Gene

KWMTBOMO08041  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA001126

Annotation

PREDICTED:_rab_proteins_geranylgeranyltransferase_component_A_1_[Amyelois_transitella]

Location

Bomo_Chr13(-):13546080-13565324      View in EpiBrowser

Full name

Rab proteins geranylgeranyltransferase component A      

Location in the cell

Cytoplasmic   Reliability : 3.576

CDS

ATGATGGATGAAGATTTTCCAACTGACTTCCAGGTCATCGTGGTGGGAACGGGCATGGTCGAGTCCATAGTGGCTGCTGCTTGCAGTAGGATAGGCAAGAATGTCCTCCACATGGACTCTAGTGATCATTATGGAGGACTCTGGGCTTCATATAATTTTGAGGGCCTACAGAAGTTCATAAAAGAGGTGAACAGTGATCCTGATAGACAAAAACAAGTGTACAACTTATCTGAAAAATGGTTTATTGAAAAGGAATCTGCACAAGGCGAAACAACTGATGAAAACAAAGGTGAACCAAGAAAAGTATGGAGCCAAGCTGATTTTGCAGCGGAGTATCGGAAATTTAACATTGATACAACTCCAAAGCTGTTGTTCTCTCGCGGCCCCCTTGTCGAGCTTCTGATCTCTTCGAACATCGCGCGCTACGCTGAGTTCCGATGCGTGACCCGCGTCTTGACCTGGCTCAACGATCAGCTGATGCCGGTTCCTTGCTCCCGAGCCGACGTATTCGCCACCGAAGCGGTCGGTATCGTCGAGAAAAGGATGCTCATGAAAATGCTGACATCGATTGTCGGTTACAGCGAAGAGGAGATGAACAATGAGTTTAAAGACTGGAACAACAAGACATTGAAGGAATACTTGACTCACAAGGGCTTGACCCCGAACCTCATTCACTACATCCTGTACGCGATCGCTGGCGGGAACAACAGCTTGCCCTGCCTCGAAGGTGTCAAGGAATGCAAGAAGTTCCTCATGAGCCTCGGAAGATATGGCAACACTCCATTCTTATGGCCCATGTATGGAAGCGGAGAATTGCCGCAATGCTTCTGCAGGCTCTGTGCAGTTTTCGGCGGGGTCTACTGCCTGAATCGGCCCATCGATAAAGTCGAAACGAAAACCGTTGATGAAGGAAAAACCGTCGTCACCATCGATAGCAAGTCGAAGAAGCTTAACTGCGATCACCTGGTCATCGGCGTCCACGAGTGCCCCGAGGAGCTGATGTCTTCGGAACCGGCTGAGAGCTGCGACATCTCCAAGGCGGTGTTCGTCACCAACGGCACCATCATGGCCAGCGAGAAGGAACCGCTCACGTTGCTCCGCTTCCCGCCGCTGGCTGACGACGACAATGCCGTCACCGTGCTAGAAGTGGGCCCCGCTACCGGATCCTGCCCCAAGGGATTGTTCGTGGTTTATTTCATAACGAAGAAAACTAAAGACGCGGAGAGCGATCTCAAACCGTACGCAGAGCGAATCTTCGATATGTCCGGGGGCGACCAGACCGCGGCCACGGATAAGCCGAAGTGCCTGTGGTCGCTGTTCTACAACGTGAAGGACACGAGCTCGCCGGTGTCGAGCGTGGTGGACAACGTGCACGTCTGCTCCGGGCCCGACGCCGGACTGGACTTCGACAGAGCCGTCGAACAGGCTGAGCAAATCTTCAAGAAGATTTGTCCGGGAGAGGAGTTTCTGCCGCGGGCGCCCAACCCCGAGGAGATAGTGTTCGAGGATGACGTCACCCACGGACCCGAATTCCAACGGGAACAAGACGAAGAAGCCGAACCGAAGGAGTAG

