Gene

KWMTBOMO08151  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA014370

Annotation

PREDICTED:_protein_toll-like_isoform_X1_[Bombyx_mori]

Location

Bomo_Chr14(-):60061-68845      View in EpiBrowser

Location in the cell

Cytoplasmic   Reliability : 1.262 Extracellular   Reliability : 1.265 PlasmaMembrane   Reliability : 1.159

CDS

ATGCGCCTGCTGCTGATGGCGCTGTGTGCGTGGTGGCTGCGTCCCGGTGTGCAGGCAGCGCGGCCCGCGTGCGGCCGGGCCCGGGACTGCGTCGCGGGACACCATCTCAACGATGAGTTCTTCTTCACTGTGCACGGTCAGAACCTAGTGATAAACTTCTCGGAGGCTCAGTATGTGGAGCTGGAGTGTCCCGAGGGCGTGGCGCTGGGCGGTGCGGGGATGCCGTCGTTCGACGGCGGCGCGCGCGTCCTCAACGTGACGCTTCGAAGGTGCAGCATCGGAGCCGACTCGCTGGCGGACGCTCTCGGAGCCCTCAACATCTCCGTCCTCGAGCGCCTGTCCCTCAAGGACACGCCGCCCGGCTCGCTCTCCGCGCTGCACCTGCGGGGCCTCGAGCACCTCTTGCGACTTGACCTCGAAGGGACCAGAGGCATGCCTCTCAGGGTCGAGGCTGGTGCTTTGCTGCCTCTCGTCAACTTGCGTATGCTGCAGCTCAACCGCGTGCAGATGGCGTCCCTACAATTTCCGCCAACGTTGCATTCGCTCCAGCTTTGGTTTGTCGGTGAGACGCGATTAGATCTAAGCGGTCTCGATCAGCTGCGAGCCCTCGTGGTGCACGAAAAGGAATCAGTGACGGTGAGCGCGTTGACGGCTGGCTCGTTGGAGAGCGTGGTGCTAGACGCGAGGAGGGTGTCGTTTCCGGCGGCGTCCAGGCCGCGCTCGATTCGACGTCTCGTGCTCGTGAACTGGAACGAGACGGACCTCTCCGCGCGGTGTGACGACGTGGAGCTGCTGCAGCTGCGAGGCTGGGTCGGCGAGGAGCCGGCTCCCCCCCGTAGATGGTTATCGCACTGTAAAAAGTTGCGCGAGTTTCGAATGAGCTTCGCTCGTCAGAAGTCTGTGACTCCCGGTCTGCTGGACGGCGCAGAAAATCTCGAAGATCTAGGTCTCACTTCCTGCCAGATTGACACATTACCTGTTGATCTCTTTAAGGAGAATAGAAATCTGCGGATCATTGATTTATCCCACAACAAACTACAAACATTACCAAGTGGCTTATTTTCGAACTTACGGAACCTGAAAGAACTCAATCTATCCAACAACAAGCTGCAGGCGGCGGCTGTGGGGACTCTGGGCTCGCTAGTCTCCCTACAGGATCTCAATCTTTCCCACAACCCGCCTCTACTTGATCTCTGCTCCGGTGGTTCTGATGCGTTCATCGTCTCTGGCACTTCCCCGCTAAAAGCGCTGACGGAGTTGGAAGAGCTCAGACTGGGTCACACGGGTGTGTCTCACGTGTGCAGCGACTGGCGAACCTCCATGAAGCAACTCCGTCTTCTCGATCTCTCCTACACAAACATCACCTCCCTGTCGTACCTGGATTTCCACTACGAGCACTCTGGATCCAAAGAGCTGACCGTGAACTTCAACGGCACGCCCGTCACCGAGCTCACCGTCGACGCGGGGAACTACAAGTCTGTGATCGCCGACCTGGCATCTGCATCGGTCAAGATAATATTGAGAGCAACTTTACCGTGCGACTGCTCGGACTACTGGACGGCACTGGCGTTCGGGGACCTCAGCACTCAAGCACAAGATTCCGTAGAGCTCCTGTGTAGGGAGGAGGAGCGTGGTTCACTAGCGGATGCGTTGGAACGGGAATCTCTGGAGTGTGCGGAATCGAGCCTGTGTGAGGACCAGGAGGGCTGCACTTGCTCCGTACGCCTTGACCTCTCGCTTGGTGTGGTGGCGACCGCGTCATGTGAGGGCGCGGGTCTGGACGAAATGCCATCGCGTCTGAAGTTCAAAGAGGCTCCCGTGTGGCGCTTAATGCTCGCCCACAACCACATCCAGACCGTTCGGCTTCAGGATCTGCCCGACACGATATTGGAGTTGGACCTGAGAAACAACTCTCTGCATAGATTGGACGGCCCGACTGCTTCGAAGTTATCAACTGTCCCTCTGTGGATCGCCAACAATTCGCTGGACTGCACATGTTACGGGTACGACTTGGTGACGAAGCTAGGACCTCATGTGCGCGACATGGAGCAAGCAACGTGCGACGACGGGACTTCTCTTAAAGAAGCACAGAATGGGGATCCCAGCGAATGTAGTTCAGCATTGGTCGTCGCCACGTCATTGATCAGCGCGCTGGCTTTGTTGGCAGTGATGGTCGCAGTTACAGCCGGCTGCGTGATGCGACCCGAGATGCGGCTTAGAATCAAGGTGCTGCTGCTGCGACTGGGCTGGTTGCCACGGCGGCCGGAGCCGGACGACGGGCGTCGGTTCGATGCATTCGTGTCGTACGCGCACGAGGACGAGGCGGTGGTGGAAGAGCTCGTGAAGCGGCTCGAAGTGGGGCACGGGTACCGGCTGTGCCTGCACTACCGCGACTGGGCGCCGGGCGAGTGGATCCACGTGCAGATCGCGGCCTCGGTGCAAGCGTCGCGCCGCACCCTTATCGTAGTCTCCCGGCACTTTCTGCGCTCCAAGTGGGCGCGCCAAGAGTTCCGTCAGGCACACGCGGCCGCGCTGCGTGACATCATACCGCGCCTCGTGCTGCTGTTCCTCGAGCCGCCGCACCGCTTGCCTCTCGACGCCGAGCTGCGCTCCTACATTAGGATCAACACCTACGTGCTCTGGACCGACCCCTGGTTCTGGCACAAACTAAAGCTAGCCCTGCCGCCCCCGCGCCTCCTCCCCACCCCGCTCGAGGATGTCTCCGTTAATAAGGCGGAGAGCTCCCCTCTCCACGGGGGGCAGGACACCAAGCCCTGCTCGCCCGAAGCCGAGACGGACACGTAG

