Gene

KWMTBOMO08154

Pre Gene Modal

BGIBMGA014369

Annotation

PREDICTED:_lysosomal_acid_phosphatase-like_[Amyelois_transitella]

Location

Bomo_Chr14(-):115371-119865      View in EpiBrowser

Full name

Prostatic acid phosphatase      

Alternative Name

5'-nucleotidase
Ecto-5'-nucleotidase
Fluoride-resistant acid phosphatase
Thiamine monophosphatase

Location in the cell

PlasmaMembrane   Reliability : 0.898

CDS

ATGCGAGTCGTGTACTTTGTAGGCGTCTTGGCTGCGTTGGCCCAGCACGTCAGGGCTGGCGACGCTACAGACGGAACCGAACTGGTTTCAACTTTTTTGGTACATCGGCACGGCGACAGGACGCCGGTGGAGATCACCCTGGCCATGTCCACGGACCCCGCCGCGCTGGAGCAGGCCGCGGCTCCCTATGGCTTTGGACAACTCACTGAGTTCGGTAAGAAGACCAGCTACAAAGTGGGAGAGTACATCAAGTCACGTTACGGCGCTCTGCTCTCGGACCGATACAACGCCTCCGAGATCTTCATCCGGTCCACGGACTCGACACGCACGAAGATGACTGTCCTGACCGCGATGGCCGCTGTCTACCCACCTCCTGAAGACAACTGGAGCTCAGAGATTCACTGGACCCCCGTGCCCTACACCACCGTCCCACCTAAATATGACCATAACCTGGCAAACCTCAACTGTCCGGAGTTCATCTCGTTCTACTACGACCAGTTCATGAAACCTTCCGAGAAGATGGCCCCCTACCGCGACTTCCTGGCGAGATGGTCTGAAATTCTCGGTTTCGACCTCGTGCAGATGCCCGCCCTGGCGTACATGTTCTACGACGTATACACTGCTCAGCTCGGGCTGGGCGTCCCGCTGGACGAGGCCACGGCGCAGAAGTTCCCCGAGATCGAAGCGGCGGCCGGGGCGGCCATCGACGTCGTGTTCGGAGATGAAAACTACATCGCGCTACAAGCGGGAGTGTTGCTGAATGAGTTCTTGAAGGCGGCGGCGGCGGTGGTGGGGGGCGAGAGCGCGCGGCGGGTGCACGTGTACTCCGCGCACGACTACAACGTGTACTCCCTGATGGCCGTCTCCAGGATCAGTCCGCGACAAGGAGTGCCCAAGTACGGCTCCGTATTCTCCCTCGAGCTGAGGAAGGTCACCGCGACCGGGAAGTATGTAGTTTTGCCCGTTTATCTAAGATCTCCGTACGAGCAGATCCAGTACCTGCAGGTGGAGGGCTGCAGCGCGCTGCTGTGTGACCTGGAAGAGTTTCAGCAGCTCACCTCCCGCTACGTGCTCGAAGAGGACGAGTGGAGGACGAAGTGCGGCTTCACGCACGACCTCGAAGTGGACGACTCCAGCATTAACTAA

Protein

MRVVYFVGVLAALAQHVRAGDATDGTELVSTFLVHRHGDRTPVEITLAMSTDPAALEQAAAPYGFGQLTEFGKKTSYKVGEYIKSRYGALLSDRYNASEIFIRSTDSTRTKMTVLTAMAAVYPPPEDNWSSEIHWTPVPYTTVPPKYDHNLANLNCPEFISFYYDQFMKPSEKMAPYRDFLARWSEILGFDLVQMPALAYMFYDVYTAQLGLGVPLDEATAQKFPEIEAAAGAAIDVVFGDENYIALQAGVLLNEFLKAAAAVVGGESARRVHVYSAHDYNVYSLMAVSRISPRQGVPKYGSVFSLELRKVTATGKYVVLPVYLRSPYEQIQYLQVEGCSALLCDLEEFQQLTSRYVLEEDEWRTKCGFTHDLEVDDSSIN

Description

A non-specific tyrosine phosphatase that dephosphorylates a diverse number of substrates under acidic conditions (pH 4-6) including alkyl, aryl, and acyl orthophosphate monoesters and phosphorylated proteins. Has lipid phosphatase activity and inactivates lysophosphatidic acid in seminal plasma (By similarity).
Isoform 2: the cellular form also has ecto-5'-nucleotidase activity in dorsal root ganglion (DRG) neurons. Generates adenosine from AMP which acts as a pain suppressor.

