Gene

KWMTBOMO08113

Pre Gene Modal

BGIBMGA001063

Annotation

PREDICTED:_uncharacterized_protein_LOC101737689_[Bombyx_mori]

Location

Bomo_Chr13(+):16062267-16067407      View in EpiBrowser

Full name

HORMA domain-containing protein 2      

Location in the cell

Extracellular   Reliability : 2.255

CDS

ATGGCGGTAACCGAATGGGTCAAATTATTCCCTCGCACGGTAACTGAAACGTATACGAGTTCAGTGACCTTTATGAAACAGCTGACTGTCATAGCGGTCAGTACCGTCACGTACTTGAAGAATGTCTTCCCTGAAGACAGTTACACGCAGGAAACCTTTGGTGGTATCAAGTTGAGGGTCTTGAAGAACAAGTGTAGTGATGAACTGGCCCAGTTCGTTAGTACAGCTTTGACGCAGGCTTTCGAAGCTTTTGATAAGAAATACCTCCATCAACTGGCACTGTGTTTTTACGAAGGCGAATGTAAAGTAGAAAATCTCATAGAATATCACATTTTCGAGTACTCTTACAACCCTGATGGGGTGACCATGGACGTGCACTCCACAAGCCGGGACAGCGTTAGACGTTCCACGAGATATTCCTTCGATAACGTCAGAGAGAGGACCATACACTTGATTAGGGCTTGTGTGGTCATAATGCAAGCGTGTCAGAACGAGCTGCCCTCGACCTATGACGTCAGCTTGAGACTGTATTATAATGATGAGACTCCCGAGGGTTACCAAGCCCCGGGGTTTCTCTCTACGTTGGAGTCGGAGGACCACCTGGCCCCGTCGTACGGCGACGCGGTGAAGCTCGGCTCCGTCGAGACTCCCTACCACCGGCTCGTGGCCCGCAGCTACATGAAGGAGTCCATGCTGTCCAGTCGAGAGGCTCTCGTAAGATCGGAGCAACACAGCACGGGGACGGATGCGGAAGCGCAGGTTCGATGCCCGTGCAATAAGCAAGACGCCGACGACGCGGCACTGCTCACCTGCGGCTACTGCAAGAAGTCTCAGCACGCGGCTTGCTTCGGCGTGCGGGAGGAGGCCGCGCCCCGCCTGCCCCGCCACTGCTGCGCGGACTGCGCCGACAGGGACGCCGCCAGGAGCCCTACTGACGCCGCCCTGGCTGACCTCACTGCCAAGAAGAGAGAGGTGGGACGCTCCCAGCCACACAACCAGTATTTATTTATTTAG

Protein

MAVTEWVKLFPRTVTETYTSSVTFMKQLTVIAVSTVTYLKNVFPEDSYTQETFGGIKLRVLKNKCSDELAQFVSTALTQAFEAFDKKYLHQLALCFYEGECKVENLIEYHIFEYSYNPDGVTMDVHSTSRDSVRRSTRYSFDNVRERTIHLIRACVVIMQACQNELPSTYDVSLRLYYNDETPEGYQAPGFLSTLESEDHLAPSYGDAVKLGSVETPYHRLVARSYMKESMLSSREALVRSEQHSTGTDAEAQVRCPCNKQDADDAALLTCGYCKKSQHAACFGVREEAAPRLPRHCCADCADRDAARSPTDAALADLTAKKREVGRSQPHNQYLFI

Description

Essential for synapsis surveillance during meiotic prophase via the recruitment of ATR activity. Plays a key role in the male mid-pachytene checkpoint and the female meiotic prophase checkpoint: required for efficient build-up of ATR activity on unsynapsed chromosome regions, a process believed to form the basis of meiotic silencing of unsynapsed chromatin (MSUC) and meiotic prophase quality control in both sexes. Required for the DNA double-strand break-independent, BRCA1-dependent activation of ATR on the sex chromosomes that is essential for normal sex body formation (By similarity).

