Gene

KWMTBOMO08162

Pre Gene Modal

BGIBMGA014364

Annotation

PREDICTED:_dynein_heavy_chain_1?_axonemal-like_[Amyelois_transitella]

Location

Bomo_Chr14(-):274321-278269      View in EpiBrowser

Full name

SAGA-associated factor 11 homolog       + More
Dynein heavy chain 1, axonemal      

Alternative Name

Axonemal beta dynein heavy chain 1
Ciliary dynein heavy chain 1
mDHC7

Location in the cell

Cytoplasmic   Reliability : 3.449

CDS

ATGATCATGAGGGGACTCGTCTTCGACAAAGAGTTGTACCTCACTTCTATAGGTTTACTGGAACCGAACGTGGTCGAGTACAGGGAGCGGCTGCTCAAGGCGTACCGTCAGGCCAAAGTGCCCCTCCTCGCCTATCTTCGACAGTACGAGTGTTACACGTCTCTGTATCAGCTGGACGTGGAGCAGTATGTGGAAAAGTTCCGCGAGGAGAAGCACTCATCCTCGGAAACTCGCGAAGAGCTCCAGATGCACTACGACGCCAAACAGGAATTGATTTGGCGTCTACCGCAGTACATTGTGATAGGACCCTTCGCCATCAATGTAGACACCCTTAAACAAATGTTAGTGAATAAACGATCGGAGATCATAAAGGCGTTGCTCACGATGTGGGCGGAGGAGGTGAGGCTGGTGGTGGACGACGTGATTCAGGCCTACAGAGCCGTCATGAGGAAGCTGGGCGAGAAACCAAACACCATCGAGCACGTGTTCGAGATCAGGGAGTGGATGGAGTCCGTGCCCTTTGCTCTGAAGACTCAAGATGATATCATGAAGAAAGTCTTCACGGACTATGAAGTGCTGGACGCATTCTTCACGCCTCTGGAGAACGAAGATTTCAAGGCGCTGTGGGAAGCCATCGGATGGCCTCTGAACATCAATAAGCAAGTGGTGGCCACAATAGAGTTCTTGGAAGAAGAGCAGGAGAAGTTTTGGAAGCTCCACCAGCAGGACGAGCAGGCGCTGTTCGACAAGATCGACATGTTCACGGCGCAGTGCATGCAGCTCACCCTGCAGAACGACTTCAACAAGGTCCACGAAATAGCCAACGACATTAAAAAGGCTTGGAAGGGCATGAAGGATGCCCAGGACTGGGGCCGCCTTCTCAACCAAAGACAGAAGCTATTCGGTCAGCCGGTAGTGCCCTTCGCCGATCTCAACCGACTGGTCAAGGAATTTGAGCCGTACAGGAACCTTTGGGTAACCGCTTCGGATTTCCTGAAAGCTCGCGAGGTGTGGGTGGACAACCCGCTGATGTACGTGGACGCGGACAGCATCGAGCCGCTGGTCAACGAGTACTATAAGACCGTGCTCAAGTGCATCAAGGTTTTCGCCGATCTGCCTAAAGTTCAGAATGTAGCTATTTCCGTCAAGGTTAGTTGA

Protein

MIMRGLVFDKELYLTSIGLLEPNVVEYRERLLKAYRQAKVPLLAYLRQYECYTSLYQLDVEQYVEKFREEKHSSSETREELQMHYDAKQELIWRLPQYIVIGPFAINVDTLKQMLVNKRSEIIKALLTMWAEEVRLVVDDVIQAYRAVMRKLGEKPNTIEHVFEIREWMESVPFALKTQDDIMKKVFTDYEVLDAFFTPLENEDFKALWEAIGWPLNINKQVVATIEFLEEEQEKFWKLHQQDEQALFDKIDMFTAQCMQLTLQNDFNKVHEIANDIKKAWKGMKDAQDWGRLLNQRQKLFGQPVVPFADLNRLVKEFEPYRNLWVTASDFLKAREVWVDNPLMYVDADSIEPLVNEYYKTVLKCIKVFADLPKVQNVAISVKVS

Description

Component of the transcription regulatory histone acetylation (HAT) complex SAGA, a multiprotein complex that activates transcription by remodeling chromatin and mediating histone acetylation and deubiquitination. Within the SAGA complex, participates in a subcomplex that specifically deubiquitinates histone H2B. The SAGA complex is recruited to specific gene promoters by activators, where it is required for transcription.
Force generating protein of cilia required for sperm flagellum motility (PubMed:11371505). Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP (By similarity). Required in spermatozoa for the formation of the inner dynein arms and biogenesis of the axoneme (By similarity).

