Gene

KWMTBOMO08200  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA009495

Annotation

replication_factor_C_subunit_2_[Bombyx_mori]

Location

Bomo_Chr14(+):1669830-1672135      View in EpiBrowser

Full name

Replication factor C subunit 2      

Alternative Name

Activator 1 40 kDa subunit
Activator 1 subunit 2
Replication factor C 40 kDa subunit
Replication factor C subunit 4

Location in the cell

Cytoplasmic   Reliability : 2.002

CDS

ATGGATGATGATGATATCGTGATAATGGAAGTAGACGAACCGGAGAAGAAACAAGTAAAACCTAGTTCTAGTAAATCTACAAATTTACCATGGATAGAGAAATACAGGCCACAAACTTTCGACGATATCGTTGGCAATGAAGACACTGTGTCCCGCTTAGCCGTCTTTGCTAAAACCGGCAATGCTCCTAACATTATTATAGCTGGACCTCCTGGTGTTGGAAAAACGACGACTATACTATGCTTAGCGCGAGCTCTCCTCGGAGTATCTTTCAAAGACGCCGTATTAGAACTAAACGCCTCAAATGATCGTGGTATAGATGTCGTCCGGAATAAGATAAAAATGTTTGCGCAACAAAAGGTTACTTTGCCACCTGGTCGACATAAAATAGTGATACTAGATGAAGCGGACAGCATGACTGACGGAGCTCAACAAGCATTAAGACGCACCATGGAGCTGTATTCCAGTACAACTCGTTTTGCATTAGCAGCCAATAATAGTGAGAAGATAATAGAACCCATACAATCTAGGTGTGCTGTACTCCGGTACTCCAGGCTTAGTGATGCACAGATACTAGCAAAGGTTATAGAGATCTGCAATAAAGAAAACCTATCATACACTGAAGAAGGTGTGAGTGCAGTAGTCTTCACAGCACAGGGGGACTTGCGATCAGCCCTGAACAACCTGCAGTCAACAGCCCAGGGTTTTGGTCACATCAGCCCGGACAATGTGTTCAAAGTGTGTGATGAACCACATCCGATGGTGGTCAGGCAGATGCTTGAAGCTTGCACTAAACAGGATATACATGAGGCTTACAAGGTTATAGCAAAACTCTGCAAGATTGGCTACGCAGCAGAGGACATAGTCAGTAACATATTCAGAGTTTGCAAAACTTTAGATATATCTGAAGAGTTAAAACTGGCTTTCATCAGAGAGATTGGTTTGACACACATGAGGGTAGCAGATGGTCTTTCGTCTCCCCTGCAGCTGGCCGGTCTCCTCGCCAGGATGTGCAGGGTGGCTGCCGGCGGTGACCCGGAGTGGTGA

Protein

MDDDDIVIMEVDEPEKKQVKPSSSKSTNLPWIEKYRPQTFDDIVGNEDTVSRLAVFAKTGNAPNIIIAGPPGVGKTTTILCLARALLGVSFKDAVLELNASNDRGIDVVRNKIKMFAQQKVTLPPGRHKIVILDEADSMTDGAQQALRRTMELYSSTTRFALAANNSEKIIEPIQSRCAVLRYSRLSDAQILAKVIEICNKENLSYTEEGVSAVVFTAQGDLRSALNNLQSTAQGFGHISPDNVFKVCDEPHPMVVRQMLEACTKQDIHEAYKVIAKLCKIGYAAEDIVSNIFRVCKTLDISEELKLAFIREIGLTHMRVADGLSSPLQLAGLLARMCRVAAGGDPEW

Description

The elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the accessory proteins proliferating cell nuclear antigen (PCNA) and activator 1. Subunit 2 binds ATP.

Subunit

Heteropentamer of subunits of 140/145, 40, 38, 37, and 36.5 kDa that forms a complex with PCNA in the presence of ATP.

Similarity

Belongs to the activator 1 small subunits family.

Keywords

ATP-binding   Cell cycle   Complete proteome   DNA replication   DNA-binding   Nucleotide-binding   Nucleus   Reference proteome  

