Gene

KWMTBOMO08052

Pre Gene Modal

BGIBMGA001122

Annotation

PREDICTED:_peptidyl-prolyl_cis-trans_isomerase_E_isoform_X1_[Bombyx_mori]

Location

Bomo_Chr13(-):13680565-13686034      View in EpiBrowser

Full name

Peptidyl-prolyl cis-trans isomerase      

Location in the cell

Mitochondrial   Reliability : 1.984 Nuclear   Reliability : 1.76

CDS

ATGGTACTCATTGCTAATGTTACTATTAAATATTTAGCAAAAAGCCCAGTAAAGTGTGGTCGGGTTTCATTTGTTATCTATAAGCACCAGCCAACAAGACTTATACAGATTTCATCATTACAGCCTCCAAGATTTCCCTTATTATCAAAAGAATTCTACGCTTGTTGGTGTAACCATCAAAAAGAGCTTCAATTGGCCAAGCACAAGATAGACGATAGTCCGCCCGAGCTATTCCCGGAGTTATACTTGAAGCCGCGCCGCTTAGACTACTATGCACGACAGCTCGAAGAGAATATGAATGTTAACAAGGAACTGCTTAAAAGAATAAATCTCATACAAAGGACTGGAGGGTTTGTCGACTGCTGGATGCGACCTGAACCGACTAATACATACAACAAACTTCTGTGCAAGCAGCGTCAACGGAACCTCGATGAAATCCGGAAAAATAACCTTTACTTCTATTCGAGACTTCTTATTGCCAGATCCGAACAGCCCCTCACAAAGGAATTAGAAGAGCATTGGAAGGAGACAAAACACAAATTAATCTTGGGTGCTTCATTGCCATTTATTCTGTTCAAAACTGAAAAGATTGATCGTGATATTCGAGATCCAAGCTTTGACCGGCCGTTGAACGTTTACCGAACTAAAGTCTCTATGGAAGTTTGGGTGGTGGGCGGGTCCAAGATTGGAAAAGTAACTATAGAACTCTTCAATGATATAGTTCCAAAAACTTGTCAGCTTTTCTTGAGTCTTGTGAGAGGTGACCCCTTCGGTCACGCATACGCAGGGACGAGATTTTTCAGGATTGTGCCCGACTTGTACTGTCGAGGCGGGGACGTCATTAAAGATAACGGATTCGGCTGCTATTTACCAGAAGGGCAAACAGAACCTATGGGTGTCGAGTGCTACCGTCTCAAGCACACTGTGCCCGGTGTACTATCCATGGTTGTAAGTTCTGATAACGAAGTGTGCGCACAGTTCAATATAATATTCAAGCCGCTACCACAATTCGATGGCAAACACGTTGTTTTCGGCAGAATTATAGGGGGACCAGCACAGGCTTTAGAGCGTATCAGTGCTCTTGGGCTCCCACTGGGCACCACGACGTCAGACTGCGTCATAAGGAACTGCGGATGGTTCACTCGCTCCGGACAATACCGAGAAGGAAACCAGAACACCATCAAATTCCCTCCGAGACGTAAAGTAAAGGCATGA

Protein

MVLIANVTIKYLAKSPVKCGRVSFVIYKHQPTRLIQISSLQPPRFPLLSKEFYACWCNHQKELQLAKHKIDDSPPELFPELYLKPRRLDYYARQLEENMNVNKELLKRINLIQRTGGFVDCWMRPEPTNTYNKLLCKQRQRNLDEIRKNNLYFYSRLLIARSEQPLTKELEEHWKETKHKLILGASLPFILFKTEKIDRDIRDPSFDRPLNVYRTKVSMEVWVVGGSKIGKVTIELFNDIVPKTCQLFLSLVRGDPFGHAYAGTRFFRIVPDLYCRGGDVIKDNGFGCYLPEGQTEPMGVECYRLKHTVPGVLSMVVSSDNEVCAQFNIIFKPLPQFDGKHVVFGRIIGGPAQALERISALGLPLGTTTSDCVIRNCGWFTRSGQYREGNQNTIKFPPRRKVKA

Description

PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

Catalytic Activity

[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)

Similarity

Belongs to the cyclophilin-type PPIase family.

