Gene

KWMTBOMO08143  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA001084

Annotation

meiotic_recombination_11_[Bombyx_mori]

Location

Bomo_Chr13(-):17548168-17550159      View in EpiBrowser

Full name

Double-strand break repair protein      

Location in the cell

Nuclear   Reliability : 2.908

CDS

ATGATTGAGAACGACATTTCAGCGTGGTCTCCTGACGATACGCTAAGGATATTAATAGCCTCCGATATTCATCTTGGTTTCATGGAAAATGATCCGGTACGCGGAGAAGATAGCTTTATAGCTTTTGAAGAAGTTTTGTCTCTTGCGGTACAATGTGATGTTGATTTGATACTTTTAGGAGGTGATCTGTTTGATCAAGCTAAACCTTCTGTCAATTGTATGTTTAAATGTACAGAAATAATCCGCAAATATTGTCTTGGGGATAAACCGGTTAGTATAGAGTTGCTGTCTGACCAAATAAAAAATTTTTCAAGAACAGTTAACTATGAGGACCCCAATTTGAATATTTCTTACCCTATTCTCTCAATACACGGCAATCATGATGATCCCGTTGGCCAGGGCAGTGTGAGTTCTCTTGATATTCTCTCAATCACTGGGTTAGTTAATTATTTTGGTAAATGGACCGACTACACGCACGTAAGAATATCACCAGTACTTTTGCAAAAAGGTCTTACGAGGCTCGCCCTCTATGGACTTAGCCATTTAAAAGATCAGAGACTTTCACGTCTTTTTGCTGAAAAAAAAGTGGAAATGGAGAGACCCGATGAAACATTGGACTGGTTCAATTTATTTGTACTACATCAAAATCATGCTGACAGAGGACACAGTAACTATATTCCAGAAGGAGTGCTACCAAACTTTTTAGATCTTGTAGTGTGGGGCCATGAGCATGATAGCCATATTTGTCCAATGAAGGGAAATAAAACAGAGAAAGACAGCTTTTTTGTTGTACAACCAGGTAGTACTGTGGCAACCTCTTTAGCTGCAGGAGAAGCACTTCCTAAGCATTGTGGTTTATTAGAAATACATAAAGGAAATTTCAAGTTAACTCCTCTGCCACTGCAAACAGTAAGGCCTTTTATATTTAAAACCATAGTGCTTTCAGAGGAAAATATAGGCAGTGAGGATGTTAATGAAAATGAAAAGGTTCAAGAGTTTTTAAAAAACAGAGTTAATGAAGCTATTGATGAGGCTTCAAAGCTGAAGACTGCTGATCTGAGGCAGCCTTTACTACCACTCATCAGGTTAAGTATTTTTTATGAGCGAGAAAGTCAGAACTTTAATAGGATACGTTTTGGACAGAATTTTAATGGTTTGGTTGCAAATCCTAATGATCTATTAATAATGAAGAAAGAAAAAAAGATTAGAGAAAAAAGAGAACGTGATCCAGAAGAGGAAGGAGACATGACGGGTGTGGCTGCAGAAGCTGCTGATGTGGAGTCACTTTTACGTGCATATTATGAAGCTCAGCCGAAGGATAAGAGACTTTCTGTACTATCAGTCAGAGTCATAACTGATGCAGTTCGGGATTTTACCCTTAAGCACAATGAAGATGTCTTGCGGCGGGCATTTGATGCTCATAAACGTCGTTGCATTGCTGCACTATTGGAATCTACTGCAGAGACCGAAAAAGAAATTGCTGAACAACTAGAGGTTTGTAAGCGAGAGCTGGATGAAGCTGATGATGAGAAACTCCACACCTTAGTCGATGCAAGTGCAAGGCCATCAGCACCTGCAGCACAGCTTATAGTACCAGTTGTAAAGCTGCCCAATACTGTTGGCAAGCGCACCATTGTAGTATTGTCTAGTGATGAAGAAGAATTGTCGACACGATCTGGACGCGGCCGTACCACTCGTGCATCGCGCGGAAAGTCTCCTCGAGGAAAGAGCACCCGAGCGACTAAGGCTTCGGCACCTGCCCCCTCGCCGCCGGAACGCAGAACTCCGAGGCGTTCGGCAGCTCAGAAATCCACATCGTGGCTTCAGAATATCATGAACTCCAGTCGTCGCCGCGGTTCTAACGATATCGAAAATGACTCTGATTGA

