Gene

KWMTBOMO08253

Pre Gene Modal

BGIBMGA009520

Annotation

PREDICTED:_WD_repeat_domain_phosphoinositide-interacting_protein_4-like_[Amyelois_transitella]

Location

Bomo_Chr14(+):2833119-2844263      View in EpiBrowser

Full name

WD repeat domain phosphoinositide-interacting protein 4      

Alternative Name

WD repeat-containing protein 45
WD repeat domain X-linked 1

Location in the cell

Nuclear   Reliability : 3.161

CDS

ATGGCGCGCCGGAAGAGCAGTGGCATAACGAGCTTGAGTTTCAATCAGGACCAAGGCTGTTTCACATGCTGTCTGAAGACTGGCCTGCGTGTCTATAATGTGGAGCCCCTGGTCGAGAAGGCGCATTACAGCAAAGAGGAGCTGGGCGAGGTGTCCCTATGCGAGATGGTGTTCCGCACCAACTGGCTGCTCGTGGTGAAAGCTCGGAAGCCGTACAGCCTCCTCCTGCTGGACGACCAGCAACGTGCCTTCAAGGCTGAGGTGGTCTTCAAGTCGCCGATACGAGCGTTGCGGGCCAGGAAGGATAAGGTGGCCGTTGTCCTGACGTCCAGCGTACAGGTGTTGGCGTTGCCGACGTTCCAGCGGGTCGCGTTGCTGCGGACGCCGTCCTCCGCGAGGCCGCTGTGCGCCATCGCCACGGAACCCAACGCGACGCAGATACTGGCCGCGCCCGCGCACCGCACCGGATCCCTGCAGTTGCTCGTATGTCCTAAACGAATTAGCTTGCCACTGAGAGAGAGAGAGAGAGAGGGAGAGAGAGTGACAGAGTATGCTTTATCTATATACTAG

Protein

MARRKSSGITSLSFNQDQGCFTCCLKTGLRVYNVEPLVEKAHYSKEELGEVSLCEMVFRTNWLLVVKARKPYSLLLLDDQQRAFKAEVVFKSPIRALRARKDKVAVVLTSSVQVLALPTFQRVALLRTPSSARPLCAIATEPNATQILAAPAHRTGSLQLLVCPKRISLPLREREREGERVTEYALSIY

Description

Component of the autophagy machinery that controls the major intracellular degradation process by which cytoplasmic materials are packaged into autophagosomes and delivered to lysosomes for degradation (PubMed:21802374). Activated by the STK11/AMPK signaling pathway upon starvation, WDR45 is involved in autophagosome assembly downstream of WIPI2, regulating the size of forming autophagosomes. Probably recruited to membranes through its PtdIns3P activity.
Component of the autophagy machinery that controls the major intracellular degradation process by which cytoplasmic materials are packaged into autophagosomes and delivered to lysosomes for degradation. Activated by the STK11/AMPK signaling pathway upon starvation, WDR45 is involved in autophagosome assembly downstream of WIPI2, regulating the size of forming autophagosomes. Probably recruited to membranes through its PtdIns3P activity.

Subunit

Interacts with WIPI1. Interacts with WIPI2. Interacts with ATG2A and probably ATG2B. Interacts with ULK1. May interact with the PRKAA1, PRKAA2, PRKAB1 and PRKAG1 subunits of the AMPK kinase. May interact with NUDC.

Similarity

Belongs to the WD repeat SVP1 family.

Keywords

Autophagy   Complete proteome   Cytoplasm   Lipid-binding   Reference proteome   Repeat   WD repeat   Alternative splicing  

Feature

chain  WD repeat domain phosphoinositide-interacting protein 4
splice variant  In isoform 2.

Uniprot

H9JJ19   A0A2A4J4S2   A0A212FE34   A0A1E1W790   A0A437BPT6   A0A0N0PAJ5   + More
A0A0N0PEF1   A0A2H1VAV9   A0A3L8DAL3   A0A026VX33   E2AVG5   A0A0J7KF43   A0A1B6ETR2   A0A232EYI3   D6WAU4   A0A195FIA6   E2BG11   A0A195DML2   A0A158P229   A0A1B6K8W7   V5FXJ8   A0A2A3E5L3   A0A195AVP6   F4W6B1   A0A1B6CCC6   A0A310SM71   A0A0N0BGA0   A0A088AFS1   A0A067RIE8   K7IYT4   A0A0L7QQM6   A0A2P8Y0G2   E9IV48   A0A1Y1LTI5   A0A087UBH3   E0VDQ6   A0A154PFZ4   A0A023F363   A0A1D2N9S0   A0A146LK63   A0A146M1P0   A0A0V0GEV0   A0A0A9X9H4   A0A0A9Z0H1   A0A226E749   T1IZY0   A0A0P4VIS5   T1IAS7   A0A069DS68   J3JU06   A0A0P5SKV8   A0A0P5T0P0   A0A1E1XQK1   E9FSU7   A0A061HZC9   A0A2J8R8E2   C9J5L0   Q5U2Y0   A0A1E1XFZ8   A0A2R5L6Z6   A0A061HU59   A0A140LJJ0   A0A3N0Z758   V9L4T8   G3MNZ3   A0A023GIP4   A0A0N8E9T0   A0A0P5DJI5   Q91VM3-2   H3D7R7   A0A0N8ACD1   A0A341DE06   A0A337SL11   A0A140TAA5   G3HNC1   A0A1U8CKM2   H3D7R2   A0A341DDB3   Q91VM3   A0A3Q4GJR9   A0A293M1X8   A0A0N8DKE1   V9KW62   A0A1A6HSC9   A0A131Y346   C1BLV3   G1U133   A0A3B4YFZ7   A0A2K6CD98   A0A2K6LMI5   A0A2K5V6B2   A0A2I2YM53   A0A2K6A9D5   A0A2R9CAA1   A0A2I3MNN2   A0A2K6PT20   A0A2K5KLI2  

