Gene

KWMTBOMO08140

Pre Gene Modal

BGIBMGA001076

Annotation

hypothetical_protein_KGM_13300_[Danaus_plexippus]

Location

Bomo_Chr13(+):17489980-17495163      View in EpiBrowser

Full name

Caseinolytic peptidase B protein homolog      

Alternative Name

Suppressor of potassium transport defect 3

Location in the cell

Cytoplasmic   Reliability : 1.441 Mitochondrial   Reliability : 1.526

CDS

ATGTCGAGTCTTAGACCTGCAACGTGTTGTGTGCGTGCTTTACGACGGACGGCACGACTTGCAGGGGTGGCAGCACATCGAATATCTTCAGGATACAATAGTTCTGGAAATGAGAGGAAACAACGTTTAGATGTAAATCGTGTCACCCTAGGAGTGGGCTCATTGGCCTTGGCTCTACTCGCTGCGGATCACGTTTTTAACGAAAAAAGGTTTTTCAGAGCAGCCCAAATAGGAAATGTCGAAGAGTTAAAAAGGCAAGCGGAATACCTTATTGCTAAAGAAAGTCAGCAACCAAAGAAAGATGACGAGGGAGGCCCGGTGGATCGCCGTCACCCGCTCGGCTGGACTGCGCTCATGGTCGCGGCCGCCAACGACAAACCCGACGTCGTCCGCGAACTTATCAAACTCGGGGCCAAACCTGACCTACAGGAACAGTATGCGGGTGCGGCGACGGCCGCCTCGGCCGCCGGCATGCATCCGCTGGACGCGCTGCAACGACGGGAGGACGAGTTTTGTGGCGGCATGAACGCCCGCGCCTCCTTCCTGGGCTGGACGGCGCTGCACTACGCGGCGCTGGCCGACTCGCACGACGCCGCCGCGGCGCTGCTGGACGCCGGCGCGGACCCTGCCGCTCGCGACCACGCCGGCCGTCGCCCCCTGCACTACGCGCGGGACGCCTCGCCCACCCGCGACCTCATCCAGCGAGCCGTGCGCCGACGGGAGGAGGAAGCAGCCGCCGCCGCTGCTGAGGAGCGACGCCGCTTCCCTCTGGAGCGCCGCTTGAAGCAGTACATAGTGGGACAGCGTGCCGCCATCCACACCGTCGCCGCCGCCGTGCGCCGCAAGGAGAACGGTTGGGCCGACGACGACCATCCCCTGGTGTTCCTGTTCCTGGGGAGCTCCGGCATCGGGAAGACGGAGCTAGCGAAGCAGCTCGCCCGCTACATGCACAAGGATGACCCGGCCGCGTTCATACGTCTCGATATGTCCGAGTACCAGGAGAAACACGAGGTGGCGAAACTCATCGGAGCCCCTCCCGGATACGTGGGCCACGAGGAGGGCGGCCAGCTCACGCGGGCGCTGGCGCAGCGAGCGGACGCCGTGGTGCTGTTCGACGAGGTGGACAAGGCTCACCCCGACGTCCTCACGGTCCTGCTCCAGCTCTTTGACGAGGGCCGGCTGACGGACGGGAAGGGCAAGTTGATCGAGTGTAAGGACGCCATATTCGTGATGACGTCAAACCTGGCGGCCGACGAGATCGCGCAGTACGGGCTGCAGCTGCGCCGCGAGGCAGACGCGCTCGCCGCCACCAGGCGCGGGAAGCGGGAAGGTGAAGAAGAGGAGCAAGAGCCGACGCTAGAGGTGTCGCGGCACTTCAAGGACAACGTGGTGCGGCCCATCCTCAAGCGACAGTTCCGGCGCGACGAGTTCCTCGGTCGCATCAACGAGATCGTCTACTTCCTGCCGTTCTCTCGCGCCGAGCTGCTGGCGCTGGTGCAGGCCGAGCTGCAGCGCTGGGCGGCGCGCGCGCGCCAGCGGCACGGCATGCTGCTGCTCTGGGAGGACGACGTGCTGGGAGCCCTGGCCGACGGGTACGAGGTGCACTACGGCGCGCGCTCCATCCAGCACGAGGTGGAGCGGCGCGTGGTGAGTCAGCTGGCGCTGGCGGCGGAGCGCGGGCTGGTGGCGCGCGGCTGCACGCTGCGGCTGCGCGCGGCGCCCGCCGGCCTGGCGCTGGCGCTGCGCCCCGCCGGCGCCGCTGACTTCCAGCCGCTGCACCTGCCGCCCGCGTGA

