Gene

KWMTBOMO08241  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA009515

Annotation

pyruvate_dehydrogenase_[Bombyx_mori]

Location

Bomo_Chr14(+):2511184-2518690      View in EpiBrowser

Full name

Pyruvate dehydrogenase E1 component subunit alpha      

Location in the cell

Mitochondrial   Reliability : 3.35

CDS

ATGAGTAAATTAATTCCCTCAGCCGCTAAGTTTTTAGCCGGAAACACAATCACGAAAGTGACTGCACCGGTTGTAGCGACAAACGCAAAATACAGCACGAAAAAAGAGGCGACATTCGAAATCAAGCCCTACAAACTCCATAAATTGGATCAGGGCCCTGCAACATCAGCCACACTCACTTCTGAAGATGCTCTTAAGCTGTATGAACAACTGACGATATTGCGGAGGATTGAAACCGCATCAGGAAACCTATATAAAGAAAAGATCATCCGTGGTTTCTGTCACCTGTATTCAGGACAAGAAGCCGTGGCAGTAGGTATGAGAGCAGCGATGCGAGATGCAGACTCAGTAATCACCGCGTATCGTTGTCACGGATGGACTTATCTCATGGGCGTTAGTGTGCTGGGGGTGCTCTCGGAGCTGACGGGGCGCAGGACCGGTTGCTCCCGGGGCAAGGGAGGTTCCATGCATTTGTACGGACGCAACTTCTATGGTGGCAACGGGATTGTTGGTGCGCAGGTCCCGTTGGGAGCTGGAGTGGCCTTCGCCCACAAGTACCGCGCCGACGGCGGAGTCACGTTCGCTCTGTACGGAGACGGAGCCGCCAACCAGGGTCAACTCTTCGAAGCCTACAACATGTCTAAACTATGGGACTTGCCTTGCGTCTTCGTTTGCGAGAACAACGGATACGGCATGGGCACGAGCGTGGACCGTTCGTCGGCGAGCACGGAGTACTACACGCGCGGGGACTACGTGCCCGGCGTGTGGGTGGACGGCATGGACGTGCTCGCCACCAGGGAGGCGGCCAGGTTCGCCATCGAGTACTGCAACGCAGGGAAAGGTCCTTTGGTGATGGAGATGGAGACGTACCGTTACTCTGGTCATTCGATGTCGGACCCCGGCACGTCGTATCGGACGAGAGACGAGGTGCAGGAGGTGAGGCAGACCAGAGACCCCATCACTTCGTTCAAGGAGAAGATCTTGAATCACGAGCTCGTCACGCCAGATCAGCTCAAGGATATCGACGCCAAGGTACGTAAAGAAGTAGACGAGGCCACTAAACAATCGAAGACGGAACCAGAAGTCGGTATTGAAGAGTTGTCCGCCGATATATACTACAAGAACTTGGAACCCTTCGTCCGTGGCATCCACCCGGCTGCCCCGCTCAAACACCTTGAGGTCCAACCTCGCAACCACTAA

Protein

MSKLIPSAAKFLAGNTITKVTAPVVATNAKYSTKKEATFEIKPYKLHKLDQGPATSATLTSEDALKLYEQLTILRRIETASGNLYKEKIIRGFCHLYSGQEAVAVGMRAAMRDADSVITAYRCHGWTYLMGVSVLGVLSELTGRRTGCSRGKGGSMHLYGRNFYGGNGIVGAQVPLGAGVAFAHKYRADGGVTFALYGDGAANQGQLFEAYNMSKLWDLPCVFVCENNGYGMGTSVDRSSASTEYYTRGDYVPGVWVDGMDVLATREAARFAIEYCNAGKGPLVMEMETYRYSGHSMSDPGTSYRTRDEVQEVRQTRDPITSFKEKILNHELVTPDQLKDIDAKVRKEVDEATKQSKTEPEVGIEELSADIYYKNLEPFVRGIHPAAPLKHLEVQPRNH

Description

The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).