Subunit

Component of some SAGA transcription coactivator-HAT complexes. Within the SAGA complex, participates to a subcomplex of SAGA called the DUB module (deubiquitination module).
Consists of at least two heavy chains and a number of intermediate and light chains.

Similarity

Belongs to the SGF11 family.
Belongs to the dynein heavy chain family.

Keywords

Alternative splicing   ATP-binding   Cell projection   Cilium   Coiled coil   Complete proteome   Cytoplasm   Cytoskeleton   Dynein   Flagellum   Microtubule   Motor protein   Nucleotide-binding   Reference proteome  

Feature

chain  Dynein heavy chain 1, axonemal
splice variant  In isoform 2.

Uniprot

H9JXU6   A0A3S2M4I0   A0A2A4JDQ9   A0A2A4JE46   A0A2A4JD05   A0A2H1VXK0   + More
A0A0N1ICV2   A0A194PY69   A0A1B6CKQ5   A0A1B6E076   N6UQR0   N6TX30   N6UFR0   N6TWR8   D2A3I1   U4UG54   A0A1W4X6Z1   A0A1B6F3E5   A0A1Y1MZ10   A0A1Y1N5M7   A0A0M9A5H8   E9ID39   A0A2P8YP94   E1ZZ93   A0A154NW30   A0A3L8E2Z5   A0A310SG88   A0A195EMY8   A0A195FKE7   A0A2A3EF90   C3YFY9   A0A195BV47   A0A026VVB8   F4WVH5   A0A158NEY4   A0A2R2MMP5   A0A2R2MT18   V3ZE33   E2BXB6   A0A3S0ZN14   E0VBG0   A0A232F2K8   A0A2C9JK70   A0A195CQ90   A0A2C9JK78   A0A2T7P6M7   A0A210QDN3   K7J8F3   W5NAX8   A0A060XHS4   A0A151MEP6   A0A3M6UN98   A0A1U7RTJ0   A0A151MET3   H3BFH9   A0A1L8GPB6   A0A151MEQ2   A0A1S3LD11   A0A1S3LD14   A0A2B4S5H5   W4ZJK2   W4ZLH1   A7S0X9   K1RJM8   A0A452ISR1   A0A452IS17   A0A452ISJ8   R7VGC6   A0A2Y9IYH5   F6PIN6   A0A2D0PK64   A0A2D0PIM8   A0A2D0PK34   M7C0J0   I3MF05   A0A3P8XPP2   A0A212C9W0   L8IEV2   M3YZ26   A0A3Q7Q593   F6XWP3   A0A1A6G290   A0A2U3WQT9   A0A3M7QWJ0   H0X626   A0A1S2ZH14   A0A2U3XK15   G1LQX6   D3ZRN8   A0A095A169   A0A452V7U3   A0A384D5S8   A0A3Q7W647   A0A2Y9G1C9   G5BUL8   A0A183LAJ4   A0A0J7KYK8   E9Q8T7   H0V0D2   F1PDQ9  

Pubmed

19121390    26354079    23537049    18362917    19820115    28004739    + More
21282665    29403074    20798317    30249741    18563158    24508170    21719571    21347285    23254933    20566863    28648823    15562597    28812685    20075255    24755649    22293439    30382153    9215903    27762356    17615350    22992520    28562605    20431018    23624526    25069045    22751099    17495919    30375419    20010809    15057822    22246508    24813606    21993625    16141072    19468303    15489334    9373155    11371505    19131326    21183079    21993624    16341006   