Protein

MSSLRPATCCVRALRRTARLAGVAAHRISSGYNSSGNERKQRLDVNRVTLGVGSLALALLAADHVFNEKRFFRAAQIGNVEELKRQAEYLIAKESQQPKKDDEGGPVDRRHPLGWTALMVAAANDKPDVVRELIKLGAKPDLQEQYAGAATAASAAGMHPLDALQRREDEFCGGMNARASFLGWTALHYAALADSHDAAAALLDAGADPAARDHAGRRPLHYARDASPTRDLIQRAVRRREEEAAAAAAEERRRFPLERRLKQYIVGQRAAIHTVAAAVRRKENGWADDDHPLVFLFLGSSGIGKTELAKQLARYMHKDDPAAFIRLDMSEYQEKHEVAKLIGAPPGYVGHEEGGQLTRALAQRADAVVLFDEVDKAHPDVLTVLLQLFDEGRLTDGKGKLIECKDAIFVMTSNLAADEIAQYGLQLRREADALAATRRGKREGEEEEQEPTLEVSRHFKDNVVRPILKRQFRRDEFLGRINEIVYFLPFSRAELLALVQAELQRWAARARQRHGMLLLWEDDVLGALADGYEVHYGARSIQHEVERRVVSQLALAAERGLVARGCTLRLRAAPAGLALALRPAGAADFQPLHLPPA

Description

May function as a regulatory ATPase and be related to secretion/protein trafficking process.

Catalytic Activity

ATP + H2O = ADP + H(+) + phosphate

Similarity

Belongs to the ClpA/ClpB family.

Keywords

Acetylation   ANK repeat   ATP-binding   Complete proteome   Direct protein sequencing   Hydrolase   Mitochondrion   Nucleotide-binding   Reference proteome   Repeat   Transit peptide   Alternative splicing   Cataract   Disease mutation   Epilepsy   Polymorphism  

Feature

chain  Caseinolytic peptidase B protein homolog
splice variant  In isoform 5.
sequence variant  In MEGCANN; dbSNP:rs200032855.

Uniprot

A0A194RF89   A0A3S2LAG8   A0A212EVL5   A0A2W1BVE1   A0A2H1WSK3   A0A194QCB5   + More
D2A353   A0A0C9R1I9   E0W1P9   A0A1B6LFU2   A0A195F3L5   A0A2J7QRE5   A0A151X627   A0A151IHI6   A0A1W4WIW1   A0A1S3D5Y5   A0A232EU77   K7IY87   A0A1B6LS81   F4WH80   A0A452GHC6   A0A158NPE1   W4ZB95   B1H3I9   A0A1B6E1C0   A0A1W4WJ40   T1JLA4   Q3UGS9   E9ISR8   A0A195E5W1   A0A2C9JNP2   A0A087T6T7   A0A250YJT5   A0A154P6V3   A0A1Y1KPN5   A0A287DFJ1   E2ADV2   Q6IRH7   A0A340XS92   Q3U3U6   T1EDJ8   Q3URM1   Q60649   Q8CCN6   A0A2A3ETP3   A0A0P6J2T6   Q4R700   G3RM06   A0A0N0BG09   A0A2Y9F232   A0A2K5XK51   A0A0D9QVV8   Q3TXD4   Q5E9N5   A0A2K5X5G5   G2HEG2   F7A045   A0A2K6C1B4   A0A1S3A0Q8   A0A452SE80   A0A384DFC2   A0A2Y9DVC4   A0A2Y9I8X3   K7DLH6   W5P5H5   A0A452GA32   A0A2K6R666   A0A3Q0EFJ5   A0A2K6K9X5   U6CS37   A0A3Q7WLG7   A0A3Q7TM27   G3ICU8   A0A340XVA3   A0A1U7UIF0   A0A067R3L4   H0V6H2   Q9H078-2   A0A2Y9L846   A0A2I2ULQ1   G3U3C0   F6UA75   Q5RFS9   U3JUR8   F6XXW3   A0A1U7QVN4   A0A1S3HV43   A0A2U3VBC4   A0A2J8V1V7   A0A2K6GKN5   K9J2C5   A0A2K6UC39   F7G947   A0A3Q7QW97   A0A3Q7QWB0   A0A2Y9MWA4   W5MLW1   A0A3Q7S8C4   F7H9B9   A0A1S3HTQ1  

