0A3Q1B6M5   A0A401SMA0   G1T5K0   A0A0K0EUT2   A0A146YJH4   M3YKJ2   I3JUM9   A0A2Y9DEM0   A0A147AWT0   A0A068XX77   A0A3P9NWC9   E4XJ18   A0A146YJD2   A0A146YJL7   A0A0N4ZRH6   H3ADQ7   A0A3Q2V180   A0A3Q7PIR6   A0A2Y9JST8   A0A091GDU5   Q96RW7-2   Q96RW7   A0A226NXN6   A0A146YLE1   A0A1U7UYH7   A0A146YKT7   A0A158REM4   E0VC72   A0A1S3KK60   A0A1S3KKA0   A0A1W5AAI4   F6R9N9   A0A3M0K585   A0A0P7X0M9   M3X1M2   A0A3Q7T881   A0A194PFK9   A0A1I7RWJ4   A0A1A7ZB19   A0A1I7U000   A0A1I7U001   A0A1A8AP34   M3ZJI9   A0A158Q3H3   A0A3B4Z1V9   G7MF24  

PDB

6IAA     E-value=6.50577e-29,     Score=319

KEGG

101737476    no KO assigned | (RefSeq) roundabout homolog 3-like

GO

GO:0046872   GO:0016787   GO:0003676   GO:0005509   GO:0071711   GO:0033334   GO:0003677   GO:0016021   GO:0004725   GO:0005886   GO:0017134   GO:0005007   GO:0009617   GO:0030054   GO:0005938   GO:0005604   GO:0007049   GO:0051301   GO:0007156   GO:0038023   GO:0005201   GO:0007157   GO:0042803   GO:0062023   GO:0050839   GO:0005913   GO:0070062   GO:0007601   GO:0032154   GO:0050808   GO:0032589   GO:0005515   GO:0016705   GO:0020037   GO:0003917   GO:0016887   GO:0005634   GO:0030145   GO:0006412   GO:0016876   GO:0043039  

PANTHER

PTHR45889:SF4  

Subcellular location

Secreted   The antibody used to determine subcellular location does not distinguish between HMCN1 and HMCN2.   With evidence from 2 publications.
Extracellular space   The antibody used to determine subcellular location does not distinguish between HMCN1 and HMCN2.   With evidence from 2 publications.
Extracellular matrix   The antibody used to determine subcellular location does not distinguish between HMCN1 and HMCN2.   With evidence from 2 publications.
Basement membrane   The antibody used to determine subcellular location does not distinguish between HMCN1 and HMCN2.   With evidence from 2 publications.
Cytoplasm   The antibody used to determine subcellular location does not distinguish between HMCN1 and HMCN2.   With evidence from 2 publications.
Cell junction   The antibody used to determine subcellular location does not distinguish between HMCN1 and HMCN2.   With evidence from 2 publications.
Cleavage furrow   The antibody used to determine subcellular location does not distinguish between HMCN1 and HMCN2.   With evidence from 2 publications.

Length:

607

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.39696

Exp number, first 60 AAs:

0.39317

Total prob of N-in:

0.02070

outside

1  -  607

 

 

Pi

208.256721

Theta

163.597795

Tajima's D

0.924658

CLR

0.236796

CSRT

0.642117894105295

Interpretation

Uncertain