Gene

KWMTBOMO08082  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA001048

Annotation

PREDICTED:_low-density_lipoprotein_receptor-related_protein_6_[Bombyx_mori]

Location

Bomo_Chr13(+):15158610-15170665      View in EpiBrowser

Full name

Low-density lipoprotein receptor-related protein      

Location in the cell

Extracellular   Reliability : 0.992

CDS

ATGTTCTGGTCAGATTGGAACGAAAAGAAACCGAAGATAGAACGAGCTAATTTGGACGGCAGCGGCAGAGTCTTGCTCATCTCCGAGAAGTTGACCTGGCCTAACAGCATCGCTCTAGACACAGTCAATAATAAACTCTATTGGGGCGACGCTAGGACGCACAAGATCGAGGTTTGCAACATGGACGGGACGGAGAGGAAGGAGTTACACAGCAACGACATCATACATATATTTGGACTCACGCTACTCGACGACTACTTGTACTGGACCGACATGCAGAAACGCACGCTCGACAGGATCAATAAAAATACAGGTTTAGACAGACAGCCAGTGGTAGAACAAATGGCCAACATGATGGGTGTCAAGGCGTTCCGTTTGGGGGCGCCACTTGGCTGGAATCCTTGCGCCGATGACAACGGAGGATGCTCACACCTTTGCTTCAACAGGCCCGATGACTACATATGCGGATGTCCTTTAGGTCTAGAACTAACTGCCGACAAAAAAACGTGCGTCGAGCCAGAAGCGTTCTTAGTTTACAGCCGGAAGAACATCATCGGTCGCCTGAGCATCAAGAACGAGTACAATGACGCTGTGATACCTATTAAAGATTTGAAGGAAGTCAGCGCTCTAGCTCTGTACGTGTCAGGTTCGAAGCTGTACTGGTCGGACAGTAAGACCAAAACAATAAACCGGTGCTCCGTTAACGGTTCCGCTGTGGAGAAGATCGTGGAGTGGCTGGGACTCGTGGAAGGCTTAGCGATAGATTGGTCGGGACAGAACATTTACTGGACCGACACGACAACGCAGCGCATAGAGGTATCCAGGCTCGACGGCTCCAGTCGAAGGGCCATCATATGGCAGGGATTGAAGAAACCAAAGAGCATAGTGCTCGACCCTAAGAAAGGCTACATGTACTGGTCAGAGTTGGGTTCGAAGAGTATCAAACGCGCCGCAATGGACGGCTCCTCGGTGTCGGTGTTCATGGAGCAGGTCGGGCGCGTCCACGCCCTCGCCATAGACTACGAGAGGCGCGCCATCTACTGGGCGGCCCTCGACCCTCCCGTGGTCGAGTTCGCGTTCCTCAACGGCACGGGCCGCCAGACCTTGGCCGACAACATACCCATGCCCTATGCTCTGGCCCTGTTCAACGATTCGGTGTATTGGGGCGATTGGAATACCGGCCAAATACAGCAAGCGAGAAAAACGGACGGCTCAAATCGAAAATCAATACGCAAGGACTTGGACTACATATCGGATTTGAAACTGTATCATCGCGCCAAGTCCATGGGCAGCAACCAATGCGGGGTCGACAACGGGGGCTGCTCGCACCTGTGCCTGCCCACCCCCGGGGACGTCCGTACCGACTACCGGTGCGCGTGCCCGGCGCACTACCGCCTCAACAAGGACAACATCACGTGTTCCGAACCCGAAGAGTTTCTGCTTTTCGCTCAAAAGAACGCCGTCGGCCGGATCATGGTCGCGAACGGAGAGTGCAACGACGCCTACATACCGCTCACCGGCCTCAAGAACGTCCGCGCTATCGAGTATGACCCGGTCGAGAAGCAACTGTACTGGATGGACGACGATTCGCATTCGATCCGACGCGTGCCCATATCGTACTCGAGCACGTCTGCCGTCGCGGACTCGGCCGCCGTGGTCACCGGCCTCTCGCGCCCCTACCACATGGTGCTGGACGTGCTGGGCCGCACGATGTACTGGACGTGCGCCGACCGGGACTCGATCAACGCGACCTCCATCGACAACAACTCGTCGACCGGCGTCATCGTCAGGGGCGACCGAATGCTGCCCAGGCACCTGGCCTTCCATCAGACTAAACGCTACCTGATCTGGAACGACGTGGGTCGGGGCGCCATAATGCGCGCGAACGTGGACGGCACCGGGCGCGTGGAGCTGGCGCGCGCCGACAACGCGACCGCGCTGGCGCTGGACCAGAGCGCCGGCACCGTCTACTGGGCCGTCAGCAGGCAGTTGCACGCCGTCGACCTAGACTCCTCTAACAGACGCGTGGTGTGGCAGGGGGGCTGGGCGGGCGCGCTGGCGGCGCAGGGCGGCGGGGTGTACGTGTGCGGGGGGGAGCGGGCGGCGCGGGTGCCGCTGCACCGCCGCGACGCGCCCGCCACCCCGCTCCCGCACCTCGTGCGTCTGCTCGCCCTGGTCGCCGTGCACAAGGTACCCACTACCGTCTGCAACTTAACTTAA

