Gene

KWMTBOMO08204  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA009496

Annotation

PREDICTED:_ADP-ribosylation_factor_GTPase-activating_protein_3_isoform_X1_[Amyelois_transitella]

Location

Bomo_Chr14(+):1712470-1726303      View in EpiBrowser

Full name

ADP-ribosylation factor GTPase-activating protein 2      

Alternative Name

GTPase-activating protein ZNF289
Zinc finger protein 289

Location in the cell

Nuclear   Reliability : 2.723

CDS

ATGGCTGACTCTGGGCCGAGTAAAAGCGATATTGAAGCAGTTTTTCAAAGATTACGAGCGATTCCTGCTAATAAAGCATGTTTCGACTGCAACGCCAAAAATCCTACGTGGTCATCTGTGACGTACGGTGTATTCATATGTCTCGACTGCTCGGCGGTGCACCGAAGCTTGGGAGTCCATCTCACCTTCGTTCGTTCGACTCAACTGGACACTAATTGGACATGGAAACAGCTGAGAAACATGCAACTTGGCGGGAACATAAATGCTATACAATTCTTCCGCACCCACGGGCTGGTGACAGAGGATGCTCGTCAGAAGTACAGTTCACGAGTGGCACAGATGTATCGTGACAAACTTAATTTACTCTCTGAACAGGCTATGAAAACACATGGGACCAAGTTACACATAGAAGCTACAGCACCGGAGCCCAAGGAGAATAAGGAGGCCGAGGTAGATTGGTTTTCACAACACGGAAAGTCGACAAGCACTAACACAAACGAGTTTGCAAATGCCTCCCAGGCCAATAAACAGGAGCCCCTGAGTTCAGAAGCTCGTTTATGGGACTCTGGTCCAGCGCTGGGATCGAACGCTGACACCCCTCGCCCGTCAACCATCGGGAGCAGGAAACCTGCTGCCAAACGAACCGGGCTGGGCGCGCGTAAGGGTTTGGGAGCCACGAAGGTGTCAGCTAATTTTGAAGACATCGAACGCGAGGCTATCATGGCCGAGAAGCTCAAGATGGAGACGAAGGCTTCGGAGCAGAGAGCCACGCTGGAGAACGTGGAACAGGAAGTGGCCTCGTTGCGACTGGCGTACCGGGAACCCAGCAACAAGCCCAACTCTGAGCGGCTGGGTATAGCTGGAGCGAACAGGGCGAACACATCCGGCGTGTCCCACTCGGCCGCGTCGGACATGACCATCATCGAGCAGGAGGGGTCCGCAGCGCCACCCACGCACCTGGACGACATCGACGACTTCACCTCCTCGTTCACCATGATCAGGAGCGAGCCCTTCAGCAACAGCCGCGCTCTGGACAGGATGTTCGGTGAGGCGGACCGGCCGGAGCGCAAGTTCTCGCTGGAGAGCGCGCAGCACATCGAGCCGGAGCCGGCGCGGCCCGTGCACTCCATGTTCGCGGACGAGCGGCCCCCCGCGCCCGCCCCGCCCCGCCCCCGCGCCAAGAAGAACGCGCCAGAGCCCGAAGATGACTCCGCCGTGCGCAAGTTCGGCTCGGCCAAGGCTATCAGTTCCGCGCAGTTCTTCGGAGAGCAGGATCGTTCGTGGGAGACGTCGGGCAGCACGGCGTCCAGGTTTGGCGGCAGCAGCAGCATCTCGTCCGCCGAGTACTTCGGGGACTCCGCCCCGCAGCGCCCGCCCTCGTTCTCCGTGTCGGCGCCGCACCTCGACGACGTGCGCGAGTCGGTGCGCGCGGGCGTGACGCGCGTGGCGGGCCGCCTGTCGTCGCTGGCCAACGGCGTCGTGTCCTCCATCCAGGAGAAGTACGGCTACTGA

