SGID Silkworm Genome Informatics Database
Gene
KWMTBOMO08144
Pre Gene Modal
BGIBMGA001079
Annotation
receptor_protein-tyrosine_phosphatase_10d_[Danaus_plexippus]
Full name
Tyrosine-protein phosphatase 10D      
Alternative Name
Receptor-linked protein-tyrosine phosphatase 10D
Location in the cell
Mitochondrial   Reliability : 1.285 Nuclear   Reliability : 1.042 PlasmaMembrane   Reliability : 1.203
 

Sequence

CDS
ATGACGTGGAAAAGGTTGAACTTGCAAGCGACTGGAGGATGCGCACGCGCTGCGGCCCTGGCACTGCTTCTAGTTATCCTTGCGTGCATGACGAGGTGCGGCTCGTGTGCCGACCTGGTGATCGAGATCCCGGGCTCCGGCGCGGGCGAGGATGGAGACAGCGTGAGCGGCTTGTACCGGCTAGACTACCGGCCGCCCGAGGGCACGCCCGCCCCGAACCACACCGTCCCCGCGCGCGCCTCTACCATTAACTTTCAAGGCCTGCCCGGCACCAAGTATCATTTCATGCTCTACTACTCCAACTCTACCTTCCCTGATTTGCTCACCTGGAACCAAACGATAATTACGGCGCCGGAGCCGCCAACGAACTTGACGGTGACCTTGGGCCGCAACAAGCAAGCCACCATATCCTGGTCGCCACCCACCCAGGGTAACTATACGGGCTTTCGTTTTAAGGTGATCCCGCTGACGGAGCGCGCGGAGGGCGGCCAGCGCAACATCACGGTGGAGCGCGGCAACGACACGCACGTGCTGCGCGACCTGTTCCCCGGCGCCACCTACCAGCTGCACGCCTTCACGCTGCTGCACGACAAGGAGAGCGCCGCCTACGCCTCGCGCAACTTCACCACAAAGCCTAACACGCCCGGCAAGTTCATCGTGTGGTTCCGCAACGAGACCACGCTGCTGGTGCTGTGGCAGCCGCCCTACCCGCCCGGCGCCTACACGCACTACAAGGTGTCGATCGAGCCGCCCGATGCTCGCGACTCGGTGCTATACGTGGAGAAGGAGGGCGAGCCGCCCGGCCCCGCCCAGGCCGCCTTCAAAGGTCTGGTGCCCGGGCGGGCCTACAACATCTCGGTGCAGACCGTCTCCGAGCCCGAGATCTCGGCGCCCACCACCGCCAAGTACCGCACCGTGCCGCTGCGGCCGCGCAACGTGACCGCGCCGCCCGACGACCTGCGCGAGACTGCCTTCCGCGTCACGTGGCTGCCGCCCCTGGAGGAGAGCGAGTTCGAGAAGTACCAGGTGTCGGTGTCCGGGGGCGGGGCGGCCCGCCGGCTGAGCCCGCTGCTGCTGGGCCGCGACGAGGAGCCGTCCTGCTGGTTCAGGCGGCTGGACCCGGGCGCGCACTACTCGCTCACCGTCAAGACCATGGCCGGGAAGGTGACCTCCTGGCCCGCCGCCCTCGACCTCACGCTCAAGCCGCTGCCGGTGCGGCGCCTGCTGGTGAGCTCGGCGGAGGGCGGGCTGGGCGTGGCGTGGCAGCCCGCCGACGGCAGCGCGCAGGACGAGTACAAGGTCTCCTACCACGAGGCGGGCCCCTCGCGCGACGACAGCAACACGCTGACCACCACCGACACCAACGTGACGCTGGACGCGCTGCTGCCCGGCCGCAACTACACCGTGTCCGTGCGCGCGCTGTCCCGCGCCGTGGAGTCCAACGAGACCTGGGGCTGGGGCGCCACGCGGCCGCTGGCCCCCGTGGTGGTGCGCGTGGAGGCCGCCGCCGCCGCCCTGCGCCTGCACTGGCGCTCCGACGTCAACTCGCGCCAGACGCGCTACGTGCTGCGCTACCGGGCGCGCGTGCCGGAGCCCGGGCCGCCGGCCGAGTGGCGCCAGCTGCGGACCGAGGACACCAGCGCGCTGCTGGCCGACCTGTTCCCGGGCGCCGTGTACGAGATCGAGCTCGCCGCCATGAGCCACGACCTGCCGAGCGAGGCGCACCGCATGCTCAAGCCCGTGCGGCCGCTGGCTGCCACCCGCCTGTGGGTGGAGCGCGCCTCCTCCAACAGCGCGCTGGTGCAGTGGCGCGGCCCGCCGCCCGCCCGCAGCGTGCTGGGCCACTACGCGCTGCGCTACCGCACGCTGTCCGCCGCGCGCTTCACCGAGCTGGACCTGCTGCCGCCCGACGCCGCGTCCGCCGAGATCACCAACATGACGCACGGGGAGCGCTACGTCATCCAGCTGGACACGGTCAGCGAGCCCGGCGACGGCGGCGAGGTGGTGGAGAGCGGGCAGCCGCTGTACGCCGAGCACACCATCCGTCCCAACCCGGTGTCCGAGGTGGCGCAGCTGGTGGGCACCCGCAACGTCACGCTCGAATGGCTGAACGGCTCCGGACGCGTCGACCGGTACGAGGTGCGCTGGTGGCCCACGGACCACGCCGAGCTGGCCGGGCTGGAGGGCACCGACGAGGACTCTGCGCGGGGCGCGGCGGGCGGCGAGCGGGCCCGCAACCTCACGGCGCCGCCGGCGCTGCTGGCGGGGCTGGCGCCGGGCGTGGGCTACACGCTGACCCTGGCCGCGCACTCCTACAACCTCACCAGCGACCTGCTCACCATACACACGCGAACACGTCCGCTGATCCTGTCCGAGATGACCATCGTGAACGAGCCCAGCGACGACGAGGAGGCGCCGCCCGGCATCATCGTTCTGTTCACGCCGACGCCGAGCTCCGCCACGCGCTTCGACCAGTACCGCTTCCTGCTGGAGGGCGCCGCCGACGAGCCGCCGCGCGACGCCGCCCTGCCCGCGCAGCCCGCGCCCCCCGCGCCGCGCCGCGTGCACTGGCCCGGCCTCGTGCCCGGCCGCCTCTATGACGTCACCATGTGGACGCTCAGCGCCAACGTGACCTCGCACCCCGTGCAGCGCCAGACCAGGCTGCACCCGCGGCCCGTGCGCGCGCTCAACACGACGCGCGTGGGTGCGCGGTTCGTGACGCTGACCTGGGAGCGGCCTGGGGGCGACCACACTGACTTCGAGCTCCAGTATTTCGCCGACGAACAAGTCCGCACCCTGGTCACCGACCGGCTGTCCATCAACGCGACCGACTTGGAGCCGTACACGTCGTACGATTTCACCGTCAGGGTGCGGTCCGGGGACGGCGGCGGCCTGCGCATGGTGTCTCCGGAGCGCAGCGTGGCCGTCCGCACCGCCGAGGACGTGCCCGCCGCGCCCGCCGACTTCCGGCCGGCCGACGCGCGGCCCAGCTCCCTCACCATGGCGTGGCGGCTGTCGGCGGCGCAGGCCCACGGACTGCTGCGCCGCTACGTGCTCACGTACGCCCCGCACGGCCGCCCCGAGCTCACGCGCTCGCTGGAGCTGGCGGCGGAGGCCACGCGCGTCACGGTGGAGGGCTTGTCGCCCGGGGTCACGTACGAACTGAGTCTGCACGGGGAGACGGGCGCCGGCCCGGGGGCGGCCGCGCACTGGACGCAGCACATGGCCATCGGCGCGCCGCCCGCCCCGCCGCCGGACGTGGCGCCGGCCGCCGTGCGCGCTACCACCACGACGGTCGTGGTGCGGTTCCGCTCTGACTACTTCTCGGCAGTCAACGGCAACGTGACCGCGTACACGCTGGTGCTGGCGCAGGAGAACCGCTCGGAGACGCCGGCGCGGCTGCCGTCCTGGCGCGACGTGCACGCGCTGCCGGTGTGGCCGCCCTACCAGGTGACGGAGCCCTACTACCCGTTCCTGTCGTCGCCGGTGGAGGAGTTCACGCTGGGTTCGGAGCGGTGCGAGGGAGGGGGCCGGGCATACTGCAACGGTCCGCTGAAGGCAGGCACGCGATACTTCTTGAAGCTGCGCGCCTTCACCGCGCCCGACAAGTTCGCCGACACCGCCTACGTCGCCGTGGCCACGGAGGTGGACAACACGGCGTGGATCATCGGCGGCAGCGTGTGCGGGCTGGCGGTGGCGGGCGCGGCGCTGGCGGCGCTGGCTGCCTCCCGCCGCCGCCGCCGGGCCGCGCGCGCACCGGCCGCGCCCGCGCCGCGCCGCACCTCCCGCCCCGTGCGCGTGGCGGACTTCATCGACCACTACCGAGCCATGTCCGCCGACTCCGACTTCAAGTTCAGCGAGGAGTTCGAGGAGCTGAAGGACGTGGGCCGCGAGCAGCCGTGCACGGCGGCCGACCTGCCCGTGAACCGTCCCAAGAACCGGTTCACCAACATCCTGCCGTACGACCACTCGCGCTACAAGCTGCAGCCCGTCGACGACGAGGAGGGCTCCGACTACATCAACGCCAACTACCTGCCCGGGTACAACTCGCCCCGGGAGTTCATCGTGACGCAGGGCCCGCTGCACTGCACCCGGGACGACTTCTGGCGCATGTGCTGGGAGTCGGGCTCGCGCGCCGTCGTGATGCTGACTCGCTGCGTGGAGAAGGGCCGCGAGAAGTGCGACCGGTACTGGCCCTACGACACGCGGCCCGTGTACTACGGGGACATCGCCGTGACCGCGCTGAACGAGAGCCGCTACCCCGACTGGACCGTCACGGAGCTGCTGGTGAGCCGCGGCAAGGAGCAGCGCGTGCTGCTGCACTTCCACTTCACCACGTGGCCAGACTTCGGCGTGCCCGAGCCGCCCACCACGCTGGCGCGCTTCGTGCGGGCCTTCCGCGAGCGCTGCCCGGCCGACGGCCGCCCCGTGGTGGTGCACTGCAGCGCCGGCGTGGGCCGCTCCGGCACCTTCATCACGCTGGACACGGCGCTGCAGCAGCTGGCGGCGCGCGACGACTACGTCGACATCTTCGGCATGGTGTACAACATGCGCCGCGAGCGCGTGGCCATGGTGCAGTCGGAGCAGCAGTACATCTGCATCCACCAGTGCCTCGTGGCCGTGCTGGAGGGCCAGGACCTGACGCCCCCGCACAACAACAACCACCACCACAACCCGGCCTTCGAAGACGACGAGGGCATCGCGGAGTCCGGGATGTGA