Protein

MFWSDWNEKKPKIERANLDGSGRVLLISEKLTWPNSIALDTVNNKLYWGDARTHKIEVCNMDGTERKELHSNDIIHIFGLTLLDDYLYWTDMQKRTLDRINKNTGLDRQPVVEQMANMMGVKAFRLGAPLGWNPCADDNGGCSHLCFNRPDDYICGCPLGLELTADKKTCVEPEAFLVYSRKNIIGRLSIKNEYNDAVIPIKDLKEVSALALYVSGSKLYWSDSKTKTINRCSVNGSAVEKIVEWLGLVEGLAIDWSGQNIYWTDTTTQRIEVSRLDGSSRRAIIWQGLKKPKSIVLDPKKGYMYWSELGSKSIKRAAMDGSSVSVFMEQVGRVHALAIDYERRAIYWAALDPPVVEFAFLNGTGRQTLADNIPMPYALALFNDSVYWGDWNTGQIQQARKTDGSNRKSIRKDLDYISDLKLYHRAKSMGSNQCGVDNGGCSHLCLPTPGDVRTDYRCACPAHYRLNKDNITCSEPEEFLLFAQKNAVGRIMVANGECNDAYIPLTGLKNVRAIEYDPVEKQLYWMDDDSHSIRRVPISYSSTSAVADSAAVVTGLSRPYHMVLDVLGRTMYWTCADRDSINATSIDNNSSTGVIVRGDRMLPRHLAFHQTKRYLIWNDVGRGAIMRANVDGTGRVELARADNATALALDQSAGTVYWAVSRQLHAVDLDSSNRRVVWQGGWAGALAAQGGGVYVCGGERAARVPLHRRDAPATPLPHLVRLLALVAVHKVPTTVCNLT

Description

Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes.

Subunit

Homodimer; disulfide-linked. Forms phosphorylated oligomer aggregates on Wnt-signaling.

Similarity

Belongs to the LDLR family.