Uniprot

A0A212EX06   A0A3S2NYK6   Q2F611   A0A2A4JK20   A0A2H1VVT0   A0A194QC44   + More
H9IV42   A0A194RBU3   A0A1Y1M875   J9KSD8   A0A1W4XCN7   A0A151WXK6   A0A195ETQ3   A0A2A3EAA9   K7J2E1   A0A232F0N5   A0A195EKW6   D6WBV8   A0A026WSE8   A0A224XD69   A0A2R7VY50  

EC Number

5.2.1.8

Pubmed

22118469    26354079    19121390    28004739    20075255    28648823    + More
18362917    19820115    24508170   

EMBL

AGBW02011847    OWR46032.1    RSAL01000023    RVE52282.1    DQ311261    ABD36206.1    + More
NWSH01001158    PCG72311.1    ODYU01004741    SOQ44939.1    KQ459439    KPJ01006.1    BABH01000410    KQ460397    KPJ15308.1    GEZM01037699    JAV81982.1    ABLF02007382    ABLF02007383    ABLF02007384    ABLF02037453    ABLF02051027    KQ982678    KYQ52395.1    KQ981979    KYN31259.1    KZ288325    PBC28001.1    AAZX01007551    NNAY01001391    OXU24142.1    KQ978739    KYN28878.1    KQ971315    EEZ97862.1    KK107119    EZA58581.1    GFTR01006069    JAW10357.1    KK854164    PTY12426.1   

Proteomes

UP000007151    UP000283053    UP000218220    UP000053268    UP000005204    UP000053240    + More
UP000007819    UP000192223    UP000075809    UP000078541    UP000242457    UP000002358    UP000215335    UP000078492    UP000007266    UP000053097   

PRIDE

Q2F611    H9IV42   

Pfam

PF13879   KIAA1430        + More
PF00160   Pro_isomerase
PF04263   TPK_catalytic
PF04265   TPK_B1_binding

Interpro

IPR029488   Hmw/CFAP97D1        + More
IPR029000   Cyclophilin-like_dom_sf       
IPR002130   Cyclophilin-type_PPIase_dom       
IPR007371   TPK_catalytic       
IPR007373   Thiamin_PyroPKinase_B1-bd       
IPR036371   TPK_B1-bd_sf       
IPR036759   TPK_catalytic_sf       
IPR006282   Thi_PPkinase       

SUPFAM

SSF50891   SSF50891        + More
SSF63862   SSF63862       
SSF63999   SSF63999       

Gene 3D

2.40.100.10     3.40.50.10240    

CDD

cd07995  TPK

ProteinModelPortal

A0A212EX06   A0A3S2NYK6   Q2F611   A0A2A4JK20   A0A2H1VVT0   A0A194QC44   + More
H9IV42   A0A194RBU3   A0A1Y1M875   J9KSD8   A0A1W4XCN7   A0A151WXK6   A0A195ETQ3   A0A2A3EAA9   K7J2E1   A0A232F0N5   A0A195EKW6   D6WBV8   A0A026WSE8   A0A224XD69   A0A2R7VY50  

PDB

4JCP     E-value=1.23072e-23,     Score=272

KEGG

692873    no KO assigned | (RefSeq) peptidyl-prolyl cis-trans isomerase E

GO

GO:0003755   GO:0016021   GO:0016874   GO:0006772   GO:0004788   GO:0009229   GO:0030975   GO:0005524   GO:0051082   GO:0042026   GO:0016018   GO:0000413   GO:0006457   GO:0006397   GO:0005515   GO:0005737   GO:0006429   GO:0006412   GO:0016876   GO:0043039  

Length:

404

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.00712000000000001

Exp number, first 60 AAs:

0.000820000000000001

Total prob of N-in:

0.01561

outside

1  -  404

 

 

Pi

19.59909

Theta

20.966069

Tajima's D

-0.669773

CLR

0.837439

CSRT

0.2020398980051

Interpretation

Uncertain