Protein

MRLLLMALCAWWLRPGVQAARPACGRARDCVAGHHLNDEFFFTVHGQNLVINFSEAQYVELECPEGVALGGAGMPSFDGGARVLNVTLRRCSIGADSLADALGALNISVLERLSLKDTPPGSLSALHLRGLEHLLRLDLEGTRGMPLRVEAGALLPLVNLRMLQLNRVQMASLQFPPTLHSLQLWFVGETRLDLSGLDQLRALVVHEKESVTVSALTAGSLESVVLDARRVSFPAASRPRSIRRLVLVNWNETDLSARCDDVELLQLRGWVGEEPAPPRRWLSHCKKLREFRMSFARQKSVTPGLLDGAENLEDLGLTSCQIDTLPVDLFKENRNLRIIDLSHNKLQTLPSGLFSNLRNLKELNLSNNKLQAAAVGTLGSLVSLQDLNLSHNPPLLDLCSGGSDAFIVSGTSPLKALTELEELRLGHTGVSHVCSDWRTSMKQLRLLDLSYTNITSLSYLDFHYEHSGSKELTVNFNGTPVTELTVDAGNYKSVIADLASASVKIILRATLPCDCSDYWTALAFGDLSTQAQDSVELLCREEERGSLADALERESLECAESSLCEDQEGCTCSVRLDLSLGVVATASCEGAGLDEMPSRLKFKEAPVWRLMLAHNHIQTVRLQDLPDTILELDLRNNSLHRLDGPTASKLSTVPLWIANNSLDCTCYGYDLVTKLGPHVRDMEQATCDDGTSLKEAQNGDPSECSSALVVATSLISALALLAVMVAVTAGCVMRPEMRLRIKVLLLRLGWLPRRPEPDDGRRFDAFVSYAHEDEAVVEELVKRLEVGHGYRLCLHYRDWAPGEWIHVQIAASVQASRRTLIVVSRHFLRSKWARQEFRQAHAAALRDIIPRLVLLFLEPPHRLPLDAELRSYIRINTYVLWTDPWFWHKLKLALPPPRLLPTPLEDVSVNKAESSPLHGGQDTKPCSPEAETDT

Similarity

Belongs to the Toll-like receptor family.

Uniprot

H9JXV2   A0A2H1W8Q3   A4GVU0   A0A212F0F7   A0A0P4VMK0   A0A146L775   + More
A0A0A9XC66   T1HYZ2   A0A2R7WSN3   A0A0M8ZY10   A0A224X644   A0A151JAL5   A0A067R3H7   A0A0L7QLM2   A0A310S7W9   A0A195F0C9   A0A088AG15   A0A0C9PYP0   F4W4T1   A0A1L8E2X4   A0A2J7QHL1   A0A026W7S0   B4NIA8   A0A2A3EQD4   A0A232FI58   A0A154NYN7   A0A2C9H6H6   A0A0L0CQI3   K7ITQ2   A0A1Q3F421   J9JPZ4   E2BBY4   A0A1S4FH10   A0A1Q3F420   A0A1Q3F3Z4   A0A1Q3F3Z7   A0A1Q3F3T6   B4K8Y1   A0A1Q3F412   Q8MQU9   A0A1Q3F3X6   A0A1Q3F3V2   A0A1Q3F3T9   A0A2C9GWS9   Q171K9   A0A0M5J9C0   W8PWC1   K7ITR1   A0A182M8X8   A0A410SF83   A0A182KC65   A1C1P2   W8PVP4   A0A232FKD9   A0A1I8PSW5   A0A0D3QDL8   B2WSC9   D7EZ50   A0A182PVM9   B4LWB8   Q56RA0   A0A0D3QDD7   A0A182IDR8   A0A2C9GH57   Q56R98   Q24622   A0A2H8TRP1   Q6V669   Q6V672   B4QWS2   A0A084WPQ0   D2CGM6   Q29B96   A0A182HE56   E5D2L0   A0A3B0K7X3   A0A182HE57   Q6V670   Q6V666   V9I193   A0A0D3QDC7   Q8WRE5   A0A0D3QCR2   A0A0D3QDL3   A0A0D3QCQ2   A0A0D3QD03   Q6V673   B4PSC7   Q6V667   A0A2C9GV86   A0A0D3QCQ7  

Pubmed

19121390    17606296    22118469    27129103    26823975    25401762    + More
24845553    21719571    24508170    30249741    17994087    28648823    26108605    20075255    20798317    17510324    12542637    17056116    25552603    18321728    18057021    15545653    16547107    8112609    12930753    24438588    15632085    26483478    24398262    12213252    12364791    14747013    17210077    17550304   

