Gene

KWMTBOMO08206

Pre Gene Modal

BGIBMGA014459

Annotation

PREDICTED:_prolyl_3-hydroxylase_sudestada1?_partial_[Bombyx_mori]

Location

Bomo_Chr14(+):1738490-1745692      View in EpiBrowser

Full name

Prolyl 3-hydroxylase sudestada1       + More
Prolyl 3-hydroxylase OGFOD1      

Alternative Name

2-oxoglutarate and iron-dependent oxygenase domain-containing protein 1 homolog
uS12 prolyl 3-hydroxylase
2-oxoglutarate and iron-dependent oxygenase domain-containing protein 1

Location in the cell

Nuclear   Reliability : 2.724

CDS

ATGAGTTCGGCTATCAATGATGCCGAGGAACCATCGAGCACGACTCCTGAAGACAATGCTGCGACCAAGAGTGAGGTCGAAAACTCGACTACGGACGATGTACGTCCACCCGCCAAGCGGCGTCTTTCTAGCACAGTTATTGAGATATCTGATACTGAAAGTGACGACTCTGATGTTTGTGCTGTGAATTCATATCAAGCATCTGCTGATGAAGTTAAAAGAATACGCGGAGATTATTCTTCATCATCATCATCGTCATCTGACTATAGTTCGGACTCTGAGTGTGAAGATGACTCGATTGTCTTGGAGGACAAGATCATAAGTAAATCAATGCAGCTACAACGTAACCCTAGAGCAAATAGAATGGAAGATCCCAAATTTAATATTTTAATTACATCTCAAGAAATTATAGATGAGTTATCGACAAGTTGGAAAGAGTTGAAGAATCACACAAGCTCAAATGTGACAATCACATGTAACCCATTTAGATTGTGTCAGATACACAAATTTCTGATGAATCCTGACATTATAAATAATATTGTGGATGATATAAACACATTAGATTGGACTAGGAAAAAGATGGATTTGTATGAGTTCCACCAGACTACAGACCTGGCTAGCTTGAGCTGGCAGAGGAGTATTCGAGGGATATATGATCTACTGAAGACTGATGTTATGAATTGGGTATCAAAGGTAACAGGCTTAGAGCTGACGTCAGTATCAGCATCATGTTCACTTTATGGTCCGGGGGATCATTTGCTCGTTCACGACGACTTGCTTGGAGATCGAAGAGTGGCTTTCATCTTCTATCTTGCGCCCTGGACACTGCCACGGCAAGCAGTTGAGAATGGAGGAGGGGATCATAATATACAGGTTGATGATCAGTGTGGAGGCTGGAAAGAAGAAATGGGTGGAGCCCTAGAACTTTTCGCTAAGGATGAGGAAGGTCGGCCTACAGAGGTGGTGCACCGAATATACCCTAAGAACAATATGTTAGCTTTCTTCAAAGTCGGTGTTGATTCATACCACCAAGTAAGCGAGGTCCTGTCGTTGGAGCTGCCCCGCCTGTCCATCAACGGCTGGTTCCACGGACCGGAGCCGGGCCCCCCGCCCCCCGCCGCGCCGCCCGCCCCCGCGCCGCCCTACCTGCCCCCCACACCCCCGCATTCGGAAGTCGTGCTATTGAACCAGTGGGTGGAGGGCAGCTACCTGTCGGCCCGCAGCCGCGCGCAGGTGCAGGCGCAGATGGAGCGGGAGAGCGAGGTGTGTCTGCACGCGCTGCTGCTGGACCACAAGTACCGGCAGCTGCTGGAGGCGCTGCGCGACCCGGCCGTGCCGTGGGAGCCGTGCGGCCCGTCCAACCTGCGCCGCTACTCGCGCGTGCCCCCCGACTGGCTGCAAGCCCAGGACAAGCAGCACCCCATCCGGGAGCTGGTCCAGTTGATCACCAGCAACGTGTTCTTCAGGCTGCTCACGGACTGCACGGACCTGGGGCTGGCCACCTGCGAGAAGCTGGAGGTGCAGCAGTGGACGGCCGGCTGCTTCACCCTGCTGCCGCCCCGCGAGCAGTACCAGCAGGCGCGCCTGGAGGCCGTGCTGTACGTGGGCGCGCCGGCCCGGGGCTGCGCCCCCACGCACTACCTGGCGCCCGAGGAGGCGGGCGGCGCGGAGCCCGGCGCGCTGGTGTCGCTGCCGCCGGCCAACAACGCGCTCAACCTCGTGTACTGCGACGCCGGCGCCGCCTCCTTCACCAAGTACCTCGGCCGCATGGCCATGAGGGACCGCGCGCCCTTCTACATCGTCACTTGCATGTACAAGGAGTGA

