Gene

KWMTBOMO08243

Pre Gene Modal

BGIBMGA009452

Annotation

PREDICTED:_multidrug_resistance_protein_homolog_49-like_[Bombyx_mori]

Location

Bomo_Chr14(-):2533149-2544373      View in EpiBrowser

Full name

Multidrug resistance protein homolog 65      

Alternative Name

P-glycoprotein 65

Location in the cell

PlasmaMembrane   Reliability : 2.338

CDS

ATGTCGCTGCGCGGTCGGTACTACCAGCTGGTGCTGGAGAATGAGCCCAGTATGGCGCCAGGGGCCGCCTCAAGCAACGACATGCAGAAACATGCGAGAATCCGGAAGCCCAAACTACAAAAATTGGCTTCCGTCGACTCGATCAAGAGCAATTTTACCCAAGACGACTCCGGCTCGGAGGACAGTGTGATGCTGGATGAGCCCAAAGAGGAGGAGATCAAACCGACGACTTGGGACATAATGAAACTGTGCGAGCCGGAGAAGTGGCTGATGATCGTCGGTGTCCTAGCCGCCTTCTCTGTAGGCTCCTCCTTCCCGATGTTCGCGATCTTGTTCGGCGAAACTTACGGGTTATTGGAGAATCGTAACGACGAGTGGGTCCGGGGCGAGACCAACATGATAGCGGTCCTGTTCATATTGGTGGGCGTCTTAACCGGAGTGGGGATATTCTTCCAAATTTACATCTTCAATTTAACTGGAGTCAGGCTGACGGCTAGGCTAAGGGTGGCGGTATTCCGTAAGATGTTAGCTCAGGAGATCGGCTGGTTCGACGATCCAAAGAACGGAGTCGGAGCGCTCTGCGCCAGGCTAGCCGCTGATGCTGCAGCAGTACAAGGCGCAACTGGCACACGGATAGGCGCATTAATGCAAGCCACAGCTACAATCGTGATAGGGATCGCCCTCTCGCTGTACTACACGTGGCAGATGACGCTAGTGTCCTTGGTCTCAGTCCCTATGGTCATTGGAGCGGTCGTGCTGGAAGGGCGGGTGCTGTCTGAAGGAATAGCCGAGGTCAGGGAGGCCTCCGACCGTGCTACAACCATAGCCACGGAGGCCATCACGAACATCAGGACGGTCTCTGCTTTCTGCGGCGAGGAGGGGGCGCTGCGGCGGTACGAGGAGGCGGGGGGCGCGGCGCAACGCACTGCGCGGCGCTCGCTGCGGTGGCGCGGCGCCGTGTTCTCGTTCGGGCAGACGGCGCCCGTGGCCGGGTACGCACTGGCGCTCTGGTACGGCGGCGTGCTCGTCGCCAACCGGGAGCTGCACTACAAGTCCGTCATCAAGGTATCGGAGGCGCTAGTGTTCGGCGCGTGGATGATGGGGCAGGCGCTCGCGTTCGCCCCGAACTTCGGCGCGGCGATGAGCGCGGCCGGCCGCGTCATGACGCTGCTGCAGCGGCGGGCGCTCGTCGAGGACACGCACGCGCCCGCCCTGCACGAAAACTACGTGGCAGAAGGCAAGATCCAGTACAAGAACATAAAGTTCCGGTACCCGACGCGGCGCGAGGTGGAGGTGCTGGCCGGCCTGAGCCTCGCGATCCCGCGCGGGGTGCGCGCCGCGCTCGTGGGGCCCAGCGGCTGCGGCAAGTCCACGCTCATACAGCTGCTGCAGCGGCTCTACGACCCGGACGACGGGAACGTATACCTGGACGACTACAGCATTACATCGGACATGCGCTTGTCGACGCTGCGGCGGAACCTGGGCATAGTCTCCCAGGAGCCGGTGCTATTCGACCGGACCATCGCCGACAACATCGCGTACGGCGACAACACCAGAGACGTGCCCATCGAGGAAATTGTCAAAGCGGCTAAAGAGGCGAACGTTCATACCTTTATATCCGCTCTGCCGAATGGCTACGACACGCGACTGGGGGCTCGCGCGTCGCAGCTGTCGGGGGGACAGAAGCAGCGCATCGCCATCGCGCGAGCGCTCGTGCGGAACCCGCGCGTGTTACTGCTCGACGAGGCGACATCAGCACTCGACACTCACAGCGAAAAGGTGGTCCAAGAAGCACTGGACAAGGCCAGCGAAGGCCGCACGTGCCTCATCATAGCTCACCGTCTGTCGACGATACAGAACGCGGATATTATCTGCGTCATCGATAAAGGGGTGGTCGCCGAAACCGGGACGCATCGCGAACTGATCAAGAGAAAGGGAATTTACGCCAAGCTGTACGAGCTGCAGTGCGGCTTCGTCGAGGAAAGCGAAGAGAATCTGCATAACGAATAG

