Gene

KWMTBOMO08148

Pre Gene Modal

BGIBMGA001083

Annotation

PREDICTED:_palmitoyltransferase_ZDHHC17-like_[Papilio_machaon]

Location

Bomo_Chr13(+):17678390-17681991      View in EpiBrowser

Full name

Palmitoyltransferase       + More
Palmitoyltransferase Hip14      

Alternative Name

Huntingtin-interacting protein 14 homolog

Location in the cell

PlasmaMembrane   Reliability : 4.023

CDS

ATGATGTACGACAGTACTTGTGGTGCAGCGGCGACTGGCCAGTGTGGCCCTGCGCAGGCTGAACGAGAACCTCCAGAACCGCGGGAACCTCCACCACCACCAACTGAACGAGATTACAGCGGCTACGATATCGTGAAAGCAACGCAGTACGGAGCATTTGTGCGCGTTAAAGAACTCGTCGAAGCTGGCTGGGACGTGAACCGACCCGACGGCGAAACGGTGACCTTGCTGCACTGGGCTGCAATCAACAACAGACGCGACATCATCCAGTACTTGCTGTCGAAGGGTGCGAATGTCGATGCAGTTGGGGGAGAGTTACAGTCGACACCGCTACACTGGGCGACGCGGCAAGGGCACCTGGACGCGACTGTGCTGCTGGTCCGCGCGGGAGCCGACCCTTCGCTGCGTGACGCCGAGGGCTGCGCGTGCCTACACCTGGCAGCACAATTCGGTCACACTGCTGTGGTGGCGTACCTAGTGGCACGAGGTGTGACTGTGGATGAACCTGATGCAGGTGGCATGACGGCGCTCATGTGGGCAAGCTGGAAGGTTGCAGCTGTGGACCCAACACGTTTACTCCTCACTTTAGGTGCATCAACACAACCAGCTGATCGTGGCCATGGTAACACAGCCCTGCACTGGGCTATTCTGGCACGTAACACTACGGCCATATCCACTCTGATACTTTATGGTGATGCTAATTTGGATGTACCCAACCTGCGAGGAGTGACTCCATTGCAGATGTTACAGGCGAGTGCTGATTCCTTATGGGTTGGCTCTAAAGTTTCAGACAAAATAAAGGAACGTACAATGGAGTCAGAAAGATTATCAATATTTAGAAGATTGACATATGACAAGAAATTCAGATGGTGGTGTGTGGTAGTAATGCCATTCATGGCATTCTACTTGACTGGCCTCATCCTGGAGACGGACTTGAACTATCCTCTAAAAACCTTAATCTTGATTGGTTTCTACTCACTTTTACATTTTACTAGTAACTTGTTATTTGATGATGAACTCAAAAACATATTTCCCCTGAGTATATATCTCGCAACCAAGGTGTGGTTCTACATAACGTGGGTGGTGTTTATCCTTCCGGTGGTGGGGTGGAGCTGGTCTCTGGGGTTCGCAGTTTGCTCGGGGTTGCTGTGGGTGACATTCCTGCGCTCGTGGCGTTCCGATCCTGGCGTCATTACAGCTTCCAAAGCTGACAAGTTCAGGACGATCATCGAGCTGTCGGAGGCGGCGGGCGGCGGGTTCGAGTCGTCGCGGTTCTGCTCGGCGTGCCTGGTGCGGCGCCCGCTGCGGTCCAAGCACTGCGCCGTGTGCAACCGCTGCGTCGCCAAGTTCGACCACCACTGTCCCTGGGTCGGCAACTGCATCGGCGCCAACAACCACCGCCACTTCATCGGCTTCCTGTGCAGCCTCATCCTCATGTGCTGCTGGATGCTGTGGGGCGGCGCGCGCTACCTGCGCGACCAGTGCCCCGCGCCCGCCGAGCCGCTCGCCTGGGTCTCCTGCAACGGCTGGATCTCGTGGGTGATGCTCAATGCCGCGTTCCACCTGTTCTGGGTGACGGTGCTCACCGGCTTCCAGATGTACCTGGTGGTGTGCCTCGGCATGACCACCAACGAGCAGCTGAACCGCGGCCGCTACAAGCACTTCCAGGCGCGCGGCGGCCGCTCGCCCTTCAGCCGCGGCCCGCTCGCCAACTGCTTGGAGCTGCTCGGCTGCCGGTCGCCCCGGGACCACGCCGACCTGGACCACGGCGTGTGA