EMBL

BABH01040360    BABH01040361    ODYU01007053    SOQ49485.1    EF442782    ABO21763.1    + More
AGBW02011129    OWR47184.1    GDKW01003048    JAI53547.1    GDHC01015553    GDHC01008551    JAQ03076.1    JAQ10078.1    GBHO01026374    GBHO01026373    GBHO01026372    GBHO01026370    JAG17230.1    JAG17231.1    JAG17232.1    JAG17234.1    ACPB03009442    KK855435    PTY22556.1    KQ435801    KOX73247.1    GFTR01008481    JAW07945.1    KQ979262    KYN22067.1    KK852931    KDR13629.1    KQ414914    KOC59528.1    KQ775195    OAD52269.1    KQ981880    KYN33933.1    GBYB01006639    GBYB01006641    GBYB01006643    JAG76406.1    JAG76408.1    JAG76410.1    GL887553    EGI70800.1    GFDF01000994    JAV13090.1    NEVH01013973    PNF28085.1    KK107356    QOIP01000010    EZA52048.1    RLU17569.1    CH964272    EDW83690.1    KZ288197    PBC33714.1    NNAY01000160    OXU30431.1    KQ434773    KZC03990.1    JRES01000062    KNC34506.1    GFDL01012744    JAV22301.1    ABLF02029217    GL447175    EFN86808.1    GFDL01012745    JAV22300.1    GFDL01012806    JAV22239.1    GFDL01012753    JAV22292.1    GFDL01012819    JAV22226.1    CH933806    EDW16578.1    GFDL01012754    JAV22291.1    AY124195    AAM97774.1    GFDL01012785    JAV22260.1    GFDL01012814    JAV22231.1    GFDL01012813    JAV22232.1    CH477452    EAT40665.1    CP012526    ALC46724.1    KJ188410    AHL39100.1    AXCM01000253    MH178390    QAT92918.1    DQ923424    ABK58729.1    KJ188411    AHL39101.1    NNAY01000105    OXU30928.1    KP274553    AJC98699.1    EF407561    ABQ59330.1    EU433386    ACC68670.1    CH940650    EDW67652.2    KRF83383.1    AY754607    AAX13182.1    KP274549    AJC98695.1    APCN01004779    APCN01004780    AY754609    AAX13184.1    L25390    AAA28942.1    GFXV01005058    MBW16863.1    AY349921    AAQ64872.1    AY349918    AAQ64869.1    CM000364    EDX14589.1    ATLV01025119    KE525369    KFB52194.1    EF117252    ABO38434.1    CM000070    EAL27102.2    JXUM01035187    JXUM01035188    JXUM01035189    GU014556    ADK55066.1    OUUW01000005    SPP81101.1    JXUM01035190    KQ561051    KXJ79871.1    AY349920    AAQ64871.1    AY349924    AAQ64875.1    JF895474    AEI25533.1    KP274533    KP274534    KP274535    KP274536    KP274537    KP274538    KP274539    KP274540    KP274541    KP274544    KP274551    AJC98679.1    AJC98680.1    AJC98681.1    AJC98682.1    AJC98683.1    AJC98684.1    AJC98685.1    AJC98686.1    AJC98687.1    AJC98690.1    AJC98697.1    AF444780    AAAB01008811    AAL37901.1    EAA45376.1    KP274552    AJC98698.1    KP274545    KP274548    KP274550    AJC98691.1    AJC98694.1    AJC98696.1    KP274542    AJC98688.1    KP274543    KP274546    AJC98689.1    AJC98692.1    AY349917    AAQ64868.1    CM000160    EDW98589.2    AY349922    AY349923    AAQ64873.1    AAQ64874.1    KP274547    AJC98693.1   

Proteomes

UP000005204    UP000007151    UP000015103    UP000053105    UP000078492    UP000027135    + More
UP000053825    UP000078541    UP000005203    UP000007755    UP000235965    UP000053097    UP000279307    UP000007798    UP000242457    UP000215335    UP000076502    UP000075920    UP000037069    UP000002358    UP000007819    UP000008237    UP000009192    UP000075900    UP000008820    UP000092553    UP000075883    UP000075881    UP000095300    UP000075903    UP000075885    UP000008792    UP000075840    UP000069272    UP000000304    UP000030765    UP000001819    UP000069940    UP000268350    UP000249989    UP000007062    UP000002282    UP000075884   