Feature

chain  Low-density lipoprotein receptor-related protein

Uniprot

H9IUW8   A0A194Q7P7   A0A2H1W340   A0A212ERU9   A0A2W1C4L5   A0A067QSV8   + More
A0A2A3E6R5   A0A1A9ZGJ1   A0A1I8PWX5   A0A1B0G7N5   A0A1A9XP08   A0A1A9V5E9   A0A0L0C8A9   A0A1A9WIS8   A0A0M8ZSK8   A0A1B6BXD2   A0A1I8MEY3   A0A1V1FQJ8   A0A195CCJ2   Q28ZT5   E2A3U3   B4GGT4   A0A3B0JHZ3   A0A0J9RBX9   A0A3B0J5Q4   Q95V09   B4HQJ0   A0A026WGG7   A0A151WS83   B3NRK7   A0A3B0JQS3   Q9NHE9   A1Z9D7   B4QEE0   Q6AWJ8   A0A3L8DL26   A0A1W4V4L1   K7IYY2   A0A0M4E6V3   B4P4H3   W8BVL4   A0A232ETC2   B4MS00   B3MGY8   A0A0K8UBG2   B4MCL5   B4KML3   A0A0A1WEM1   F4X5W2   B4JVN1   A0A151JTX8   A0A151I365   A0A151J3V0   A0A158NMF6   E2B7S9   A0A3M0JP49   A0A1U7S9W6   A0A093GKY3   A0A091H044   A0A091V1W0   A0A151P774   E9FT42   A0A099Z6R5   R0M6N4   A0A087RAA4   A0A091QNI3   A0A091F4W2   A0A218V8V8   A0A091UQ35   H0ZR52   A0A091GCV0   A0A094L4S3   A0A093FGS6   A0A091TRW2   A0A094MQ93   A0A3Q1N1B3   A0A1D5PJP6   U3JIW2   A0A0A0A6B0   H0VNB8   A0A093CYB6   A0A091MMZ1   A0A091JQZ9   L8IYM7   F1MDE1   K7FPL3   A0A1V4K8J6   A0A091PLM9   A0A093LPA8   A0A0P6JF39   I3MPK9   A0A286XQY2   A0A2J8SR09   W5QI86   W5QI85   B7ZLD0   A0A093QR18   A0A2I0MKN4  

Pubmed

19121390    26354079    22118469    28756777    24845553    26108605    + More
25315136    28410430    15632085    17994087    23185243    20798317    22936249    11029006    24508170    18057021    10731132    12537568    12537572    12537573    12537574    16110336    17569856    17569867    26109357    26109356    30249741    20075255    17550304    24495485    28648823    25830018    21719571    21347285    22293439    21292972    20360741    19393038    15592404    21993624    22751099    17381049    20809919    15489334    23371554   

EMBL

BABH01000258    BABH01000259    BABH01000260    BABH01000261    KQ459439    KPJ01020.1    + More
ODYU01005992    SOQ47443.1    AGBW02012947    OWR44189.1    KZ149891    PZC79083.1    KK853320    KDR08547.1    KZ288349    PBC27447.1    CCAG010016887    JRES01000762    KNC28501.1    KQ435916    KOX68763.1    GEDC01031356    GEDC01010247    JAS05942.1    JAS27051.1    FX985390    BAX07403.1    KQ977957    KYM98435.1    CM000071    EAL25528.2    KRT02342.1    KRT02343.1    GL436500    EFN71887.1    CH479183    EDW35704.1    OUUW01000001    SPP75010.1    CM002911    KMY93508.1    SPP75012.1    AY005815    AAF91072.1    CH480816    EDW47725.1    KK107238    EZA54791.1    KQ982782    KYQ50720.1    CH954179    EDV56159.1    SPP75011.1    AF223365    AAF28358.1    AE013599    BT133102    AAF58373.2    AEX98022.1    CM000362    EDX06930.1    BT015250    AAT94479.1    QOIP01000007    RLU21016.1    CP012524    ALC42304.1    CM000158    EDW90612.2    GAMC01009214    GAMC01009213    JAB97341.1    NNAY01002297    OXU21592.1    CH963850    EDW74889.2    CH902619    EDV37906.1    KPU77098.1    KPU77099.1    GDHF01028396    JAI23918.1    CH940659    EDW71403.1    CH933808    EDW10860.2    GBXI01016965    JAC97326.1    GL888742    EGI58202.1    CH916375    EDV98499.1    KQ981847    KYN34995.1    KQ976507    KYM82832.1    KQ980246    KYN17111.1    ADTU01020439    GL446209    EFN88222.1    QRBI01000131    RMC02798.1    KL216675    KFV70935.1    KL519762    KFO89201.1    KL410527    KFQ96929.1    AKHW03000678    KYO44759.1    GL732524    EFX89307.1    KL890090    KGL77431.1    KB742459    EOB08293.1    KL226237    KFM10408.1    KK678631    KFQ11004.1    KK718466    KFO56930.1    MUZQ01000026    OWK62464.1    KK460825    KFQ79036.1    ABQF01033720    ABQF01033721    KL447981    KFO79166.1    KL359541    KFZ64477.1    KK633243    KFV56907.1    KK403593    KFQ80976.1    KL254678    KFZ56776.1    AADN05000523    AGTO01021643    KL870627    KGL88953.1    AAKN02030896    AAKN02030897    AAKN02030898    KL468338    KFV17874.1    KK831018    KFP76552.1    KK501303    KFP14071.1    JH880581    ELR60499.1    AGCU01035577    AGCU01035578    AGCU01035579    AGCU01035580    AGCU01035581    AGCU01035582    AGCU01035583    AGCU01035584    AGCU01035585    AGCU01035586    LSYS01004200    OPJ80681.1    KL393377    KFP92425.1    KK576232    KFW10606.1    GEBF01000740    JAO02893.1    AGTP01068588    AGTP01068589    AGTP01068590    AGTP01068591    AGTP01068592    AGTP01068593    AGTP01068594    AGTP01068595    AGTP01068596    AGTP01068597    NDHI03003554    PNJ23205.1    AMGL01083299    AMGL01083300    AMGL01083301    AMGL01083302    AMGL01083303    AMGL01083304    AMGL01083305    BC143725    AAI43726.1    KL428690    KFW90996.1    AKCR02000008    PKK30239.1   