Protein

MSLRGRYYQLVLENEPSMAPGAASSNDMQKHARIRKPKLQKLASVDSIKSNFTQDDSGSEDSVMLDEPKEEEIKPTTWDIMKLCEPEKWLMIVGVLAAFSVGSSFPMFAILFGETYGLLENRNDEWVRGETNMIAVLFILVGVLTGVGIFFQIYIFNLTGVRLTARLRVAVFRKMLAQEIGWFDDPKNGVGALCARLAADAAAVQGATGTRIGALMQATATIVIGIALSLYYTWQMTLVSLVSVPMVIGAVVLEGRVLSEGIAEVREASDRATTIATEAITNIRTVSAFCGEEGALRRYEEAGGAAQRTARRSLRWRGAVFSFGQTAPVAGYALALWYGGVLVANRELHYKSVIKVSEALVFGAWMMGQALAFAPNFGAAMSAAGRVMTLLQRRALVEDTHAPALHENYVAEGKIQYKNIKFRYPTRREVEVLAGLSLAIPRGVRAALVGPSGCGKSTLIQLLQRLYDPDDGNVYLDDYSITSDMRLSTLRRNLGIVSQEPVLFDRTIADNIAYGDNTRDVPIEEIVKAAKEANVHTFISALPNGYDTRLGARASQLSGGQKQRIAIARALVRNPRVLLLDEATSALDTHSEKVVQEALDKASEGRTCLIIAHRLSTIQNADIICVIDKGVVAETGTHRELIKRKGIYAKLYELQCGFVEESEENLHNE

Catalytic Activity

ATP + H(2)O + xenobiotic(Side 1) = ADP + phosphate + xenobiotic(Side 2).

Similarity

Belongs to the ABC transporter superfamily. ABCB family. Multidrug resistance exporter (TC 3.A.1.201) subfamily.

Keywords

ATP-binding   Complete proteome   Glycoprotein   Membrane   Nucleotide-binding   Reference proteome   Repeat   Translocase   Transmembrane   Transmembrane helix   Transport  

Feature

chain  Multidrug resistance protein homolog 65

Uniprot

H9JIV1   A0A0N0PA82   A0A212ET05   E9LP51   A0A2W1BV45   A0A0N0PE45   + More
A0A3S2TQJ8   A0A2J7QW29   A0A084WK59   A0A182J704   V9IMF3   A0A088AUI4   A0A0L7R809   A0A2J7QW27   A0A2A3ESQ2   A0A1Q3FP82   Q16T64   A0A1S4FQ34   A0A182G123   E2BJG5   A0A182USB7   A0A182QE27   B0XBG2   A0A182WII8   A0A182XMX5   A0A182Y197   A0A182HWT0   A0A154NXY7   Q7Q6W2   A0A182TME4   A0A1S4GPX1   A0A0H5BV84   A0A182PHL7   A0A1J1IAJ6   A0A182RF89   A0A182NGV6   A0A195DC82   A0A336LJ59   A0A151IFD5   A0A3L8D5X6   A0A026W1C9   A0A151WQI1   A0A0C9Q8D0   A0A182FDS3   W5JEE9   A0A336LRH3   A0A182MMK3   A0A195BSY8   A0A158P227   A0A0J7NX21   F4WMD9   E2AWB0   A0A1B0C915   A0A1I8PQ14   W8AR03   A0A0K8WK76   A0A0K8UH35   A0A0K8V3U2   A0A1I8NNJ9   T1GYN9   A0A034V7U7   A0A034V643   A0A0A1WXZ6   A0A0L0C7Z8   A0A1W4WGR5   A0A1I8MLA5   T1P7X7   A0A1I8MLA6   B4LM40   A0A0M4EWA8   A0A1B6E6B2   A0A034W640   A0A1B6E1J7   B4J512   A0A0L0CS11   B4MJQ1   B4PJN0   A0A0N0BDS9   B3NGG7   B4HUT1   B4KVQ2   B4H190   A0A0J9RRF0   B4N3X9   B4IY56   W8BN80   A0A087SVL8   A0A0K8WAV1   A0A1W4V9J1   A0A3B0KMW3   A0A1B0BVA0   A0A1A9YPC7   A0A1W4VPQ3   B4LI86   B4QJC9   Q00748   B3M9Z3  