EMBL

BABH01040386    BABH01040387    RSAL01000037    RVE51194.1    NWSH01001830    PCG69979.1    + More
PCG69978.1    PCG69977.1    ODYU01005066    SOQ45577.1    KQ460889    KPJ11050.1    KQ459585    KPI98286.1    GEDC01023330    JAS13968.1    GEDC01005987    JAS31311.1    APGK01006694    APGK01006695    KB736894    ENN83116.1    APGK01011640    KB738536    ENN82568.1    APGK01023382    KB740488    ENN80560.1    APGK01012459    APGK01012460    KB738739    ENN82483.1    KQ971338    EFA01906.2    KB632308    ERL92012.1    GECZ01025168    JAS44601.1    GEZM01017152    GEZM01017150    GEZM01017148    GEZM01017146    GEZM01017143    GEZM01017142    JAV90879.1    GEZM01017151    GEZM01017145    JAV90907.1    KQ435750    KOX76363.1    GL762454    EFZ21488.1    PYGN01000453    PSN46069.1    GL435311    EFN73508.1    KQ434772    KZC03876.1    QOIP01000001    RLU27110.1    KQ761502    OAD57478.1    KQ978625    KYN29645.1    KQ981490    KYN41140.1    KZ288260    PBC30453.1    GG666510    EEN60794.1    KQ976401    KYM92457.1    KK108281    EZA46779.1    GL888387    EGI61796.1    ADTU01013325    ADTU01013326    ADTU01013327    ADTU01013328    ADTU01013329    ADTU01013330    ADTU01013331    ADTU01013332    ADTU01013333    ADTU01013334    KB202619    ESO89348.1    GL451230    EFN79699.1    RQTK01000491    RUS78759.1    DS235030    EEB10716.1    NNAY01001204    OXU24749.1    KQ977444    KYN02642.1    PZQS01000006    PVD29059.1    NEDP02004067    OWF46845.1    AHAT01014842    AHAT01014843    AHAT01014844    FR905415    CDQ79158.1    AKHW03006215    KYO22998.1    RCHS01001119    RMX55115.1    KYO22999.1    AFYH01005848    AFYH01005849    AFYH01005850    AFYH01005851    AFYH01005852    AFYH01005853    AFYH01005854    AFYH01005855    AFYH01005856    AFYH01005857    CM004472    OCT85694.1    KYO22997.1    LSMT01000171    PFX24646.1    AAGJ04100766    AAGJ04100767    AAGJ04100768    AAGJ04100769    AAGJ04100770    AAGJ04100771    AAGJ04100772    AAGJ04100773    DS469562    EDO42618.1    JH816168    EKC41830.1    AMQN01004546    AMQN01004547    KB293809    ELU15361.1    AAMC01048030    AAMC01048031    AAMC01048032    AAMC01048033    KB535020    EMP33877.1    AGTP01005611    AGTP01005612    MKHE01000024    OWK02778.1    JH881365    ELR54718.1    AEYP01001932    LZPO01107936    OBS59920.1    REGN01004975    RNA15335.1    AAQR03061720    AAQR03061721    AAQR03061722    AAQR03061723    AAQR03061724    AAQR03061725    AAQR03061726    AAQR03061727    ACTA01154541    ACTA01162540    ACTA01170538    AABR07072490    AC095672    AC099108    KL251154    KGB39209.1    JH171963    EHB12979.1    UZAI01000160    VDO49358.1    LBMM01002025    KMQ95378.1    AK053204    AC108416    CH466573    BC023155    Z83815    AAKN02001401    AAKN02001402    AAEX03012197   

Proteomes

UP000005204    UP000283053    UP000218220    UP000053240    UP000053268    UP000019118    + More
UP000007266    UP000030742    UP000192223    UP000053105    UP000245037    UP000000311    UP000076502    UP000279307    UP000078492    UP000078541    UP000242457    UP000001554    UP000078540    UP000053097    UP000007755    UP000005205    UP000085678    UP000030746    UP000008237    UP000271974    UP000009046    UP000215335    UP000076420    UP000078542    UP000245119    UP000242188    UP000002358    UP000018468    UP000193380    UP000050525    UP000275408    UP000189705    UP000008672    UP000186698    UP000087266    UP000225706    UP000007110    UP000001593    UP000005408    UP000291020    UP000014760    UP000248482    UP000008143    UP000221080    UP000031443    UP000005215    UP000265140    UP000000715    UP000286641    UP000002280    UP000092124    UP000245340    UP000276133    UP000005225    UP000079721    UP000245341    UP000008912    UP000002494    UP000291021    UP000261680    UP000286642    UP000248480    UP000006813    UP000050790    UP000277204    UP000036403    UP000000589    UP000005447    UP000002254   

PRIDE

H9JXU6    D3ZRN8    E9Q8T7   

Pfam

PF08393   DHC_N2        + More
PF12774   AAA_6
PF17852   Dynein_AAA_lid
PF07992   Pyr_redox_2
PF14721   AIF_C
PF12781   AAA_9
PF18198   AAA_lid_11
PF12780   AAA_8
PF03028   Dynein_heavy
PF12777   MT
PF17857   AAA_lid_1
PF18199   Dynein_C
PF08209   Sgf11