Protein

MADSGPSKSDIEAVFQRLRAIPANKACFDCNAKNPTWSSVTYGVFICLDCSAVHRSLGVHLTFVRSTQLDTNWTWKQLRNMQLGGNINAIQFFRTHGLVTEDARQKYSSRVAQMYRDKLNLLSEQAMKTHGTKLHIEATAPEPKENKEAEVDWFSQHGKSTSTNTNEFANASQANKQEPLSSEARLWDSGPALGSNADTPRPSTIGSRKPAAKRTGLGARKGLGATKVSANFEDIEREAIMAEKLKMETKASEQRATLENVEQEVASLRLAYREPSNKPNSERLGIAGANRANTSGVSHSAASDMTIIEQEGSAAPPTHLDDIDDFTSSFTMIRSEPFSNSRALDRMFGEADRPERKFSLESAQHIEPEPARPVHSMFADERPPAPAPPRPRAKKNAPEPEDDSAVRKFGSAKAISSAQFFGEQDRSWETSGSTASRFGGSSSISSAEYFGDSAPQRPPSFSVSAPHLDDVRESVRAGVTRVAGRLSSLANGVVSSIQEKYGY

Description

GTPase-activating protein (GAP) for ADP ribosylation factor 1 (ARF1). May regulate coatomer-mediated protein transport from the Golgi complex to the endoplasmic reticulum. Hydrolysis of ARF1-bound GTP may lead to dissociation of coatomer from Golgi-derived membranes to allow fusion with target membranes (By similarity).

Subunit

Interacts with the coatomer complex. Interacts with the C-terminal appendage domain of COPG1 (By similarity).

Keywords

3D-structure   Acetylation   Coiled coil   Complete proteome   Cytoplasm   ER-Golgi transport   Golgi apparatus   GTPase activation   Membrane   Metal-binding   Phosphoprotein   Protein transport   Reference proteome   Transport   Zinc   Zinc-finger  

Feature

chain  ADP-ribosylation factor GTPase-activating protein 2

Uniprot

H9JIZ5   A0A212EU21   A0A2A4JQB5   A0A0L7LAE9   A0A0N1I800   A0A2W1BEX5   + More
E0VKG7   A0A067RL05   A0A2J7PGE9   A0A0A9WLG0   A0A0K8SPK8   A0A087TKX9   A0A2J7PGE5   A0A0M4EGH1   A0A0A1X7M1   A0A0M5J179   A0A0K8VL98   E9G5B9   W8C0I9   B4LF75   A0A0Q9XP30   B4KX23   A0A2P8Y081   A0A0P4VU45   R4G8T1   A0A1W4URD0   B3MB77   A0A182GVG6   A0A0Q9XEA8   A0A0Q9WV75   A0A1Y1KF27   A0A023EWG1   A0A0T6BFY1   D2A2A4   A0A1Y1K9S0   A0A1B0CJE7   A0A1L8DML5   A0A1B6D9B9   A0A2I4CYV2   A0A1B0DMH9   A0A3Q3G4L3   U5EX70   A0A1L8DML0   A0A3P9AFG3   G3GYJ9   A0A3Q2XHX6   G1KS32   A0A1B6E547   Q32PR4   F1RB32   W5MDV1   A0A3B4T4S8   A0A3P8VCW7   A0A402EPW3   A0A146MLW3   F1KYS0   A0A0F7ZBB9   A0A2G8KB42   A0A3P8YWT5   A0A0P6JHD0   A0A3Q3MJP9   A0A3Q3IJU4   W5MDT3   A0A0K8S2U6   T1DDV0   A0A1S2ZGR1   A0A3Q4B081   A0A3Q2Z1H2   A0A3B4Z4N8   A0A146ZK70   A0A1B6G4N3   A0A3Q1JNI8   A0A1W4ZDQ8   A0A1W7RJM4   A0A452DQA6   K9IL45   T1KHG6   A0A0M3HRF4   A0A1U7Q5M4   A0A1A8MRN7   A0A3P8VDG8   B7PHG6   A0A1A8SLF6   Q3MID3   A0A3Q1CKX3   V5H1Z4   A0A1W4Z524   A0A1S3W6G1   A0A1A8NTC4   A0A3Q7R230   A0A0K8S465  