EC Number

7.6.2.2

Pubmed

19121390    26354079    22118469    23170973    28756777    24438588    + More
17510324    26483478    20798317    25244985    12364791    30249741    24508170    20920257    23761445    21347285    21719571    24495485    25348373    25830018    26108605    25315136    17994087    17550304    18057021    22936249    2072901    11012721    10731132    12537572    17893096   

EMBL

BABH01023141    BABH01023142    BABH01023143    BABH01023144    KQ458751    KPJ05317.1    + More
AGBW02012702    OWR44581.1    HQ116792    ADV76537.1    KZ149927    PZC77504.1    KQ459986    KPJ18849.1    RSAL01000021    RVE52405.1    NEVH01009768    PNF32793.1    ATLV01024094    KE525349    KFB50603.1    JR052801    AEY61791.1    KQ414636    KOC67015.1    PNF32772.1    KZ288192    PBC34312.1    GFDL01005636    JAV29409.1    CH477659    EAT37643.1    JXUM01038032    JXUM01038033    KQ561151    KXJ79549.1    GL448571    EFN84122.1    AXCN02000366    DS232633    EDS44274.1    APCN01001536    KQ434778    KZC04441.1    AAAB01008960    EAA11754.3    LK392613    CDS25229.1    CVRI01000043    CRK95982.1    KQ980989    KYN10498.1    UFQT01000028    SSX18184.1    KQ977799    KYM99610.1    QOIP01000012    RLU15877.1    KK107488    EZA49880.1    KQ982831    KYQ50090.1    GBYB01010488    JAG80255.1    ADMH02001746    ETN61204.1    UFQT01000131    SSX20626.1    AXCM01001297    KQ976418    KYM89470.1    ADTU01001125    LBMM01001080    KMQ96965.1    GL888217    EGI64783.1    GL443280    EFN62270.1    AJWK01001744    GAMC01018075    GAMC01018073    JAB88482.1    GDHF01000751    JAI51563.1    GDHF01026669    JAI25645.1    GDHF01018836    JAI33478.1    CAQQ02139675    GAKP01021334    JAC37618.1    GAKP01021335    JAC37617.1    GBXI01010353    JAD03939.1    JRES01000780    KNC28376.1    KA644629    AFP59258.1    CH940648    EDW59960.2    CP012524    ALC42337.1    GEDC01030994    GEDC01003837    JAS06304.1    JAS33461.1    GAKP01009734    JAC49218.1    GEDC01005495    JAS31803.1    CH916367    EDW01718.1    JRES01000089    KNC34214.1    CH963846    EDW72340.2    CM000159    EDW93629.1    KQ435850    KOX70881.1    CH954178    EDV51133.1    CH480817    EDW50702.1    CH933809    EDW18426.1    KRG06188.1    CH479202    EDW30067.1    CM002912    KMY97909.1    CH964095    EDW79334.1    CH916366    EDV96506.1    GAMC01015408    GAMC01015406    JAB91149.1    KK112167    KFM56907.1    GDHF01004130    JAI48184.1    OUUW01000009    SPP85148.1    JXJN01021173    CH940647    EDW69653.1    KRF84496.1    CM000363    EDX09438.1    M59077    AF251287    AF251286    AE014296    CH902618    EDV41213.1   

Proteomes

UP000005204    UP000053268    UP000007151    UP000053240    UP000283053    UP000235965    + More
UP000030765    UP000075880    UP000005203    UP000053825    UP000242457    UP000008820    UP000069940    UP000249989    UP000008237    UP000075903    UP000075886    UP000002320    UP000075920    UP000076407    UP000076408    UP000075840    UP000076502    UP000007062    UP000075902    UP000075885    UP000183832    UP000075900    UP000075884    UP000078492    UP000078542    UP000279307    UP000053097    UP000075809    UP000069272    UP000000673    UP000075883    UP000078540    UP000005205    UP000036403    UP000007755    UP000000311    UP000092461    UP000095300    UP000015102    UP000037069    UP000192223    UP000095301    UP000008792    UP000092553    UP000001070    UP000007798    UP000002282    UP000053105    UP000008711    UP000001292    UP000009192    UP000008744    UP000054359    UP000192221    UP000268350    UP000092460    UP000092443    UP000000304    UP000000803    UP000007801   

