Gene

KWMTBOMO08194  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA009473

Annotation

PREDICTED:_apoptosis-inducing_factor_1?_mitochondrial-like_[Bombyx_mori]

Location

Bomo_Chr14(-):1547541-1560419      View in EpiBrowser

Full name

Putative apoptosis-inducing factor 1, mitochondrial      

Location in the cell

Mitochondrial   Reliability : 1.398

CDS

ATGCTCAGAGCGGTTTCCGTGTTGTGTGGAGAAAGTCAATCTTTTTTACTTTATACCACCGCTAGGAGAGATGCCTACAAACTCTTCCGTAATACATATGCCTCTGCCTCGACATCATCACAGACTGTCCTTACATCGGAAGCATCACAAGCATCACACAGCCCCAGTGTACATTCACCCCCTCCTGCACAATCAAGTCCACCTCCTACACCGCCATCACAGTCTCCGCGGCGATCATGGACTGTTGCAGCAGCCCTAGCACTCACCGCATCGGTTGGTGGAATATATTTCTTTCGTAAGCTGAGTGAAGAAGAAAAGAAAATCATATCCTCTGAAGATGCACCAAAAAAGAATGTTGGGCCAGTACGGACACCCATCCCGGCGTCTGCGGATCAGCTCCCGCGACACGTACAGTTCCTGCTGGTCGGTGCTGGTACTGCCTCGTTTGCAGCCATGAGGGCGATACGCAGTCAAAAACCCGACGCCCAGGTGCTGATGGTGGGTTCGGAGTACCAGCTGCCGTACATGCGGCCTCCGCTCACCAAGGAGCTGTGGCGGGAGCCAGACCTGGACAAAGTCACAGACCTCGACTCCTTGACCTTTAAACAGTGGAACGGCAGGGTGAGAAGCCTGGCGTACGAGCCGAGCGCGTTCTACACGCCCGTGGAGCAGCTGGAGGAGCGCGGCGCGGGGTGCGGGGTGGCGCGGGGCTGGGCGGTGCGGCGCCTGGACGTGGCGCGGCGCCGGGCCACGCTGGAGGGCGCGGGGGGCACGCACACGCTCACGTACGACTACTGCCTCGTCGCGACCGGCGTGGTGGCGCGGCGCTCGGCGGCGCTGGCGGGCGCGCGGGGCGCGGGGCGGGCGCGCACGCTGCGCACGGCGGATGACGTCACGCAGCTGGCGGCGCGGCTGGCGGGGGGGGACGTGCAGCGCGTGGCGGTGCTGGGCGGGGGGCTGCTGGCCACCGAGCTCAGCGCCGCGCTCGCCGCCAGATTAAAGGATACGGGTAAAACAGTATTAGAATTGTACCGAGAGAGTAGTCCTCTAGCGTCCATCCTGCCCTCCTACCTCGCGGAGGAGGCCGCCCGGAGGCTCCAAGAAGCGGGGGTCACACTCCTGCCTGAAGCGGACGTGGTAGATTCTATAGTGGTTGATGACAAAGTGCTGATGCGACTTGCGAGTGGCGCCGAGGTGGAGGCCGACTACGTGGTGGAGTGTGTCGGCACGGAGTTCGATCCCGCGCTGGCCGACGCCTCCGAGCTGGAGGTTCACCCCGAGCTGGGCGGGGTGGTCGTCAACCCTGAGCTGCAGGCCCCAACATAA

Protein

MLRAVSVLCGESQSFLLYTTARRDAYKLFRNTYASASTSSQTVLTSEASQASHSPSVHSPPPAQSSPPPTPPSQSPRRSWTVAAALALTASVGGIYFFRKLSEEEKKIISSEDAPKKNVGPVRTPIPASADQLPRHVQFLLVGAGTASFAAMRAIRSQKPDAQVLMVGSEYQLPYMRPPLTKELWREPDLDKVTDLDSLTFKQWNGRVRSLAYEPSAFYTPVEQLEERGAGCGVARGWAVRRLDVARRRATLEGAGGTHTLTYDYCLVATGVVARRSAALAGARGAGRARTLRTADDVTQLAARLAGGDVQRVAVLGGGLLATELSAALAARLKDTGKTVLELYRESSPLASILPSYLAEEAARRLQEAGVTLLPEADVVDSIVVDDKVLMRLASGAEVEADYVVECVGTEFDPALADASELEVHPELGGVVVNPELQAPT

Description

Probable NADH oxidoreductase (By similarity). Mitochondrial effector of cell death that plays roles in developmentally regulated cell death and normal mitochondrial function.

