Gene

KWMTBOMO08244

Pre Gene Modal

BGIBMGA009452

Annotation

PREDICTED:_multidrug_resistance_protein_homolog_49-like_[Bombyx_mori]

Location

Bomo_Chr14(-):2545662-2555113      View in EpiBrowser

Full name

Multidrug resistance protein homolog 49      

Alternative Name

P-glycoprotein 49

Location in the cell

PlasmaMembrane   Reliability : 2.735

CDS

ATGAATTTCGCCACCAAGGTCTCTGATGACTTGGAGAAGTTTCGCGAGGGTATAGGTGAGAAAGTCCCCATGCTCATCTATCTGGTGATGTCCTTTGTGACCGCTGTCATTATCTCGTTCGTGTATGGCTGGGAGCTCACGCTGGTCATTCTGTCTTGTACCCCGGTGGTGATCGCAACAACCGCTATAGTTGCAAAGGTGCAGTCATCGCTGACGACGCAAGAGCTGAAAGCCTATAGTGTGGCTGGTATCGTGGCTGAAGAGGTTCTGTCTTCAATCAGAACTGTCGTTGCTTTCGGAGGCGAAGAGAAAGAAATTAAAAGGTACAGCGTCCGCTTGGAGCCGGCGAACAAGATGGGGACACGTAAAGGAATATTTTCGGGCTTCGGAAGCGGGGTCATGTGGCTCATTATATACGGGACATACGCGCTGTCCTTCTGGTACGGAGTCGGCCTCATCCTGAAGTCTCGCCACCAGGAAACGCCTGTGTACACTCCAGCTGTGTTGATGATTATTTTCTTCAGTGTACTCCAAGGGGCTCAGAACGTTGGTCTTACCGCTCCTCATTTAGAGGCCATAGCGAACGCGCGAGCTTCTGCGGCCTCCGTCTATGCCGTCATCGATAGGAAACCGACTATTGACAGTCTCTCCACGGAAGGCGCCAAACCAGAGTTCAAGGGAGACCTGGAACTGGAAGACGTGGTCTTTAGATATCCGGCGAGAGCGGATGTGCAGGTTCTCAATGGATTAAATCTGAAAATAAACGAGAACGAAACGATAGCGCTGGTGGGTCCGAGCGGCTGCGGTAAGTCCACGGTCCTGCAGCTCTTACAGAGGATGTACGACCCCGACCAGGGCTCCGTGAGGGCCAGCGGCCATGACTTGCGGACCATGAACGTGAGGCACCTCAGAAATCACATCGCTGTCGTCGGCCAAGAACCAGTGCTGTTCGCGGGGACCATCAAAGAGAATATCCGAATGAGCAATCCATCTTGCACTGATGATGAGGTCATCGTAGCCGCTAAACAAGCTTACTGCCATGATTTCATAAGGAAATTGCCGGATGGCTACGACACGCCCATAGGCGAGCGCGGCGCCCAGCTCTCCGGCGGACAGAAGCAGCGCATCGCCATAGCTCGCGCGCTGGTGCGGCGCCCCAAGCTGCTGCTGCTGGACGAGGCCACGTCGGCGCTGGACTCGCACAGCGAGGCCAAGGTGCAGCGCGCGCTGGACGCCGCCGCGCACGGACGCACCACCGTCATGGTCTCGCACAGGTACATCTTTTTTTAA

Protein

MNFATKVSDDLEKFREGIGEKVPMLIYLVMSFVTAVIISFVYGWELTLVILSCTPVVIATTAIVAKVQSSLTTQELKAYSVAGIVAEEVLSSIRTVVAFGGEEKEIKRYSVRLEPANKMGTRKGIFSGFGSGVMWLIIYGTYALSFWYGVGLILKSRHQETPVYTPAVLMIIFFSVLQGAQNVGLTAPHLEAIANARASAASVYAVIDRKPTIDSLSTEGAKPEFKGDLELEDVVFRYPARADVQVLNGLNLKINENETIALVGPSGCGKSTVLQLLQRMYDPDQGSVRASGHDLRTMNVRHLRNHIAVVGQEPVLFAGTIKENIRMSNPSCTDDEVIVAAKQAYCHDFIRKLPDGYDTPIGERGAQLSGGQKQRIAIARALVRRPKLLLLDEATSALDSHSEAKVQRALDAAAHGRTTVMVSHRYIFF

Catalytic Activity

ATP + H(2)O + xenobiotic(Side 1) = ADP + phosphate + xenobiotic(Side 2).