Pubmed

19121390    22118469    26227816    26354079    28756777    20566863    + More
24845553    25401762    26823975    25830018    21292972    24495485    17994087    18057021    29403074    27129103    26483478    28004739    24945155    18362917    19820115    25069045    21804562    23594743    24487278    21685128    29023486    25727380    23758969    26358130    15489334    22673903   

EMBL

BABH01023051    AGBW02012474    OWR45002.1    NWSH01000904    PCG73600.1    JTDY01001946    + More
KOB72473.1    KQ460889    KPJ11077.1    KZ150093    PZC73662.1    DS235243    EEB13847.1    KK852614    KDR20211.1    NEVH01025635    PNF15407.1    GBHO01035343    GDHC01003843    JAG08261.1    JAQ14786.1    GBRD01010621    JAG55203.1    KK115693    KFM65768.1    PNF15413.1    CP012525    ALC43515.1    GBXI01014991    GBXI01007614    JAC99300.1    JAD06678.1    ALC45248.1    GDHF01012653    JAI39661.1    GL732532    EFX85179.1    GAMC01011416    JAB95139.1    CH940647    EDW70263.1    CH933809    KRG06732.1    KRG06734.1    EDW19666.2    PYGN01001092    PSN37667.1    GDKW01000522    JAI56073.1    GAHY01000432    JAA77078.1    CH902618    EDV41378.1    JXUM01090910    KQ563874    KXJ73131.1    KRG06733.1    KRF84814.1    GEZM01088372    JAV58235.1    GAPW01000804    JAC12794.1    LJIG01000722    KRT86218.1    KQ971338    EFA02163.1    GEZM01088374    JAV58232.1    AJWK01014538    AJWK01014539    AJWK01014540    AJWK01014541    GFDF01006385    JAV07699.1    GEDC01015021    JAS22277.1    AJVK01001346    GANO01000208    JAB59663.1    GFDF01006386    JAV07698.1    JH000067    EGW03939.1    GEDC01004247    JAS33051.1    BC108014    AAI08015.1    CU469519    AHAT01036572    BDOT01000029    GCF46255.1    GCES01165803    JAQ20519.1    JI168188    ADY43024.1    GBEX01000135    JAI14425.1    MRZV01000727    PIK45202.1    GEBF01003276    JAO00357.1    GBKD01000085    JAG47533.1    GAAZ01000104    GBKC01000144    JAA97839.1    JAG45926.1    GCES01020056    JAR66267.1    GECZ01012375    JAS57394.1    GDAY02000093    JAV51320.1    LWLT01000015    GABZ01005557    JAA47968.1    CAEY01000075    HAEF01018077    SBR59236.1    ABJB010102593    ABJB010860213    ABJB011006329    DS712856    EEC06038.1    HAEH01014786    HAEI01016732    SBS19201.1    BC101917    GALX01001588    JAB66878.1    HAEG01004695    SBR72283.1    GBKD01000078    JAG47540.1   

Proteomes

UP000005204    UP000007151    UP000218220    UP000037510    UP000053240    UP000009046    + More
UP000027135    UP000235965    UP000054359    UP000092553    UP000000305    UP000008792    UP000009192    UP000245037    UP000192221    UP000007801    UP000069940    UP000249989    UP000007266    UP000092461    UP000192220    UP000092462    UP000261660    UP000265140    UP000001075    UP000264820    UP000001646    UP000000437    UP000018468    UP000261420    UP000265120    UP000288954    UP000230750    UP000261640    UP000261600    UP000079721    UP000261620    UP000261360    UP000265000    UP000265040    UP000192224    UP000291000    UP000015104    UP000036681    UP000189706    UP000001555    UP000002494    UP000257160    UP000286641   