Protein

MSSAINDAEEPSSTTPEDNAATKSEVENSTTDDVRPPAKRRLSSTVIEISDTESDDSDVCAVNSYQASADEVKRIRGDYSSSSSSSSDYSSDSECEDDSIVLEDKIISKSMQLQRNPRANRMEDPKFNILITSQEIIDELSTSWKELKNHTSSNVTITCNPFRLCQIHKFLMNPDIINNIVDDINTLDWTRKKMDLYEFHQTTDLASLSWQRSIRGIYDLLKTDVMNWVSKVTGLELTSVSASCSLYGPGDHLLVHDDLLGDRRVAFIFYLAPWTLPRQAVENGGGDHNIQVDDQCGGWKEEMGGALELFAKDEEGRPTEVVHRIYPKNNMLAFFKVGVDSYHQVSEVLSLELPRLSINGWFHGPEPGPPPPAAPPAPAPPYLPPTPPHSEVVLLNQWVEGSYLSARSRAQVQAQMERESEVCLHALLLDHKYRQLLEALRDPAVPWEPCGPSNLRRYSRVPPDWLQAQDKQHPIRELVQLITSNVFFRLLTDCTDLGLATCEKLEVQQWTAGCFTLLPPREQYQQARLEAVLYVGAPARGCAPTHYLAPEEAGGAEPGALVSLPPANNALNLVYCDAGAASFTKYLGRMAMRDRAPFYIVTCMYKE

Description

Prolyl 3-hydroxylase that catalyzes 3-hydroxylation of 'Pro-62' of small ribosomal subunit uS12 (RpS23), thereby regulating protein translation termination efficiency.
Prolyl 3-hydroxylase that catalyzes 3-hydroxylation of 'Pro-62' of small ribosomal subunit uS12 (rps23), thereby regulating protein translation termination efficiency. Involved in stress granule formation.

Catalytic Activity

2-oxoglutarate + [ribosomal protein uS12]-L-proline + O2 = [ribosomal protein uS12]-(3S)-3-hydroxy-L-proline + CO2 + succinate

Cofactor

Fe(2+)
L-ascorbate

Subunit

Monomer.

Similarity

Belongs to the TPA1 family.

Keywords

Complete proteome   Cytoplasm   Dioxygenase   Iron   Metal-binding   Nucleus   Oxidoreductase   Reference proteome   Vitamin C  

