Gene

KWMTBOMO08031

Pre Gene Modal

BGIBMGA001129

Annotation

PREDICTED:_protein_scalloped_isoform_X1_[Amyelois_transitella]

Location

Bomo_Chr13(-):13103621-13130004      View in EpiBrowser

Full name

Protein scalloped       + More
Transcriptional enhancer factor TEF-3      

Alternative Name

TEA domain family member 4
Transcription factor 13-like 1
Transcription factor RTEF-1

Transcription factor

TEA

Location in the cell

Cytoplasmic   Reliability : 1.838 Nuclear   Reliability : 1.587

CDS

ATGCGCGGACGGGTAGCGAGCGGCGCGCTCGCAGCCGGCACCATTGCGTCTCCGTGGAGCACGCCGGCCGGCGCGCCCGACACCAATGGATCGGGCGGCGCTGACGCCAAGCATCTCGATGTCGGAGACGCTAGTGACGATGAGAAGGACATGTCGGCGGCGGACGCGGAGGGCGTCTGGAGTCCCGACATCGAACAGAGCTTCCAAGAGGCGCTGGCGATATACCCGCCCTGTGGACGACGCAAAATTATTCTCTCCGACGAGGGCAAGATGTACGGAAGGAACGAGTTAATAGCGAGGTATATTAAACTAAGGACAGGCAAAACGCGTACGAGAAAACAAGTCTCGTCACACATACAGGTGCTAGCTAGGCGAAAACTACGAGAAATTCAAGCCAAACTTAAAGTGCAATTTTGGCAGCCAGGCCTACAAGCCGGCACATCACAGGATGTGAAGCCTTTCCCCGGTGCGGGCTACAAAGGCGTCCCCGGTGTCGGAGGCGTCGGAGTGCCGAGCGGCACCGACGTGGCGCCGCCGCCGCCCTGGGAGGGACGCGCCATCGCCACACACAAACTGAGACTCGTAGAGTTCTCCGCCTTCGTCGAGCATCCCCGGGATCCTGATACGTACCCACCGAGCACGGCGCCGGCGCAACATCTCTTCGTTCACATAGGCGGTACGGTCACATACGCGGATCCTTTATTAGAGTCAGTAGACGTTCAGCAGATAAACGACAAATTCCCTGAGAAGAAGGGCGGTCTGAAGGAACTGTACGAGAAAGGTCCGAGGAACGCCTTCTTCCTGGTCAAGTTCTGGGCGGATCTCAACACGAACAACCTCGACGACCCCGGCGCCTTCTACGGCGTCACTAGTGTATACGAAAGTAATGAGAACATGACGATAACGTGTAGCACGAAAGTGTGTTCGTTCGGGAAGCAGGTGGTCGAAAAGGTGGAAACTGAATACGCCCGGTTCGAGGGCGGTCGCTTCGTGTACCGCATCCACAGGTCGCCGATGTGCGAGTACATGGTCAACTTCATACACAAACTGAAACATCTGCCCGAGAAGTACATGATGAACAGCGTACTAGAAAACTTCACTATACTACAGGTAGTTTCAAACCGAGACACGCAAGAGACATTACTGTGCGCCGCGTTCGTATTTGAAGTGTCGAACAGTGAGCACGGGGCGCAGCATCACATCTACAGGCTCGTCAAAGATTGA

Protein

MRGRVASGALAAGTIASPWSTPAGAPDTNGSGGADAKHLDVGDASDDEKDMSAADAEGVWSPDIEQSFQEALAIYPPCGRRKIILSDEGKMYGRNELIARYIKLRTGKTRTRKQVSSHIQVLARRKLREIQAKLKVQFWQPGLQAGTSQDVKPFPGAGYKGVPGVGGVGVPSGTDVAPPPPWEGRAIATHKLRLVEFSAFVEHPRDPDTYPPSTAPAQHLFVHIGGTVTYADPLLESVDVQQINDKFPEKKGGLKELYEKGPRNAFFLVKFWADLNTNNLDDPGAFYGVTSVYESNENMTITCSTKVCSFGKQVVEKVETEYARFEGGRFVYRIHRSPMCEYMVNFIHKLKHLPEKYMMNSVLENFTILQVVSNRDTQETLLCAAFVFEVSNSEHGAQHHIYRLVKD