Similarity

Belongs to the ABC transporter superfamily. ABCB family. Multidrug resistance exporter (TC 3.A.1.201) subfamily.

Keywords

ATP-binding   Complete proteome   Glycoprotein   Membrane   Nucleotide-binding   Polymorphism   Reference proteome   Repeat   Translocase   Transmembrane   Transmembrane helix   Transport  

Feature

chain  Multidrug resistance protein homolog 49

Uniprot

H9JIV1   A0A0N0PE45   A0A0N0PA82   A0A437BPS5   A0A212ET05   E9LP51   + More
A0A2A4JRP4   A0A2W1BV45   A0A154NXY7   A0A158P227   F4WMD9   E2AWB0   A0A2P8XKH6   A0A0J7NX21   A0A3L8D5X6   A0A026W1C9   A0A088AUI4   A0A0H5BV84   A0A195F362   A0A195DC82   A0A0C9Q8D0   A0A182J704   A0A182Y197   A0A182RF89   A0A182PHL7   A0A182G123   A0A1J1IAJ6   A0A182TME4   A0A182WII8   A0A182MMK3   A0A084WK59   A0A1S4FQ34   Q16T64   A0A182LJ50   A0A182USB7   A0A0L7R809   Q7Q6W2   A0A1S4GPX1   A0A182XMX5   A0A182HWT0   A0A182QE27   W5JEE9   B0XBG2   A0A1Q3FP82   A0A182FDS3   A0A182NGV6   A0A0L0C7Z8   A0A2J7QW27   A0A1I8PQ14   A0A1I8NNJ9   A0A1B0A9F0   A0A1A9X3Q1   B4J512   A0A1A9YPC7   A0A1A9USS9   A0A1B0G5W0   A0A1B0BVA0   B4LM40   B4KSV5   W8AR03   B4MJQ1   A0A034V7U7   A0A034V643   B4QDW6   A0A0K8W331   T1P7X7   A0A1I8MLA5   A0A1I8MLA6   A0A0A1WXZ6   B3MDC5   A0A336LRH3   A0A0K8V3U2   A0A0K8UH35   A0A0K8WK76   A0A336LJ59   A0A0M4EWA8   A0A3B0J5Z9   B4P4W4   A0A1W4VPQ3   A0A0J9RBI5   A0A075E224   B4HPY9   B3NRS9   Q00449   Q290X0   B4GB35   A0A075E1M5   A0A075E1X2   A0A1B0C915   A0A452IUD0   A0A0P4W9E0   Q3B7L2   A0A0G2KA64   Q924L6   A8WG28   K7FJS5   A0A3B3BHS7   A0A0A7AS38   A0A3P9KPY7   A0A0P5TXY7  

EC Number

7.6.2.2

Pubmed

19121390    26354079    22118469    23170973    28756777    21347285    + More
21719571    20798317    29403074    30249741    24508170    25244985    26483478    24438588    17510324    20966253    12364791    20920257    23761445    26108605    17994087    24495485    25348373    25315136    25830018    17550304    22936249    25367643    2072901    10731132    12537572    12537569    15632085    25053285    28562605    15489334    15057822    22673903    17381049    29451363    17554307   