Protein

MMYDSTCGAAATGQCGPAQAEREPPEPREPPPPPTERDYSGYDIVKATQYGAFVRVKELVEAGWDVNRPDGETVTLLHWAAINNRRDIIQYLLSKGANVDAVGGELQSTPLHWATRQGHLDATVLLVRAGADPSLRDAEGCACLHLAAQFGHTAVVAYLVARGVTVDEPDAGGMTALMWASWKVAAVDPTRLLLTLGASTQPADRGHGNTALHWAILARNTTAISTLILYGDANLDVPNLRGVTPLQMLQASADSLWVGSKVSDKIKERTMESERLSIFRRLTYDKKFRWWCVVVMPFMAFYLTGLILETDLNYPLKTLILIGFYSLLHFTSNLLFDDELKNIFPLSIYLATKVWFYITWVVFILPVVGWSWSLGFAVCSGLLWVTFLRSWRSDPGVITASKADKFRTIIELSEAAGGGFESSRFCSACLVRRPLRSKHCAVCNRCVAKFDHHCPWVGNCIGANNHRHFIGFLCSLILMCCWMLWGGARYLRDQCPAPAEPLAWVSCNGWISWVMLNAAFHLFWVTVLTGFQMYLVVCLGMTTNEQLNRGRYKHFQARGGRSPFSRGPLANCLELLGCRSPRDHADLDHGV

Description

Probable palmitoyltransferase which is required for photoreceptor synaptic transmission and for the correct expression and localization of palmitoylated protein Csp and synaptosomal-associated protein Snap25 (PubMed:18158335, PubMed:18032660). Probably palmitoylates Csp (PubMed:18158335). Probably also palmitoylates the dorsal-ventral patterning protein Sog and promotes its secretion and activity and the stabilization of the membrane-bound form (PubMed:20599894). Required for synaptic vesicle exocytosis (PubMed:18158335).

Catalytic Activity

hexadecanoyl-CoA + L-cysteinyl-[protein] = CoA + S-hexadecanoyl-L-cysteinyl-[protein]

Subunit

Interacts with dorsal-ventral patterning protein Sog.

Similarity

Belongs to the DHHC palmitoyltransferase family.
Belongs to the DHHC palmitoyltransferase family. AKR/ZDHHC17 subfamily.

Keywords

Acyltransferase   ANK repeat   Cell junction   Cell membrane   Complete proteome   Golgi apparatus   Lipoprotein   Membrane   Palmitate   Reference proteome   Repeat   Synapse   Transferase   Transmembrane   Transmembrane helix  

Feature

chain  Palmitoyltransferase Hip14

Uniprot

H9IV03   A0A2H1VR64   A0A2A4JGZ5   A0A194REK0   A0A2W1B5J2   A0A194QCD4   + More
A0A182FKP1   A0A2M4APL5   W5JDI0   A0A182NPQ1   A0A182QDB5   A0A182P6X8   A0A182RIG0   A0A182YL43   A0A182SZY8   A0A182WEC7   A0A182JZP8   A0A182M6N3   A0A084VIP0   A0A1Q3FVR8   A0A1Q3FW47   A0A182INR1   A0A182G5W6   A0A2Y9D3G6   A0A182V4Y4   A0A182L4K3   Q7PZ51   A0A1I8P9M2   A0A336K7Y1   B4N727   M9PFE4   Q9VUW9   A0A1A9XT26   A0A1B0B966   Q29D93   B4H7T3   W8BBQ0   B4ITV5   B3M9T9   B3NDQ1   A0A034VE00   A0A1A9WGH9   B4QLS4   A0A1B0FAV5   B4KYH8   A0A0K8UBM9   A0A1W4VAE9   A0A0K8U1C2   A0A0K8UW18   B4J3N8   A0A0M3QWV8   A0A1B0AIE9   A0A3B0J517   A0A1A9VAQ6   B4LDZ7   A0A0L0CRG4   T1PI12   A0A1B0CA01   A0A1B0GNL3   A0A1W4WS98   A0A1L8DY41   A0A182HH43   A0A1W4X375   D2A2T8   A0A1J1J6T8   A0A1Y1KH18   A0A182TRT0   A0A2J7QBB1   A0A1W4X1X2   E0VXZ2   N6USQ5   A0A1B6CWK0   U4USR9   A0A067R5K5   A0A2M4ARK8   A0A1J1IG59   A0A154NW13   T1HWS6   A0A0A9YIY7   A0A023F1G3   A0A2P8ZB90   A0A087ZX11   A0A423T4A1   A0A0N0BHP6   E2AAK6   E2BT41   A0A0L7R635   A0A2A3EKM2   A0A026W0G8   A0A232ERU2   A0A151WSR4   A0A310SKT0   A0A195BVE3   A0A3Q0ISL3   A0A195FPW6   A0A3L8DDG7   A0A195CAV7   A0A2P2I5D9   A0A158NV05   F4WJF9  

