Gene

KWMTBOMO08107

Pre Gene Modal

BGIBMGA001102

Annotation

PREDICTED:_phosphatidylinositol_N-acetylglucosaminyltransferase_subunit_A_[Papilio_polytes]

Location

Bomo_Chr13(-):16022725-16024336      View in EpiBrowser

Full name

Tryptophan 2,3-dioxygenase      

Alternative Name

Tryptamin 2,3-dioxygenase
Tryptophan oxygenase
Tryptophan pyrrolase
Tryptophanase

Location in the cell

PlasmaMembrane   Reliability : 3.669

CDS

ATGGATACTAGAAAAAAGAGGCAAGTTGTTTGTATGGCTTCAGATTTCTTTTACCCGAATACCGGAGGTGTAGAAGAGCATATATTTAATTTGTCACAATGTCTCATTAAACGAGGCCACAAAGTCATAGTACTAACTCACTCTTATGGCGACAGAGTCGGTATCCGATATTTAACCGCAGGCTTAAAAGTTTACTATTTACCTATTAGAGTATTTTATGCCCAGTGCGTATTGCCAACAATGATATGTAATATAGCTTTAATAAGAAATATATTGATAAGAGAATGCATTGAAATAGTTCATGGTCATTCTGCTTTTAGTGTTTTGTGTCATGAAGTATGTATTATAGGCAAATTAATGGGATTAAAAACTGTATTCACTGACCACAGTTTATTTGGGTTTGCTGACACATCAGCTGTACTGACAAACAAGTATTTACAAATATGTCTCAGTGAGATTGATCATTGCATATGTGTATCTCACACTGGCAAAGAGAACACAGTGTTAAGGGCCAAAGTTCAAGCTCACAAAGTTTCGGTGATCCCAAATGCAGTTGATGCATTTTCTTTCATTCCTGATCCATGCCAAAGAGATCAAAAATTTATAACCATAGTCATAGTCTCAAGATTAGTGTACCGAAAAGGTGTTAATCTCATGGCTGCCGTTATAGCAGATATGTGCCCACGGTATCCAAACTTAAGATTCATCATAGGTGGAGATGGTCCTAAGATGTGGCTACTACAAGAAGTCCGAGAAAAAATAGGTTGTCAAGAATCTGTTAGATTGTTAGGCAGCTTAAAACATTCAGAAGTTAGAAATGTTTTAGTGAAGGGTGACATTTTTTTAAATACATCACTGACAGAAGCATATTGTATGGCTATAGTAGAAGCTGCAGCTTGTGGACTAAAAGTTGTTTCTACAAAAGTAGGAGGAATACCTGAAGTACTACCAGAAAGTATGATCTATCTTACGGAGCCAAATGTAGGCAGCCTGGTCAGAGGAATTGAGAAAGCAATAACTGATATTAAAGAAGGAAACATAATGTGTCCATTTAAATGCAATAGACTGGTTCGAGAGATGTACAGTTGGATGGACATTACAAAAAGAACTGAGATAGTTTATGATAGAATATTACTAAACAAAAATAAACCACTAGGGCAACAGTTACGTAGCTACCTTAATTCTGGTGTTTGGCCCTTTCTATTAGTGATAAGTTTAATGTATATATTACTACAATTAACTGAGAGAATTTATAAAAGGAAGTATATTGACAAAGCAAGAGACTTAAGACTATAA

Protein

MDTRKKRQVVCMASDFFYPNTGGVEEHIFNLSQCLIKRGHKVIVLTHSYGDRVGIRYLTAGLKVYYLPIRVFYAQCVLPTMICNIALIRNILIRECIEIVHGHSAFSVLCHEVCIIGKLMGLKTVFTDHSLFGFADTSAVLTNKYLQICLSEIDHCICVSHTGKENTVLRAKVQAHKVSVIPNAVDAFSFIPDPCQRDQKFITIVIVSRLVYRKGVNLMAAVIADMCPRYPNLRFIIGGDGPKMWLLQEVREKIGCQESVRLLGSLKHSEVRNVLVKGDIFLNTSLTEAYCMAIVEAAACGLKVVSTKVGGIPEVLPESMIYLTEPNVGSLVRGIEKAITDIKEGNIMCPFKCNRLVREMYSWMDITKRTEIVYDRILLNKNKPLGQQLRSYLNSGVWPFLLVISLMYILLQLTERIYKRKYIDKARDLRL

Description

Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L-tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety.