PRIDE

H9JIZ5    G3GYJ9    Q32PR4    F1RB32    Q3MID3   

Pfam

PF01412   ArfGap

Interpro

IPR001164   ArfGAP_dom        + More
IPR038508   ArfGAP_dom_sf       
IPR037278   ARFGAP/RecO       

SUPFAM

SSF57863   SSF57863       

Gene 3D

3.30.40.160    

ProteinModelPortal

H9JIZ5   A0A212EU21   A0A2A4JQB5   A0A0L7LAE9   A0A0N1I800   A0A2W1BEX5   + More
E0VKG7   A0A067RL05   A0A2J7PGE9   A0A0A9WLG0   A0A0K8SPK8   A0A087TKX9   A0A2J7PGE5   A0A0M4EGH1   A0A0A1X7M1   A0A0M5J179   A0A0K8VL98   E9G5B9   W8C0I9   B4LF75   A0A0Q9XP30   B4KX23   A0A2P8Y081   A0A0P4VU45   R4G8T1   A0A1W4URD0   B3MB77   A0A182GVG6   A0A0Q9XEA8   A0A0Q9WV75   A0A1Y1KF27   A0A023EWG1   A0A0T6BFY1   D2A2A4   A0A1Y1K9S0   A0A1B0CJE7   A0A1L8DML5   A0A1B6D9B9   A0A2I4CYV2   A0A1B0DMH9   A0A3Q3G4L3   U5EX70   A0A1L8DML0   A0A3P9AFG3   G3GYJ9   A0A3Q2XHX6   G1KS32   A0A1B6E547   Q32PR4   F1RB32   W5MDV1   A0A3B4T4S8   A0A3P8VCW7   A0A402EPW3   A0A146MLW3   F1KYS0   A0A0F7ZBB9   A0A2G8KB42   A0A3P8YWT5   A0A0P6JHD0   A0A3Q3MJP9   A0A3Q3IJU4   W5MDT3   A0A0K8S2U6   T1DDV0   A0A1S2ZGR1   A0A3Q4B081   A0A3Q2Z1H2   A0A3B4Z4N8   A0A146ZK70   A0A1B6G4N3   A0A3Q1JNI8   A0A1W4ZDQ8   A0A1W7RJM4   A0A452DQA6   K9IL45   T1KHG6   A0A0M3HRF4   A0A1U7Q5M4   A0A1A8MRN7   A0A3P8VDG8   B7PHG6   A0A1A8SLF6   Q3MID3   A0A3Q1CKX3   V5H1Z4   A0A1W4Z524   A0A1S3W6G1   A0A1A8NTC4   A0A3Q7R230   A0A0K8S465  

PDB

5NZS     E-value=1.04144e-73,     Score=705

KEGG

101746692    K12493 ADP-ribosylation factor GTPase-activating protein 2/3 | (RefSeq) ADP-ribosylation factor GTPa

PATHWAY

04144    Endocytosis - Bombyx mori (domestic silkworm)

GO

GO:0046872   GO:0005096   GO:0048205   GO:0006890   GO:0005802   GO:0006888   GO:0000139   GO:0005912   GO:0001745   GO:0005737   GO:0005829   GO:0009306   GO:0005794   GO:0005886   GO:0015031   GO:0008270   GO:0005515   GO:0046983   GO:0005634   GO:0030145   GO:0006412   GO:0016876   GO:0043039  

Subcellular location

Cytoplasm   Also found on peripheral punctate structures likely to be endoplasmic reticulum-Golgi intermediate compartment.   With evidence from 2 publications.
Golgi apparatus membrane   Also found on peripheral punctate structures likely to be endoplasmic reticulum-Golgi intermediate compartment.   With evidence from 2 publications.

Length:

503

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.04526

Exp number, first 60 AAs:

0.04334

Total prob of N-in:

0.00346

outside

1  -  503

 

 

Pi

177.565268

Theta

156.992748

Tajima's D

0.310569

CLR

1.160792

CSRT

0.457977101144943

Interpretation

Uncertain