Protein
MTWKRLNLQATGGCARAAALALLLVILACMTRCGSCADLVIEIPGSGAGEDGDSVSGLYRLDYRPPEGTPAPNHTVPARASTINFQGLPGTKYHFMLYYSNSTFPDLLTWNQTIITAPEPPTNLTVTLGRNKQATISWSPPTQGNYTGFRFKVIPLTERAEGGQRNITVERGNDTHVLRDLFPGATYQLHAFTLLHDKESAAYASRNFTTKPNTPGKFIVWFRNETTLLVLWQPPYPPGAYTHYKVSIEPPDARDSVLYVEKEGEPPGPAQAAFKGLVPGRAYNISVQTVSEPEISAPTTAKYRTVPLRPRNVTAPPDDLRETAFRVTWLPPLEESEFEKYQVSVSGGGAARRLSPLLLGRDEEPSCWFRRLDPGAHYSLTVKTMAGKVTSWPAALDLTLKPLPVRRLLVSSAEGGLGVAWQPADGSAQDEYKVSYHEAGPSRDDSNTLTTTDTNVTLDALLPGRNYTVSVRALSRAVESNETWGWGATRPLAPVVVRVEAAAAALRLHWRSDVNSRQTRYVLRYRARVPEPGPPAEWRQLRTEDTSALLADLFPGAVYEIELAAMSHDLPSEAHRMLKPVRPLAATRLWVERASSNSALVQWRGPPPARSVLGHYALRYRTLSAARFTELDLLPPDAASAEITNMTHGERYVIQLDTVSEPGDGGEVVESGQPLYAEHTIRPNPVSEVAQLVGTRNVTLEWLNGSGRVDRYEVRWWPTDHAELAGLEGTDEDSARGAAGGERARNLTAPPALLAGLAPGVGYTLTLAAHSYNLTSDLLTIHTRTRPLILSEMTIVNEPSDDEEAPPGIIVLFTPTPSSATRFDQYRFLLEGAADEPPRDAALPAQPAPPAPRRVHWPGLVPGRLYDVTMWTLSANVTSHPVQRQTRLHPRPVRALNTTRVGARFVTLTWERPGGDHTDFELQYFADEQVRTLVTDRLSINATDLEPYTSYDFTVRVRSGDGGGLRMVSPERSVAVRTAEDVPAAPADFRPADARPSSLTMAWRLSAAQAHGLLRRYVLTYAPHGRPELTRSLELAAEATRVTVEGLSPGVTYELSLHGETGAGPGAAAHWTQHMAIGAPPAPPPDVAPAAVRATTTTVVVRFRSDYFSAVNGNVTAYTLVLAQENRSETPARLPSWRDVHALPVWPPYQVTEPYYPFLSSPVEEFTLGSERCEGGGRAYCNGPLKAGTRYFLKLRAFTAPDKFADTAYVAVATEVDNTAWIIGGSVCGLAVAGAALAALAASRRRRRAARAPAAPAPRRTSRPVRVADFIDHYRAMSADSDFKFSEEFEELKDVGREQPCTAADLPVNRPKNRFTNILPYDHSRYKLQPVDDEEGSDYINANYLPGYNSPREFIVTQGPLHCTRDDFWRMCWESGSRAVVMLTRCVEKGREKCDRYWPYDTRPVYYGDIAVTALNESRYPDWTVTELLVSRGKEQRVLLHFHFTTWPDFGVPEPPTTLARFVRAFRERCPADGRPVVVHCSAGVGRSGTFITLDTALQQLAARDDYVDIFGMVYNMRRERVAMVQSEQQYICIHQCLVAVLEGQDLTPPHNNNHHHNPAFEDDEGIAESGM

