Gene

KWMTBOMO08236

Pre Gene Modal

BGIBMGA009512

Annotation

PREDICTED:_jerky_protein_homolog-like_[Bombyx_mori]

Location

Bomo_Chr14(+):2474563-2475957      View in EpiBrowser

Full name

Fatty acyl-CoA reductase       + More
NAD-dependent protein deacylase      

Alternative Name

Regulatory protein SIR2 homolog

Location in the cell

Cytoplasmic   Reliability : 1.626

CDS

ATGGGAGCCCGTACGGCTTTTACGGCCGATGAGGAACTGAAAATTGAGGAATGGGTCCTTGAATTAGCGAGAAAAGGATTTCCCGTTTCGAAAGGAACCTTTTTAATAAGCATGAAAAGATTAGCCGCTCAATTAGGGAAGGACATTTTCCGTGATAAGGTTCCATCCAAAAAGTGGTATGGCAGTTTTATGAGTAGACACCCTCGGATTTCTAATCGCGTTGCCCAAAATTTAACAAAGAGCAGGAGCTCAATAACAAACGAGCAATTAGACGGCTGGAAGAATGACGTTTATACGTATTTAGAGGGAAACGGATTGGCGAGCGTCTTGGATGACCCCAAACGCGTATTTAACGCTGATGAGACAGCATTTTTCTTGCAACCAAAAGCCGGAAAAGTTATGGCTGAACGCGGTTGTAAAAATATTTATCAAGCGGTTGGTAATGACGAGAAAGAGTGCATTACAGTTCTCTTTACGGGCAATGCTAATGGAGATCTTGCACCACCCTTGGTAGTTTTCCATTATACACGTATTCCGCTCCATATCACCGTAAATGTGCCCACATCATGGGCTATAGGAAAAAGTGAGCAGGGATGGATGACCTGCGCAATTTTTTATGAGTACATTGGAAACCAGTTCATTCCATGGCTGGAAAAAGAAAAGATAGTGCGGCCAGTACTAATTTTTGTTGATGGCCACGTCTCCCATCTATCTATGGAGGTTAGTCAGTTTTGCAGCCAAAATGACATCGTTTTAGTGGCCTTATACCCCAACGCCACCCATTTGCTGCAACCGATGGACGTCTCCGTATTTCATACGCTGAAAGCTTCGTGGAAGGAGAAAGCTTTACAACATCGATTAAGCGGTGGTGAAGTGTCAAAAAGTAATTTTTGCGCCTTACTTAATCAACTTTTATTGGATGTGTATCGGCCAGAAATTTTGACGAATGGGTTCAAAAAATGTGGGTTAGTGCCCTGGAACCCTTTGGAAGTCACTGTTAGGCCTGGTGCGCCACCGAAGGCAACTGAACCCAATACAAAAACTAATTTATGCTGTCCTAATTGTATTCCGTGGCTGAAGACAGTAATCGGGGCAGAAAAAATTGCTTCTTTTAGTGGGAATAAAGATTCCATCCCTGTTACCGATCATTCCCTGTACGAGCTATGGAAGAAGGTGACAACAGGATTAGAAAAAAATACTGTGACTATTTTGGAAGCCCCTTTAGCAAATGCAGAGGATCCTGTTGAAGACGGAATGGAAATTTCCCTTTTCATTTCCAGCCGCCAAGGGTGA

Protein

MGARTAFTADEELKIEEWVLELARKGFPVSKGTFLISMKRLAAQLGKDIFRDKVPSKKWYGSFMSRHPRISNRVAQNLTKSRSSITNEQLDGWKNDVYTYLEGNGLASVLDDPKRVFNADETAFFLQPKAGKVMAERGCKNIYQAVGNDEKECITVLFTGNANGDLAPPLVVFHYTRIPLHITVNVPTSWAIGKSEQGWMTCAIFYEYIGNQFIPWLEKEKIVRPVLIFVDGHVSHLSMEVSQFCSQNDIVLVALYPNATHLLQPMDVSVFHTLKASWKEKALQHRLSGGEVSKSNFCALLNQLLLDVYRPEILTNGFKKCGLVPWNPLEVTVRPGAPPKATEPNTKTNLCCPNCIPWLKTVIGAEKIASFSGNKDSIPVTDHSLYELWKKVTTGLEKNTVTILEAPLANAEDPVEDGMEISLFISSRQG

Description

Catalyzes the reduction of fatty acyl-CoA to fatty alcohols.
NAD-dependent protein deacylase. Catalyzes the NAD-dependent hydrolysis of acyl groups from lysine residues.

