SGID Silkworm Genome Informatics Database
Gene
KWMTBOMO08158
Pre Gene Modal
BGIBMGA014367
Annotation
Dynein_heavy_chain_1?_axonemal_[Papilio_xuthus]
Full name
Dynein heavy chain 1, axonemal       + More
SAGA-associated factor 11 homolog      
Alternative Name
Axonemal beta dynein heavy chain 1
Ciliary dynein heavy chain 1
Heat shock regulated protein 1
hDHC7
Location in the cell
Mitochondrial   Reliability : 1.377 PlasmaMembrane   Reliability : 1.362
 

Sequence

CDS
ATGTATGAGAGTAGGATGAAAAATGATTGGCTGGTGTTCTCGCTGAGCGTGTTCCACGGCGTGGTGCTGGAGAGGCGCAAGTTCGGGCCGCTGGGCTTCAACGTGCCCTACGAGTTCACAGACGGGGACCTCCGCATCTGCCTCTCGCAGCTCAGCATCTTCCTGCGGGAATACTCTGAGATACCGCTCAACATGCTGACGTACACGGCGGGCCACATCAACTACGGAGGCCGCGTCACGGACGACTGGGACCGGCGCTGCCTGCTCACGCTGCTGGCCGACTACTACTCGCCCGCCGTGCTCTCCGACAGATACATCTTCGACGAATCCGGGGCCTACAAGCAGTTGCCGTCGTCAGCTACAATAGAAGACTACATGAACTACATAAAGACCCTCCCCCTGAACGACGACCCGTCGCTGTTCGGTCTGCACCCCAACGCCAACATTAGCTACGCCATGTCCGAGACCAACGCTTGTCTCGGTAACCTCCGCAGCCTGCAGGCGCGCGGGGTGAGCGAGGCGGGCGCGGGCTCGGAGCGGGGCCCGGAGCGCGCGGCGCGGGACGTGCTGGCCGCGCTGCCGCCGCCGCTGGACCTGCCGCGCATACACGCCGCGTACCCGGTAATGTACAAGGAGTCCCTGAACACGGTGCTGATCCAGGAGGCCACCAGGTACAACAGGCTCCTCAAAGTCATCGACGACTCTCTCACGGAGGTGTGCCGCGCGCTGCAGGGGCTGGCGGCCATGTCCCGCGGCGCCGAGGAGGCGGCCGACGCCCTGGCGCGCGCGCTGGTGCCGCCGCGGTGGACGCGCGCCGCCTACCCCTCGCTCAAGCCGCTCGGCGCGTGGGTGCGGGACCTGGCGCAGCGCGTGGAGTTCCTGCGCTCGTGGGCGGAGCTGGGCATCCCCACCGTGTTCTGGATCTCGGGGCTGTTCTTCCCGCAGGCCTTCCTCACGGGCGCGCTGCAGAACTACGCCAGGAAGCACGTCGTCGCCATCGACACGCTCTCCTACGGCTTCGAGCCCCTGGCCGCCGCGCCGCCGAAGAGGCCGGACGACGGCTGCTGCATCCGGGGACTGTTCCTGGAGGGCGCTCGCTGGAACATGGGGGACATGAGCCTGGACGAGAGCCGGCCCAAGGAGCTGTACACAGACATGGCGCCGCTGTACCTGCGGCCGGAGCAGCACCGGCGGGCGGCGCAGGGCTCCGCGGACTGCCCCGTGTACAAGACGCTGCTGCGCGCCGGCACGCTGTCCACCACGGGCCACTCCACCAACTACGTGCTGACCGTGGAGCTGCCCACCAAGAAGCCGCCGGCGCACTGGGTCAAGCGCGGGGTCGCCTTGTTCTGCGCCCTCGACTACTGA
Protein
MYESRMKNDWLVFSLSVFHGVVLERRKFGPLGFNVPYEFTDGDLRICLSQLSIFLREYSEIPLNMLTYTAGHINYGGRVTDDWDRRCLLTLLADYYSPAVLSDRYIFDESGAYKQLPSSATIEDYMNYIKTLPLNDDPSLFGLHPNANISYAMSETNACLGNLRSLQARGVSEAGAGSERGPERAARDVLAALPPPLDLPRIHAAYPVMYKESLNTVLIQEATRYNRLLKVIDDSLTEVCRALQGLAAMSRGAEEAADALARALVPPRWTRAAYPSLKPLGAWVRDLAQRVEFLRSWAELGIPTVFWISGLFFPQAFLTGALQNYARKHVVAIDTLSYGFEPLAAAPPKRPDDGCCIRGLFLEGARWNMGDMSLDESRPKELYTDMAPLYLRPEQHRRAAQGSADCPVYKTLLRAGTLSTTGHSTNYVLTVELPTKKPPAHWVKRGVALFCALDY