Catalytic Activity

a phosphate monoester + H2O = an alcohol + phosphate
a ribonucleoside 5'-phosphate + H2O = a ribonucleoside + phosphate

Subunit

Homodimer; dimer formation is required for phosphatase activity.

Similarity

Belongs to the histidine acid phosphatase family.

Keywords

Alternative splicing   Cell membrane   Complete proteome   Disulfide bond   Glycoprotein   Hydrolase   Lysosome   Membrane   Reference proteome   Secreted   Signal  

Feature

chain  Prostatic acid phosphatase
splice variant  In isoform 2.

Uniprot

H9JXV1   A0A437B8H1   A0A2A4K724   A0A2H1W2M4   A0A2H1W2H8   A0A2A4K8E9   + More
A0A2A4K851   I4DJY6   A0A194PY59   A0A0N1IF44   A0A1E1WMB7   H9JIY7   I4DR67   A0A437AY25   S4NSI3   A0A1E1W159   A0A194PS41   A0A194R7T8   A0A2A4JFS4   A0A3S2LGG3   A0A212EPG3   H9J9I3   A0A2H1VAX3   A0A2A4K986   A0A212F630   A0A0N0PBK2   A0A194PY67   A0A2H1WGF6   K7IQ61   A0A232EEI8   A0A250YH28   I3N6C9   G1SYZ1   A0A2K6FQ70   A0A0L7LP95   A0A1Y1KWW5   A0A1Y1KWT0   F1Q4D3   A0A1U7V1N2   A0A2U3X1Y4   G3WUE8   G3WUE9   Q8CE08   A0A452EWS2   A0A2K5RDL6   Q8CE08-2   A0A3Q7UDM5   A0A1U7RXA5   U3KDB9   A0A151P351   A0A1U8CY71   A0A3Q0CY15   A0A2K6SJD8   K9IJ78   A0A1U7QX17   U3BAN4   U3BVD3   A0A2K5DU51   Q3I1Z6   A6H730   W5PH63   A0A2K5KUD1   K9IXP4   Q3I1Y9   A0A0D9RDS3   F6Y5Y5   A0A1D5QQZ0   A0A093I7X9   G3STE9   K7IQ63   H2PBF8   A0A1S3WUQ9   A0A287AFE9   A0A2J8U3K3   D2A428   A0A0G2K4B4   A0A2K5I5Z0   F1SPF0   A0A3Q1M6R0   A0A2K6RIZ6   Q3I1Z7   A0A2R8N8D9   A0A2U3XZS1   A0A2Y9G6Q0   Q3I1Z9   Q3I1Z8   L8IIS0   G5BKQ9   A0A2Y9G9V7   A0A093ERJ0   G7NXZ7   A0A0G2JSL5   A0A3Q7Q7F7   A0A3Q7PWT8   A0A3Q2HX16   H2R438  

EC Number

3.1.3.2

Pubmed

19121390    22651552    26354079    23622113    22118469    20075255    + More
28648823    28087693    21993624    26227816    28004739    16341006    21709235    16141072    19468303    15489334    17638863    18940592    20084276    22293439    25243066    16170411    20809919    18464734    17431167    18362917    19820115    15057822    19393038    25362486    22751099    21993625    22002653    19892987    16136131   