Proteomes

UP000005204    UP000053268    UP000007151    UP000027135    UP000242457    UP000092445    + More
UP000095300    UP000092444    UP000092443    UP000078200    UP000037069    UP000091820    UP000053105    UP000095301    UP000078542    UP000001819    UP000000311    UP000008744    UP000268350    UP000001292    UP000053097    UP000075809    UP000008711    UP000000803    UP000000304    UP000279307    UP000192221    UP000002358    UP000092553    UP000002282    UP000215335    UP000007798    UP000007801    UP000008792    UP000009192    UP000007755    UP000001070    UP000078541    UP000078540    UP000078492    UP000005205    UP000008237    UP000269221    UP000189705    UP000053875    UP000053283    UP000050525    UP000000305    UP000053641    UP000053286    UP000052976    UP000197619    UP000007754    UP000053760    UP000009136    UP000000539    UP000016665    UP000053858    UP000005447    UP000053119    UP000007267    UP000190648    UP000005215    UP000002356    UP000053872   

PRIDE

H9IUW8    Q95V09    Q9NHE9    A1Z9D7    Q6AWJ8    F1MDE1    + More
B7ZLD0   

Pfam

PF00058   Ldl_recept_b        + More
PF00057   Ldl_recept_a
PF00211   Guanylate_cyc

Interpro

IPR023415   LDLR_class-A_CS        + More
IPR000742   EGF-like_dom       
IPR011042   6-blade_b-propeller_TolB-like       
IPR000033   LDLR_classB_rpt       
IPR002172   LDrepeatLR_classA_rpt       
IPR036055   LDL_receptor-like_sf       
IPR001881   EGF-like_Ca-bd_dom       
IPR013032   EGF-like_CS       
IPR009030   Growth_fac_rcpt_cys_sf       
IPR017049   LRP5/6       
IPR029787   Nucleotide_cyclase       
IPR001054   A/G_cyclase       