Cofactor

FAD

Similarity

Belongs to the FAD-dependent oxidoreductase family.

Keywords

Alternative splicing   Apoptosis   Complete proteome   FAD   Flavoprotein   Mitochondrion   NAD   Oxidoreductase   Reference proteome   Transit peptide  

Feature

chain  Putative apoptosis-inducing factor 1, mitochondrial
splice variant  In isoform A.

Uniprot

A0A2H1W831   A0A212FC61   A0A0N1PH97   A0A3S2LV53   A0A194PZY4   A0A0C9QS22   + More
A0A1B6DIK6   A0A1Y1LC16   B4G966   Q29MI5   A0A0R3NY98   A0A0Q9X3C3   B4KGB9   B4JAR0   A0A151K0C0   A0A0K8VG98   A0A0K8U3V8   A0A0K8WFS2   A0A034WSC9   A0A2H8TVU6   A0A0P5Q211   B4MVU2   V5GXJ4   A0A0K8URX9   A0A034WNU7   A0A0K8V3Q0   A0A034WSR9   A0A0P5FRE2   A0A0P5VK51   A0A2S2PEQ0   A0A0P4WP23   A0A0P5BQF3   A0A151IAI0   A0A0P5Q6U6   A0A0P5I6F7   A0A0P5HWQ5   B4Q7N0   A0A0P5SLX2   A0A0P5T8B7   A0A0P5BBX7   A0A0J9QU21   A0A0P6GCM6   A0A0N8EEA1   A0A0P5RV82   A0A0P5RU69   A0A0P4Y062   A0A0P5J0M1   A0A0P5JEU1   A0A0P4WPP2   A0A0P4WSA2   A0A0P6G8K0   A0A0P5ATI5   A0A0P5BJ72   A0A0P5AQW0   A0A0P5XIR9   A0A0P5BIH7   A0A0P6FP79   A0A0P5H8Z7   A0A0P6B0G9   A0A0P5E3W8   A0A0P5YAJ9   A0A0N8C166   A0A151J8E8   A0A0P5QDI6   A0A0P4ZUI1   A0A0P4YA23   A0A0N7ZEH1   A0A0P5WI87   A0A0P5KP06   A0A0P5ECD8   J9JWN7   A0A0P5ZZC3   A0A0P5Q058   A0A0P5EKU5   A0A0N8EBC1   Q9VQ79-1   A0A0P5XGU3   B4IM59   A0A0N8E409   A0A0R1DL02   A0A0P5J329   A0A0P5GR20   A0A0P5EVM0   A0A0P5PJB6   A0A0P6FLN1   A0A0P4WTB0   A0A0N8ARE7   A0A0P4Z9V0   A0A0Q5WI30   A0A0P5IFX4   A0A0P6GHA3   A0A0P5HGL4   A0A0P5WIY5   A0A0N8E8W3   A0A0J7L085   A0A0P5SYR0   A0A0P4Z3H5   A0A0P5GMA5  

EC Number

1.1.1.-

Pubmed

22118469    26354079    28004739    17994087    15632085    25348373    + More
22936249    18309327    10731132    12537572    12537569    17550304   