Description

Transcription factor which plays a key role in the Hippo/SWH (Sav/Wts/Hpo) signaling pathway, a signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein Hippo (Hpo), in complex with its regulatory protein Salvador (Sav), phosphorylates and activates Warts (Wts) in complex with its regulatory protein Mats, which in turn phosphorylates and inactivates the Yorkie (Yki) oncoprotein. The Hippo/SWH signaling pathway inhibits the activity of the transcriptional complex formed by Scalloped (sd) and Yki and the target genes of this pathway include cyclin-E (cycE), diap1 and bantam. Sd promotes nuclear localization of Yki. Involved in the regulation of cell-specific gene expression during development, particularly in the differentiation of the nervous system. When in combination with vestigial (vg) it acts as a transcriptional activation complex that regulates gene expression in the wing. Binding to vg switches the DNA target selectivity of sd. Required autonomously for cell proliferation and viability within the wing blade. Required for proper sensory organ precursor (SOP) differentiation at the wing margin; required for correct expression of sens.
Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds specifically and non-cooperatively to the Sph and GT-IIC 'enhansons' (5'-GTGGAATGT-3') and activates transcription. Binds to the M-CAT motif.

Subunit

The C-terminus of sd interacts with the C-terminal serine-rich protein domain of vg, to form a complex which acts as a selector for wing development. Interacts (via C-terminus) with yki (via N-terminus) and this interaction enhances its transcriptional activity.
Interacts with YAP1 and WWTR1/TAZ.

Keywords

Activator   Cell cycle   Complete proteome   Developmental protein   Differentiation   DNA-binding   Metal-binding   Nucleus   Reference proteome   Transcription   Transcription regulation   Zinc   Zinc-finger   3D-structure   Alternative splicing   Polymorphism  

Feature

chain  Protein scalloped
splice variant  In isoform 2.
sequence variant  In dbSNP:rs11550887.

Uniprot

A0A3S2LCM2   A0A194Q613   A0A2H1VAA5   A0A212FNC3   A0A0C9R9L0   A0A0C9RQS6   + More
A0A139WNC8   V5GMS9   K7J393   A0A1Y1KDP4   A0A1L8DI62   A0A1L8DIG7   A0A1L8DI59   A0A067RFV2   A0A1B6DTM2   A0A0K8TR30   A0A2H8TUZ6   A0A2S2PBS3   A0A2S2QV00   Q7PRX0   Q16FQ6   A0A2M4CJG5   A0A2M3ZGL2   A0A2M4CVJ3   A0A1S4G9U5   T1DGI8   A0A2M4CVI4   A0A1B6GKI7   A0A2M3ZGK2   A0A182FJN6   A0A182HGL4   A0A2M4A745   A0A2M4A734   A0A2M4A7M8   A0A182QEF3   A0A2M4A9C0   W8BCP9   M1V8P8   A0A182JBP5   U5ETI6   A0A034W2Z3   W8ANL6   A0A0K8UCT2   A0A0A1WRN1   A0A1I8MIZ1   T1DQ03   A0A0Q9X3Z9   A0A1W4VFR6   A0A1I8MJ00   B4IKD9   E1JJ99   A0A3B0JZI8   Q058U0   A0A1W4V3E8   A0A0Q9WTQ5   A0A0Q9X389   A0A2M4AHM3   A0A1W4VF78   A8JUY5   A0A0Q9WCZ8   A0A0Q9WMY7   A8JUY9   P30052   F3YDC4   A0A0Q9WMV6   A0A1S3W8Y7   F1NIL6   B4M2R1   B4L4E3   A0A0R3NVF1   C8KHR2   A0A0Q9WCX7   A0A0R3P0D1   Q8IR25   A0A0Q9WYG0   A0A0F7R2P5   A0A1W5A554   A0A3B1JJG7   A0A0R3NVC7   A0A2K5TT96   A0A2I3MK68   A0A2K6P3K4   A0A2K5I3U0   A0A2K5R0Y3   A0A2J8TAT2   A0A384D8H3   A0A286ZNY3   Q15561-3   A0A0A0MRF3   A0A2K6TE98   G1QR68   A0A0R3NVU9   F1MED8   A0A2K6MCE9   X2JFL9   A0A2I3LPP6   A0A2K6DL87   A0A2I3SFQ9   A0A2R8MSV9   A0A286XDD8  

Pubmed

26354079    22118469    18362917    19820115    20075255    28004739    + More
24845553    26369729    12364791    17510324    24330624    24495485    23493422    25348373    25830018    25315136    17994087    10731132    12537568    12537572    12537573    12537574    16110336    17569856    17569867    26109357    26109356    1547938    9869635    9869643    11112330    11546746    12782275    18313299    18258485    15592404    18057021    15632085    25329095    25362486    8921372    17974005    16541075    15489334    8702974    18579750    19324877    20123908    19393038    16136131    21993624   

