Gene

KWMTBOMO08040  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA001035

Annotation

PREDICTED:_inosine-5'-monophosphate_dehydrogenase_[Amyelois_transitella]

Location

Bomo_Chr13(+):13542655-13544280      View in EpiBrowser

Full name

Inosine-5'-monophosphate dehydrogenase      

Alternative Name

Protein raspberry

Location in the cell

Cytoplasmic   Reliability : 1.609 Mitochondrial   Reliability : 1.583

CDS

ATGTCATTAAAGACGGAAGGCGACCTCCGAGATGGGTTATCTGCTGAGGATACCTTCGCTAACAGTGAAGGACTTACATATAACGATTTCTTACTGCTGCCTGGATATATAGATTTTACAGCAGAAGAAGTCGATTTGACATCTCCACTCACTAAGAAAATTCTGTTAAAAGCACCTCTAGTGTCTACTCCAATGGACACAGTGACAGAAGCTGACATGGCCATATCCATGGCGCTTTGCGGTGGAATTGGCATTATACACCACAACTGTACTCCAGAATACCAAGCTAATGAAGTTCACAAAGTGAAGAAGTATAAGCATGGATTTATTAGAGACCCCGTTTGCATGGGTCCTGAGAACACAGTCGCTGATGTCTTGGAAGCTAAGAAGAAGAACGGATTCACTGGCTATCCTATCACTCAGAATGGTAAACTTGGTGGACGTCTAATTGGCATTGTTACATCTCGTGACATTGATTTTAGAGAAGGGGACCCACACCTAAGTTTGAAAGAAGTAATGACTCCCATAAATGATATGATTACTGCACAATTGGGTGTCACTTTACAAGATGCTAATTACATATTAGAGAAGAGCAAAAAAGGAAAATTACCAATCATTAATAATGATGGTGAACTTGTTGCATTGATTGCTAGAACTGATTTAAAGAAAGCGAGAAGTTATCCAAATGCATCTAAAGATTCCAACAAGCAATTGTTAGTAGGGGCGGCAATTGGGACTCGTGATACAGACAGAGAACGGCTGAAGTTGCTTGTGAACAATGGTGTAGATGTGATTGTCCTCGATTCATCTCAGGGAAATTCAACCTACCAAATCAAGATGATAAAATACATAAAGGAAACTTATCCAGAAATACAGGTAGTTGGTGGTAATGTAGTGACAAGAATGCAAGCTAAAAATTTAATTGACGCAGGAGTTGATGCCTTGAGAGTCGGAATGGGTAGTGGCTCTATTTGTATCACACAAGAAGTGATGGCTTGTGGTTGTCCTCAAGCCACTGCAGTGTACCAAGTAGCTTCCTATGCTCGTCATTTTAATGTACCAGTCATTGCCGATGGTGGAATTCAGTCAGTTGGTCATATTATTAAATCATTGGCCCTTGGGGCATCGACTGTAATGATGGGATCACTCCTTGCGGGGACATCTGAGGCCCCTGGAGAATACTTCTTCTCTGATGGAGTTCGGCTCAAGAAATACAGAGGAATGGGAAGCTTAGAAGCTATGGAAAGTAAAGATGGTAAAGGATCTGCTATGAGTAGATACTTCCACAAAGAATCTGACAAACATAGAGTTGCTCAGGGAGTTAGTGGTAGTATTGTTGATAAAGGTTCAGTACTAAGATTCCTACCTTATTTGCAAGCCGGCATGCAACACAGTTGCCAAGATCTTGGAGCTCGATCTGTTAGTGTGTTGCGTGAAATGAGTCATTCTGGAGATCTGAGATTCATGAAAAGGACTTACTCAGCCCAACTGGAAGGCAATGTCCATGGTCTGTTCTCTTATGAGAAAAGATTATTTTAA