Feature

chain  Prolyl 3-hydroxylase sudestada1

Uniprot

A0A212EU28   A0A2H1WUM9   A0A0N1PFI0   A0A2W1BIZ6   A0A0K8TLQ3   A0A0A1XSX7   + More
A0A0Q9X5S8   A0A3B0JE21   A0A0A1XG59   W8C6B5   Q29A08   A0A0K8UY84   B4G3K8   A0A034W9W3   Q9I7H9   A0A1Y1MT75   B4INZ7   A0A0R1EAY6   A0A0Q9WDG4   A0A0P8YP15   A0A084W570   B3LX03   A0A1W4VLM0   A0A182LYL9   A0A1I8PF04   A0A336KT59   D6X1U2   B4JYA2   A0A182TFF4   N6UJN0   F5HKE4   A0A182IMZ4   A0A1I8M0S9   A0A1I8JW99   A0A2M4BIF7   A0A2M4BIA2   A0A1S4FGZ1   A0A0L0CQJ2   A0A182JXQ6   A0A182HTZ1   W5JJA0   A0A182NZD5   A0A0M4EUJ5   A0A182VRR3   A0A182UY32   A0A182LG37   B4IJB6   A0A182GU49   H6WAR0   A0A182RPB7   A0A1B0DKP7   A0A182XV12   A0A182FNT1   A0A182NLH8   A0A1A9ZGD9   A0A1A9VTW3   A0A1A9XDK3   A0A1B0DFW2   A0A1B0BTU3   A0A1A9WRR7   A0A224Y2Y7   A0A131Z0V5   A0A1B0CEZ4   A0A2L2Y7W0   L7M768   A0A067RLY1   A0A210PHT0   A7RTS5   Q6DE73  

EC Number

1.14.11.-

Pubmed

22118469    26354079    28756777    26369729    25830018    17994087    + More
24495485    15632085    25348373    10731132    12537572    12537569    24550463    28004739    17550304    24438588    18362917    19820115    23537049    12364791    14747013    17210077    25315136    26108605    20920257    23761445    20966253    26483478    23055932    25244985    28797301    26830274    26561354    25576852    24845553    28812685    17615350   

EMBL

AGBW02012474    OWR45000.1    ODYU01011129    SOQ56676.1    KQ460889    KPJ11080.1    + More
KZ150093    PZC73664.1    GDAI01002527    JAI15076.1    GBXI01000629    JAD13663.1    CH933806    KRG01178.1    OUUW01000005    SPP80335.1    GBXI01003928    JAD10364.1    GAMC01004369    JAC02187.1    CM000070    EAL27543.1    GDHF01020811    GDHF01019829    JAI31503.1    JAI32485.1    CH479179    EDW25016.1    GAKP01007458    JAC51494.1    AE014297    AY058522    GEZM01023518    JAV88338.1    CH677315    EDW48752.1    CM000160    KRK04506.1    CH940652    KRF78709.1    CH902617    KPU80499.1    ATLV01020511    KE525302    KFB45364.1    EDV43842.2    AXCM01000497    UFQS01000993    UFQT01000993    SSX08310.1    SSX28333.1    KQ971371    EFA10164.1    CH916377    EDV90664.1    APGK01017188    APGK01017189    KB739998    KB631984    ENN81950.1    ERL87639.1    AAAB01008859    EGK96696.1    GGFJ01003600    MBW52741.1    GGFJ01003644    MBW52785.1    JRES01000062    KNC34516.1    APCN01000594    ADMH02001019    ETN64437.1    CP012526    ALC46780.1    CH480848    EDW51107.1    JXUM01088539    JXUM01088540    JXUM01088541    KQ563708    KXJ73459.1    JQ042683    AEZ67828.1    AJVK01035672    AJVK01015145    JXJN01020367    GFPF01000781    MAA11927.1    GEDV01004786    JAP83771.1    AJWK01009480    IAAA01012348    IAAA01012349    LAA04233.1    GACK01004913    JAA60121.1    KK852597    KDR20583.1    NEDP02076682    OWF36048.1    DS469538    EDO45080.1    BC077268   

Proteomes

UP000007151    UP000053240    UP000009192    UP000268350    UP000001819    UP000008744    + More
UP000000803    UP000001292    UP000002282    UP000008792    UP000007801    UP000030765    UP000192221    UP000075883    UP000095300    UP000007266    UP000001070    UP000075902    UP000019118    UP000030742    UP000007062    UP000075880    UP000095301    UP000076407    UP000037069    UP000075881    UP000075840    UP000000673    UP000075885    UP000092553    UP000075920    UP000075903    UP000075882    UP000069940    UP000249989    UP000075900    UP000092462    UP000076408    UP000069272    UP000075884    UP000092445    UP000078200    UP000092443    UP000092460    UP000091820    UP000092461    UP000027135    UP000242188    UP000001593   