Summary

Description
Force generating protein of cilia required for sperm flagellum motility. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Required in spermatozoa for the formation of the inner dynein arms and biogenesis of the axoneme (PubMed:24360805).
Component of the transcription regulatory histone acetylation (HAT) complex SAGA, a multiprotein complex that activates transcription by remodeling chromatin and mediating histone acetylation and deubiquitination. Within the SAGA complex, participates in a subcomplex that specifically deubiquitinates histone H2B. The SAGA complex is recruited to specific gene promoters by activators, where it is required for transcription.
Subunit
Consists of at least two heavy chains and a number of intermediate and light chains.
Component of some SAGA transcription coactivator-HAT complexes. Within the SAGA complex, participates to a subcomplex of SAGA called the DUB module (deubiquitination module).
Similarity
Belongs to the dynein heavy chain family.
Belongs to the SGF11 family.
Keywords
Alternative splicing   ATP-binding   Cell projection   Ciliopathy   Cilium   Coiled coil   Complete proteome   Cytoplasm   Cytoskeleton   Disease mutation   Dynein   Flagellum   Kartagener syndrome   Microtubule   Motor protein   Nucleotide-binding   Polymorphism   Primary ciliary dyskinesia   Reference proteome  
Feature
chain  Dynein heavy chain 1, axonemal
splice variant  In isoform 3.
sequence variant  In dbSNP:rs10460963.
EMBL
KQ459585    KPI98285.1    KQ460889    KPJ11048.1    BABH01040380    BABH01040381    + More
BABH01040382    BABH01040383    BABH01040384    KQ971338    EFA01907.1    KZ288260    PBC30455.1    KQ434772    KZC03876.1    KQ435750    KOX76366.1    AK052631    BAC35070.1    KQ762237    OAD55987.1    QUSF01000032    RLV99506.1    GECZ01027881    JAS41888.1    MRZV01000992    PIK41734.1    QRBI01000145    RMB99998.1    MUZQ01000011    OWK63544.1    AGTP01005611    AGTP01005612    LSYS01004144    OPJ80791.1    DS235030    EEB10716.1    KL224918    KFW65598.1    AAQR03061720    AAQR03061721    AAQR03061722    AAQR03061723    AAQR03061724    AAQR03061725    AAQR03061726    AAQR03061727    BC127557    AAI27558.1    BC159123    AAI59124.1    AMQN01004546    AMQN01004547    KB293809    ELU15361.1    NDHI03003498    PNJ32495.1    AQIB01131957    AQIB01131958    KE161789    EPQ05307.1    ABGA01132802    ABGA01132803    ABGA01132804    ABGA01132805    ABGA01132806    ABGA01132807    REGN01004975    RNA15333.1    HM005373    AEE60973.1    NBAG03000218    PNI80296.1    AEYP01001932    AGTO01011004    PZQS01000006    PVD29060.1    AJFE02064152    AJFE02064153    AJFE02064154    AJFE02064155    AACZ04000327    CABD030021461    JSUE03023635    KL205959    KFV77546.1    AQIA01039753    ABQF01031696    ABQF01031697    AB037831    AK023766    AK074130    AK125990    AB290163    AC092045    KF459588    AJ132083    AJ132094    U61738    Z83804    U83571    AY221994    AL117428    ADFV01173429    ADFV01173430    ADFV01173431    ADFV01173432    ADFV01173433    ADFV01173434    ADFV01173435    ADFV01173436    ADFV01173437    ADFV01173438    AAMC01048030    AAMC01048031    AAMC01048032    AAMC01048033    CM004472    OCT85694.1    NIVC01001001    PAA73625.1    GAMS01001321    JAB21815.1    AHZZ02020092    AHZZ02020093    AAPE02022324    AAPE02022325    LZPO01107936    OBS59920.1    JH816168    EKC41830.1    ACTA01154541    ACTA01162540    ACTA01170538    AAGW02044169    AAGW02044170    AAGW02044171   
Pfam
PF12781   AAA_9        + More
PF12774   AAA_6
PF08393   DHC_N2
PF17857   AAA_lid_1
PF12777   MT
PF18199   Dynein_C
PF17852   Dynein_AAA_lid
PF18198   AAA_lid_11
PF12780   AAA_8
PF03028   Dynein_heavy
PF08209   Sgf11
Interpro
IPR042222   Dynein_2_N        + More
IPR035706   AAA_9       
IPR041589   DNAH3_AAA_lid_1       
IPR024317   Dynein_heavy_chain_D4_dom       
IPR024743   Dynein_HC_stalk       
IPR026975   DNAH1       
IPR027417   P-loop_NTPase       
IPR041466   Dynein_AAA5_ext       
IPR003593   AAA+_ATPase       
IPR004273   Dynein_heavy_D6_P-loop       
IPR013602   Dynein_heavy_dom-2       
IPR026983   DHC_fam       
IPR042219   AAA_lid_11_sf       
IPR035699   AAA_6       
IPR042228   Dynein_2_C       
IPR041228   Dynein_C       
IPR041658   AAA_lid_11       
IPR013246   SAGA_su_Sgf11       
IPR013243   SCA7_dom       
SUPFAM
SSF52540   SSF52540       
Gene 3D
PDB
3VKH     E-value=1.96757e-17,     Score=219

Ontologies

Topology

Subcellular location
Cytoplasm  
Cytoskeleton  
Cilium axoneme  
Cell projection  
Cilium  
Flagellum  
Nucleus  
Length:
455
Number of predicted TMHs:
0
Exp number of AAs in TMHs:
5.70449
Exp number, first 60 AAs:
0.08596
Total prob of N-in:
0.08744
outside
1  -  455
 
 

Population Genetic Test Statistics

Pi
286.147665
Theta
175.871931
Tajima's D
2.388663
CLR
0.154159
CSRT
0.936353182340883
Interpretation
Uncertain
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