EMBL

BABH01040368    RSAL01000117    RVE46811.1    NWSH01000059    PCG80075.1    ODYU01005909    + More
SOQ47287.1    SOQ47289.1    PCG80073.1    PCG80074.1    AK401604    BAM18226.1    KQ459585    KPI98276.1    KQ460778    KPJ12419.1    GDQN01003058    JAT87996.1    BABH01022999    BABH01023000    AK404965    BAM20407.1    RSAL01000278    RVE43078.1    GAIX01014082    JAA78478.1    GDQN01010326    JAT80728.1    KQ459601    KPI93945.1    KQ460855    KPJ11936.1    NWSH01001685    PCG70424.1    RSAL01000014    RVE53289.1    AGBW02013469    OWR43369.1    BABH01004863    ODYU01001406    SOQ37542.1    NWSH01000024    PCG80629.1    AGBW02010086    OWR49186.1    KQ460889    KPJ11041.1    KPI98277.1    ODYU01008500    SOQ52158.1    NNAY01005308    OXU16770.1    GFFW01001898    JAV42890.1    AGTP01046392    AGTP01046393    AGTP01046394    AGTP01046395    AGTP01046396    AGTP01046397    AGTP01046398    AGTP01046399    AGTP01046400    AGTP01046401    JTDY01000422    KOB77267.1    GEZM01071381    GEZM01071374    JAV65852.1    GEZM01071378    GEZM01071370    JAV65859.1    AAEX03013595    AEFK01201456    AEFK01201457    AEFK01201458    AEFK01201459    AF210243    AK029273    AK076383    CT030733    BC139826    LWLT01000001    AGTO01001245    AKHW03001210    KYO43349.1    GABZ01006540    JAA46985.1    GAMT01002023    JAB09838.1    GAMT01002022    JAB09839.1    DQ150472    AAZ82242.1    BC146093    AMGL01011780    AMGL01011781    AMGL01011782    GABZ01006299    JAA47226.1    DQ150475    AAZ82249.1    AQIB01076356    AQIB01076357    AQIB01076358    JSUE03024841    KL206987    KFV87975.1    ABGA01305496    ABGA01305497    ABGA01305498    ABGA01305499    ABGA01305500    ABGA01305501    ABGA01305502    NDHI03003471    PNJ39852.1    AEMK02000088    PNJ39853.1    KQ971348    EFA05605.1    AABR07071383    DQ150471    AAZ82241.1    DQ150469    AAZ82239.1    DQ150470    AAZ82240.1    JH881123    ELR56450.1    JH170773    GEBF01004118    EHB09870.1    JAN99514.1    KK369956    KFV43052.1    AQIA01037926    CM001277    EHH51672.1    AACZ04048175   

Proteomes

UP000005204    UP000283053    UP000218220    UP000053268    UP000053240    UP000007151    + More
UP000002358    UP000215335    UP000005215    UP000001811    UP000233160    UP000037510    UP000002254    UP000189704    UP000245340    UP000007648    UP000000589    UP000291000    UP000233040    UP000286640    UP000189705    UP000016665    UP000050525    UP000189706    UP000233220    UP000233020    UP000009136    UP000002356    UP000233060    UP000029965    UP000002279    UP000006718    UP000053584    UP000007646    UP000001595    UP000079721    UP000008227    UP000007266    UP000002494    UP000233080    UP000233200    UP000008225    UP000245341    UP000248481    UP000006813    UP000009130    UP000233100    UP000286641    UP000002281    UP000002277   

PRIDE

H9JXV1    H9JIY7    H9J9I3    Q8CE08    A6H730    F1SPF0    + More

Pfam

PF00328   His_Phos_2        + More
PF18701   DUF5641
PF00665   rve

Interpro

IPR029033   His_PPase_superfam        + More
IPR029630   Api_m_3       
IPR000560   His_Pase_clade-2       
IPR033379   Acid_Pase_AS       
IPR012337   RNaseH-like_sf       
IPR001584   Integrase_cat-core       
IPR036397   RNaseH_sf       
IPR040676   DUF5641       