Protein

MSLKTEGDLRDGLSAEDTFANSEGLTYNDFLLLPGYIDFTAEEVDLTSPLTKKILLKAPLVSTPMDTVTEADMAISMALCGGIGIIHHNCTPEYQANEVHKVKKYKHGFIRDPVCMGPENTVADVLEAKKKNGFTGYPITQNGKLGGRLIGIVTSRDIDFREGDPHLSLKEVMTPINDMITAQLGVTLQDANYILEKSKKGKLPIINNDGELVALIARTDLKKARSYPNASKDSNKQLLVGAAIGTRDTDRERLKLLVNNGVDVIVLDSSQGNSTYQIKMIKYIKETYPEIQVVGGNVVTRMQAKNLIDAGVDALRVGMGSGSICITQEVMACGCPQATAVYQVASYARHFNVPVIADGGIQSVGHIIKSLALGASTVMMGSLLAGTSEAPGEYFFSDGVRLKKYRGMGSLEAMESKDGKGSAMSRYFHKESDKHRVAQGVSGSIVDKGSVLRFLPYLQAGMQHSCQDLGARSVSVLREMSHSGDLRFMKRTYSAQLEGNVHGLFSYEKRLF

Description

Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.

Catalytic Activity

H2O + IMP + NAD(+) = H(+) + NADH + XMP

Cofactor

K(+)

Subunit

Homotetramer.

Similarity

Belongs to the IMPDH/GMPR family.

Keywords

CBS domain   Complete proteome   Cytoplasm   GMP biosynthesis   Metal-binding   NAD   Oxidoreductase   Phosphoprotein   Potassium   Purine biosynthesis   Reference proteome   Repeat  

Feature

chain  Inosine-5'-monophosphate dehydrogenase

Uniprot

H9IUV5   A0A2H1UZU7   A0A0N0PEW2   A0A194RCV6   S4PG58   A0A0L7LSA9   + More
Q16WB3   A0A182NZP6   A0A336KX26   A0A182X5P8   Q7QHD0   A0A1S4H5T8   A0A182TPA4   A0A182HW99   A0A182KL07   A0A023EUH8   A0A182JWZ7   A0A182UVK4   A0A182N290   A0A182RW44   A0A182YB03   A0A0K8TPP4   A0A182SCF6   W8BA97   A0A0A1XHQ0   W5JN05   A0A034W0T2   A0A0K8VZ52   A0A2M4AB86   A0A182Q952   A0A182FW38   A0A182MPN7   A0A194Q7M2   A0A1Q3EWZ0   A0A1J1J3M4   A0A2M3Z269   A0A2M4BKR2   A0A182WDL1   B0WW86   A0A1I8QE28   A4V488   Q07152   B4PXZ1   T1P9Q0   B4MJ75   B3MSB7   A0A3B0JYW0   A0A1W4UNW8   A0A0L0C2R1   B3NW07   Q29IQ0   A0A182IPX8   B4MES0   A0A1A9ZRR6   B4JK62   A0A0M3QZA3   U5EIP0   A0A1A9WCQ4   A0A1B0ATC8   A0A1A9XAI2   A0A1A9UPG8   A0A1A9VPM0   A0A1A9WDG8   A0A1B0FR56   A0A1A9YA98   A0A1A9ZJM4   B4R7M3   B4IDT3   A0A1B0GGT8   B4H2U5   A0A1L8DXU5   A0A084WM01   A0A067RHP6   A0A0C9R572   E2BHJ7   A0A154P3W3   A0A2P8XQG3   A0A1Y1JWM5   A0A0M9A7J8   A0A2J7Q0K4   A0A232F3Y3   A0A0P4VV19   A0A2A3EIS3   A0A088A653   A0A0L7R1T3   A0A2R7W2W8   A0A151I6G9   A0A151I6F4   A0A0V0G8A7   A0A224XAV9   A0A069DUB9   A0A1Y1JWM0   A0A1W4WQG2   A0A151IUY9   E2A771   A0A151K3Z5   F4WE14   A0A195BAH6   A0A158NUS4   A0A1B6EDT5  

EC Number

1.1.1.205

Pubmed

19121390    26354079    23622113    26227816    17510324    12364791    + More
20966253    24945155    25244985    26369729    24495485    25830018    20920257    23761445    25348373    10731132    12537568    12537572    12537573    12537574    16110336    17569856    17569867    26109357    26109356    7911114    7904480    7476879    12537569    18327897    17994087    17550304    25315136    26108605    15632085    23185243    24438588    24845553    20798317    29403074    28004739    28648823    27129103    26334808    21719571    21347285   