Pubmed

19121390    22118469    26354079    30249741    24508170    20798317    + More
28648823    18362917    19820115    21347285    21719571    24845553    20075255    29403074    21282665    28004739    20566863    25474469    27289101    26823975    25401762    27129103    26334808    22516182    23537049    29209593    21292972    23929341    15772651    15489334    21802374    28503490    19468303    21183079    24402279    22216098    10857745    16141072    15496914    17975172    15057822    21804562    29704459    25186727    21993624    22398555    22722832    25362486   

EMBL

BABH01023169    NWSH01003080    PCG66981.1    AGBW02008987    OWR51968.1    GDQN01008239    + More
JAT82815.1    RSAL01000021    RVE52416.1    KQ458751    KPJ05308.1    KQ459986    KPJ18840.1    ODYU01001573    SOQ37979.1    QOIP01000010    RLU17540.1    KK107670    EZA48195.1    GL443111    EFN62575.1    LBMM01008210    KMQ89053.1    GECZ01028488    JAS41281.1    NNAY01001634    OXU23369.1    KQ971312    EEZ98685.1    KQ981523    KYN40405.1    GL448096    EFN85413.1    KQ980724    KYN14072.1    ADTU01006971    GEBQ01032086    JAT07891.1    GALX01006076    JAB62390.1    KZ288391    PBC26361.1    KQ976731    KYM76251.1    GL887707    EGI70246.1    GEDC01026205    JAS11093.1    KQ763867    OAD54679.1    KQ435789    KOX74481.1    KK852614    KDR20207.1    KQ414786    KOC60816.1    PYGN01001092    PSN37664.1    GL766116    EFZ15578.1    GEZM01048873    JAV76311.1    KK119097    KFM74712.1    DS235083    EEB11512.1    KQ434896    KZC10737.1    GBBI01003029    JAC15683.1    LJIJ01000130    ODN01998.1    GDHC01011452    JAQ07177.1    GDHC01004901    JAQ13728.1    GECL01000322    JAP05802.1    GBHO01027308    JAG16296.1    GBHO01008294    GBRD01000427    JAG35310.1    JAG65394.1    LNIX01000006    OXA52914.1    JH431728    GDKW01002681    JAI53914.1    ACPB03005971    GBGD01002006    JAC86883.1    BT126717    KB632368    AEE61679.1    ERL93687.1    GDIP01138507    JAL65207.1    GDIP01137250    JAL66464.1    GFAA01001880    JAU01555.1    GL732524    EFX89757.1    KE685981    ERE63758.1    NDHI03003731    PNJ04776.1    AC231657    BC085816    GFAC01001179    JAT98009.1    GGLE01001119    MBY05245.1    ERE63759.1    AL671995    RJVU01007007    ROL54104.1    JW873627    AFP06144.1    JO843594    AEO35211.1    GBBM01001587    GBBM01001586    JAC33832.1    GDIQ01047828    JAN46909.1    GDIP01161290    GDIQ01118607    JAJ62112.1    JAL33119.1    AF229635    AK008427    AK145616    BC011479    GDIP01161289    LRGB01003123    JAJ62113.1    KZS04431.1    AANG04002273    AC130624    JH000543    RAZU01000328    EGW06093.1    RLQ59968.1    GFWV01008256    MAA32985.1    GDIP01025119    JAM78596.1    JW870280    AFP02798.1    LZPO01017290    OBS81124.1    GEFM01002868    JAP72928.1    BT075582    ACO10006.1    AAGW02040247    AAGW02040248    AAGW02040249    AQIA01084524    CABD030124443    CABD030124444    AJFE02020939    AHZZ02037104   