EMBL

ODYU01006927    SOQ49207.1    AGBW02009223    OWR51313.1    KQ460889    KPJ11067.1    + More
RSAL01000178    RVE45002.1    KQ459585    KPI98304.1    GBYB01003442    JAG73209.1    GEDC01011769    JAS25529.1    GEZM01061486    JAV70438.1    CH479180    EDW28896.1    CH379060    EAL33709.3    KRT04133.1    CH933807    KRG02527.1    EDW11106.2    CH916368    EDW03868.1    KQ981319    KYN42729.1    GDHF01029919    GDHF01014446    GDHF01007738    GDHF01004258    JAI22395.1    JAI37868.1    JAI44576.1    JAI48056.1    GDHF01030900    JAI21414.1    GDHF01002298    JAI50016.1    GAKP01001750    JAC57202.1    GFXV01006234    MBW18039.1    GDIQ01120229    JAL31497.1    CH963857    EDW75812.2    GALX01001969    JAB66497.1    GDHF01022862    JAI29452.1    GAKP01001751    JAC57201.1    GDHF01018886    JAI33428.1    GAKP01001752    JAC57200.1    GDIQ01254295    JAJ97429.1    GDIP01100426    JAM03289.1    GGMR01014767    MBY27386.1    GDIP01252765    JAI70636.1    GDIP01185335    JAJ38067.1    KQ978221    KYM96276.1    GDIQ01124930    JAL26796.1    GDIQ01218781    JAK32944.1    GDIQ01221184    JAK30541.1    CM000361    CM002910    EDX03410.1    KMY87587.1    GDIP01138138    JAL65576.1    GDIP01129578    JAL74136.1    GDIP01186631    JAJ36771.1    KMY87588.1    GDIQ01035261    JAN59476.1    GDIQ01035260    JAN59477.1    GDIQ01096183    JAL55543.1    GDIQ01096184    JAL55542.1    GDIP01234431    JAI88970.1    GDIQ01204837    JAK46888.1    GDIQ01206351    JAK45374.1    GDIP01253412    JAI69989.1    GDIP01253370    JAI70031.1    GDIQ01036970    JAN57767.1    GDIP01199071    JAJ24331.1    GDIP01184131    JAJ39271.1    GDIP01209724    JAJ13678.1    GDIP01071501    JAM32214.1    GDIP01199072    JAJ24330.1    GDIQ01047456    JAN47281.1    GDIQ01236431    JAK15294.1    GDIP01035702    JAM68013.1    GDIP01196886    GDIP01148483    LRGB01001361    JAJ74919.1    KZS12716.1    GDIP01061989    JAM41726.1    GDIQ01124931    JAL26795.1    KQ979533    KYN21118.1    GDIQ01115631    GDIQ01115630    JAL36096.1    GDIP01208533    JAJ14869.1    GDIP01230526    JAI92875.1    GDIP01253369    JAI70032.1    GDIP01086083    JAM17632.1    GDIQ01181298    JAK70427.1    GDIP01148484    JAJ74918.1    ABLF02015073    GDIP01037003    JAM66712.1    GDIQ01128124    JAL23602.1    GDIQ01270706    JAJ81018.1    GDIQ01043500    JAN51237.1    AE014134    AY052083    AY058696    BT044192    GDIP01084635    JAM19080.1    CH480936    EDW44539.1    GDIQ01063996    JAN30741.1    CM000157    KRJ97117.1    GDIQ01251733    GDIQ01216594    GDIQ01207701    JAK44024.1    GDIQ01238838    JAK12887.1    GDIQ01267305    JAJ84419.1    GDIQ01137828    JAL13898.1    GDIQ01045657    JAN49080.1    GDIP01251116    JAI72285.1    GDIQ01250283    JAK01442.1    GDIP01218981    JAJ04421.1    CH954177    KQS69982.1    GDIQ01217685    JAK34040.1    GDIQ01045658    JAN49079.1    GDIQ01250284    JAK01441.1    GDIP01086082    JAM17633.1    GDIQ01050364    JAN44373.1    LBMM01001670    KMQ95914.1    GDIP01138137    JAL65577.1    GDIP01218982    JAJ04420.1    GDIQ01245846    GDIQ01245845    JAK05880.1   

Proteomes

UP000007151    UP000053240    UP000283053    UP000053268    UP000008744    UP000001819    + More
UP000009192    UP000001070    UP000078541    UP000007798    UP000078542    UP000000304    UP000076858    UP000078492    UP000007819    UP000000803    UP000001292    UP000002282    UP000008711    UP000036403   