EMBL

BABH01000426    ODYU01000029    SOQ34111.1    LADI01003404    KPJ20584.1    KQ460397    + More
KPJ15299.1    GAIX01003777    JAA88783.1    JTDY01000244    KOB78081.1    CH477571    EAT38872.1    UFQS01001062    UFQT01000002    UFQT01001062    SSX08781.1    SSX17088.1    AAAB01008816    EAA05291.2    APCN01001478    GAPW01001007    JAC12591.1    GDAI01001733    JAI15870.1    GAMC01012602    JAB93953.1    GBXI01003781    JAD10511.1    ADMH02000909    ETN64698.1    GAKP01010675    GAKP01010674    GAKP01010673    GAKP01010672    JAC48279.1    GDHF01008464    JAI43850.1    GGFK01004699    MBW38020.1    AXCN02001731    AXCM01004806    KQ459439    KPJ00995.1    GFDL01015221    JAV19824.1    CVRI01000064    CRL05489.1    GGFM01001871    MBW22622.1    GGFJ01004412    MBW53553.1    DS232140    EDS35918.1    AE014298    BT125958    AAN09265.1    ADX35937.1    L14847    L22608    S80430    AY089553    CM000162    EDX02963.1    KA645471    AFP60100.1    CH963738    EDW72164.1    CH902622    EDV34672.1    OUUW01000003    SPP78869.1    JRES01000982    KNC26522.1    CH954180    EDV46140.1    CH379063    EAL32603.2    CH940664    EDW63045.1    CH916370    EDV99964.1    CP012528    ALC49073.1    GANO01002555    JAB57316.1    JXJN01003238    CCAG010000549    CM000366    EDX17582.1    CH480830    EDW45741.1    AJWK01000737    AJWK01000738    CH479204    EDW30662.1    GFDF01002816    JAV11268.1    ATLV01024336    ATLV01024337    KE525351    KFB51245.1    KK852463    KDR23322.1    GBYB01007932    JAG77699.1    GL448301    EFN84850.1    KQ434809    KZC06512.1    PYGN01001531    PSN34238.1    GEZM01098856    GEZM01098855    GEZM01098854    GEZM01098852    GEZM01098851    GEZM01098848    JAV53712.1    KQ435719    KOX78850.1    NEVH01019967    PNF22099.1    NNAY01001108    OXU25107.1    GDKW01000711    JAI55884.1    KZ288229    PBC31703.1    KQ414667    KOC64822.1    KK854265    PTY13929.1    KQ978473    KYM93699.1    KYM93697.1    GECL01001804    JAP04320.1    GFTR01006899    JAW09527.1    GBGD01001161    JAC87728.1    GEZM01098853    GEZM01098850    GEZM01098849    JAV53714.1    KQ980926    KYN11389.1    GL437267    EFN70727.1    LKEZ01003766    KYN50721.1    GL888102    EGI67452.1    KQ976532    KYM81551.1    ADTU01026689    GEDC01001215    JAS36083.1   

Proteomes

UP000005204    UP000053268    UP000053240    UP000037510    UP000008820    UP000075885    + More
UP000076407    UP000007062    UP000075902    UP000075840    UP000075882    UP000075881    UP000075903    UP000075884    UP000075900    UP000076408    UP000075901    UP000000673    UP000075886    UP000069272    UP000075883    UP000183832    UP000075920    UP000002320    UP000095300    UP000000803    UP000002282    UP000095301    UP000007798    UP000007801    UP000268350    UP000192221    UP000037069    UP000008711    UP000001819    UP000075880    UP000008792    UP000092445    UP000001070    UP000092553    UP000091820    UP000092460    UP000092443    UP000078200    UP000092444    UP000000304    UP000001292    UP000092461    UP000008744    UP000030765    UP000027135    UP000008237    UP000076502    UP000245037    UP000053105    UP000235965    UP000215335    UP000242457    UP000005203    UP000053825    UP000078542    UP000192223    UP000078492    UP000000311    UP000078541    UP000007755    UP000078540    UP000005205   