Catalytic Activity

[dihydrolipoyllysine-residue acetyltransferase]-(R)-N(6)-lipoyl-L-lysine + H(+) + pyruvate = [dihydrolipoyllysine-residue acetyltransferase]-(R)-N(6)-(S(8)-acetyldihydrolipoyl)-L-lysine + CO2

Cofactor

thiamine diphosphate

Uniprot

A5JTL8   A0A0N0PAJ7   A0A437BPU4   A0A2W1BXW5   S4PXR8   A0A2A4JRJ1   + More
A0A212ESV9   A0A2S2NZ66   A0A1B6M3Y6   A0A0C9QDB3   A0A0C9RRH2   A0A0A9Y9I6   A0A1B6DVK9   A0A026WVP5   A0A3L8DGS5   E2C7V7   A0A195CB45   E9JB76   A0A195EHE3   J3JUE0   E1ZY08   A0A1Y1MIF2   I4DPY8   A0A2J7Q2F5   A0A1B6CAI5   A0A2J7Q2F1   A0A2J7Q2G6   A0A151WQS8   A0A195FFP7   F4WYA1   A0A195AX33   A0A0J7LAI1   A0A158NHT6   A0A2J7PS46   A0A182QUR0   A0A0P6AGL6   A0A1Q3FGZ9   A0A0P5GZ01   A0A0P5MF12   A0A0N8BZZ5   A0A1Q3FGV8   A0A1Q3FGX0   A0A0N7ZLT7   A0A0P5Z1K7   A0A0P5VG56   A0A1Q3FGT1   A0A084W9R4   A0A1L8E1F1   A0A182RXD8   A0A1Q3FH60   U5EVL9   A0A067R0R7   A0A067QZL9   A0A2S2QEB3   A0A182WYI5   A0A182M7S9   A0A182LI51   A0A182HXK7   A0A182GYR7   A0A182VCQ3   Q7Q2S3   A0A182PNZ5   A0A0P5Y8W6   A0A0P5PEW3   A0A0P5BFW3   A0A0N7ZYG3   A0A0P6ITL9   A0A182TLB5   A0A2R7W6G5   A0A1B0CJ15   A0A182NNE9   A0A182YI05   A0A1S4FA91   A0A182WCP1   A0A1S4FA55   B0WB92   A0A0P5AS70   A0A0P5FBZ2   Q17AH2   Q17AH1   A0A023ERW4   A0A0K8TMP8   A0A182T6P5   A0A182K060   A0A069DSV5   A0A1W4WC31   A0A0T6B565   E9GLQ3   A0A0N1IN45   A0A0P5BF25   T1K3K9   A0A444SK23   U5ESX3   A0A0P4VQK4   D6WH06   T1I2E4   A0A1W4WNC4   A0A0V0G6G4   A0A2A3E2W8   V9IBV5  

EC Number

1.2.4.1

Pubmed

19121390    26354079    28756777    23622113    22118469    25401762    + More
26823975    24508170    30249741    20798317    21282665    22516182    28004739    22651552    21719571    21347285    24438588    24845553    20966253    26483478    12364791    14747013    17210077    25244985    17510324    24945155    26369729    26334808    21292972    27129103    18362917    19820115   