EMBL

BABH01023141    BABH01023142    BABH01023143    BABH01023144    KQ459986    KPJ18849.1    + More
KQ458751    KPJ05317.1    RSAL01000021    RVE52406.1    AGBW02012702    OWR44581.1    HQ116792    ADV76537.1    NWSH01000813    PCG74082.1    KZ149927    PZC77504.1    KQ434778    KZC04441.1    ADTU01001125    GL888217    EGI64783.1    GL443280    EFN62270.1    PYGN01001855    PSN32510.1    LBMM01001080    KMQ96965.1    QOIP01000012    RLU15877.1    KK107488    EZA49880.1    LK392613    CDS25229.1    KQ981855    KYN34821.1    KQ980989    KYN10498.1    GBYB01010488    JAG80255.1    JXUM01038032    JXUM01038033    KQ561151    KXJ79549.1    CVRI01000043    CRK95982.1    AXCM01001297    ATLV01024094    KE525349    KFB50603.1    CH477659    EAT37643.1    KQ414636    KOC67015.1    AAAB01008960    EAA11754.3    APCN01001536    AXCN02000366    ADMH02001746    ETN61204.1    DS232633    EDS44274.1    GFDL01005636    JAV29409.1    JRES01000780    KNC28376.1    NEVH01009768    PNF32772.1    CH916367    EDW01718.1    CCAG010007476    CCAG010007477    JXJN01021173    CH940648    EDW59960.2    CH933808    EDW08452.1    GAMC01018075    GAMC01018073    JAB88482.1    CH963846    EDW72340.2    GAKP01021334    JAC37618.1    GAKP01021335    JAC37617.1    CM000362    EDX06860.1    GDHF01007029    JAI45285.1    KA644629    AFP59258.1    GBXI01010353    JAD03939.1    CH902619    EDV36373.1    UFQT01000131    SSX20626.1    GDHF01018836    JAI33478.1    GDHF01026669    JAI25645.1    GDHF01000751    JAI51563.1    UFQT01000028    SSX18184.1    CP012524    ALC42337.1    OUUW01000001    SPP75152.1    CM000158    EDW90685.1    CM002911    KMY93381.1    KF293379    AIA09025.1    CH480816    EDW47652.1    CH954179    EDV56231.1    M59076    AE013599    AY058791    BT044206    BT081353    CM000071    EAL25242.2    CH479181    EDW32137.1    KF293375    AIA09021.1    KF293376    AIA09022.1    AJWK01001744    GDRN01078022    JAI62650.1    BC107560    AAI07561.1    AABR07059500    AABR07059501    AABR07059502    AABR07059503    AABR07072972    AC133679    AF286167    AAK83023.2    BC154556    AAI54557.1    AGCU01060446    AGCU01060447    AGCU01060448    AGCU01060449    KF906269    AHK05634.1    GDIP01120472    JAL83242.1   

Proteomes

UP000005204    UP000053240    UP000053268    UP000283053    UP000007151    UP000218220    + More
UP000076502    UP000005205    UP000007755    UP000000311    UP000245037    UP000036403    UP000279307    UP000053097    UP000005203    UP000078541    UP000078492    UP000075880    UP000076408    UP000075900    UP000075885    UP000069940    UP000249989    UP000183832    UP000075902    UP000075920    UP000075883    UP000030765    UP000008820    UP000075882    UP000075903    UP000053825    UP000007062    UP000076407    UP000075840    UP000075886    UP000000673    UP000002320    UP000069272    UP000075884    UP000037069    UP000235965    UP000095300    UP000092445    UP000091820    UP000001070    UP000092443    UP000078200    UP000092444    UP000092460    UP000008792    UP000009192    UP000007798    UP000000304    UP000095301    UP000007801    UP000092553    UP000268350    UP000002282    UP000192221    UP000001292    UP000008711    UP000000803    UP000001819    UP000008744    UP000092461    UP000291020    UP000002494    UP000007267    UP000261560    UP000265180   

PRIDE

H9JIV1    Q00449   

Pfam

PF00005   ABC_tran        + More
PF00664   ABC_membrane
PF00017   SH2

Interpro

IPR003439   ABC_transporter-like        + More
IPR017871   ABC_transporter_CS       
IPR039421   Type_I_exporter       
IPR011527   ABC1_TM_dom       
IPR027417   P-loop_NTPase       
IPR036640   ABC1_TM_sf       
IPR003593   AAA+_ATPase       
IPR036860   SH2_dom_sf       
IPR000980   SH2       
IPR030275   MDR3       