Summary

Description
May have a role in axon outgrowth and guidance.
Catalytic Activity
H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate
Miscellaneous
This protein is translated by readthrough of a stop codon. Readthrough of the terminator codon TAG occurs between the codons for Arg-1631 and His-1633. There is currently no sequence that provides the identity of residue 1632.
Similarity
Belongs to the protein-tyrosine phosphatase family. Receptor class subfamily.
Keywords
3D-structure   Alternative splicing   Complete proteome   Developmental protein   Differentiation   Glycoprotein   Hydrolase   Membrane   Neurogenesis   Protein phosphatase   Reference proteome   Repeat   Signal   Transmembrane   Transmembrane helix  
Feature
chain  Tyrosine-protein phosphatase 10D
splice variant  In isoform H.
EC Number
3.1.3.48
EMBL
AGBW02012175    OWR45519.1    CH477837    EAT35785.1    AAAB01008880    GFDL01009042    + More
JAV26003.1    GFDL01009049    JAV25996.1    EAA08669.6    APCN01005052    GGFM01006595    MBW27346.1    GGFK01001238    MBW34559.1    GANO01001941    JAB57930.1    GGFL01002740    MBW66918.1    GGFL01002759    MBW66937.1    EGK97027.1    GGFJ01000390    MBW49531.1    GGFJ01000311    MBW49452.1    DS231918    EDS26250.1    AXCN02001565    QOIP01000010    RLU17864.1    ADMH02001135    ETN63979.1    AXCM01006824    JXUM01019910    JXUM01019911    JXUM01019912    KQ560558    KXJ81897.1    ODYU01008831    SOQ52776.1    GGFL01002913    MBW67091.1    GL439483    EFN67223.1    KA646689    AFP61318.1    GAMC01018227    JAB88328.1    GDHF01028645    JAI23669.1    OUUW01000011    SPP86358.1    GL762758    EFZ20845.1    KQ971338    EFA02044.2    GDHC01009939    JAQ08690.1    GBXI01011546    JAD02746.1    GDKW01000965    JAI55630.1    CCAG010010328    M80465    M80538    AE014298    BT004474    BT126065    ADTU01010120    ADTU01010121    ADTU01010122    JXJN01000507    JXJN01000508    JRES01001303    KNC23771.1    CH902630    EDV38451.2    GBBI01003536    JAC15176.1    CH964239    EDW82297.2    GL888235    EGI64344.1    KQ760548    OAD59929.1    GFDF01006802    JAV07282.1    CH379063    EAL32708.3    GFDF01006806    JAV07278.1    GDHF01022251    JAI30063.1    KYB27808.1    CM000162    EDX02501.2    GBYB01009662    JAG79429.1    GBXI01009525    JAD04767.1    NNAY01000335    OXU29119.1    GDHF01032239    JAI20075.1    CH916370    EDV99959.1    CH954180    EDV46021.2    AJVK01006392    CH480851    EDW51417.1    CVRI01000004    CRK87652.1    CRK87650.1    GBYB01009664    JAG79431.1    CRK87651.1    KK107167    EZA56383.1    CH933812    EDW05881.2    KB632168    ERL89353.1    UFQT01002832    SSX34115.1    SSX34114.1    NEVH01004429    PNF39381.1    KK854622    PTY17382.1   
Pfam
PF00041   fn3        + More
PF00102   Y_phosphatase
Interpro
IPR003961   FN3_dom        + More
IPR000387   TYR_PHOSPHATASE_dom       
IPR013783   Ig-like_fold       
IPR000242   PTPase_domain       
IPR036116   FN3_sf       
IPR003595   Tyr_Pase_cat       
IPR029021   Prot-tyrosine_phosphatase-like       
IPR016130   Tyr_Pase_AS       
SUPFAM
SSF49265   SSF49265        + More
SSF52799   SSF52799       
Gene 3D
PDB
3S3K     E-value=4.45797e-127,     Score=1170

Ontologies

Topology

Subcellular location
Membrane  
SignalP
Position:   1 - 33,         Likelihood:  0.897590
 
 
Length:
1572
Number of predicted TMHs:
1
Exp number of AAs in TMHs:
35.11395
Exp number, first 60 AAs:
16.40336
Total prob of N-in:
0.78619
POSSIBLE N-term signal
sequence
outside
1  -  1218
TMhelix
1219  -  1241
inside
1242  -  1572
 
 

Population Genetic Test Statistics

Pi
0.802293
Theta
4.105012
Tajima's D
-2.184137
CLR
1623.589933
CSRT
0.00414979251037448
Interpretation
Possibly Positive selection
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