Catalytic Activity

a long-chain fatty acyl-CoA + 2 H(+) + 2 NADPH = a long-chain primary fatty alcohol + CoA + 2 NADP(+)
H2O + N(6)-acetyl-L-lysyl-[protein] + NAD(+) = 2''-O-acetyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide

Cofactor

Zn(2+)

Similarity

Belongs to the fatty acyl-CoA reductase family.
Belongs to the sirtuin family. Class II subfamily.

Uniprot

A0A1Y1KC33   A0A224XMA5   A0A0A9X0L6   A0A0J7KF01   A0A3L8DK92   A0A1B0DJ12   + More
J9LC60   A0A1S3D9K7   J9M4D1   A0A1S4EH29   A0A2H1WY43   A0A1Y1LYU9   J9K1I8   X1WWX4   X1WKJ5   K7JEG9   A0A2H8TYF0   A0A2S2NUN9   J9JM91   A0A2S2NKL5   A0A2S2NH94   J9L8K0   J9K4C6   A0A0N0PCP7   J9KY69   A0A1S4EWX1   X1X6K2   J9M2D0   A0A151I654   A0A2H1V3I1   J9L927   A0A1W7R612   A0A336MFM0   A0A0J7MZB4   A0A0J7K1X7   K7JP93   A0A1W7R625   K7JIQ4   A0A0P6IZY2   H9JU07   A0A182RZX0   A0A2G8JN90   A0A1B0GPZ0   J9LX87   A0A2H1V177   A8E0Z6   K7JHX5   B0XEX5   A0A182PX43   J9KSQ5   A0A1Y1LYQ2   A0A2G8KHW0   K7JGS0   A0A1B0D656   A0A182VSM6   A0A232EES1   A0A182H7V6   A0A336MIV7   A0A0C9R9L5   K7JRR6   A0A2C9KVQ1   B0WJR5   A0A2C9KFK5   A0A336M977   W4YP12   W4XWS8   A0A1B0CYT8   K7JMB7   A0A0J7N979   W4Z3A9   A0A336L8N8   A0A336JYX5  

EC Number

1.2.1.84
3.5.1.-

Pubmed

28004739    25401762    30249741    20075255    26354079    17510324    + More
26999592    19121390    29023486    28648823    26483478    15562597   

EMBL

GEZM01087011    JAV58914.1    GFTR01007287    JAW09139.1    GBHO01029337    JAG14267.1    + More
LBMM01008491    KMQ88832.1    QOIP01000007    RLU20864.1    AJVK01063592    ABLF02023847    ABLF02017444    ODYU01011524    SOQ57304.1    GEZM01043833    JAV78742.1    ABLF02038792    ABLF02017764    ABLF02025656    ABLF02025658    AAZX01007240    AAZX01008809    AAZX01008867    AAZX01017227    AAZX01018662    AAZX01023390    AAZX01023918    AAZX01026511    GFXV01007016    MBW18821.1    GGMR01008133    MBY20752.1    ABLF02017693    GGMR01005058    MBY17677.1    GGMR01003952    MBY16571.1    ABLF02006580    ABLF02013955    KQ460474    KPJ14372.1    ABLF02007555    ABLF02044498    ABLF02023591    KQ978511    KYM93390.1    ODYU01000509    SOQ35403.1    ABLF02039566    GEHC01001063    JAV46582.1    UFQS01000961    UFQS01001389    UFQT01000961    UFQT01001389    SSX07977.1    SSX10646.1    SSX28211.1    LBMM01013145    KMQ85800.1    LBMM01016829    KMQ84299.1    AAZX01014012    GEHC01001021    JAV46624.1    AAZX01014011    GDUN01000556    JAN95363.1    BABH01003862    MRZV01001531    PIK37236.1    AJVK01064480    ABLF02004752    ABLF02012523    ABLF02057313    ODYU01000215    SOQ34613.1    AM850132    CAO98966.1    AAZX01012377    DS232879    EDS26306.1    ABLF02018314    ABLF02018316    GEZM01043830    JAV78744.1    MRZV01000572    PIK47582.1    AJVK01025749    NNAY01005248    OXU16828.1    JXUM01116986    KQ566040    KXJ70432.1    UFQS01001187    UFQT01001187    SSX09595.1    SSX29391.1    GBYB01003325    GBYB01009612    JAG73092.1    JAG79379.1    AAZX01004404    DS231963    EDS29408.1    UFQT01000563    SSX25343.1    AAGJ04160524    AAGJ04120197    AJVK01009344    AAZX01012375    LBMM01008012    KMQ89220.1    AAGJ04093992    UFQS01002322    UFQT01002322    SSX13789.1    SSX33210.1    UFQS01000016    UFQT01000016    SSW97401.1    SSX17787.1   