EMBL

BABH01023139    EF569585    ABQ42597.1    KQ458751    KPJ05318.1    RSAL01000021    + More
RVE52404.1    KZ149927    PZC77526.1    GAIX01004563    JAA87997.1    NWSH01000813    PCG74083.1    AGBW02012702    OWR44582.1    GGMR01009884    MBY22503.1    GEBQ01009326    JAT30651.1    GBYB01012403    JAG82170.1    GBYB01009941    JAG79708.1    GBHO01015851    GBRD01013345    GDHC01012462    JAG27753.1    JAG52481.1    JAQ06167.1    GEDC01007588    GEDC01007533    JAS29710.1    JAS29765.1    KK107109    EZA59159.1    QOIP01000008    RLU19650.1    GL453466    EFN75992.1    KQ978023    KYM98084.1    GL770938    EFZ09930.1    KQ978957    KYN27279.1    BT126853    AEE61815.1    GL435164    EFN73927.1    GEZM01035985    JAV83057.1    AK403850    BAM19978.1    NEVH01019371    PNF22766.1    GEDC01026791    JAS10507.1    PNF22768.1    PNF22767.1    KQ982813    KYQ50262.1    KQ981636    KYN38849.1    GL888439    EGI60858.1    KQ976725    KYM76607.1    LBMM01000040    KMR05206.1    ADTU01016037    NEVH01021939    PNF19149.1    AXCN02001909    GDIP01029994    JAM73721.1    GFDL01008236    JAV26809.1    GDIQ01234308    JAK17417.1    GDIQ01157029    JAK94696.1    GDIQ01128299    JAL23427.1    GFDL01008300    JAV26745.1    GFDL01008266    JAV26779.1    GDIP01232841    JAI90560.1    GDIP01063396    JAM40319.1    GDIP01100384    LRGB01000626    JAM03331.1    KZS17591.1    GFDL01008275    JAV26770.1    ATLV01021858    KE525324    KFB46958.1    GFDF01001759    JAV12325.1    GFDL01008171    JAV26874.1    GANO01003347    JAB56524.1    KK852798    KDR16354.1    KK852854    KDR14971.1    GGMS01006866    MBY76069.1    AXCM01008722    APCN01005316    JXUM01098911    KQ564456    KXJ72252.1    AAAB01008968    EAA13136.4    GDIP01062096    JAM41619.1    GDIQ01129592    JAL22134.1    GDIP01200234    JAJ23168.1    GDIP01200233    JAJ23169.1    GDIQ01027915    JAN66822.1    KK854356    PTY15028.1    AJWK01013951    DS231878    EDS42236.1    GDIP01198784    JAJ24618.1    GDIP01149454    JAJ73948.1    CH477335    EAT43250.1    EAT43251.1    GAPW01001650    JAC11948.1    GDAI01001981    JAI15622.1    GBGD01001864    JAC87025.1    LJIG01009760    KRT82436.1    GL732551    EFX79543.1    KPJ05319.1    GDIP01185231    JAJ38171.1    CAEY01001383    SAUD01033757    RXG53673.1    GANO01003029    JAB56842.1    GDKW01001857    JAI54738.1    KQ971321    EFA00132.1    ACPB03021036    GECL01002460    JAP03664.1    KZ288466    PBC25441.1    JR038136    AEY58127.1   

Proteomes

UP000005204    UP000053268    UP000283053    UP000218220    UP000007151    UP000053097    + More
UP000279307    UP000008237    UP000078542    UP000078492    UP000000311    UP000235965    UP000075809    UP000078541    UP000007755    UP000078540    UP000036403    UP000005205    UP000075886    UP000076858    UP000030765    UP000075900    UP000027135    UP000076407    UP000075883    UP000075882    UP000075840    UP000069940    UP000249989    UP000075903    UP000007062    UP000075885    UP000075902    UP000092461    UP000075884    UP000076408    UP000075920    UP000002320    UP000008820    UP000075901    UP000075881    UP000192223    UP000000305    UP000015104    UP000288706    UP000007266    UP000015103    UP000242457   

PRIDE

A5JTL8   

Pfam

PF00676   E1_dh        + More
PF01965   DJ-1_PfpI
PF00650   CRAL_TRIO

Interpro

IPR029061   THDP-binding        + More
IPR017597   Pyrv_DH_E1_asu_subgrp-y       
IPR001017   DH_E1       
IPR006287   DJ-1       
IPR002818   DJ-1/PfpI       
IPR029062   Class_I_gatase-like       
IPR001251   CRAL-TRIO_dom       
IPR036273   CRAL/TRIO_N_dom_sf       
IPR036865   CRAL-TRIO_dom_sf       