EC Number

2.3.1.225

Pubmed

19121390    26354079    28756777    20920257    23761445    25244985    + More
24438588    26483478    20966253    12364791    14747013    17210077    17994087    10731132    12537568    12537572    12537573    12537574    16110336    17569856    17569867    12537569    18158335    18032660    18719403    20599894    15632085    24495485    17550304    25348373    22936249    26108605    25315136    18362917    19820115    28004739    20566863    23537049    24845553    25401762    25474469    29403074    20798317    24508170    28648823    30249741    21347285    21719571   

EMBL

BABH01000003    ODYU01003924    SOQ43287.1    NWSH01001493    PCG71089.1    KQ460297    + More
KPJ16263.1    KZ150387    PZC71058.1    KQ459439    KPJ01096.1    GGFK01009227    MBW42548.1    ADMH02001696    ETN61393.1    AXCN02001661    AXCM01000779    ATLV01013376    KE524854    KFB37834.1    GFDL01003407    JAV31638.1    GFDL01003402    JAV31643.1    JXUM01044388    KQ561398    KXJ78710.1    AAAB01008986    EAA00049.3    UFQS01000115    UFQT01000115    SSW99922.1    SSX20302.1    CH964168    EDW80166.2    AE014296    AGB94603.1    AY094779    AAM11132.1    JXJN01010285    CH379070    EAL30521.2    CH479219    EDW34723.1    GAMC01007900    JAB98655.1    CH891734    EDW99818.2    CH902618    EDV40130.2    CH954178    EDV52184.2    GAKP01019189    JAC39763.1    CM000363    CM002912    EDX10623.1    KMY99892.1    CCAG010022451    CH933809    EDW18789.2    GDHF01028232    JAI24082.1    GDHF01032179    JAI20135.1    GDHF01021759    JAI30555.1    CH916366    EDV97269.1    CP012525    ALC44789.1    OUUW01000002    SPP76797.1    CH940647    EDW70040.2    JRES01000005    KNC34955.1    KA648324    AFP62953.1    AJWK01003138    AJVK01029539    GFDF01002750    JAV11334.1    APCN01002385    KQ971339    EFA01463.1    CVRI01000074    CRL08133.1    GEZM01086196    JAV59681.1    NEVH01016301    PNF25878.1    DS235842    EEB18248.1    APGK01017930    APGK01017931    APGK01017932    KB740060    ENN81782.1    GEDC01019481    JAS17817.1    KB632433    ERL95568.1    KK852729    KDR17567.1    GGFK01010083    MBW43404.1    CVRI01000047    CRK98524.1    KQ434772    KZC03869.1    ACPB03005829    ACPB03005830    GBHO01010557    JAG33047.1    GBBI01003350    JAC15362.1    PYGN01000117    PSN53756.1    QCYY01002305    ROT71356.1    KQ435746    KOX76561.1    GL438128    EFN69553.1    GL450325    EFN81171.1    KQ414648    KOC66289.1    KZ288219    PBC32315.1    KK107519    EZA49450.1    NNAY01002550    OXU21075.1    KQ982769    KYQ50878.1    KQ761502    OAD57473.1    KQ976401    KYM92594.1    KQ981335    KYN42635.1    QOIP01000009    RLU18497.1    KQ978023    KYM97942.1    IACF01003631    LAB69242.1    ADTU01026871    GL888182    EGI65737.1   

Proteomes

UP000005204    UP000218220    UP000053240    UP000053268    UP000069272    UP000000673    + More
UP000075884    UP000075886    UP000075885    UP000075900    UP000076408    UP000075901    UP000075920    UP000075881    UP000075883    UP000030765    UP000075880    UP000069940    UP000249989    UP000076407    UP000075903    UP000075882    UP000007062    UP000095300    UP000007798    UP000000803    UP000092443    UP000092460    UP000001819    UP000008744    UP000002282    UP000007801    UP000008711    UP000091820    UP000000304    UP000092444    UP000009192    UP000192221    UP000001070    UP000092553    UP000092445    UP000268350    UP000078200    UP000008792    UP000037069    UP000095301    UP000092461    UP000092462    UP000192223    UP000075840    UP000007266    UP000183832    UP000075902    UP000235965    UP000009046    UP000019118    UP000030742    UP000027135    UP000076502    UP000015103    UP000245037    UP000005203    UP000283509    UP000053105    UP000000311    UP000008237    UP000053825    UP000242457    UP000053097    UP000215335    UP000075809    UP000078540    UP000079169    UP000078541    UP000279307    UP000078542    UP000005205    UP000007755   

PRIDE

H9IV03    M9PFE4    Q9VUW9   

Pfam

PF01529   DHHC        + More
PF12796   Ank_2
PF00023   Ank
PF03647   Tmemb_14

Interpro

IPR020683   Ankyrin_rpt-contain_dom        + More
IPR036770   Ankyrin_rpt-contain_sf       
IPR030289   ZDHHC17       
IPR002110   Ankyrin_rpt       
IPR001594   Palmitoyltrfase_DHHC       
IPR005349   TMEM14       