Protein

MIENDISAWSPDDTLRILIASDIHLGFMENDPVRGEDSFIAFEEVLSLAVQCDVDLILLGGDLFDQAKPSVNCMFKCTEIIRKYCLGDKPVSIELLSDQIKNFSRTVNYEDPNLNISYPILSIHGNHDDPVGQGSVSSLDILSITGLVNYFGKWTDYTHVRISPVLLQKGLTRLALYGLSHLKDQRLSRLFAEKKVEMERPDETLDWFNLFVLHQNHADRGHSNYIPEGVLPNFLDLVVWGHEHDSHICPMKGNKTEKDSFFVVQPGSTVATSLAAGEALPKHCGLLEIHKGNFKLTPLPLQTVRPFIFKTIVLSEENIGSEDVNENEKVQEFLKNRVNEAIDEASKLKTADLRQPLLPLIRLSIFYERESQNFNRIRFGQNFNGLVANPNDLLIMKKEKKIREKRERDPEEEGDMTGVAAEAADVESLLRAYYEAQPKDKRLSVLSVRVITDAVRDFTLKHNEDVLRRAFDAHKRRCIAALLESTAETEKEIAEQLEVCKRELDEADDEKLHTLVDASARPSAPAAQLIVPVVKLPNTVGKRTIVVLSSDEEELSTRSGRGRTTRASRGKSPRGKSTRATKASAPAPSPPERRTPRRSAAQKSTSWLQNIMNSSRRRGSNDIENDSD

Description

Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing.

Cofactor

Mn(2+)

Similarity

Belongs to the MRE11/RAD32 family.

Uniprot

H9IV04   Q9GZJ8   A0A0L7KVX1   A0A3S2TD27   A0A212EVJ6   A0A194RG19   + More
A0A194Q6T3   S4Q0C9   A0A2H1WIB5   A0A2A4JJT4   A0A2W1BJN3   A0A2Z5U614   A0A1Q3F3S7   B0WC67   Q0C777   A0A182G980   A0A1S4EUR8   Q16SG2   A0A2J7RR63   A0A0K8WKH3   A0A0K8U9D9   A0A0K8VFK0   A0A182QWK1   B4KH95   A0A182N7G6   Q7QID8   A0A1I8PL13   A0A182WI41   A0A1A9UJZ6   A0A0A1WSX9   W8C4T0   A0A0L0CLS9   A0A1B6E3M7   A0A1B6HCZ2   A0A182K4C4   A0A224X8V9   A0A1B0FHD3   B4N7B0   A0A0P4VXG1   B6UX44   A0A1A9YTB0   A0A0V0G7T3   A0A182R6N9   A0A023FAL1   A0A0M4EQK8   B4LQF8   A0A1A9WU80   A0A1I8M9Z7   A0A1Y1N0S8   A0A1W4VYM8   A0A1Y1N3V5   B6UX35   T1I572   B4JPJ1   B3MMU9   T1P9X4   B4P1G0   A0A0R1DM63   A0A1B6LSK9   B6UX46   B6UX41   B6UX36   B6UX48   B4G6M8   B4HX38   B6UX39   B6UX38   B4QAD4   Q29M26   B6UX47   A0A182PIW7   B6UX57   B6UX56   B6UX66   B6UX53   B3N4J0   A0A1S3HKK7   Q9XYZ4   B6UX37   B6UX42   B6UX63   B6UX40   A0A1B0BIS2   A0A182MQD9   A0A3R7LYQ0   A0A3B0JAY6   A0A336LS54   B6UX45   A0A210QGS1  