Proteomes

UP000005204    UP000218220    UP000007151    UP000283053    UP000053268    UP000053240    + More
UP000279307    UP000053097    UP000000311    UP000036403    UP000215335    UP000007266    UP000078541    UP000008237    UP000078492    UP000005205    UP000242457    UP000078540    UP000007755    UP000053105    UP000005203    UP000027135    UP000002358    UP000053825    UP000245037    UP000054359    UP000009046    UP000076502    UP000094527    UP000198287    UP000015103    UP000030742    UP000000305    UP000030759    UP000005640    UP000002494    UP000000589    UP000007303    UP000076858    UP000252040    UP000011712    UP000001075    UP000273346    UP000189706    UP000261580    UP000092124    UP000001811    UP000261360    UP000233120    UP000233180    UP000233100    UP000001519    UP000233140    UP000240080    UP000028761    UP000233200    UP000233060   

PRIDE

H9JJ19    C9J5L0    Q5U2Y0    Q91VM3    G3HNC1   

Pfam

PF00400   WD40        + More
PF03208   PRA1

Interpro

IPR036322   WD40_repeat_dom_sf        + More
IPR015943   WD40/YVTN_repeat-like_dom_sf       
IPR001680   WD40_repeat       
IPR017986   WD40_repeat_dom       
IPR032910   WIPI4       
IPR004895   Prenylated_rab_accept_PRA1       

SUPFAM

SSF50978   SSF50978       

Gene 3D

2.130.10.10    

ProteinModelPortal

H9JJ19   A0A2A4J4S2   A0A212FE34   A0A1E1W790   A0A437BPT6   A0A0N0PAJ5   + More
A0A0N0PEF1   A0A2H1VAV9   A0A3L8DAL3   A0A026VX33   E2AVG5   A0A0J7KF43   A0A1B6ETR2   A0A232EYI3   D6WAU4   A0A195FIA6   E2BG11   A0A195DML2   A0A158P229   A0A1B6K8W7   V5FXJ8   A0A2A3E5L3   A0A195AVP6   F4W6B1   A0A1B6CCC6   A0A310SM71   A0A0N0BGA0   A0A088AFS1   A0A067RIE8   K7IYT4   A0A0L7QQM6   A0A2P8Y0G2   E9IV48   A0A1Y1LTI5   A0A087UBH3   E0VDQ6   A0A154PFZ4   A0A023F363   A0A1D2N9S0   A0A146LK63   A0A146M1P0   A0A0V0GEV0   A0A0A9X9H4   A0A0A9Z0H1   A0A226E749   T1IZY0   A0A0P4VIS5   T1IAS7   A0A069DS68   J3JU06   A0A0P5SKV8   A0A0P5T0P0   A0A1E1XQK1   E9FSU7   A0A061HZC9   A0A2J8R8E2   C9J5L0   Q5U2Y0   A0A1E1XFZ8   A0A2R5L6Z6   A0A061HU59   A0A140LJJ0   A0A3N0Z758   V9L4T8   G3MNZ3   A0A023GIP4   A0A0N8E9T0   A0A0P5DJI5   Q91VM3-2   H3D7R7   A0A0N8ACD1   A0A341DE06   A0A337SL11   A0A140TAA5   G3HNC1   A0A1U8CKM2   H3D7R2   A0A341DDB3   Q91VM3   A0A3Q4GJR9   A0A293M1X8   A0A0N8DKE1   V9KW62   A0A1A6HSC9   A0A131Y346   C1BLV3   G1U133   A0A3B4YFZ7   A0A2K6CD98   A0A2K6LMI5   A0A2K5V6B2   A0A2I2YM53   A0A2K6A9D5   A0A2R9CAA1   A0A2I3MNN2   A0A2K6PT20   A0A2K5KLI2  

PDB

6IYY     E-value=2.63116e-19,     Score=230

KEGG

101736697    K22991 WD repeat-containing protein 45 | (RefSeq) WD repeat domain phosphoinositide-interacting prot

GO

GO:0006497   GO:0000422   GO:0034045   GO:0000045   GO:0032266   GO:0005829   GO:0034497   GO:0019898   GO:0080025   GO:0006914   GO:0000407   GO:1901981   GO:0009267   GO:0019901   GO:0016021  

PANTHER

PTHR11227:SF44  

Subcellular location

Preautophagosomal structure   Diffusely localized in the cytoplasm under nutrient-rich conditions. Localizes to autophagic structures during starvation-induced autophagy.   With evidence from 1 publications.
Cytoplasm   Diffusely localized in the cytoplasm under nutrient-rich conditions. Localizes to autophagic structures during starvation-induced autophagy.   With evidence from 1 publications.

Length:

189

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

5.4463

Exp number, first 60 AAs:

0.00075

Total prob of N-in:

0.47636

outside

1  -  189

 

 

Pi

257.396242

Theta

163.695794

Tajima's D

2.465917

CLR

0.239809

CSRT

0.941702914854257

Interpretation

Uncertain