Gene

KWMTBOMO08187

Pre Gene Modal

BGIBMGA009488

Annotation

PREDICTED:_venom_acid_phosphatase_Acph-1-like_[Papilio_xuthus]

Location

Bomo_Chr14(+):1161961-1192896      View in EpiBrowser

Full name

Prostatic acid phosphatase      

Location in the cell

Cytoplasmic   Reliability : 2.121

CDS

ATGCTGAAATATTTAATATTCGTCTATTTGCTGATGCAAGTGAACACATCCCCCGGCAACGTCACCAACCGGGAGGCGAACGATGACATGGAACTGTTGATGGTTTATTTTGTGAACAGACATGGCGAGAGAGCTCCCGATGATGTGGAGCTTTCTCTTTCTGATCAGCAGGAAGAACTGAAGAGCCTCACTCACGTAGAAGGTCCTGAAGGCTTGACCAACGTCGGTAAAAGAAGGGCATACCAAATTGGCAAGTTCATCCGTCAGCGCTACGGATCCGAGGGTTCGAAAATCTTATCCAAAGTCTACCTGAAGGATGAGATTCTCGTTAGAAGCACAGATAAGGATCGGACGAAGATGACGGCGCTAGTAGCCATGTCTGCTGCCTACCCCCCGGAACCAGTTCAGCAATGGGATGAGTCACTGGGAAAGATCTGGCAGCCAGTCCCTTACTACTCTGTTCCACTAAACGAGGATTATCTTCGCTACTTCTCCAACTGCGACAGGTTTGTGGAGCTGATGAGGAACGCCAAGGACGAATCCATTCGGCAAGAATTCGCACCGTACCTGGACGTCATGCAGTTGCTCTCGAGGAGAACCGGCCAGAATTTTGTTGAGAACCCGCTGCTTCTGCAAGCCCTGTTCGACTTATTCAGGAGCTCGTTGGCCCTTGGTTTGAACATACCGGAGTGGGCAAAGCCCTTTCTGGAGAGCTTAAGCGAAGGAGCCAGGCTCGCCTACAAGTTGTACTTCAGAACTAATGAAATGAAAAAAATTGCTGGAGGGGTCCTACTCAACAAGTTCACAGAACAGGCCCTGATCGCGGCATCAGGTAAAGAGATCAAGCCCCGTCTCCACGTATTCTCCTCGCACGACTTCAACTTGGGCGCGTTCATGGAGGTGTCCAGGGTCCGCAGCAACCACGGCATCCCGGAGTACGGCGCTGCTTTCGCATTAGAACTGTACCGGTCGAAGGTCACAGGAGAACTTAGCGTCTTGCCGGTGTACCTTCCGCAAGCAGGAGACTCCACGCCCCAGGTGTTGCAGGTCAACGGCTGCGACGCAAACCCCTGCGGCCTGACAAAGTTCATGGAATTGACTAAAGATTTCCTACTACCCGAACATGAATATTACAGAATATGTAACATTAAGACAGAGTTATAA

Protein

MLKYLIFVYLLMQVNTSPGNVTNREANDDMELLMVYFVNRHGERAPDDVELSLSDQQEELKSLTHVEGPEGLTNVGKRRAYQIGKFIRQRYGSEGSKILSKVYLKDEILVRSTDKDRTKMTALVAMSAAYPPEPVQQWDESLGKIWQPVPYYSVPLNEDYLRYFSNCDRFVELMRNAKDESIRQEFAPYLDVMQLLSRRTGQNFVENPLLLQALFDLFRSSLALGLNIPEWAKPFLESLSEGARLAYKLYFRTNEMKKIAGGVLLNKFTEQALIAASGKEIKPRLHVFSSHDFNLGAFMEVSRVRSNHGIPEYGAAFALELYRSKVTGELSVLPVYLPQAGDSTPQVLQVNGCDANPCGLTKFMELTKDFLLPEHEYYRICNIKTEL

Description

A non-specific tyrosine phosphatase that dephosphorylates a diverse number of substrates under acidic conditions (pH 4-6) including alkyl, aryl, and acyl orthophosphate monoesters and phosphorylated proteins. Has lipid phosphatase activity and inactivates lysophosphatidic acid in seminal plasma (By similarity).

Catalytic Activity

a phosphate monoester + H2O = an alcohol + phosphate

Subunit

Homodimer; dimer formation is required for phosphatase activity.

Similarity

Belongs to the histidine acid phosphatase family.