SUPFAM

SSF52540   SSF52540        + More
SSF90123   SSF90123       
SSF55550   SSF55550       

Gene 3D

1.20.1560.10    

ProteinModelPortal

H9JIV1   A0A0N0PE45   A0A0N0PA82   A0A437BPS5   A0A212ET05   E9LP51   + More
A0A2A4JRP4   A0A2W1BV45   A0A154NXY7   A0A158P227   F4WMD9   E2AWB0   A0A2P8XKH6   A0A0J7NX21   A0A3L8D5X6   A0A026W1C9   A0A088AUI4   A0A0H5BV84   A0A195F362   A0A195DC82   A0A0C9Q8D0   A0A182J704   A0A182Y197   A0A182RF89   A0A182PHL7   A0A182G123   A0A1J1IAJ6   A0A182TME4   A0A182WII8   A0A182MMK3   A0A084WK59   A0A1S4FQ34   Q16T64   A0A182LJ50   A0A182USB7   A0A0L7R809   Q7Q6W2   A0A1S4GPX1   A0A182XMX5   A0A182HWT0   A0A182QE27   W5JEE9   B0XBG2   A0A1Q3FP82   A0A182FDS3   A0A182NGV6   A0A0L0C7Z8   A0A2J7QW27   A0A1I8PQ14   A0A1I8NNJ9   A0A1B0A9F0   A0A1A9X3Q1   B4J512   A0A1A9YPC7   A0A1A9USS9   A0A1B0G5W0   A0A1B0BVA0   B4LM40   B4KSV5   W8AR03   B4MJQ1   A0A034V7U7   A0A034V643   B4QDW6   A0A0K8W331   T1P7X7   A0A1I8MLA5   A0A1I8MLA6   A0A0A1WXZ6   B3MDC5   A0A336LRH3   A0A0K8V3U2   A0A0K8UH35   A0A0K8WK76   A0A336LJ59   A0A0M4EWA8   A0A3B0J5Z9   B4P4W4   A0A1W4VPQ3   A0A0J9RBI5   A0A075E224   B4HPY9   B3NRS9   Q00449   Q290X0   B4GB35   A0A075E1M5   A0A075E1X2   A0A1B0C915   A0A452IUD0   A0A0P4W9E0   Q3B7L2   A0A0G2KA64   Q924L6   A8WG28   K7FJS5   A0A3B3BHS7   A0A0A7AS38   A0A3P9KPY7   A0A0P5TXY7  

PDB

6QEX     E-value=4.24681e-120,     Score=1104

KEGG

101741850    K05658 ATP-binding cassette, subfamily B (MDR/TAP), member 1 [EC:7.6.2.2] | (RefSeq) multidrug resis

PATHWAY

02010    ABC transporters - Bombyx mori (domestic silkworm)

GO

GO:0005524   GO:0042626   GO:0016021   GO:0005886   GO:0097254   GO:0001666   GO:0017085   GO:0008354   GO:0015562   GO:0015238   GO:0008559   GO:0005887   GO:0042908   GO:0009636   GO:0006855   GO:0043190   GO:1904478   GO:1902065   GO:0043278   GO:1905233   GO:2001025   GO:0033762   GO:0071475   GO:0071312   GO:0071407   GO:0001890   GO:0016020   GO:0071217   GO:0009914   GO:0071549   GO:1905231   GO:0032355   GO:0036146   GO:0071548   GO:1990962   GO:0033189   GO:0042493   GO:0071392   GO:0014072   GO:0031526   GO:0010033   GO:0046618   GO:0046686   GO:0050892   GO:0071236   GO:1904446   GO:0060548   GO:1902396   GO:0045177   GO:0032496   GO:0007623   GO:0007420   GO:1905235   GO:0097068   GO:0033231   GO:1903416   GO:0007595   GO:0043215   GO:1990963   GO:0010046   GO:1905232   GO:0060856   GO:0031667   GO:0035633   GO:0014070   GO:1905237   GO:0033280   GO:0016324   GO:0097327   GO:0019534   GO:0015462   GO:0006810   GO:0016887   GO:0005634   GO:0030145   GO:0006412   GO:0016876   GO:0043039   GO:0055085  

PANTHER

PTHR24221   PTHR24221:SF241  

Subcellular location

Membrane  

Length:

429

Number of predicted TMHs:

4

Exp number of AAs in TMHs:

78.53628

Exp number, first 60 AAs:

33.41281

Total prob of N-in:

0.52916

POSSIBLE N-term signal

sequence

outside

1  -  21

TMhelix

22  -  44

inside

45  -  45

TMhelix

46  -  65

outside

66  -  131

TMhelix

132  -  154

inside

155  -  160

TMhelix

161  -  180

outside

181  -  429

 

 

Pi

160.918079

Theta

161.962617

Tajima's D

0.954968

CLR

0.127501

CSRT

0.653267336633168

Interpretation

Uncertain