SUPFAM

SSF57424   SSF57424        + More
SSF57184   SSF57184       
SSF55073   SSF55073       

Gene 3D

2.120.10.30     4.10.400.10    

CDD

cd00112  LDLa

ProteinModelPortal

H9IUW8   A0A194Q7P7   A0A2H1W340   A0A212ERU9   A0A2W1C4L5   A0A067QSV8   + More
A0A2A3E6R5   A0A1A9ZGJ1   A0A1I8PWX5   A0A1B0G7N5   A0A1A9XP08   A0A1A9V5E9   A0A0L0C8A9   A0A1A9WIS8   A0A0M8ZSK8   A0A1B6BXD2   A0A1I8MEY3   A0A1V1FQJ8   A0A195CCJ2   Q28ZT5   E2A3U3   B4GGT4   A0A3B0JHZ3   A0A0J9RBX9   A0A3B0J5Q4   Q95V09   B4HQJ0   A0A026WGG7   A0A151WS83   B3NRK7   A0A3B0JQS3   Q9NHE9   A1Z9D7   B4QEE0   Q6AWJ8   A0A3L8DL26   A0A1W4V4L1   K7IYY2   A0A0M4E6V3   B4P4H3   W8BVL4   A0A232ETC2   B4MS00   B3MGY8   A0A0K8UBG2   B4MCL5   B4KML3   A0A0A1WEM1   F4X5W2   B4JVN1   A0A151JTX8   A0A151I365   A0A151J3V0   A0A158NMF6   E2B7S9   A0A3M0JP49   A0A1U7S9W6   A0A093GKY3   A0A091H044   A0A091V1W0   A0A151P774   E9FT42   A0A099Z6R5   R0M6N4   A0A087RAA4   A0A091QNI3   A0A091F4W2   A0A218V8V8   A0A091UQ35   H0ZR52   A0A091GCV0   A0A094L4S3   A0A093FGS6   A0A091TRW2   A0A094MQ93   A0A3Q1N1B3   A0A1D5PJP6   U3JIW2   A0A0A0A6B0   H0VNB8   A0A093CYB6   A0A091MMZ1   A0A091JQZ9   L8IYM7   F1MDE1   K7FPL3   A0A1V4K8J6   A0A091PLM9   A0A093LPA8   A0A0P6JF39   I3MPK9   A0A286XQY2   A0A2J8SR09   W5QI86   W5QI85   B7ZLD0   A0A093QR18   A0A2I0MKN4  

PDB

5FWW     E-value=7.57249e-118,     Score=1087

KEGG

101738889    K03068 low density lipoprotein receptor-related protein 5/6 | (RefSeq) low-density lipoprotein recep

PATHWAY

04150    mTOR signaling pathway - Bombyx mori (domestic silkworm)
04310    Wnt signaling pathway - Bombyx mori (domestic silkworm)

GO

GO:0016021   GO:0005509   GO:0071936   GO:0007616   GO:0007399   GO:0042813   GO:0005770   GO:0005886   GO:0001745   GO:0017147   GO:0007367   GO:0060070   GO:0005769   GO:0048076   GO:0090254   GO:0008587   GO:0035223   GO:0015026   GO:0007275   GO:0035556   GO:0009190   GO:0016849   GO:0034392   GO:0051091   GO:0005794   GO:0019210   GO:0014029   GO:0014033   GO:1990909   GO:0005901   GO:0005109   GO:0009986   GO:0071901   GO:0072659   GO:0045787   GO:0019534   GO:0045944   GO:0042803   GO:1990851   GO:0071397   GO:0005041   GO:0090009   GO:0060535   GO:0042475   GO:0030901   GO:0048596   GO:0060059   GO:0034185   GO:0021587   GO:0090245   GO:0060026   GO:0035261   GO:0045202   GO:0060021   GO:0060325   GO:0003344   GO:0043025   GO:0007268   GO:0090118   GO:0060349   GO:0009880   GO:0046849   GO:0021794   GO:0090244   GO:0001702   GO:0009952   GO:0001843   GO:0030917   GO:0021987   GO:0060444   GO:0030326   GO:0005515   GO:0003676   GO:0005840   GO:0006412   GO:0015934   GO:0015914   GO:0046872   GO:0016876   GO:0043039  

Length:

739

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.32187

Exp number, first 60 AAs:

0.00061

Total prob of N-in:

0.00183

outside

1  -  739

 

 

Pi

16.185343

Theta

16.304072

Tajima's D

-0.598849

CLR

0.338455

CSRT

0.221388930553472

Interpretation

Uncertain