PRIDE

Q9I7H9   

Pfam

PF10637   Ofd1_CTDD        + More
PF13661   2OG-FeII_Oxy_4
PF10510   PIG-S
PF02383   Syja_N
PF12456   hSac2
PF00781   DAGK_cat

Interpro

IPR006620   Pro_4_hyd_alph        + More
IPR019601   Oxoglutarate/Fe-dep_Oase_C       
IPR005123   Oxoglu/Fe-dep_dioxygenase       
IPR039558   TPA1/OFD1_N       
IPR019540   PtdIno-glycan_biosynth_class_S       
IPR034753   hSac2       
IPR022158   Inositol_phosphatase       
IPR002013   SAC_dom       
IPR017438   ATP-NAD_kinase_N       
IPR016064   NAD/diacylglycerol_kinase_sf       
IPR001206   Diacylglycerol_kinase_cat_dom       

SUPFAM

SSF111331   SSF111331       

Gene 3D

3.40.50.10330    

ProteinModelPortal

A0A212EU28   A0A2H1WUM9   A0A0N1PFI0   A0A2W1BIZ6   A0A0K8TLQ3   A0A0A1XSX7   + More
A0A0Q9X5S8   A0A3B0JE21   A0A0A1XG59   W8C6B5   Q29A08   A0A0K8UY84   B4G3K8   A0A034W9W3   Q9I7H9   A0A1Y1MT75   B4INZ7   A0A0R1EAY6   A0A0Q9WDG4   A0A0P8YP15   A0A084W570   B3LX03   A0A1W4VLM0   A0A182LYL9   A0A1I8PF04   A0A336KT59   D6X1U2   B4JYA2   A0A182TFF4   N6UJN0   F5HKE4   A0A182IMZ4   A0A1I8M0S9   A0A1I8JW99   A0A2M4BIF7   A0A2M4BIA2   A0A1S4FGZ1   A0A0L0CQJ2   A0A182JXQ6   A0A182HTZ1   W5JJA0   A0A182NZD5   A0A0M4EUJ5   A0A182VRR3   A0A182UY32   A0A182LG37   B4IJB6   A0A182GU49   H6WAR0   A0A182RPB7   A0A1B0DKP7   A0A182XV12   A0A182FNT1   A0A182NLH8   A0A1A9ZGD9   A0A1A9VTW3   A0A1A9XDK3   A0A1B0DFW2   A0A1B0BTU3   A0A1A9WRR7   A0A224Y2Y7   A0A131Z0V5   A0A1B0CEZ4   A0A2L2Y7W0   L7M768   A0A067RLY1   A0A210PHT0   A7RTS5   Q6DE73  

PDB

4NHY     E-value=1.00341e-30,     Score=335

KEGG

101739241    no KO assigned | (RefSeq) prolyl 3-hydroxylase sudestada1

GO

GO:0031418   GO:0016706   GO:0005506   GO:0016705   GO:0016740   GO:0005737   GO:0005634   GO:0031543   GO:0006417   GO:0055114   GO:0019511   GO:0018126   GO:0016255   GO:0042765   GO:0006449   GO:0042578   GO:0003951   GO:0008283   GO:0034063   GO:0031544   GO:0010494   GO:0016491   GO:0030145   GO:0006412   GO:0016876   GO:0043039  

PANTHER

PTHR21072  

Subcellular location

Nucleus  
Cytoplasm  

Length:

607

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.03525

Exp number, first 60 AAs:

0

Total prob of N-in:

0.00077

outside

1  -  607

 

 

Pi

258.274239

Theta

197.114267

Tajima's D

1.020726

CLR

0.154159

CSRT

0.665866706664667

Interpretation

Uncertain