Protein

MMDEDFPTDFQVIVVGTGMVESIVAAACSRIGKNVLHMDSSDHYGGLWASYNFEGLQKFIKEVNSDPDRQKQVYNLSEKWFIEKESAQGETTDENKGEPRKVWSQADFAAEYRKFNIDTTPKLLFSRGPLVELLISSNIARYAEFRCVTRVLTWLNDQLMPVPCSRADVFATEAVGIVEKRMLMKMLTSIVGYSEEEMNNEFKDWNNKTLKEYLTHKGLTPNLIHYILYAIAGGNNSLPCLEGVKECKKFLMSLGRYGNTPFLWPMYGSGELPQCFCRLCAVFGGVYCLNRPIDKVETKTVDEGKTVVTIDSKSKKLNCDHLVIGVHECPEELMSSEPAESCDISKAVFVTNGTIMASEKEPLTLLRFPPLADDDNAVTVLEVGPATGSCPKGLFVVYFITKKTKDAESDLKPYAERIFDMSGGDQTAATDKPKCLWSLFYNVKDTSSPVSSVVDNVHVCSGPDAGLDFDRAVEQAEQIFKKICPGEEFLPRAPNPEEIVFEDDVTHGPEFQREQDEEAEPKE

Description

Substrate-binding subunit (component A) of the Rab geranylgeranyltransferase (GGTase) complex. Binds unprenylated Rab proteins and presents the substrate peptide to the catalytic component B. The component A is thought to be regenerated by transferring its prenylated Rab back to the donor membrane.

Similarity

Belongs to the Rab GDI family.

Uniprot

H9IV46   A0A194QC37   A0A212FFT1   A0A2A4IXX4   A0A3S2N7V2   A0A2H1V3M3   + More
A0A0L7KQC3   A0A1B6CWS9   A0A2S2P5Y6   J9K9C3   A0A195C9H4   E9J9I3   A0A026VWA4   A0A158NBY8   A0A195FKT8   A0A3L8DTP1   A0A0J7N7T4   A0A151IUN6   F4WHV5   E2B971   E1ZY69   A0A067QKS8   A0A2J7PZ13   K7IYS1   A0A2A3E1M3   V9IG24   A0A0L7R752   A0A1B6JH27   A0A1B6MEN3   A0A2S2PVQ7   A0A232FEZ7   A0A154PC34   A0A0M8ZNW6   A0A195BFY6   A0A1Y1MNS6   A0A1W4XR02   D2A2F3   J3JU15   A0A1W7R713   A0A023EWM5   E0VTH2   A0A2S2QHD1   A0A0P6J5Y6   U4U5Z3   Q17D49   A0A1Q3FC76   A0A1Q3FC07   B0WTT3   A0A182YLY3   A0A182R9D5   A0A182LZF3   A0A182HX79   A0A182LN83   A0A182XB06   A0A182UDX7   A0A182NDJ5   R7V2R3   Q7QDU2   W5J7J5   C3YZ95   A0A2M4AFT5   A0A1B6F6G6   A0A182V3D9   A0A336K9D5   A0A2M4AFS0   A0A182IWI9   A0A182FM11   A0A182QBG7   A0A2M4BI28   A0A084VBW6   A0A1I8PKI0   A0A2M4BHS2   A0A182W3R2   A0A1Y1MKX2   T1J4P5   A0A3Q3XB46   A0A1L8DLH9   A0A1V9WZU3   A0A0N8CL14   A0A0P5J331   A0A0P6GSK1   A0A0P5LXG9   A0A0N8A9I9   A0A1I8N8X6   A0A182K005   A0A0P4YNN0   T1PGN8   A0A0P4YBV5   A0A0L0BTR0   A0A2Y9RCV3   A0A0P5ZM65   A0A2R7X5U4   A0A0P5YTD3   A0A182SRW8   A0A2D0T0J0   W8AX30  