Pubmed

19121390    26227816    22118469    26354079    23622113    28756777    + More
26760975    17510324    26483478    17519023    17994087    12364791    14747013    17210077    25830018    24495485    26108605    27129103    18984573    25474469    18057021    25315136    28004739    17550304    22936249    15632085    10731132    12537568    12537572    12537573    12537574    16110336    17569856    17569867    26109357    26109356    28812685   

EMBL

BABH01000030    AB038379    BAB11924.1    JTDY01005187    KOB67275.1    RSAL01000324    + More
RVE42534.1    AGBW02012175    OWR45520.1    KQ460297    KPJ16255.1    KQ459439    KPJ01084.1    GAIX01000008    JAA92552.1    ODYU01008831    SOQ52777.1    NWSH01001282    PCG71854.1    KZ150011    PZC75078.1    FX985791    BBA93678.1    GFDL01012829    JAV22216.1    DS231886    EDS43312.1    CH477186    EAT48950.1    JXUM01153566    KQ571741    KXJ68122.1    EF173378    CH477673    ABM68620.1    EAT37438.1    NEVH01000611    PNF43324.1    GDHF01000959    JAI51355.1    GDHF01029339    JAI22975.1    GDHF01014686    JAI37628.1    AXCN02000573    CH933807    EDW13312.1    AAAB01008807    EAA04178.4    GBXI01012764    JAD01528.1    GAMC01005299    JAC01257.1    JRES01000310    KNC32384.1    GEDC01004799    JAS32499.1    GECU01035307    GECU01035146    GECU01027789    GECU01025812    GECU01021565    GECU01015021    GECU01009676    JAS72399.1    JAS72560.1    JAS79917.1    JAS81894.1    JAS86141.1    JAS92685.1    JAS98030.1    GFTR01007629    JAW08797.1    CCAG010023021    CH964182    EDW80251.1    GDKW01001239    JAI55356.1    FJ219092    ACI97143.1    GECL01001929    JAP04195.1    GBBI01000171    JAC18541.1    CP012523    ALC39312.1    CH940649    EDW63408.1    KRF81091.1    GEZM01016952    JAV91018.1    GEZM01016953    JAV91016.1    FJ219083    ACI97134.1    ACPB03011506    CH916372    EDV98821.1    CH902620    EDV30974.1    KA644748    AFP59377.1    CM000157    EDW88067.2    KRJ97565.1    GEBQ01013306    JAT26671.1    FJ219094    FJ219098    FJ219100    FJ219102    FJ219103    FJ219106    FJ219109    FJ219110    FJ219113    ACI97145.1    ACI97149.1    ACI97151.1    ACI97153.1    ACI97154.1    ACI97157.1    ACI97160.1    ACI97161.1    ACI97164.1    FJ219089    ACI97140.1    FJ219084    ACI97135.1    FJ219096    FJ219097    FJ219108    FJ219115    ACI97147.1    ACI97148.1    ACI97159.1    ACI97166.1    CH479180    EDW29142.1    CH480818    EDW52583.1    FJ219087    ACI97138.1    FJ219086    ACI97137.1    CM000361    CM002910    EDX04689.1    KMY89749.1    CH379060    EAL33869.2    FJ219095    ACI97146.1    FJ219105    ACI97156.1    FJ219104    ACI97155.1    FJ219114    ACI97165.1    FJ219101    ACI97152.1    CH954177    EDV58902.1    AF132144    AE014134    AAD33591.1    AAF53093.1    FJ219085    ACI97136.1    FJ219090    ACI97141.1    FJ219111    ACI97162.1    FJ219088    ACI97139.1    JXJN01015151    JXJN01015152    JXJN01015153    JXJN01015154    AXCM01002970    QCYY01002879    ROT66880.1    OUUW01000004    SPP79507.1    UFQT01000144    SSX20836.1    FJ219093    ACI97144.1    NEDP02003741    OWF47973.1   