PRIDE

H9JIV1    Q00748   

Pfam

PF00005   ABC_tran        + More
PF00664   ABC_membrane

Interpro

IPR003439   ABC_transporter-like        + More
IPR017871   ABC_transporter_CS       
IPR039421   Type_I_exporter       
IPR011527   ABC1_TM_dom       
IPR027417   P-loop_NTPase       
IPR036640   ABC1_TM_sf       
IPR003593   AAA+_ATPase       
IPR002016   Haem_peroxidase       
IPR030278   BSEP       

SUPFAM

SSF52540   SSF52540        + More
SSF90123   SSF90123       

Gene 3D

1.20.1560.10    

ProteinModelPortal

H9JIV1   A0A0N0PA82   A0A212ET05   E9LP51   A0A2W1BV45   A0A0N0PE45   + More
A0A3S2TQJ8   A0A2J7QW29   A0A084WK59   A0A182J704   V9IMF3   A0A088AUI4   A0A0L7R809   A0A2J7QW27   A0A2A3ESQ2   A0A1Q3FP82   Q16T64   A0A1S4FQ34   A0A182G123   E2BJG5   A0A182USB7   A0A182QE27   B0XBG2   A0A182WII8   A0A182XMX5   A0A182Y197   A0A182HWT0   A0A154NXY7   Q7Q6W2   A0A182TME4   A0A1S4GPX1   A0A0H5BV84   A0A182PHL7   A0A1J1IAJ6   A0A182RF89   A0A182NGV6   A0A195DC82   A0A336LJ59   A0A151IFD5   A0A3L8D5X6   A0A026W1C9   A0A151WQI1   A0A0C9Q8D0   A0A182FDS3   W5JEE9   A0A336LRH3   A0A182MMK3   A0A195BSY8   A0A158P227   A0A0J7NX21   F4WMD9   E2AWB0   A0A1B0C915   A0A1I8PQ14   W8AR03   A0A0K8WK76   A0A0K8UH35   A0A0K8V3U2   A0A1I8NNJ9   T1GYN9   A0A034V7U7   A0A034V643   A0A0A1WXZ6   A0A0L0C7Z8   A0A1W4WGR5   A0A1I8MLA5   T1P7X7   A0A1I8MLA6   B4LM40   A0A0M4EWA8   A0A1B6E6B2   A0A034W640   A0A1B6E1J7   B4J512   A0A0L0CS11   B4MJQ1   B4PJN0   A0A0N0BDS9   B3NGG7   B4HUT1   B4KVQ2   B4H190   A0A0J9RRF0   B4N3X9   B4IY56   W8BN80   A0A087SVL8   A0A0K8WAV1   A0A1W4V9J1   A0A3B0KMW3   A0A1B0BVA0   A0A1A9YPC7   A0A1W4VPQ3   B4LI86   B4QJC9   Q00748   B3M9Z3  

PDB

4LSG     E-value=2.30276e-132,     Score=1212

KEGG

101741850    K05658 ATP-binding cassette, subfamily B (MDR/TAP), member 1 [EC:7.6.2.2] | (RefSeq) multidrug resis

GO

GO:0005524   GO:0042626   GO:0016021   GO:0005886   GO:0004601   GO:0020037   GO:0006979   GO:0097254   GO:0001666   GO:0017085   GO:0008354   GO:0060857   GO:0005919   GO:0015562   GO:0008559   GO:0043190   GO:0042908   GO:0009636   GO:0006810   GO:0016887   GO:0005634   GO:0030145   GO:0006412   GO:0016876   GO:0043039   GO:0055085  

PANTHER

PTHR24221   PTHR24221:SF165  

Subcellular location

Membrane  

Length:

669

Number of predicted TMHs:

5

Exp number of AAs in TMHs:

121.12504

Exp number, first 60 AAs:

0.00018

Total prob of N-in:

0.80863

inside

1  -  88

TMhelix

89  -  111

outside

112  -  133

TMhelix

134  -  156

inside

157  -  211

TMhelix

212  -  234

outside

235  -  318

TMhelix

319  -  341

inside

342  -  360

TMhelix

361  -  383

outside

384  -  669

 

 

Pi

220.286167

Theta

130.118417

Tajima's D

2.140608

CLR

0.257413

CSRT

0.900654967251637

Interpretation

Uncertain