SUPFAM

SSF52518   SSF52518        + More
SSF52317   SSF52317       
SSF46938   SSF46938       
SSF52087   SSF52087       

Gene 3D

3.40.50.880     3.40.525.10    

CDD

cd00170  SEC14

ProteinModelPortal

A5JTL8   A0A0N0PAJ7   A0A437BPU4   A0A2W1BXW5   S4PXR8   A0A2A4JRJ1   + More
A0A212ESV9   A0A2S2NZ66   A0A1B6M3Y6   A0A0C9QDB3   A0A0C9RRH2   A0A0A9Y9I6   A0A1B6DVK9   A0A026WVP5   A0A3L8DGS5   E2C7V7   A0A195CB45   E9JB76   A0A195EHE3   J3JUE0   E1ZY08   A0A1Y1MIF2   I4DPY8   A0A2J7Q2F5   A0A1B6CAI5   A0A2J7Q2F1   A0A2J7Q2G6   A0A151WQS8   A0A195FFP7   F4WYA1   A0A195AX33   A0A0J7LAI1   A0A158NHT6   A0A2J7PS46   A0A182QUR0   A0A0P6AGL6   A0A1Q3FGZ9   A0A0P5GZ01   A0A0P5MF12   A0A0N8BZZ5   A0A1Q3FGV8   A0A1Q3FGX0   A0A0N7ZLT7   A0A0P5Z1K7   A0A0P5VG56   A0A1Q3FGT1   A0A084W9R4   A0A1L8E1F1   A0A182RXD8   A0A1Q3FH60   U5EVL9   A0A067R0R7   A0A067QZL9   A0A2S2QEB3   A0A182WYI5   A0A182M7S9   A0A182LI51   A0A182HXK7   A0A182GYR7   A0A182VCQ3   Q7Q2S3   A0A182PNZ5   A0A0P5Y8W6   A0A0P5PEW3   A0A0P5BFW3   A0A0N7ZYG3   A0A0P6ITL9   A0A182TLB5   A0A2R7W6G5   A0A1B0CJ15   A0A182NNE9   A0A182YI05   A0A1S4FA91   A0A182WCP1   A0A1S4FA55   B0WB92   A0A0P5AS70   A0A0P5FBZ2   Q17AH2   Q17AH1   A0A023ERW4   A0A0K8TMP8   A0A182T6P5   A0A182K060   A0A069DSV5   A0A1W4WC31   A0A0T6B565   E9GLQ3   A0A0N1IN45   A0A0P5BF25   T1K3K9   A0A444SK23   U5ESX3   A0A0P4VQK4   D6WH06   T1I2E4   A0A1W4WNC4   A0A0V0G6G4   A0A2A3E2W8   V9IBV5  

PDB

6CFO     E-value=3.82494e-118,     Score=1087

KEGG

100101211    K00161 pyruvate dehydrogenase E1 component alpha subunit [EC:1.2.4.1] | (RefSeq) L(b002); pyruvate d

PATHWAY

00010    Glycolysis / Gluconeogenesis - Bombyx mori (domestic silkworm)
00020    Citrate cycle (TCA cycle) - Bombyx mori (domestic silkworm)
00620    Pyruvate metabolism - Bombyx mori (domestic silkworm)
01100    Metabolic pathways - Bombyx mori (domestic silkworm)
01200    Carbon metabolism - Bombyx mori (domestic silkworm)

GO

GO:0006086   GO:0043231   GO:0004739   GO:0016624   GO:0005739   GO:0008152   GO:0005634   GO:0030145   GO:0006412   GO:0016876   GO:0043039  

Length:

399

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

2.35561

Exp number, first 60 AAs:

0.06316

Total prob of N-in:

0.04996

outside

1  -  399

 

 

Pi

188.483658

Theta

23.962084

Tajima's D

0.453388

CLR

5.937118

CSRT

0.504324783760812

Interpretation

Uncertain