SUPFAM

SSF48403   SSF48403       

Gene 3D

1.25.40.20    

CDD

cd00204  ANK

ProteinModelPortal

H9IV03   A0A2H1VR64   A0A2A4JGZ5   A0A194REK0   A0A2W1B5J2   A0A194QCD4   + More
A0A182FKP1   A0A2M4APL5   W5JDI0   A0A182NPQ1   A0A182QDB5   A0A182P6X8   A0A182RIG0   A0A182YL43   A0A182SZY8   A0A182WEC7   A0A182JZP8   A0A182M6N3   A0A084VIP0   A0A1Q3FVR8   A0A1Q3FW47   A0A182INR1   A0A182G5W6   A0A2Y9D3G6   A0A182V4Y4   A0A182L4K3   Q7PZ51   A0A1I8P9M2   A0A336K7Y1   B4N727   M9PFE4   Q9VUW9   A0A1A9XT26   A0A1B0B966   Q29D93   B4H7T3   W8BBQ0   B4ITV5   B3M9T9   B3NDQ1   A0A034VE00   A0A1A9WGH9   B4QLS4   A0A1B0FAV5   B4KYH8   A0A0K8UBM9   A0A1W4VAE9   A0A0K8U1C2   A0A0K8UW18   B4J3N8   A0A0M3QWV8   A0A1B0AIE9   A0A3B0J517   A0A1A9VAQ6   B4LDZ7   A0A0L0CRG4   T1PI12   A0A1B0CA01   A0A1B0GNL3   A0A1W4WS98   A0A1L8DY41   A0A182HH43   A0A1W4X375   D2A2T8   A0A1J1J6T8   A0A1Y1KH18   A0A182TRT0   A0A2J7QBB1   A0A1W4X1X2   E0VXZ2   N6USQ5   A0A1B6CWK0   U4USR9   A0A067R5K5   A0A2M4ARK8   A0A1J1IG59   A0A154NW13   T1HWS6   A0A0A9YIY7   A0A023F1G3   A0A2P8ZB90   A0A087ZX11   A0A423T4A1   A0A0N0BHP6   E2AAK6   E2BT41   A0A0L7R635   A0A2A3EKM2   A0A026W0G8   A0A232ERU2   A0A151WSR4   A0A310SKT0   A0A195BVE3   A0A3Q0ISL3   A0A195FPW6   A0A3L8DDG7   A0A195CAV7   A0A2P2I5D9   A0A158NV05   F4WJF9  

PDB

5W7I     E-value=6.15963e-75,     Score=716

KEGG

101746431    K20032 palmitoyltransferase ZDHHC13/17 [EC:2.3.1.225] | (RefSeq) palmitoyltransferase ZDHHC17

GO

GO:0016021   GO:0019706   GO:0000139   GO:0005794   GO:0050714   GO:0007268   GO:0018345   GO:0045202   GO:0030054   GO:0008021   GO:0007283   GO:0016079   GO:0042734   GO:0015095   GO:0016491   GO:0016409   GO:0005515   GO:0008270   GO:0005488   GO:0016791   GO:0005634   GO:0030145   GO:0006412   GO:0016876   GO:0043039  

PANTHER

PTHR24161:SF18  

Subcellular location

Golgi apparatus membrane   Localizes to the Golgi apparatus in non-neuronal cells and located primarily in presynaptic terminals in neurons.   With evidence from 5 publications.
Cell junction   Localizes to the Golgi apparatus in non-neuronal cells and located primarily in presynaptic terminals in neurons.   With evidence from 5 publications.
Synapse   Localizes to the Golgi apparatus in non-neuronal cells and located primarily in presynaptic terminals in neurons.   With evidence from 5 publications.
Presynaptic cell membrane   Localizes to the Golgi apparatus in non-neuronal cells and located primarily in presynaptic terminals in neurons.   With evidence from 5 publications.

Length:

591

Number of predicted TMHs:

6

Exp number of AAs in TMHs:

126.16845

Exp number, first 60 AAs:

0

Total prob of N-in:

0.98083

inside

1  -  289

TMhelix

290  -  308

outside

309  -  317

TMhelix

318  -  336

inside

337  -  342

TMhelix

343  -  365

outside

366  -  368

TMhelix

369  -  388

inside

389  -  468

TMhelix

469  -  491

outside

492  -  517

TMhelix

518  -  540

inside

541  -  591

 

 

Pi

5.053229

Theta

6.595845

Tajima's D

-1.084509

CLR

0.101596

CSRT

0.11704414779261

Interpretation

Uncertain