Subunit

Interacts with HORMAD1.

Keywords

Chromosome   Complete proteome   Meiosis   Nucleus   Phosphoprotein   Reference proteome   Alternative splicing  

Feature

chain  HORMA domain-containing protein 2
splice variant  In isoform 2.

Uniprot

H9IUY3   A0A3S2TQF2   A0A212ETR3   A0A2A4K2V5   A0A2H1WWE6   A0A194Q7S3   + More
A0A194REG7   A0A067R097   A0A2C9KAD6   A0A2J7R272   T1IXW8   A0A1X7VCZ0   A0A1S3IZ22   G4VLQ7   A0A183K5Z2   A0A0X3PWY7   A0A3Q0KSN1   A0A3S1B4A8   A0A183NU57   E2QXH7   G3TMX0   H9KUV6   A0A3Q7RHR8   A0A2Y9R4L9   A0A2Y9R7S4   A0A1B6K9P6   A0A1S3A4R9   A0A1B6L3N7   F6TTZ3   A0A2I2UE08   A0A3Q2IHH6   D2H228   G1LMR6   A0A384DP87   M3YP70   A0A2Y9KZR3   A0A3Q7MZI1   A0A2Y9I6B0   A0A2U3VX66   A0A3Q7UK63   A0A3Q7TX31   F7GV48   A0A3M7Q3J7   W5P853   G3W0J9   A0A1W3JSB0   A0A452G3W9   A0A340XIK6   A6QQY4   F1MS88   G7YVP8   A0A2U4CJY4   A0A452C9B6   A0A1B6FBL4   H0XDS0   A0A383Z6U5   A0A3M7RQG5   F1PIP8   A0A096NJF9   A0A2K5YSZ9   A0A1U7TH23   A0A0D9RAY6   A0A341DA53   L8J111   A0A1B6HKR0   A0A2K5HVG5   A0A2K5VW16   A0A2K6B5H2   A0A2K6M968   F6RD07   A0A2K5KNU1   A0A341DCN8  

Pubmed

19121390    22118469    26354079    24845553    15562597    22253936    + More
16341006    19892987    17975172    20010809    30375419    20809919    21709235    19393038    22023798    22751099    17431167   

EMBL

BABH01000164    RSAL01000023    RVE52272.1    AGBW02012542    OWR44857.1    NWSH01000210    + More
PCG78379.1    ODYU01011528    SOQ57312.1    KQ459439    KPJ01045.1    KQ460297    KPJ16228.1    KK852832    KDR15312.1    NEVH01008200    PNF34926.1    JH431663    HE601629    CCD80412.1    UZAK01033770    VDP39792.1    GEEE01007555    JAP55670.1    RQTK01000805    RUS74719.1    UZAL01027140    VDP29602.1    AAEX03014796    GEBQ01031798    GEBQ01018306    JAT08179.1    JAT21671.1    GEBQ01021726    GEBQ01013076    JAT18251.1    JAT26901.1    AANG04000189    GL192437    EFB25726.1    ACTA01104046    AEYP01066034    AEYP01066035    AEYP01066036    AEYP01066037    AEYP01066038    REGN01007608    RNA05772.1    AMGL01039848    AEFK01073308    AEFK01073309    AEFK01073310    LWLT01000018    BC120469    BC150041    DF144501    GAA57028.1    GECZ01022255    JAS47514.1    AAQR03069907    AAQR03069908    AAQR03069909    REGN01002908    RNA25528.1    AHZZ02001081    AHZZ02001082    AQIB01136827    AQIB01136828    JH880346    ELR62386.1    GECU01032475    JAS75231.1    AQIA01007325    AQIA01007326    JSUE03005284    JSUE03005285   