Catalytic Activity

L-tryptophan + O2 = N-formyl-L-kynurenine

Cofactor

heme

Subunit

Homotetramer. Dimer of dimers.

Similarity

Belongs to the tryptophan 2,3-dioxygenase family.

Uniprot

H9IV22   A0A3S2NNN1   A0A0L7KQ62   A0A0L7KLE8   A0A0L7K3A9   S4PBW5   + More
A0A212ETS1   A0A2P8YCF1   A0A087ZSH3   A0A0L7RA36   A0A0M8ZT40   A0A2A3ED53   K7JCX9   A0A067R1I8   A0A3L8DSA7   D6WMV9   E2BGW2   A0A310SIC5   A0A232F677   E9JCK3   A0A158NHG6   A0A195AV25   A0A1B6GWA2   A0A1B6JHI6   E2AJJ6   A0A0J7KGJ8   A0A195D4E7   N6UDH8   U4UXZ2   J3JVX8   A0A195FWR3   A0A1B6MT62   A0A154PBE8   F4WDB6   A0A2J7QVI0   A0A151XFF3   A0A195E2X2   A0A2S2QLV1   A0A1B6D3B5   A0A2S2NLC4   J9JRN9   A0A1Y1K0N5   A0A1W4X9R6   A0A023F415   A0A1Q3G1F4   T1HF81   A0A1W4XK61   A0A1Q3G1F2   A0A1L8E3Z1   E0VJ33   A0A1B0FY58   Q179Y5   A0A1S4FAQ9   A0A2H1WW88   A0A1Y1K6K6   A0A182Q6V2   A0A182JLZ3   A0A182YIV0   A0A182PWE4   A0A182NV45   A0A182HYB5   A0A182FVE9   W5JC44   A0A182REL8   A0A1S4H781   A0A182WYS0   A0A182UMW5   A0A182TF14   A0A0P4YYC7   A0A0P5C6U4   A0A0A9YY67   A0A1I8PX39   A0A182H9D4   A0A0P5CHJ2   A0A0P5FBW7   A0A0P4XWI3   A0A182MEU3   E9FRT0   A0A0P6DK33   A0A1J1HXX0   A0A182JSR7   A0A182W9M6   A0A1Y1NEH3   B0WDE0   A0A0P4ZRJ3   A0A0L8G4J0   A0A0P6FP95   A0A210PV17   A0A3R7PWR9   Q7QHN7   C3ZXB6   A0A182SMQ4   A0A1Z5LFC9   A0A1X0RWD4   A0A367JXR2   A0A367JQ78   A0A168PLQ4   A0A2G4TA98  

EC Number

1.13.11.11

Pubmed

19121390    26227816    23622113    22118469    29403074    20075255    + More
24845553    30249741    18362917    19820115    20798317    28648823    21282665    21347285    23537049    22516182    21719571    28004739    25474469    20566863    17510324    25244985    20920257    23761445    12364791    25401762    26823975    26483478    21292972    28812685    18563158    28528879    27956601    29674435   

EMBL

BABH01000168    RSAL01000023    RVE52267.1    JTDY01007400    KOB65235.1    JTDY01009065    + More
JTDY01003664    KOB64137.1    KOB69190.1    JTDY01012558    KOB52256.1    GAIX01004416    JAA88144.1    AGBW02012542    OWR44851.1    PYGN01000705    PSN41939.1    KQ414619    KOC67725.1    KQ435903    KOX69083.1    KZ288280    PBC29640.1    AAZX01005171    KK853097    KDR11448.1    QOIP01000005    RLU22739.1    KQ971343    EFA04308.1    GL448228    EFN85094.1    KQ760974    OAD58574.1    NNAY01000869    OXU26135.1    GL771844    EFZ09450.1    ADTU01015804    ADTU01015805    ADTU01015806    KQ976737    KYM75907.1    GECZ01003136    JAS66633.1    GECU01008986    JAS98720.1    GL440027    EFN66391.1    LBMM01007854    KMQ89369.1    KQ976870    KYN07752.1    APGK01032712    KB740848    ENN78681.1    KB632411    ERL95236.1    BT127396    AEE62358.1    KQ981208    KYN44878.1    GEBQ01000889    JAT39088.1    KQ434868    KZC09171.1    GL888086    EGI67843.1    NEVH01010475    PNF32591.1    KQ982194    KYQ59065.1    KQ979763    KYN19234.1    GGMS01009546    MBY78749.1    GEDC01017130    JAS20168.1    GGMR01005374    MBY17993.1    ABLF02014276    GEZM01096214    JAV55049.1    GBBI01002521    JAC16191.1    GFDL01001418    JAV33627.1    ACPB03010315    GFDL01001413    JAV33632.1    GFDF01000829    JAV13255.1    DS235219    EEB13389.1    AJVK01031256    AJVK01031257    CH477343    EAT43050.1    ODYU01011528    SOQ57318.1    GEZM01096216    JAV55046.1    AXCN02001805    APCN01004514    ADMH02001629    ETN61696.1    AAAB01008816    GDIP01229894    GDIP01221186    GDIP01161345    GDIP01154999    JAJ02216.1    GDIP01175352    JAJ48050.1    GBHO01022343    GBHO01006490    GDHC01012304    JAG21261.1    JAG37114.1    JAQ06325.1    JXUM01120466    KQ566395    KXJ70160.1    GDIP01175351    JAJ48051.1    GDIQ01257320    JAJ94404.1    GDIP01245655    JAI77746.1    AXCM01003607    GL732523    EFX89900.1    GDIQ01076554    JAN18183.1    CVRI01000027    CRK92402.1    GEZM01004857    JAV96292.1    DS231896    EDS44453.1    GDIP01222332    JAJ01070.1    KQ423905    KOF71962.1    GDIQ01045111    JAN49626.1    NEDP02005475    OWF40323.1    QCYY01003913    ROT61933.1    EAA05194.3    GG666710    EEN42796.1    GFJQ02000885    JAW06085.1    KV921393    ORE16218.1    PJQL01000544    RCH94736.1    PJQL01000876    RCH92104.1    AMYB01000001    OAD07906.1    KZ303842    PHZ17944.1   

Proteomes

UP000005204    UP000283053    UP000037510    UP000007151    UP000245037    UP000005203    + More
UP000053825    UP000053105    UP000242457    UP000002358    UP000027135    UP000279307    UP000007266    UP000008237    UP000215335    UP000005205    UP000078540    UP000000311    UP000036403    UP000078542    UP000019118    UP000030742    UP000078541    UP000076502    UP000007755    UP000235965    UP000075809    UP000078492    UP000007819    UP000192223    UP000015103    UP000009046    UP000092462    UP000008820    UP000075886    UP000075880    UP000076408    UP000075885    UP000075884    UP000075840    UP000069272    UP000000673    UP000075900    UP000076407    UP000075903    UP000075902    UP000095300    UP000069940    UP000249989    UP000075883    UP000000305    UP000183832    UP000075881    UP000075920    UP000002320    UP000053454    UP000242188    UP000283509    UP000007062    UP000001554    UP000075901    UP000242381    UP000252139    UP000077051    UP000242254   

PRIDE

H9IV22   

Pfam

PF00534   Glycos_transf_1        + More
PF08288   PIGA
PF03301   Trp_dioxygenase
PF13439   Glyco_transf_4