Keywords

Complete proteome   Disulfide bond   Glycoprotein   Hydrolase   Reference proteome   Secreted   Signal  

Feature

chain  Prostatic acid phosphatase

Uniprot

H9JIY7   A0A2A4JFS4   A0A437AY25   I4DR67   A0A1E1WMB7   A0A2H1VAX3   + More
S4NSI3   A0A212EPG3   A0A194PY67   A0A0N0PBK2   A0A1E1W159   A0A0L7LBD9   H9J9I3   A0A2A4K986   A0A194PS41   A0A2H1W2H8   A0A3S2LGG3   A0A194R7T8   H9JXV1   A0A437B8H1   A0A212F630   A0A2H1WGF6   A0A2H1W2M4   I4DJY6   A0A2A4K8E9   A0A194PY59   A0A2A4K851   A0A2A4K724   A0A2S2NL16   K7IZV4   A0A1A9WGA5   A0A0L7LP95   A0A0C9RY44   J9K7T8   A0A1W6EVT0   A0A2H8TD02   C1IC99   A0A2U4B980   A0A2S2QXE2   J9K623   D3TNZ8   A0A0L7QWI3   A0A1A9ZSA2   A0A1B0BCK4   A0A1Q3EW11   A0A1Q3EVW8   A0A1Q3EW78   A0A1Q3EVW7   K7IZV5   A0A384A0X1   K7IQ63   Q17L85   K7IQ61   A0A340WSB5   K7IQ62   E2C1V8   A0A0M4EIW0   A0A1B0GD38   A0A3B0JV23   B4MXK6   A0A0K8TLP0   A0A369SGB3   F1SPF0   B0XEX3   A0A287AFE9   A0A1J1I6C6   A0A452EWS2   A0A232ESQ6   A0A341CZH3   A0A2A4K8T7   A0A1Y1KWW5   A0A195E0B2   L8IIS0   A0A1Y1KWT0   W5PH63   A6H730   A0A3Q1M6R0   A0A232EEI8   A0A023EQR2   A0A1L8DYV9   G3STE9   A0A210R3A2   A0A310SN00   B4H982   B4J1A8   F1Q4D3   A0A151P351   J3JY56   E2C1V9   A0A3Q7UDM5   A0A1W7R8D5   E2ARU9   A0A1W4WJR1   K9IJ78   A0A060GL20   A0A067QNZ9   F4WFK0  

EC Number

3.1.3.2

Pubmed

19121390    22651552    23622113    22118469    26354079    26227816    + More
20075255    18448143    20353571    17510324    20798317    17994087    26369729    30042472    28648823    28004739    22751099    20809919    19393038    24945155    28812685    16341006    22293439    22516182    24845553    21719571   

EMBL

BABH01022999    BABH01023000    NWSH01001685    PCG70424.1    RSAL01000278    RVE43078.1    + More
AK404965    BAM20407.1    GDQN01003058    JAT87996.1    ODYU01001406    SOQ37542.1    GAIX01014082    JAA78478.1    AGBW02013469    OWR43369.1    KQ459585    KPI98277.1    KQ460889    KPJ11041.1    GDQN01010326    JAT80728.1    JTDY01001815    KOB72803.1    BABH01004863    NWSH01000024    PCG80629.1    KQ459601    KPI93945.1    ODYU01005909    SOQ47289.1    RSAL01000014    RVE53289.1    KQ460855    KPJ11936.1    BABH01040368    RSAL01000117    RVE46811.1    AGBW02010086    OWR49186.1    ODYU01008500    SOQ52158.1    SOQ47287.1    AK401604    BAM18226.1    NWSH01000059    PCG80073.1    KPI98276.1    PCG80074.1    PCG80075.1    GGMR01005235    MBY17854.1    JTDY01000422    KOB77267.1    GBYB01012831    JAG82598.1    ABLF02038965    KY563421    ARK19830.1    GFXV01000178    MBW11983.1    EU365869    ACA60733.1    GGMS01013238    MBY82441.1    ABLF02019532    EZ423150    ADD19426.1    KQ414714    KOC62926.1    JXJN01012024    GFDL01015589    JAV19456.1    GFDL01015590    JAV19455.1    GFDL01015587    JAV19458.1    GFDL01015588    JAV19457.1    CH477217    EAT47490.1    GL452008    EFN78070.1    CP012525    ALC44752.1    CCAG010002313    CCAG010002314    OUUW01000002    SPP76591.1    CH963876    EDW76775.2    GDAI01002763    JAI14840.1    NOWV01000013    RDD45829.1    AEMK02000088    DS232876    EDS26304.1    CVRI01000042    CRK95747.1    LWLT01000001    NNAY01002389    OXU21381.1    PCG80631.1    GEZM01071381    GEZM01071374    JAV65852.1    KQ979955    KYN18558.1    JH881123    ELR56450.1    GEZM01071378    GEZM01071370    JAV65859.1    AMGL01011780    AMGL01011781    AMGL01011782    BC146093    NNAY01005308    OXU16770.1    GAPW01001661    JAC11937.1    GFDF01002423    JAV11661.1    NEDP02000657    OWF55488.1    KQ762196    OAD56135.1    CH479227    EDW35306.1    CH916366    EDV97977.1    AAEX03013595    AKHW03001210    KYO43349.1    BT128180    AEE63141.1    EFN78071.1    GEHC01000248    JAV47397.1    GL442175    EFN63832.1    GABZ01006540    JAA46985.1    KJ710422    AIB53032.1    KK853123    KDR11063.1    GL888120    EGI66977.1   