Proteomes

UP000005204    UP000283053    UP000007151    UP000218220    UP000053268    UP000053240    + More
UP000027135    UP000076420    UP000235965    UP000007879    UP000085678    UP000008854    UP000050789    UP000271974    UP000050791    UP000002254    UP000007646    UP000286640    UP000248480    UP000079721    UP000002281    UP000011712    UP000008912    UP000261680    UP000000715    UP000248482    UP000286641    UP000248481    UP000245340    UP000286642    UP000008225    UP000276133    UP000002356    UP000007648    UP000291000    UP000265300    UP000009136    UP000245320    UP000261681    UP000005225    UP000028761    UP000233140    UP000189704    UP000029965    UP000252040    UP000233080    UP000233100    UP000233120    UP000233180    UP000006718    UP000233060   

PRIDE

H9IUY3    A6QQY4   

Pfam

PF02301   HORMA        + More
PF00628   PHD

Interpro

IPR011011   Znf_FYVE_PHD        + More
IPR013083   Znf_RING/FYVE/PHD       
IPR036570   HORMA_dom_sf       
IPR003511   HORMA_dom       
IPR016066   A-D-PHexomutase_CS       
IPR001965   Znf_PHD       
IPR036390   WH_DNA-bd_sf       
IPR019787   Znf_PHD-finger       

SUPFAM

SSF57903   SSF57903        + More
SSF56019   SSF56019       
SSF46785   SSF46785       

Gene 3D

3.30.40.10     3.30.900.10    

ProteinModelPortal

H9IUY3   A0A3S2TQF2   A0A212ETR3   A0A2A4K2V5   A0A2H1WWE6   A0A194Q7S3   + More
A0A194REG7   A0A067R097   A0A2C9KAD6   A0A2J7R272   T1IXW8   A0A1X7VCZ0   A0A1S3IZ22   G4VLQ7   A0A183K5Z2   A0A0X3PWY7   A0A3Q0KSN1   A0A3S1B4A8   A0A183NU57   E2QXH7   G3TMX0   H9KUV6   A0A3Q7RHR8   A0A2Y9R4L9   A0A2Y9R7S4   A0A1B6K9P6   A0A1S3A4R9   A0A1B6L3N7   F6TTZ3   A0A2I2UE08   A0A3Q2IHH6   D2H228   G1LMR6   A0A384DP87   M3YP70   A0A2Y9KZR3   A0A3Q7MZI1   A0A2Y9I6B0   A0A2U3VX66   A0A3Q7UK63   A0A3Q7TX31   F7GV48   A0A3M7Q3J7   W5P853   G3W0J9   A0A1W3JSB0   A0A452G3W9   A0A340XIK6   A6QQY4   F1MS88   G7YVP8   A0A2U4CJY4   A0A452C9B6   A0A1B6FBL4   H0XDS0   A0A383Z6U5   A0A3M7RQG5   F1PIP8   A0A096NJF9   A0A2K5YSZ9   A0A1U7TH23   A0A0D9RAY6   A0A341DA53   L8J111   A0A1B6HKR0   A0A2K5HVG5   A0A2K5VW16   A0A2K6B5H2   A0A2K6M968   F6RD07   A0A2K5KNU1   A0A341DCN8  

PDB

4TZQ     E-value=6.4337e-06,     Score=118

KEGG

101737689    no KO assigned | (RefSeq) uncharacterized LOC101737689

GO

GO:0046872   GO:0000287   GO:0051177   GO:0005634   GO:0005694   GO:0051321   GO:0000795  

Subcellular location

Nucleus   Preferentially localizes to unsynapsed or desynapsed chromosomal regions during the male and female prophase I stage of meiosis. TRIP13 is required for depletion from synapsed chromosomes (By similarity).   With evidence from 1 publications.
Chromosome   Preferentially localizes to unsynapsed or desynapsed chromosomal regions during the male and female prophase I stage of meiosis. TRIP13 is required for depletion from synapsed chromosomes (By similarity).   With evidence from 1 publications.

Length:

337

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.12829

Exp number, first 60 AAs:

0.12809

Total prob of N-in:

0.01726

outside

1  -  337

 

 

Pi

22.924004

Theta

5.38633

Tajima's D

-1.415504

CLR

2.724516

CSRT

0.0631468426578671

Interpretation

Uncertain