Feature

chain  Replication factor C subunit 2

Uniprot

H9JIZ4   Q60GE7   A0A3S2LVP1   A0A0N0PBU5   A0A212EW79   A0A194PYA2   + More
A0A2A4JNE6   A0A2W1BFU3   S4NT32   A0A1Q3EXN7   B0VZJ1   A0A182GXT3   A0A182JB41   A0A084WNA0   U5EV45   W5JRP3   A0A182FF42   A0A182MRS4   A0A182VDF2   A0A182KGH8   A0A182I3A5   A0A182KRC2   A0A182U182   A0A1I8MP82   A0A182S7T7   Q7QJE6   A0A182X3R4   A0A182QT42   A0A182XYW1   A0A0P6JS08   A0A0L7LAH0   A0A0L0C9Z6   A0A0T6B1B8   A0A1I8PJQ7   A0A336LWV6   A0A034W201   A0A0V0G645   A0A146LRR5   A0A146MDJ8   W8C2R8   N6UL65   R4FL91   A0A1A9V4P4   A0A0K8T2R4   A0A0K8UA74   A0A182PQF3   A0A154P8A8   A0A023F8X5   A0A1Y1LD99   A0A0A1WY16   A0A1L8DWT2   D3TS38   B4N3J7   B4L9D9   A0A1A9ZLX9   A0A1A9WAT6   A0A1B0C945   B4LB85   A0A195CFP7   B4J1E1   K7IMQ4   A0A182RSN2   A0A0L7RDR1   B4HU02   B4QQ45   A0A1W4W4I9   A0A0M4EZC3   A0A0N0U436   E2AG75   A0A2T7PCM7   P53034   B4PHP8   A0A310SQG9   A0A2J7QRU6   A0A232F9J5   A0A182WJ86   A0A0L8HHW0   A0A1B6KNQ8   A0A3B0JUP4   A0A1W4X0W3   E2BC66   B3NG38   A0A1B6EQ14   D7ELV8   A0A2R7W037   A0A0J7L2V6   A0A1S3DK53   A0A1B6C2G3   A0A195F9P0   F4X840   A0A402EMH7   A0A182NHV7   A0A067RQC0   A0A0N8AG98   B3M4V2   A0A164MZD4   A0A158NCB2   A0A452DYI2   E9IME3   A0A195BW97  

Pubmed

19121390    26354079    22118469    28756777    23622113    26483478    + More
24438588    20920257    23761445    20966253    25315136    12364791    14747013    17210077    25244985    26999592    26227816    26108605    25348373    26823975    24495485    23537049    25474469    28004739    25830018    20353571    17994087    20075255    22936249    20798317    7789770    10731132    12537572    12537569    11438670    17550304    28648823    18362917    19820115    21719571    24845553    21347285    21282665   

EMBL

BABH01023047    AB177621    BAD61055.1    RSAL01000178    RVE44995.1    KQ460889    + More
KPJ11072.1    AGBW02012057    OWR45752.1    KQ459585    KPI98312.1    NWSH01000904    PCG73595.1    KZ150093    PZC73658.1    GAIX01013812    JAA78748.1    GFDL01015077    JAV19968.1    DS231814    EDS31728.1    JXUM01020780    KQ560581    KXJ81815.1    ATLV01024580    KE525352    KFB51694.1    GANO01002032    JAB57839.1    ADMH02000549    ETN65953.1    AXCM01005343    APCN01000204    AAAB01008807    EAA04621.4    AXCN02000379    GDUN01000788    JAN95131.1    JTDY01001946    KOB72472.1    JRES01000713    KNC29035.1    LJIG01016346    KRT80878.1    UFQT01000259    SSX22532.1    GAKP01010793    GAKP01010792    JAC48160.1    GECL01002928    JAP03196.1    GDHC01008824    JAQ09805.1    GDHC01000825    JAQ17804.1    GAMC01000323    JAC06233.1    APGK01019085    KB740092    KB632429    ENN81426.1    ERL95468.1    ACPB03001111    GAHY01002189    JAA75321.1    GBRD01006352    GBRD01006351    JAG59470.1    GDHF01028833    GDHF01026860    JAI23481.1    JAI25454.1    KQ434842    KZC08102.1    GBBI01000822    JAC17890.1    GEZM01063721    JAV68997.1    GBXI01010328    JAD03964.1    GFDF01003191    JAV10893.1    CCAG010000815    EZ424240    ADD20516.1    CH964095    EDW79202.1    CH933816    EDW17314.1    AJWK01001897    CH940647    EDW68649.1    KQ977873    KYM99126.1    CH916366    EDV95832.1    KQ414612    KOC69127.1    CH480817    EDW50423.1    CM000363    CM002912    EDX09165.1    KMY97508.1    CP012525    ALC44037.1    KQ435840    KOX71452.1    GL439266    EFN67566.1    PZQS01000004    PVD31174.1    U15967    AE014296    AY094829    CM000159    EDW93357.1    KQ761679    OAD57175.1    NEVH01011885    PNF31300.1    NNAY01000685    OXU26987.1    KQ418097    KOF88843.1    GEBQ01026907    JAT13070.1    OUUW01000002    SPP77429.1    GL447256    EFN86693.1    CH954178    EDV50867.1    GECZ01029779    JAS39990.1    KQ971431    EFA12420.2    KK854187    PTY12808.1    LBMM01001179    KMQ96769.1    GEDC01029586    JAS07712.1    KQ981727    KYN37096.1    GL888912    EGI57389.1    BDOT01000024    GCF45414.1    KK852529    KDR21944.1    GDIP01150353    JAJ73049.1    CH902618    EDV40526.1    LRGB01002914    KZS05513.1    ADTU01011781    LWLT01000031    GL764132    EFZ18260.1    KQ976396    KYM92857.1   