Proteomes

UP000005204    UP000218220    UP000283053    UP000007151    UP000053268    UP000053240    + More
UP000037510    UP000002358    UP000091820    UP000007819    UP000245320    UP000053825    UP000092445    UP000092460    UP000261681    UP000008820    UP000265300    UP000008237    UP000092553    UP000092444    UP000268350    UP000007798    UP000253843    UP000008227    UP000002320    UP000183832    UP000291000    UP000215335    UP000252040    UP000078492    UP000002356    UP000009136    UP000007646    UP000242188    UP000008744    UP000001070    UP000002254    UP000050525    UP000286640    UP000000311    UP000192223    UP000027135    UP000007755   

PRIDE

H9JIY7    H9J9I3    H9JXV1    F1SPF0    A6H730   

Pfam

PF00328   His_Phos_2        + More
PF18701   DUF5641
PF00665   rve
PF01395   PBP_GOBP

Interpro

IPR000560   His_Pase_clade-2        + More
IPR033379   Acid_Pase_AS       
IPR029630   Api_m_3       
IPR029033   His_PPase_superfam       
IPR012337   RNaseH-like_sf       
IPR001584   Integrase_cat-core       
IPR036397   RNaseH_sf       
IPR040676   DUF5641       
IPR036728   PBP_GOBP_sf       
IPR006170   PBP/GOBP       

SUPFAM

SSF53254   SSF53254        + More
SSF53098   SSF53098       
SSF47565   SSF47565       

Gene 3D

3.40.50.1240     3.30.420.10     1.10.238.20    

CDD

cd07061  HP_HAP_like

ProteinModelPortal

H9JIY7   A0A2A4JFS4   A0A437AY25   I4DR67   A0A1E1WMB7   A0A2H1VAX3   + More
S4NSI3   A0A212EPG3   A0A194PY67   A0A0N0PBK2   A0A1E1W159   A0A0L7LBD9   H9J9I3   A0A2A4K986   A0A194PS41   A0A2H1W2H8   A0A3S2LGG3   A0A194R7T8   H9JXV1   A0A437B8H1   A0A212F630   A0A2H1WGF6   A0A2H1W2M4   I4DJY6   A0A2A4K8E9   A0A194PY59   A0A2A4K851   A0A2A4K724   A0A2S2NL16   K7IZV4   A0A1A9WGA5   A0A0L7LP95   A0A0C9RY44   J9K7T8   A0A1W6EVT0   A0A2H8TD02   C1IC99   A0A2U4B980   A0A2S2QXE2   J9K623   D3TNZ8   A0A0L7QWI3   A0A1A9ZSA2   A0A1B0BCK4   A0A1Q3EW11   A0A1Q3EVW8   A0A1Q3EW78   A0A1Q3EVW7   K7IZV5   A0A384A0X1   K7IQ63   Q17L85   K7IQ61   A0A340WSB5   K7IQ62   E2C1V8   A0A0M4EIW0   A0A1B0GD38   A0A3B0JV23   B4MXK6   A0A0K8TLP0   A0A369SGB3   F1SPF0   B0XEX3   A0A287AFE9   A0A1J1I6C6   A0A452EWS2   A0A232ESQ6   A0A341CZH3   A0A2A4K8T7   A0A1Y1KWW5   A0A195E0B2   L8IIS0   A0A1Y1KWT0   W5PH63   A6H730   A0A3Q1M6R0   A0A232EEI8   A0A023EQR2   A0A1L8DYV9   G3STE9   A0A210R3A2   A0A310SN00   B4H982   B4J1A8   F1Q4D3   A0A151P351   J3JY56   E2C1V9   A0A3Q7UDM5   A0A1W7R8D5   E2ARU9   A0A1W4WJR1   K9IJ78   A0A060GL20   A0A067QNZ9   F4WFK0  

PDB

1ND6     E-value=3.98705e-30,     Score=328

KEGG

101745800    K19283 prostatic aicd phosphatase [EC:3.1.3.2 3.1.3.5] | (RefSeq) prostatic acid phosphatase-like

GO

GO:0003993   GO:0016021   GO:0051289   GO:0005886   GO:0051930   GO:0042131   GO:0052642   GO:0005615   GO:0042803   GO:0046085   GO:0006772   GO:0009117   GO:0012506   GO:0060168   GO:0006144   GO:0030175   GO:0008253   GO:0005549   GO:0016311   GO:0016791   GO:0006508   GO:0004181   GO:0008270   GO:0005515   GO:0005634   GO:0030145   GO:0006412   GO:0016876   GO:0043039  

PANTHER

PTHR11567:SF183  

Subcellular location

Secreted  

SignalP

Position:   1 - 16,         Likelihood:  0.917123

 

 

Length:

387

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.01136

Exp number, first 60 AAs:

0.01055

Total prob of N-in:

0.00285

outside

1  -  387

 

 

Pi

236.671474

Theta

153.555293

Tajima's D

1.92492

CLR

0.200267

CSRT

0.868556572171391

Interpretation

Uncertain