Gene
KWMTBOMO08044 Validated by peptides from experiments
Pre Gene Modal
BGIBMGA001124
Annotation
ap_endonuclease_[Danaus_plexippus]
Full name
DNA-(apurinic or apyrimidinic site) lyase
Location in the cell
Nuclear Reliability : 4.612
Sequence
CDS
ATGGCACCAAGATCAGCAAAAGCTAAGAAAGCAGCAGAAGCAAAAGTAGCAGACAATGATGCACCTAAAAAAGGAAGAGGCAAAGCAAAAGTAGTTGAAGATCCTGAAACGGAGTCTGTAGAAGCTGAAGTTGATGAAAAGAACATTGTATCTGAAAAGAAAACCAAACGCGGAAGGAAAGCTGCCGGTGACACAAATGGACAAGATGAGAATGGTAAAATAGAGGAAACAGCACCAAAAAAAGGAAGGAAGAAGAATGTAGAGGAACCTCCGGTGGAAAATAAATCTACTGATGAACCCTCAGTTGAAGATGAAGTGGCAGTGTCTGAGGAAAATAATCCTAGTGAAGATGGTTCAGAAACAAATGGTCACATAGAAGAAGAACAAGTTCCTTCAGGTAGGGGACGTAAGAAACAAACCAAAAAGGAAGTTAAAAAACCAGAGCCTAGAACAGGCAGAGGTAGGAAACCTAAACAAGAAATAGAAGATGAAGTTGAAGACAAACCAAAAGGTAGGGGCAGAGGACGCAAAGCCAAAGCTGAAGAAGCTGAGTCTGATATATCTGAAACTGTTGAGGATGAAGGAAAGCCAGAAGCTGCTAAAGGCAAGAAGAAAGTTCAGAACCAAGCTGTTGAGAAGCCTGCAGAGAATGATGATGATGAAGTAGAAGAGGAAAATGTAGAGGAACCAAAAAAGAAGGAAACCAAAAGTCGCAAAAATCAGGGCAAAAAAGTAGCAGCCAAAGAAGAGACTGATGATGCTGTGAGGGAAGATGAACCAGCTTCTAAGAAAAGGAAGGTCACAAAAAAAGATGAAAAACAAAAAGCTGCACAAAATGAAGACGATAATGTTGATGAAGAGGAAAAACCTGAACCAAAGCCTGCAAAAGGAAGGCGGGGTCAAAAGAAGGCAGAAGTATCTGCTGAATCCCATGAGGAGCCACAGGACACTGGTGAGCCAACTACAAAACGTCGACGCAAGCCTGTCGAAGAAAAGGTGAACACCGAAGACGCGAAAAAGAAAGCACCGCCCAAGAATAAATCCACGACAAATTACGAAGATATTGACTTTACAAATGAATCGAAGACGACGCAAGGCAAAGAATGGAACTTCAAGATAGCGAGTTGGAACGTTGACGGGATCAGAGCGTGGATGAGCAAAGGAGGCTTGGATTACATCAAATACGAGAAGCCGGACATTTTCTGTTTGCAAGAGACGAAATGTGCAACGGACAAATTGCCAGACGAAGTGGCTAATGTTCCAGGCTATCATGCGTACTGGTTGGCCGGGGACAAAGATGGCTACGCAGGCGTAGGCATTTACACGACAAAGCTAGCGATGAATGTCAAATATGGCTTGCAAAATGAAGAGCTGGACGATGAAGGTCGCATTATAACGGCGGAGTACGAACAGTTTTACTTGATTTGTACGTACGTACCGAACGCGGGCCGGAAACTAGTCACAATGCCCAAAAGGCTGCGATGGAACGAGGAATTCCTCAAACACGTCAAAGAATTAGATAAGAAGAAACCTGTGATAATATGCGGCGACATGAACGTTTCCCATAAGGAAATCGATTTAGCGAATCCGAAGACGAACAGAAAGAATGCCGGCTTCACGGACGAGGAGCGCGCCGGCATGACGCAGCTGCTCGGCGACGGGTTCGTCGACACCTTCCGACATTTCCACCCCGACCAGACGGGCTCGTACACTTTCTGGACGTACATGATGAATTCCCGTTCGAAGAACGTCGGATGGCGTTTGGATTACTTCATAGTTTCCGACAGACTGATTCCGTCGGTCTGCGACAACGTCATCCGCGACAAGGTGTATGGCAGCGACCACTGTCCGATAGCGCTCTTTCTAAATCTAACAACAGCCGAGAAACCGAAGGAATAA
Protein
MAPRSAKAKKAAEAKVADNDAPKKGRGKAKVVEDPETESVEAEVDEKNIVSEKKTKRGRKAAGDTNGQDENGKIEETAPKKGRKKNVEEPPVENKSTDEPSVEDEVAVSEENNPSEDGSETNGHIEEEQVPSGRGRKKQTKKEVKKPEPRTGRGRKPKQEIEDEVEDKPKGRGRGRKAKAEEAESDISETVEDEGKPEAAKGKKKVQNQAVEKPAENDDDEVEEENVEEPKKKETKSRKNQGKKVAAKEETDDAVREDEPASKKRKVTKKDEKQKAAQNEDDNVDEEEKPEPKPAKGRRGQKKAEVSAESHEEPQDTGEPTTKRRRKPVEEKVNTEDAKKKAPPKNKSTTNYEDIDFTNESKTTQGKEWNFKIASWNVDGIRAWMSKGGLDYIKYEKPDIFCLQETKCATDKLPDEVANVPGYHAYWLAGDKDGYAGVGIYTTKLAMNVKYGLQNEELDDEGRIITAEYEQFYLICTYVPNAGRKLVTMPKRLRWNEEFLKHVKELDKKKPVIICGDMNVSHKEIDLANPKTNRKNAGFTDEERAGMTQLLGDGFVDTFRHFHPDQTGSYTFWTYMMNSRSKNVGWRLDYFIVSDRLIPSVCDNVIRDKVYGSDHCPIALFLNLTTAEKPKE
Summary
Catalytic Activity
The C-O-P bond 3' to the apurinic or apyrimidinic site in DNA is broken by a beta-elimination reaction, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate.
Similarity
Belongs to the DNA repair enzymes AP/ExoA family.
Uniprot
EC Number
4.2.99.18
EMBL
Proteomes
PRIDE
Pfam
PF03372 Exo_endo_phos
Interpro
SUPFAM
SSF56219
SSF56219
Gene 3D
ProteinModelPortal
PDB
2O3H
E-value=1.02014e-86,
Score=818
Ontologies
GO
PANTHER
Topology
Length:
632
Number of predicted TMHs:
0
Exp number of AAs in TMHs:
0.000710000000000001
Exp number, first 60 AAs:
0
Total prob of N-in:
0.00217
outside
1 - 632
Population Genetic Test Statistics
Pi
24.209221
Theta
19.281645
Tajima's D
0.986965
CLR
1.614536
CSRT
0.654817259137043
Interpretation
Uncertain