Proteomes

UP000005204    UP000037510    UP000283053    UP000007151    UP000053240    UP000053268    + More
UP000218220    UP000002320    UP000008820    UP000069940    UP000249989    UP000235965    UP000075886    UP000009192    UP000075884    UP000007062    UP000095300    UP000075920    UP000078200    UP000037069    UP000075881    UP000092444    UP000007798    UP000092443    UP000075900    UP000092553    UP000008792    UP000091820    UP000095301    UP000192221    UP000015103    UP000001070    UP000007801    UP000002282    UP000008744    UP000001292    UP000000304    UP000001819    UP000075885    UP000008711    UP000085678    UP000000803    UP000092460    UP000075883    UP000283509    UP000268350    UP000242188   

PRIDE

H9IV04    Q9GZJ8    Q9XYZ4   

Pfam

PF04152   Mre11_DNA_bind        + More
PF00149   Metallophos

Interpro

IPR004843   Calcineurin-like_PHP_ApaH        + More
IPR038487   Mre11_DNA-bd_sf       
IPR003701   Mre11       
IPR007281   Mre11_DNA-bd       
IPR041796   Mre11_N       
IPR029052   Metallo-depent_PP-like       

Gene 3D

3.30.110.110     3.60.21.10    

CDD

cd00840  MPP_Mre11_N

ProteinModelPortal

H9IV04   Q9GZJ8   A0A0L7KVX1   A0A3S2TD27   A0A212EVJ6   A0A194RG19   + More
A0A194Q6T3   S4Q0C9   A0A2H1WIB5   A0A2A4JJT4   A0A2W1BJN3   A0A2Z5U614   A0A1Q3F3S7   B0WC67   Q0C777   A0A182G980   A0A1S4EUR8   Q16SG2   A0A2J7RR63   A0A0K8WKH3   A0A0K8U9D9   A0A0K8VFK0   A0A182QWK1   B4KH95   A0A182N7G6   Q7QID8   A0A1I8PL13   A0A182WI41   A0A1A9UJZ6   A0A0A1WSX9   W8C4T0   A0A0L0CLS9   A0A1B6E3M7   A0A1B6HCZ2   A0A182K4C4   A0A224X8V9   A0A1B0FHD3   B4N7B0   A0A0P4VXG1   B6UX44   A0A1A9YTB0   A0A0V0G7T3   A0A182R6N9   A0A023FAL1   A0A0M4EQK8   B4LQF8   A0A1A9WU80   A0A1I8M9Z7   A0A1Y1N0S8   A0A1W4VYM8   A0A1Y1N3V5   B6UX35   T1I572   B4JPJ1   B3MMU9   T1P9X4   B4P1G0   A0A0R1DM63   A0A1B6LSK9   B6UX46   B6UX41   B6UX36   B6UX48   B4G6M8   B4HX38   B6UX39   B6UX38   B4QAD4   Q29M26   B6UX47   A0A182PIW7   B6UX57   B6UX56   B6UX66   B6UX53   B3N4J0   A0A1S3HKK7   Q9XYZ4   B6UX37   B6UX42   B6UX63   B6UX40   A0A1B0BIS2   A0A182MQD9   A0A3R7LYQ0   A0A3B0JAY6   A0A336LS54   B6UX45   A0A210QGS1  

PDB

3T1I     E-value=3.3774e-103,     Score=960

KEGG

692385    K10865 double-strand break repair protein MRE11 | (RefSeq) Mre11; meiotic recombination 11

PATHWAY

03440    Homologous recombination - Bombyx mori (domestic silkworm)
03450    Non-homologous end-joining - Bombyx mori (domestic silkworm)

GO

GO:0030870   GO:0008408   GO:0006302   GO:0004519   GO:0030145   GO:0051321   GO:0004527   GO:0005634   GO:0016233   GO:0007095   GO:0031573   GO:0097552   GO:0008296   GO:0042138   GO:0006303   GO:0000724   GO:0000723   GO:0003677   GO:0051276   GO:0016787   GO:0006412   GO:0016876   GO:0043039  

Subcellular location

Nucleus  

Length:

628

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.00516

Exp number, first 60 AAs:

0.00044

Total prob of N-in:

0.00069

outside

1  -  628

 

 

Pi

1.67634

Theta

4.293619

Tajima's D

-1.703047

CLR

832.811501

CSRT

0.0301484925753712

Interpretation

Possibly Positive selection