Proteomes

UP000036403    UP000279307    UP000092462    UP000007819    UP000079169    UP000002358    + More
UP000053240    UP000078542    UP000005204    UP000075900    UP000230750    UP000002320    UP000075885    UP000075920    UP000215335    UP000069940    UP000249989    UP000076420    UP000007110   

PRIDE

H9JU07   

Pfam

PF03184   DDE_1        + More
PF03221   HTH_Tnp_Tc5
PF05225   HTH_psq
PF16012   DUF4780
PF03015   Sterile
PF07993   NAD_binding_4
PF17921   Integrase_H2C2
PF18701   DUF5641
PF00665   rve
PF00628   PHD
PF02146   SIR2

Interpro

IPR009057   Homeobox-like_sf        + More
IPR006600   HTH_CenpB_DNA-bd_dom       
IPR004875   DDE_SF_endonuclease_dom       
IPR007889   HTH_Psq       
IPR019786   Zinc_finger_PHD-type_CS       
IPR011011   Znf_FYVE_PHD       
IPR002219   PE/DAG-bd       
IPR019787   Znf_PHD-finger       
IPR031961   DUF4780       
IPR001965   Znf_PHD       
IPR013083   Znf_RING/FYVE/PHD       
IPR026055   FAR       
IPR033640   FAR_C       
IPR013120   Male_sterile_NAD-bd       
IPR036291   NAD(P)-bd_dom_sf       
IPR036397   RNaseH_sf       
IPR041588   Integrase_H2C2       
IPR040676   DUF5641       
IPR012337   RNaseH-like_sf       
IPR001584   Integrase_cat-core       
IPR013087   Znf_C2H2_type       
IPR029035   DHS-like_NAD/FAD-binding_dom       
IPR026590   Ssirtuin_cat_dom       
IPR026587   Sirtuin_class_II       
IPR026591   Sirtuin_cat_small_dom_sf       
IPR003000   Sirtuin       

SUPFAM

SSF46689   SSF46689        + More
SSF57903   SSF57903       
SSF51735   SSF51735       
SSF53098   SSF53098       
SSF52467   SSF52467       

Gene 3D

3.30.40.10     3.30.420.10     3.30.1600.10    

CDD

cd09071  FAR_C

ProteinModelPortal

A0A1Y1KC33   A0A224XMA5   A0A0A9X0L6   A0A0J7KF01   A0A3L8DK92   A0A1B0DJ12   + More
J9LC60   A0A1S3D9K7   J9M4D1   A0A1S4EH29   A0A2H1WY43   A0A1Y1LYU9   J9K1I8   X1WWX4   X1WKJ5   K7JEG9   A0A2H8TYF0   A0A2S2NUN9   J9JM91   A0A2S2NKL5   A0A2S2NH94   J9L8K0   J9K4C6   A0A0N0PCP7   J9KY69   A0A1S4EWX1   X1X6K2   J9M2D0   A0A151I654   A0A2H1V3I1   J9L927   A0A1W7R612   A0A336MFM0   A0A0J7MZB4   A0A0J7K1X7   K7JP93   A0A1W7R625   K7JIQ4   A0A0P6IZY2   H9JU07   A0A182RZX0   A0A2G8JN90   A0A1B0GPZ0   J9LX87   A0A2H1V177   A8E0Z6   K7JHX5   B0XEX5   A0A182PX43   J9KSQ5   A0A1Y1LYQ2   A0A2G8KHW0   K7JGS0   A0A1B0D656   A0A182VSM6   A0A232EES1   A0A182H7V6   A0A336MIV7   A0A0C9R9L5   K7JRR6   A0A2C9KVQ1   B0WJR5   A0A2C9KFK5   A0A336M977   W4YP12   W4XWS8   A0A1B0CYT8   K7JMB7   A0A0J7N979   W4Z3A9   A0A336L8N8   A0A336JYX5  

KEGG

101741701    no KO assigned | (RefSeq) jerky protein homolog-like

GO

GO:0003677   GO:0003676   GO:0005634   GO:0046872   GO:0035556   GO:0016021   GO:0102965   GO:0080019   GO:0006629   GO:0015074   GO:0070403   GO:0008270   GO:0006471   GO:0034979   GO:0005759   GO:0016887   GO:0016491   GO:0016705   GO:0030145   GO:0006412   GO:0016876   GO:0043039  

PANTHER

PTHR11011  

Subcellular location

Nucleus  
Mitochondrion matrix  

Length:

430

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.00809999999999999

Exp number, first 60 AAs:

0.00037

Total prob of N-in:

0.00959

outside

1  -  430

 

 

Pi

180.454984

Theta

204.075764

Tajima's D

-0.372465

CLR

0.133903

CSRT

0.271886405679716

Interpretation

Uncertain