Pubmed

19121390    26354079    22118469    26227816    21282665    24508170    + More
21347285    30249741    21719571    20798317    24845553    20075255    28648823    28004739    18362917    19820115    22516182    24945155    20566863    26999592    23537049    17510324    25244985    20966253    23254933    12364791    14747013    17210077    20920257    23761445    18563158    24438588    28327890    25315136    26108605    24495485   

EMBL

BABH01000425    BABH01000426    KQ459439    KPJ00996.1    AGBW02008770    OWR52587.1    + More
NWSH01004789    PCG64685.1    RSAL01000232    RVE43821.1    ODYU01000498    SOQ35376.1    JTDY01007357    KOB65271.1    GEDC01019665    JAS17633.1    GGMR01011687    MBY24306.1    ABLF02017129    KQ978068    KYM97472.1    GL769313    EFZ10521.1    KK107785    EZA47796.1    ADTU01011496    KQ981491    KYN41033.1    QOIP01000004    RLU23706.1    LBMM01008675    KMQ88710.1    KQ980949    KYN11218.1    GL888170    EGI66184.1    GL446459    EFN87777.1    GL435171    EFN73918.1    KK853238    KDR09526.1    NEVH01020341    PNF21571.1    KZ288449    PBC25598.1    JR040758    JR040759    AEY59279.1    AEY59280.1    KQ414642    KOC66700.1    GECU01009090    JAS98616.1    GEBQ01005559    JAT34418.1    GGMS01000393    MBY69596.1    NNAY01000335    OXU29123.1    KQ434869    KZC09381.1    KQ435951    KOX68110.1    KQ976500    KYM83080.1    GEZM01028230    JAV86360.1    KQ971338    EFA02190.1    BT126726    AEE61688.1    GEHC01000735    JAV46910.1    GAPW01000664    JAC12934.1    DS235765    EEB16678.1    GGMS01007933    MBY77136.1    GDUN01000326    JAN95593.1    KB632166    ERL89309.1    CH477300    EAT44271.1    GFDL01009957    JAV25088.1    GFDL01009930    JAV25115.1    DS232092    EDS34624.1    AXCM01001040    APCN01005148    AMQN01005315    KB295685    ELU12757.1    AAAB01008849    EAA07234.4    ADMH02002024    ETN59936.1    GG666566    EEN54166.1    GGFK01006334    MBW39655.1    GECZ01024088    JAS45681.1    UFQS01000117    UFQT01000117    SSW99985.1    SSX20365.1    GGFK01006302    MBW39623.1    AXCN02001759    GGFJ01003470    MBW52611.1    ATLV01009632    KE524540    KFB35460.1    GGFJ01003469    MBW52610.1    GEZM01028229    JAV86361.1    JH431846    GFDF01006766    JAV07318.1    MNPL01031396    OQR66697.1    GDIP01121335    JAL82379.1    GDIQ01230142    JAK21583.1    GDIP01223223    GDIQ01245388    GDIQ01190859    GDIQ01149732    GDIQ01030291    JAJ00179.1    JAN64446.1    GDIQ01209405    GDIQ01190858    GDIQ01188158    GDIQ01149731    JAK63567.1    GDIP01169225    JAJ54177.1    GDIP01225035    JAI98366.1    KA647864    AFP62493.1    GDIP01229732    JAI93669.1    JRES01001473    KNC22619.1    GDIP01055259    JAM48456.1    KK857416    PTY27146.1    GDIP01053757    JAM49958.1    GAMC01015868    JAB90687.1   

Proteomes

UP000005204    UP000053268    UP000007151    UP000218220    UP000283053    UP000037510    + More
UP000007819    UP000078542    UP000053097    UP000005205    UP000078541    UP000279307    UP000036403    UP000078492    UP000007755    UP000008237    UP000000311    UP000027135    UP000235965    UP000002358    UP000242457    UP000053825    UP000215335    UP000076502    UP000053105    UP000078540    UP000192223    UP000007266    UP000009046    UP000030742    UP000008820    UP000002320    UP000076408    UP000075900    UP000075883    UP000075840    UP000075882    UP000076407    UP000075902    UP000075884    UP000014760    UP000007062    UP000000673    UP000001554    UP000075903    UP000075880    UP000069272    UP000075886    UP000030765    UP000095300    UP000075920    UP000261620    UP000192247    UP000095301    UP000075881    UP000037069    UP000248480    UP000075901    UP000221080   