Interpro

IPR042222   Dynein_2_N        + More
IPR042228   Dynein_2_C       
IPR013602   Dynein_heavy_dom-2       
IPR035699   AAA_6       
IPR027417   P-loop_NTPase       
IPR041466   Dynein_AAA5_ext       
IPR016156   FAD/NAD-linked_Rdtase_dimer_sf       
IPR029324   AIF_C       
IPR036188   FAD/NAD-bd_sf       
IPR023753   FAD/NAD-binding_dom       
IPR041658   AAA_lid_11       
IPR041228   Dynein_C       
IPR004273   Dynein_heavy_D6_P-loop       
IPR042219   AAA_lid_11_sf       
IPR026983   DHC_fam       
IPR024743   Dynein_HC_stalk       
IPR026975   DNAH1       
IPR024317   Dynein_heavy_chain_D4_dom       
IPR035706   AAA_9       
IPR041589   DNAH3_AAA_lid_1       
IPR003593   AAA+_ATPase       
IPR013246   SAGA_su_Sgf11       
IPR013243   SCA7_dom       

SUPFAM

SSF52540   SSF52540        + More
SSF51905   SSF51905       
SSF55424   SSF55424       

Gene 3D

1.20.140.100     3.20.180.20     3.30.390.30     3.50.50.60     1.10.8.720    

ProteinModelPortal

H9JXU6   A0A3S2M4I0   A0A2A4JDQ9   A0A2A4JE46   A0A2A4JD05   A0A2H1VXK0   + More
A0A0N1ICV2   A0A194PY69   A0A1B6CKQ5   A0A1B6E076   N6UQR0   N6TX30   N6UFR0   N6TWR8   D2A3I1   U4UG54   A0A1W4X6Z1   A0A1B6F3E5   A0A1Y1MZ10   A0A1Y1N5M7   A0A0M9A5H8   E9ID39   A0A2P8YP94   E1ZZ93   A0A154NW30   A0A3L8E2Z5   A0A310SG88   A0A195EMY8   A0A195FKE7   A0A2A3EF90   C3YFY9   A0A195BV47   A0A026VVB8   F4WVH5   A0A158NEY4   A0A2R2MMP5   A0A2R2MT18   V3ZE33   E2BXB6   A0A3S0ZN14   E0VBG0   A0A232F2K8   A0A2C9JK70   A0A195CQ90   A0A2C9JK78   A0A2T7P6M7   A0A210QDN3   K7J8F3   W5NAX8   A0A060XHS4   A0A151MEP6   A0A3M6UN98   A0A1U7RTJ0   A0A151MET3   H3BFH9   A0A1L8GPB6   A0A151MEQ2   A0A1S3LD11   A0A1S3LD14   A0A2B4S5H5   W4ZJK2   W4ZLH1   A7S0X9   K1RJM8   A0A452ISR1   A0A452IS17   A0A452ISJ8   R7VGC6   A0A2Y9IYH5   F6PIN6   A0A2D0PK64   A0A2D0PIM8   A0A2D0PK34   M7C0J0   I3MF05   A0A3P8XPP2   A0A212C9W0   L8IEV2   M3YZ26   A0A3Q7Q593   F6XWP3   A0A1A6G290   A0A2U3WQT9   A0A3M7QWJ0   H0X626   A0A1S2ZH14   A0A2U3XK15   G1LQX6   D3ZRN8   A0A095A169   A0A452V7U3   A0A384D5S8   A0A3Q7W647   A0A2Y9G1C9   G5BUL8   A0A183LAJ4   A0A0J7KYK8   E9Q8T7   H0V0D2   F1PDQ9  

KEGG

NA   

GO

GO:0005858   GO:0003777   GO:0003341   GO:0016887   GO:0005524   GO:0016021   GO:0046983   GO:0016491   GO:0050660   GO:0008569   GO:0045505   GO:0031514   GO:0035721   GO:0005930   GO:0007018   GO:0005868   GO:0060271   GO:0045503   GO:0051959   GO:0030286   GO:0000124   GO:0071819   GO:0003713   GO:0008270   GO:0016578   GO:0045893   GO:0030317   GO:0060294   GO:0003351   GO:0036159   GO:0036126   GO:0036156   GO:0007288   GO:0005874  

PANTHER

PTHR10676   PTHR10676:SF358  

Subcellular location

Nucleus  
Cytoplasm  
Cytoskeleton  
Cilium axoneme  
Cell projection  
Cilium  
Flagellum  

Length:

385

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.0830599999999999

Exp number, first 60 AAs:

0.00056

Total prob of N-in:

0.01006

outside

1  -  385

 

 

Pi

279.606299

Theta

174.559304

Tajima's D

1.754865

CLR

0.100214

CSRT

0.845307734613269

Interpretation

Uncertain