PRIDE

H9JXV2   

Pfam

PF13676   TIR_2        + More
PF13855   LRR_8
PF01582   TIR
PF13306   LRR_5
PF01462   LRRNT
PF00560   LRR_1
PF12366   Casc1
PF01463   LRRCT

Interpro

IPR000157   TIR_dom        + More
IPR001611   Leu-rich_rpt       
IPR032675   LRR_dom_sf       
IPR035897   Toll_tir_struct_dom_sf       
IPR003591   Leu-rich_rpt_typical-subtyp       
IPR000483   Cys-rich_flank_reg_C       
IPR026906   LRR_5       
IPR000372   LRRNT       
IPR022110   Casc1_domain       

SUPFAM

SSF52200   SSF52200       

Gene 3D

3.40.50.10140     3.80.10.10    

ProteinModelPortal

H9JXV2   A0A2H1W8Q3   A4GVU0   A0A212F0F7   A0A0P4VMK0   A0A146L775   + More
A0A0A9XC66   T1HYZ2   A0A2R7WSN3   A0A0M8ZY10   A0A224X644   A0A151JAL5   A0A067R3H7   A0A0L7QLM2   A0A310S7W9   A0A195F0C9   A0A088AG15   A0A0C9PYP0   F4W4T1   A0A1L8E2X4   A0A2J7QHL1   A0A026W7S0   B4NIA8   A0A2A3EQD4   A0A232FI58   A0A154NYN7   A0A2C9H6H6   A0A0L0CQI3   K7ITQ2   A0A1Q3F421   J9JPZ4   E2BBY4   A0A1S4FH10   A0A1Q3F420   A0A1Q3F3Z4   A0A1Q3F3Z7   A0A1Q3F3T6   B4K8Y1   A0A1Q3F412   Q8MQU9   A0A1Q3F3X6   A0A1Q3F3V2   A0A1Q3F3T9   A0A2C9GWS9   Q171K9   A0A0M5J9C0   W8PWC1   K7ITR1   A0A182M8X8   A0A410SF83   A0A182KC65   A1C1P2   W8PVP4   A0A232FKD9   A0A1I8PSW5   A0A0D3QDL8   B2WSC9   D7EZ50   A0A182PVM9   B4LWB8   Q56RA0   A0A0D3QDD7   A0A182IDR8   A0A2C9GH57   Q56R98   Q24622   A0A2H8TRP1   Q6V669   Q6V672   B4QWS2   A0A084WPQ0   D2CGM6   Q29B96   A0A182HE56   E5D2L0   A0A3B0K7X3   A0A182HE57   Q6V670   Q6V666   V9I193   A0A0D3QDC7   Q8WRE5   A0A0D3QCR2   A0A0D3QDL3   A0A0D3QCQ2   A0A0D3QD03   Q6V673   B4PSC7   Q6V667   A0A2C9GV86   A0A0D3QCQ7  

PDB

1O77     E-value=3.82716e-14,     Score=194

KEGG

101735468    no KO assigned | (RefSeq) protein toll-like

GO

GO:0007165   GO:0016021   GO:0045087   GO:0005515   GO:0005488   GO:0016791   GO:0005634   GO:0030145   GO:0006412   GO:0016876   GO:0043039  

SignalP

Position:   1 - 19,         Likelihood:  0.998955

 

 

Length:

934

Number of predicted TMHs:

1

Exp number of AAs in TMHs:

19.39852

Exp number, first 60 AAs:

0.00036

Total prob of N-in:

0.00053

outside

1  -  709

TMhelix

710  -  732

inside

733  -  934

 

 

Pi

224.393299

Theta

188.131927

Tajima's D

0.617556

CLR

0.411275

CSRT

0.551322433878306

Interpretation

Uncertain