EC Number

3.6.1.3

Pubmed

26354079    22118469    28756777    18362917    19820115    20566863    + More
28648823    20075255    21719571    28562605    21347285    10349636    11042159    11076861    11217851    12466851    16141073    21282665    15562597    28087693    28004739    20798317    15489334    15057822    15632090    23254933    12040188    21183079    7835694    19468303    15944441    22398555    16305752    21484476    17431167    24813606    20809919    25362486    21804562    24845553    21993624    11230166    14702039    16554811    19608861    21269460    24275569    25944712    25597510    25597511    17975172    19892987    16341006    17495919    25243066   

EMBL

KQ460297    KPJ16252.1    RSAL01000324    RVE42537.1    AGBW02012175    OWR45523.1    + More
KZ149891    PZC79052.1    ODYU01010747    SOQ56050.1    KQ459439    KPJ01076.1    KQ971338    EFA01960.1    GBYB01001825    JAG71592.1    DS235873    EEB19631.1    GEBQ01017425    JAT22552.1    KQ981836    KYN35048.1    NEVH01011898    PNF31159.1    KQ982482    KYQ55855.1    KQ977643    KYN00863.1    NNAY01002164    OXU21902.1    GEBQ01013470    JAT26507.1    GL888153    EGI66446.1    ADTU01022402    AAGJ04144578    BC161411    AAI61411.1    GEDC01005575    JAS31723.1    JH431987    AK147772    BAE28128.1    GL765434    EFZ16386.1    KQ979608    KYN20272.1    KK113700    KFM60826.1    GFFW01000992    JAV43796.1    KQ434827    KZC07553.1    GEZM01081464    JAV61625.1    AGTP01028809    AGTP01028810    GL438820    EFN68464.1    AABR07004904    AABR07071951    AC122631    BC070917    CH473956    AAH70917.1    EDM18274.1    AK154577    BAE32689.1    AMQM01007880    KB097680    ESN91999.1    AK138593    AK141383    CH466531    BAE23708.1    BAE24667.1    EDL16519.1    U09874    BC048175    AC127586    AC129609    AC159005    AK032421    BAC27861.1    KZ288189    PBC34652.1    GEBF01007007    JAN96625.1    AB169030    BAE01124.1    CABD030080096    CABD030080097    CABD030080098    CABD030080099    CABD030080100    CABD030080101    CABD030080102    CABD030080103    CABD030080104    CABD030080105    KQ435794    KOX73872.1    AQIB01134177    AQIB01134178    AK159314    BAE34982.1    BT020885    BC103469    AQIA01021325    AQIA01021326    AQIA01021327    AQIA01021328    AQIA01021329    AK305126    BAK62120.1    JSUE03012881    GABE01008702    NBAG03000097    JAA36037.1    PNI89519.1    AMGL01032362    AMGL01032363    LWLT01000015    HAAF01001308    CCP73134.1    JH001963    EGW14086.1    KK852727    KDR17615.1    AAKN02051221    AAKN02051222    AAKN02051223    AAKN02051224    AL136909    AL834484    AK023214    AK302006    AK302069    AK302158    AP000593    AP002892    AP003785    BC006404    AANG04002890    CR857073    CAH89378.1    AGTO01011075    AAEX03012823    AAEX03012824    AAEX03012825    NDHI03003437    PNJ51507.1    GABZ01004826    JAA48699.1    AHAT01003026    AHAT01003027    GAMT01000493    GAMS01009293    GAMR01009336    GAMQ01000541    GAMP01001587    JAB11368.1    JAB13843.1    JAB24596.1    JAB41310.1    JAB51168.1   

Proteomes

UP000053240    UP000283053    UP000007151    UP000053268    UP000007266    UP000009046    + More
UP000078541    UP000235965    UP000075809    UP000078542    UP000192223    UP000079169    UP000215335    UP000002358    UP000007755    UP000291020    UP000005205    UP000007110    UP000078492    UP000076420    UP000054359    UP000076502    UP000005215    UP000000311    UP000002494    UP000265300    UP000015101    UP000000589    UP000242457    UP000001519    UP000053105    UP000248484    UP000233140    UP000029965    UP000009136    UP000233100    UP000006718    UP000233120    UP000079721    UP000291022    UP000261680    UP000291021    UP000248480    UP000248481    UP000002356    UP000291000    UP000233200    UP000189704    UP000233180    UP000286642    UP000286640    UP000001075    UP000027135    UP000005447    UP000005640    UP000248482    UP000011712    UP000007646    UP000002281    UP000016665    UP000002254    UP000189706    UP000085678    UP000245340    UP000233160    UP000233220    UP000002280    UP000286641    UP000248483    UP000018468    UP000008225   