Proteomes

UP000005204    UP000283053    UP000053240    UP000007151    UP000053268    UP000218220    + More
UP000002320    UP000069940    UP000249989    UP000075880    UP000030765    UP000000673    UP000069272    UP000075883    UP000075903    UP000075881    UP000075840    UP000075882    UP000075902    UP000095301    UP000075901    UP000007062    UP000076407    UP000075886    UP000076408    UP000037510    UP000037069    UP000095300    UP000019118    UP000030742    UP000015103    UP000078200    UP000075885    UP000076502    UP000092444    UP000007798    UP000009192    UP000092445    UP000091820    UP000092461    UP000008792    UP000078542    UP000001070    UP000002358    UP000075900    UP000053825    UP000001292    UP000000304    UP000192221    UP000092553    UP000053105    UP000000311    UP000245119    UP000000803    UP000002282    UP000235965    UP000215335    UP000075920    UP000053454    UP000268350    UP000192223    UP000008237    UP000008711    UP000007266    UP000036403    UP000079169    UP000078541    UP000007755    UP000288954    UP000075884    UP000027135    UP000007801    UP000076858    UP000005205    UP000291000    UP000078540   

PRIDE

H9JIZ4    Q60GE7    P53034   

Pfam

PF08542   Rep_fac_C        + More
PF00004   AAA

Interpro

IPR003593   AAA+_ATPase        + More
IPR013748   Rep_factorC_C       
IPR003959   ATPase_AAA_core       
IPR027417   P-loop_NTPase       
IPR008921   DNA_pol3_clamp-load_cplx_C       
IPR011009   Kinase-like_dom_sf       
IPR008266   Tyr_kinase_AS       
IPR022495   Bud32       
IPR000719   Prot_kinase_dom       

SUPFAM

SSF52540   SSF52540        + More
SSF48019   SSF48019       
SSF56112   SSF56112       

ProteinModelPortal

H9JIZ4   Q60GE7   A0A3S2LVP1   A0A0N0PBU5   A0A212EW79   A0A194PYA2   + More
A0A2A4JNE6   A0A2W1BFU3   S4NT32   A0A1Q3EXN7   B0VZJ1   A0A182GXT3   A0A182JB41   A0A084WNA0   U5EV45   W5JRP3   A0A182FF42   A0A182MRS4   A0A182VDF2   A0A182KGH8   A0A182I3A5   A0A182KRC2   A0A182U182   A0A1I8MP82   A0A182S7T7   Q7QJE6   A0A182X3R4   A0A182QT42   A0A182XYW1   A0A0P6JS08   A0A0L7LAH0   A0A0L0C9Z6   A0A0T6B1B8   A0A1I8PJQ7   A0A336LWV6   A0A034W201   A0A0V0G645   A0A146LRR5   A0A146MDJ8   W8C2R8   N6UL65   R4FL91   A0A1A9V4P4   A0A0K8T2R4   A0A0K8UA74   A0A182PQF3   A0A154P8A8   A0A023F8X5   A0A1Y1LD99   A0A0A1WY16   A0A1L8DWT2   D3TS38   B4N3J7   B4L9D9   A0A1A9ZLX9   A0A1A9WAT6   A0A1B0C945   B4LB85   A0A195CFP7   B4J1E1   K7IMQ4   A0A182RSN2   A0A0L7RDR1   B4HU02   B4QQ45   A0A1W4W4I9   A0A0M4EZC3   A0A0N0U436   E2AG75   A0A2T7PCM7   P53034   B4PHP8   A0A310SQG9   A0A2J7QRU6   A0A232F9J5   A0A182WJ86   A0A0L8HHW0   A0A1B6KNQ8   A0A3B0JUP4   A0A1W4X0W3   E2BC66   B3NG38   A0A1B6EQ14   D7ELV8   A0A2R7W037   A0A0J7L2V6   A0A1S3DK53   A0A1B6C2G3   A0A195F9P0   F4X840   A0A402EMH7   A0A182NHV7   A0A067RQC0   A0A0N8AG98   B3M4V2   A0A164MZD4   A0A158NCB2   A0A452DYI2   E9IME3   A0A195BW97  

PDB

1SXJ     E-value=1.1651e-105,     Score=978

KEGG

692462    K10755 replication factor C subunit 2/4 | (RefSeq) RFC40; replication factor C subunit 2

PATHWAY

03030    DNA replication - Bombyx mori (domestic silkworm)
03420    Nucleotide excision repair - Bombyx mori (domestic silkworm)
03430    Mismatch repair - Bombyx mori (domestic silkworm)

GO

GO:0003677   GO:0006260   GO:0005524   GO:0005634   GO:0005663   GO:0006261   GO:0000076   GO:0000077   GO:0031391   GO:0004674   GO:0007062   GO:0006271   GO:0007076   GO:0016321   GO:0006272   GO:0000278   GO:0006281   GO:0046983   GO:0005515   GO:0030145   GO:0006412   GO:0016876   GO:0043039  

Subcellular location

Nucleus  

Length:

348

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.11457

Exp number, first 60 AAs:

0.00128

Total prob of N-in:

0.01769

outside

1  -  348

 

 

Pi

184.985028

Theta

166.462806

Tajima's D

0.483134

CLR

0.164742

CSRT

0.508974551272436

Interpretation

Uncertain