SUPFAM

SSF53254   SSF53254        + More
SSF53098   SSF53098       

Gene 3D

3.40.50.1240     3.30.420.10    

CDD

cd07061  HP_HAP_like

ProteinModelPortal

H9JXV1   A0A437B8H1   A0A2A4K724   A0A2H1W2M4   A0A2H1W2H8   A0A2A4K8E9   + More
A0A2A4K851   I4DJY6   A0A194PY59   A0A0N1IF44   A0A1E1WMB7   H9JIY7   I4DR67   A0A437AY25   S4NSI3   A0A1E1W159   A0A194PS41   A0A194R7T8   A0A2A4JFS4   A0A3S2LGG3   A0A212EPG3   H9J9I3   A0A2H1VAX3   A0A2A4K986   A0A212F630   A0A0N0PBK2   A0A194PY67   A0A2H1WGF6   K7IQ61   A0A232EEI8   A0A250YH28   I3N6C9   G1SYZ1   A0A2K6FQ70   A0A0L7LP95   A0A1Y1KWW5   A0A1Y1KWT0   F1Q4D3   A0A1U7V1N2   A0A2U3X1Y4   G3WUE8   G3WUE9   Q8CE08   A0A452EWS2   A0A2K5RDL6   Q8CE08-2   A0A3Q7UDM5   A0A1U7RXA5   U3KDB9   A0A151P351   A0A1U8CY71   A0A3Q0CY15   A0A2K6SJD8   K9IJ78   A0A1U7QX17   U3BAN4   U3BVD3   A0A2K5DU51   Q3I1Z6   A6H730   W5PH63   A0A2K5KUD1   K9IXP4   Q3I1Y9   A0A0D9RDS3   F6Y5Y5   A0A1D5QQZ0   A0A093I7X9   G3STE9   K7IQ63   H2PBF8   A0A1S3WUQ9   A0A287AFE9   A0A2J8U3K3   D2A428   A0A0G2K4B4   A0A2K5I5Z0   F1SPF0   A0A3Q1M6R0   A0A2K6RIZ6   Q3I1Z7   A0A2R8N8D9   A0A2U3XZS1   A0A2Y9G6Q0   Q3I1Z9   Q3I1Z8   L8IIS0   G5BKQ9   A0A2Y9G9V7   A0A093ERJ0   G7NXZ7   A0A0G2JSL5   A0A3Q7Q7F7   A0A3Q7PWT8   A0A3Q2HX16   H2R438  

PDB

1RPT     E-value=7.05579e-29,     Score=317

KEGG

101735607    K19283 prostatic aicd phosphatase [EC:3.1.3.2 3.1.3.5] | (RefSeq) prostatic acid phosphatase-like

GO

GO:0003993   GO:0016021   GO:0016311   GO:0008253   GO:0030175   GO:0006144   GO:0060168   GO:0012506   GO:0009117   GO:0006772   GO:0046085   GO:0016791   GO:0042803   GO:0005615   GO:0052642   GO:0042131   GO:0051930   GO:0005886   GO:0051289   GO:0005771   GO:0033265   GO:0045177   GO:0042802   GO:0005765   GO:0031985   GO:0030141   GO:0007165   GO:0005488   GO:0005515   GO:0005634   GO:0030145   GO:0006412   GO:0016876   GO:0043039  

PANTHER

PTHR11567:SF183  

Subcellular location

Secreted  
Cell membrane   Appears to shuttle between the cell membrane and intracellular vesicles. Colocalizes with FLOT1 at cell membrane and in intracellular vesicles (PubMed:17638863). Colocalizes with LAMP2 on the lysosome membrane (By similarity).   With evidence from 2 publications.
Lysosome membrane   Appears to shuttle between the cell membrane and intracellular vesicles. Colocalizes with FLOT1 at cell membrane and in intracellular vesicles (PubMed:17638863). Colocalizes with LAMP2 on the lysosome membrane (By similarity).   With evidence from 2 publications.

SignalP

Position:   1 - 19,         Likelihood:  0.992620

 

 

Length:

381

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.12066

Exp number, first 60 AAs:

0.02862

Total prob of N-in:

0.00795

outside

1  -  381

 

 

Pi

226.242586

Theta

182.135115

Tajima's D

0.662565

CLR

2.356611

CSRT

0.559822008899555

Interpretation

Uncertain