PRIDE

H9IV46   

Pfam

PF00996   GDI

Interpro

IPR001738   Rab_escort        + More
IPR036188   FAD/NAD-bd_sf       
IPR018203   GDP_dissociation_inhibitor       
IPR017230   Mrs6       

SUPFAM

SSF51905   SSF51905       

Gene 3D

3.50.50.60    

ProteinModelPortal

H9IV46   A0A194QC37   A0A212FFT1   A0A2A4IXX4   A0A3S2N7V2   A0A2H1V3M3   + More
A0A0L7KQC3   A0A1B6CWS9   A0A2S2P5Y6   J9K9C3   A0A195C9H4   E9J9I3   A0A026VWA4   A0A158NBY8   A0A195FKT8   A0A3L8DTP1   A0A0J7N7T4   A0A151IUN6   F4WHV5   E2B971   E1ZY69   A0A067QKS8   A0A2J7PZ13   K7IYS1   A0A2A3E1M3   V9IG24   A0A0L7R752   A0A1B6JH27   A0A1B6MEN3   A0A2S2PVQ7   A0A232FEZ7   A0A154PC34   A0A0M8ZNW6   A0A195BFY6   A0A1Y1MNS6   A0A1W4XR02   D2A2F3   J3JU15   A0A1W7R713   A0A023EWM5   E0VTH2   A0A2S2QHD1   A0A0P6J5Y6   U4U5Z3   Q17D49   A0A1Q3FC76   A0A1Q3FC07   B0WTT3   A0A182YLY3   A0A182R9D5   A0A182LZF3   A0A182HX79   A0A182LN83   A0A182XB06   A0A182UDX7   A0A182NDJ5   R7V2R3   Q7QDU2   W5J7J5   C3YZ95   A0A2M4AFT5   A0A1B6F6G6   A0A182V3D9   A0A336K9D5   A0A2M4AFS0   A0A182IWI9   A0A182FM11   A0A182QBG7   A0A2M4BI28   A0A084VBW6   A0A1I8PKI0   A0A2M4BHS2   A0A182W3R2   A0A1Y1MKX2   T1J4P5   A0A3Q3XB46   A0A1L8DLH9   A0A1V9WZU3   A0A0N8CL14   A0A0P5J331   A0A0P6GSK1   A0A0P5LXG9   A0A0N8A9I9   A0A1I8N8X6   A0A182K005   A0A0P4YNN0   T1PGN8   A0A0P4YBV5   A0A0L0BTR0   A0A2Y9RCV3   A0A0P5ZM65   A0A2R7X5U4   A0A0P5YTD3   A0A182SRW8   A0A2D0T0J0   W8AX30  

PDB

1VG9     E-value=4.65169e-86,     Score=811

KEGG

101740100    K23460 Rab proteins geranylgeranyltransferase component A | (RefSeq) rab proteins geranylgeranyltran

GO

GO:0005096   GO:0005968   GO:0005092   GO:0007264   GO:0018344   GO:0017137   GO:0006886   GO:0016740   GO:0005737   GO:0016192   GO:0005829   GO:0005634   GO:0016491   GO:0016020   GO:0006412   GO:0016876   GO:0043039  

PANTHER

PTHR11787  

Subcellular location

Cytoplasm  

Length:

523

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.786929999999999

Exp number, first 60 AAs:

0.598709999999999

Total prob of N-in:

0.01588

outside

1  -  523

 

 

Pi

26.279108

Theta

26.087679

Tajima's D

-0.904524

CLR

0.793124

CSRT

0.155192240387981

Interpretation

Uncertain