Pre Gene Modal
BGIBMGA014367
Annotation
Dynein_heavy_chain_1?_axonemal_[Papilio_xuthus]
Full name
Dynein heavy chain 1, axonemal
+ More
SAGA-associated factor 11 homolog
Alternative Name
Axonemal beta dynein heavy chain 1
Ciliary dynein heavy chain 1
Heat shock regulated protein 1
hDHC7
Location in the cell
Mitochondrial   Reliability : 1.377 PlasmaMembrane   Reliability : 1.362
Sequence
CDS
ATGTATGAGAGTAGGATGAAAAATGATTGGCTGGTGTTCTCGCTGAGCGTGTTCCACGGCGTGGTGCTGGAGAGGCGCAAGTTCGGGCCGCTGGGCTTCAACGTGCCCTACGAGTTCACAGACGGGGACCTCCGCATCTGCCTCTCGCAGCTCAGCATCTTCCTGCGGGAATACTCTGAGATACCGCTCAACATGCTGACGTACACGGCGGGCCACATCAACTACGGAGGCCGCGTCACGGACGACTGGGACCGGCGCTGCCTGCTCACGCTGCTGGCCGACTACTACTCGCCCGCCGTGCTCTCCGACAGATACATCTTCGACGAATCCGGGGCCTACAAGCAGTTGCCGTCGTCAGCTACAATAGAAGACTACATGAACTACATAAAGACCCTCCCCCTGAACGACGACCCGTCGCTGTTCGGTCTGCACCCCAACGCCAACATTAGCTACGCCATGTCCGAGACCAACGCTTGTCTCGGTAACCTCCGCAGCCTGCAGGCGCGCGGGGTGAGCGAGGCGGGCGCGGGCTCGGAGCGGGGCCCGGAGCGCGCGGCGCGGGACGTGCTGGCCGCGCTGCCGCCGCCGCTGGACCTGCCGCGCATACACGCCGCGTACCCGGTAATGTACAAGGAGTCCCTGAACACGGTGCTGATCCAGGAGGCCACCAGGTACAACAGGCTCCTCAAAGTCATCGACGACTCTCTCACGGAGGTGTGCCGCGCGCTGCAGGGGCTGGCGGCCATGTCCCGCGGCGCCGAGGAGGCGGCCGACGCCCTGGCGCGCGCGCTGGTGCCGCCGCGGTGGACGCGCGCCGCCTACCCCTCGCTCAAGCCGCTCGGCGCGTGGGTGCGGGACCTGGCGCAGCGCGTGGAGTTCCTGCGCTCGTGGGCGGAGCTGGGCATCCCCACCGTGTTCTGGATCTCGGGGCTGTTCTTCCCGCAGGCCTTCCTCACGGGCGCGCTGCAGAACTACGCCAGGAAGCACGTCGTCGCCATCGACACGCTCTCCTACGGCTTCGAGCCCCTGGCCGCCGCGCCGCCGAAGAGGCCGGACGACGGCTGCTGCATCCGGGGACTGTTCCTGGAGGGCGCTCGCTGGAACATGGGGGACATGAGCCTGGACGAGAGCCGGCCCAAGGAGCTGTACACAGACATGGCGCCGCTGTACCTGCGGCCGGAGCAGCACCGGCGGGCGGCGCAGGGCTCCGCGGACTGCCCCGTGTACAAGACGCTGCTGCGCGCCGGCACGCTGTCCACCACGGGCCACTCCACCAACTACGTGCTGACCGTGGAGCTGCCCACCAAGAAGCCGCCGGCGCACTGGGTCAAGCGCGGGGTCGCCTTGTTCTGCGCCCTCGACTACTGA
Protein
MYESRMKNDWLVFSLSVFHGVVLERRKFGPLGFNVPYEFTDGDLRICLSQLSIFLREYSEIPLNMLTYTAGHINYGGRVTDDWDRRCLLTLLADYYSPAVLSDRYIFDESGAYKQLPSSATIEDYMNYIKTLPLNDDPSLFGLHPNANISYAMSETNACLGNLRSLQARGVSEAGAGSERGPERAARDVLAALPPPLDLPRIHAAYPVMYKESLNTVLIQEATRYNRLLKVIDDSLTEVCRALQGLAAMSRGAEEAADALARALVPPRWTRAAYPSLKPLGAWVRDLAQRVEFLRSWAELGIPTVFWISGLFFPQAFLTGALQNYARKHVVAIDTLSYGFEPLAAAPPKRPDDGCCIRGLFLEGARWNMGDMSLDESRPKELYTDMAPLYLRPEQHRRAAQGSADCPVYKTLLRAGTLSTTGHSTNYVLTVELPTKKPPAHWVKRGVALFCALDY
Summary
Description
Force generating protein of cilia required for sperm flagellum motility. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Required in spermatozoa for the formation of the inner dynein arms and biogenesis of the axoneme (PubMed:24360805).
Component of the transcription regulatory histone acetylation (HAT) complex SAGA, a multiprotein complex that activates transcription by remodeling chromatin and mediating histone acetylation and deubiquitination. Within the SAGA complex, participates in a subcomplex that specifically deubiquitinates histone H2B. The SAGA complex is recruited to specific gene promoters by activators, where it is required for transcription.
Subunit
Consists of at least two heavy chains and a number of intermediate and light chains.
Component of some SAGA transcription coactivator-HAT complexes. Within the SAGA complex, participates to a subcomplex of SAGA called the DUB module (deubiquitination module).
Similarity
Belongs to the dynein heavy chain family.
Belongs to the SGF11 family.
Keywords
Alternative splicing
ATP-binding
Cell projection
Ciliopathy
Cilium
Coiled coil
Complete proteome
Cytoplasm
Cytoskeleton
Disease mutation
Dynein
Flagellum
Kartagener syndrome
Microtubule
Motor protein
Nucleotide-binding
Polymorphism
Primary ciliary dyskinesia
Reference proteome
Feature
chain Dynein heavy chain 1, axonemal
splice variant In isoform 3.
sequence variant In dbSNP:rs10460963.
PDB
3VKH
E-value=1.96757e-17,
Score=219
Ontologies
Topology
Subcellular location
Cytoplasm
Cytoskeleton
Cilium axoneme
Cell projection
Cilium
Flagellum
Nucleus
Number of predicted TMHs:
0
Exp number of AAs in TMHs:
5.70449
Exp number, first 60 AAs:
0.08596
Total prob of N-in:
0.08744
Population Genetic Test Statistics