PRIDE

Q3UGS9    Q3U3U6    Q60649    Q3TXD4    Q5E9N5    G3ICU8    + More
Q9H078   

Pfam

PF10431   ClpB_D2-small        + More
PF13606   Ank_3
PF00023   Ank
PF07724   AAA_2
PF12796   Ank_2

Interpro

IPR003959   ATPase_AAA_core        + More
IPR002110   Ankyrin_rpt       
IPR001270   ClpA/B       
IPR027417   P-loop_NTPase       
IPR019489   Clp_ATPase_C       
IPR003593   AAA+_ATPase       
IPR036770   Ankyrin_rpt-contain_sf       
IPR020683   Ankyrin_rpt-contain_dom       

SUPFAM

SSF52540   SSF52540        + More
SSF48403   SSF48403       

Gene 3D

1.25.40.20    

CDD

cd00204  ANK

ProteinModelPortal

A0A194RF89   A0A3S2LAG8   A0A212EVL5   A0A2W1BVE1   A0A2H1WSK3   A0A194QCB5   + More
D2A353   A0A0C9R1I9   E0W1P9   A0A1B6LFU2   A0A195F3L5   A0A2J7QRE5   A0A151X627   A0A151IHI6   A0A1W4WIW1   A0A1S3D5Y5   A0A232EU77   K7IY87   A0A1B6LS81   F4WH80   A0A452GHC6   A0A158NPE1   W4ZB95   B1H3I9   A0A1B6E1C0   A0A1W4WJ40   T1JLA4   Q3UGS9   E9ISR8   A0A195E5W1   A0A2C9JNP2   A0A087T6T7   A0A250YJT5   A0A154P6V3   A0A1Y1KPN5   A0A287DFJ1   E2ADV2   Q6IRH7   A0A340XS92   Q3U3U6   T1EDJ8   Q3URM1   Q60649   Q8CCN6   A0A2A3ETP3   A0A0P6J2T6   Q4R700   G3RM06   A0A0N0BG09   A0A2Y9F232   A0A2K5XK51   A0A0D9QVV8   Q3TXD4   Q5E9N5   A0A2K5X5G5   G2HEG2   F7A045   A0A2K6C1B4   A0A1S3A0Q8   A0A452SE80   A0A384DFC2   A0A2Y9DVC4   A0A2Y9I8X3   K7DLH6   W5P5H5   A0A452GA32   A0A2K6R666   A0A3Q0EFJ5   A0A2K6K9X5   U6CS37   A0A3Q7WLG7   A0A3Q7TM27   G3ICU8   A0A340XVA3   A0A1U7UIF0   A0A067R3L4   H0V6H2   Q9H078-2   A0A2Y9L846   A0A2I2ULQ1   G3U3C0   F6UA75   Q5RFS9   U3JUR8   F6XXW3   A0A1U7QVN4   A0A1S3HV43   A0A2U3VBC4   A0A2J8V1V7   A0A2K6GKN5   K9J2C5   A0A2K6UC39   F7G947   A0A3Q7QW97   A0A3Q7QWB0   A0A2Y9MWA4   W5MLW1   A0A3Q7S8C4   F7H9B9   A0A1S3HTQ1  

PDB

4D2X     E-value=4.50233e-48,     Score=484

KEGG

101736445    K03695 ATP-dependent Clp protease ATP-binding subunit ClpB | (RefSeq) caseinolytic peptidase B prote

PATHWAY

04213    Longevity regulating pathway - multiple species - Bombyx mori (domestic silkworm)

GO

GO:0005524   GO:0016021   GO:0034605   GO:0005739   GO:0016887   GO:0005515   GO:0000287   GO:0004012   GO:0015914   GO:0006412   GO:0016876   GO:0043039  

Subcellular location

Mitochondrion  

Length:

597

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

8.52441999999998

Exp number, first 60 AAs:

6.08968

Total prob of N-in:

0.43411

outside

1  -  597

 

 

Pi

3.719428

Theta

7.3751

Tajima's D

-1.648653

CLR

38.785824

CSRT

0.0380980950952452

Interpretation

Uncertain