PRIDE

Q9VQ79   

Pfam

PF14721   AIF_C        + More
PF07992   Pyr_redox_2
PF16020   Deltameth_res

Interpro

IPR036188   FAD/NAD-bd_sf        + More
IPR016156   FAD/NAD-linked_Rdtase_dimer_sf       
IPR029324   AIF_C       
IPR023753   FAD/NAD-binding_dom       
IPR031973   Deltameth_res_prag01       

SUPFAM

SSF55424   SSF55424        + More
SSF51905   SSF51905       

Gene 3D

3.30.390.30     3.50.50.60    

ProteinModelPortal

A0A2H1W831   A0A212FC61   A0A0N1PH97   A0A3S2LV53   A0A194PZY4   A0A0C9QS22   + More
A0A1B6DIK6   A0A1Y1LC16   B4G966   Q29MI5   A0A0R3NY98   A0A0Q9X3C3   B4KGB9   B4JAR0   A0A151K0C0   A0A0K8VG98   A0A0K8U3V8   A0A0K8WFS2   A0A034WSC9   A0A2H8TVU6   A0A0P5Q211   B4MVU2   V5GXJ4   A0A0K8URX9   A0A034WNU7   A0A0K8V3Q0   A0A034WSR9   A0A0P5FRE2   A0A0P5VK51   A0A2S2PEQ0   A0A0P4WP23   A0A0P5BQF3   A0A151IAI0   A0A0P5Q6U6   A0A0P5I6F7   A0A0P5HWQ5   B4Q7N0   A0A0P5SLX2   A0A0P5T8B7   A0A0P5BBX7   A0A0J9QU21   A0A0P6GCM6   A0A0N8EEA1   A0A0P5RV82   A0A0P5RU69   A0A0P4Y062   A0A0P5J0M1   A0A0P5JEU1   A0A0P4WPP2   A0A0P4WSA2   A0A0P6G8K0   A0A0P5ATI5   A0A0P5BJ72   A0A0P5AQW0   A0A0P5XIR9   A0A0P5BIH7   A0A0P6FP79   A0A0P5H8Z7   A0A0P6B0G9   A0A0P5E3W8   A0A0P5YAJ9   A0A0N8C166   A0A151J8E8   A0A0P5QDI6   A0A0P4ZUI1   A0A0P4YA23   A0A0N7ZEH1   A0A0P5WI87   A0A0P5KP06   A0A0P5ECD8   J9JWN7   A0A0P5ZZC3   A0A0P5Q058   A0A0P5EKU5   A0A0N8EBC1   Q9VQ79-1   A0A0P5XGU3   B4IM59   A0A0N8E409   A0A0R1DL02   A0A0P5J329   A0A0P5GR20   A0A0P5EVM0   A0A0P5PJB6   A0A0P6FLN1   A0A0P4WTB0   A0A0N8ARE7   A0A0P4Z9V0   A0A0Q5WI30   A0A0P5IFX4   A0A0P6GHA3   A0A0P5HGL4   A0A0P5WIY5   A0A0N8E8W3   A0A0J7L085   A0A0P5SYR0   A0A0P4Z3H5   A0A0P5GMA5  

PDB

5FS7     E-value=6.10846e-30,     Score=327

KEGG

101739771    K04727 apoptosis-inducing factor 1 [EC:1.-.-.-] | (RefSeq) apoptosis-inducing factor 1, mitochondria

PATHWAY

04214    Apoptosis - fly - Bombyx mori (domestic silkworm)

GO

GO:0046983   GO:0050660   GO:0016491   GO:0016021   GO:0010623   GO:0042775   GO:0050832   GO:0005758   GO:0005739   GO:0006915   GO:0016651   GO:0045454   GO:0005515   GO:0005634   GO:0030145   GO:0006412   GO:0016876   GO:0043039   GO:0055114  

Subcellular location

Mitochondrion intermembrane space  

Length:

441

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

4.2041

Exp number, first 60 AAs:

0.0265

Total prob of N-in:

0.09354

outside

1  -  441

 

 

Pi

180.230358

Theta

169.526299

Tajima's D

0.797057

CLR

0.784156

CSRT

0.602769861506925

Interpretation

Uncertain