PRIDE

H9IUV5    A4V488    Q07152    A0A088A653   

Pfam

PF00478   IMPDH        + More
PF00571   CBS
PF03060   NMO

Interpro

IPR001093   IMP_DH_GMPRt        + More
IPR015875   IMP_DH/GMP_Rdtase_CS       
IPR000644   CBS_dom       
IPR005990   IMP_DH       
IPR013785   Aldolase_TIM       
IPR004136   NMO       

Gene 3D

3.20.20.70    

CDD

cd00381  IMPDH

ProteinModelPortal

H9IUV5   A0A2H1UZU7   A0A0N0PEW2   A0A194RCV6   S4PG58   A0A0L7LSA9   + More
Q16WB3   A0A182NZP6   A0A336KX26   A0A182X5P8   Q7QHD0   A0A1S4H5T8   A0A182TPA4   A0A182HW99   A0A182KL07   A0A023EUH8   A0A182JWZ7   A0A182UVK4   A0A182N290   A0A182RW44   A0A182YB03   A0A0K8TPP4   A0A182SCF6   W8BA97   A0A0A1XHQ0   W5JN05   A0A034W0T2   A0A0K8VZ52   A0A2M4AB86   A0A182Q952   A0A182FW38   A0A182MPN7   A0A194Q7M2   A0A1Q3EWZ0   A0A1J1J3M4   A0A2M3Z269   A0A2M4BKR2   A0A182WDL1   B0WW86   A0A1I8QE28   A4V488   Q07152   B4PXZ1   T1P9Q0   B4MJ75   B3MSB7   A0A3B0JYW0   A0A1W4UNW8   A0A0L0C2R1   B3NW07   Q29IQ0   A0A182IPX8   B4MES0   A0A1A9ZRR6   B4JK62   A0A0M3QZA3   U5EIP0   A0A1A9WCQ4   A0A1B0ATC8   A0A1A9XAI2   A0A1A9UPG8   A0A1A9VPM0   A0A1A9WDG8   A0A1B0FR56   A0A1A9YA98   A0A1A9ZJM4   B4R7M3   B4IDT3   A0A1B0GGT8   B4H2U5   A0A1L8DXU5   A0A084WM01   A0A067RHP6   A0A0C9R572   E2BHJ7   A0A154P3W3   A0A2P8XQG3   A0A1Y1JWM5   A0A0M9A7J8   A0A2J7Q0K4   A0A232F3Y3   A0A0P4VV19   A0A2A3EIS3   A0A088A653   A0A0L7R1T3   A0A2R7W2W8   A0A151I6G9   A0A151I6F4   A0A0V0G8A7   A0A224XAV9   A0A069DUB9   A0A1Y1JWM0   A0A1W4WQG2   A0A151IUY9   E2A771   A0A151K3Z5   F4WE14   A0A195BAH6   A0A158NUS4   A0A1B6EDT5  

PDB

1JCN     E-value=0,     Score=1824

KEGG

101740233    K00088 IMP dehydrogenase [EC:1.1.1.205] | (RefSeq) inosine-5'-monophosphate dehydrogenase

PATHWAY

00230    Purine metabolism - Bombyx mori (domestic silkworm)
00983    Drug metabolism - other enzymes - Bombyx mori (domestic silkworm)
01100    Metabolic pathways - Bombyx mori (domestic silkworm)

GO

GO:0046872   GO:0003938   GO:0005737   GO:0000166   GO:0006177   GO:0006183   GO:0007411   GO:0006164   GO:0018580   GO:0003824   GO:0016491   GO:0016020   GO:0005524   GO:0006412   GO:0016876   GO:0043039   GO:0055114  

Subcellular location

Cytoplasm  

Length:

512

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.04899

Exp number, first 60 AAs:

0.00023

Total prob of N-in:

0.00220

outside

1  -  512

 

 

Pi

3.937286

Theta

5.489165

Tajima's D

-1.09177

CLR

0.216452

CSRT

0.11734413279336

Interpretation

Uncertain