Interpro

IPR001296   Glyco_trans_1        + More
IPR039507   PIG-A/GPI3       
IPR013234   PIGA_GPI_anchor_biosynthesis       
IPR004981   Trp_2_3_dOase       
IPR037217   Trp/Indoleamine_2_3_dOase-like       
IPR028098   Glyco_trans_4-like_N       

SUPFAM

SSF140959   SSF140959       

CDD

cd03796  GT1_PIG-A_like

ProteinModelPortal

H9IV22   A0A3S2NNN1   A0A0L7KQ62   A0A0L7KLE8   A0A0L7K3A9   S4PBW5   + More
A0A212ETS1   A0A2P8YCF1   A0A087ZSH3   A0A0L7RA36   A0A0M8ZT40   A0A2A3ED53   K7JCX9   A0A067R1I8   A0A3L8DSA7   D6WMV9   E2BGW2   A0A310SIC5   A0A232F677   E9JCK3   A0A158NHG6   A0A195AV25   A0A1B6GWA2   A0A1B6JHI6   E2AJJ6   A0A0J7KGJ8   A0A195D4E7   N6UDH8   U4UXZ2   J3JVX8   A0A195FWR3   A0A1B6MT62   A0A154PBE8   F4WDB6   A0A2J7QVI0   A0A151XFF3   A0A195E2X2   A0A2S2QLV1   A0A1B6D3B5   A0A2S2NLC4   J9JRN9   A0A1Y1K0N5   A0A1W4X9R6   A0A023F415   A0A1Q3G1F4   T1HF81   A0A1W4XK61   A0A1Q3G1F2   A0A1L8E3Z1   E0VJ33   A0A1B0FY58   Q179Y5   A0A1S4FAQ9   A0A2H1WW88   A0A1Y1K6K6   A0A182Q6V2   A0A182JLZ3   A0A182YIV0   A0A182PWE4   A0A182NV45   A0A182HYB5   A0A182FVE9   W5JC44   A0A182REL8   A0A1S4H781   A0A182WYS0   A0A182UMW5   A0A182TF14   A0A0P4YYC7   A0A0P5C6U4   A0A0A9YY67   A0A1I8PX39   A0A182H9D4   A0A0P5CHJ2   A0A0P5FBW7   A0A0P4XWI3   A0A182MEU3   E9FRT0   A0A0P6DK33   A0A1J1HXX0   A0A182JSR7   A0A182W9M6   A0A1Y1NEH3   B0WDE0   A0A0P4ZRJ3   A0A0L8G4J0   A0A0P6FP95   A0A210PV17   A0A3R7PWR9   Q7QHN7   C3ZXB6   A0A182SMQ4   A0A1Z5LFC9   A0A1X0RWD4   A0A367JXR2   A0A367JQ78   A0A168PLQ4   A0A2G4TA98  

PDB

3MBO     E-value=3.21412e-09,     Score=148

KEGG

101737110    K03857 phosphatidylinositol N-acetylglucosaminyltransferase subunit A [EC:2.4.1.198] | (RefSeq) phos

PATHWAY

00563    Glycosylphosphatidylinositol (GPI)-anchor biosynthesis - Bombyx mori (domestic silkworm)
01100    Metabolic pathways - Bombyx mori (domestic silkworm)

GO

GO:0017176   GO:0006506   GO:0016021   GO:0000506   GO:0046872   GO:0020037   GO:0004833   GO:0006727   GO:0019441   GO:0006886   GO:0016192   GO:0030130   GO:0030132   GO:0015914   GO:0006412   GO:0016876   GO:0043039  

Length:

431

Number of predicted TMHs:

2

Exp number of AAs in TMHs:

39.65253

Exp number, first 60 AAs:

0.21752

Total prob of N-in:

0.81080

inside

1  -  65

TMhelix

66  -  88

outside

89  -  390

TMhelix

391  -  413

inside

414  -  431

 

 

Pi

18.643446

Theta

16.607939

Tajima's D

0.386153

CLR

0.359831

CSRT

0.483925803709815

Interpretation

Uncertain