EMBL

RSAL01000232    RVE43818.1    KQ459439    KPJ00978.1    ODYU01001492    SOQ37775.1    + More
AGBW02006772    OWR55190.1    GBYB01009607    JAG79374.1    GBYB01009606    JAG79373.1    KQ971312    KYB29367.1    GALX01003062    JAB65404.1    GEZM01091359    JAV56887.1    GFDF01007926    JAV06158.1    GFDF01007924    JAV06160.1    GFDF01007925    JAV06159.1    KK852662    KDR19079.1    GEDC01008277    JAS29021.1    GDAI01000771    JAI16832.1    GFXV01006308    MBW18113.1    GGMR01014236    MBY26855.1    GGMS01012365    MBY81568.1    AAAB01008846    EAA06451.5    CH478397    EAT33072.1    GGFL01001211    MBW65389.1    GGFM01006827    MBW27578.1    GGFL01005175    MBW69353.1    GALA01001641    JAA93211.1    GGFL01005174    MBW69352.1    GECZ01006812    JAS62957.1    GGFM01006817    MBW27568.1    APCN01005666    GGFK01003241    MBW36562.1    GGFK01003231    MBW36552.1    GGFK01003317    MBW36638.1    AXCN02001268    AXCN02001269    AXCN02001270    AXCN02001271    GGFK01004044    MBW37365.1    GAMC01018971    JAB87584.1    AB698921    BAM84190.1    GANO01002762    JAB57109.1    GAKP01009006    JAC49946.1    GAMC01018977    GAMC01018975    GAMC01018973    JAB87582.1    GDHF01027928    JAI24386.1    GBXI01012800    JAD01492.1    GAMD01001510    JAB00081.1    CH964239    KRF99584.1    CH480852    EDW51531.1    AE014298    BT133072    ACZ95296.1    ACZ95297.1    AEX93157.1    AFH07412.1    OUUW01000011    SPP86483.1    BT029128    ABJ17061.1    KRF99583.1    KRF99585.1    GGFK01006901    MBW40222.1    ABW09420.1    AFH07409.1    AFH07414.1    AFH07415.1    ALI51151.1    CH940651    KRF82504.1    CH933810    KRF94047.1    ABW09421.1    ABW09422.1    ABW09423.1    AFH07410.1    AGB95424.1    AGB95425.1    M83787    BT126285    AEB39646.1    KRF94045.1    AADN05000817    EDW65965.1    KRF82503.1    EDW07421.1    KRF94046.1    CH475425    KRT05099.1    AB480200    BAI40291.1    KRF82505.1    KRT05103.1    AAN09366.1    AAS65351.1    AFH07411.1    AFH07413.1    KRF94048.1    AB918726    BAR72975.1    KRT05102.1    AQIA01009745    AQIA01009746    AQIA01009747    AQIA01009748    AQIA01009749    AHZZ02001554    AHZZ02001555    AHZZ02001556    NDHI03003510    PNJ30131.1    AEMK02000037    U63824    BX640921    AC005911    AC125807    AC131234    CH471116    BC015497    X94438    AY101179    ADFV01078201    ADFV01078202    ADFV01078203    ADFV01078204    ADFV01078205    ADFV01078206    ADFV01078207    ADFV01078208    ADFV01078209    KRT05097.1    AHN59769.1    AACZ04028131    NBAG03000351    PNI36117.1    AAKN02051628    AAKN02051629   

Proteomes

UP000283053    UP000053268    UP000007151    UP000007266    UP000002358    UP000027135    + More
UP000007062    UP000008820    UP000069272    UP000075840    UP000075886    UP000075880    UP000095301    UP000007798    UP000192221    UP000001292    UP000000803    UP000268350    UP000008792    UP000009192    UP000079721    UP000000539    UP000001819    UP000192224    UP000018467    UP000233100    UP000028761    UP000233200    UP000233080    UP000233040    UP000261680    UP000008227    UP000005640    UP000233220    UP000001073    UP000009136    UP000233180    UP000233120    UP000002277    UP000008225    UP000005447   

PRIDE

Q058U0    P30052    Q8IR25    Q15561   

Pfam

PF17725   YBD        + More
PF01285   TEA

Interpro

IPR000818   TEA/ATTS_dom        + More
IPR038096   TEA/ATTS_sf       
IPR041086   YBD       
IPR016361   TEF_metazoa       
IPR027255   TEF-3       

Gene 3D

1.10.10.1610    

ProteinModelPortal

A0A3S2LCM2   A0A194Q613   A0A2H1VAA5   A0A212FNC3   A0A0C9R9L0   A0A0C9RQS6   + More
A0A139WNC8   V5GMS9   K7J393   A0A1Y1KDP4   A0A1L8DI62   A0A1L8DIG7   A0A1L8DI59   A0A067RFV2   A0A1B6DTM2   A0A0K8TR30   A0A2H8TUZ6   A0A2S2PBS3   A0A2S2QV00   Q7PRX0   Q16FQ6   A0A2M4CJG5   A0A2M3ZGL2   A0A2M4CVJ3   A0A1S4G9U5   T1DGI8   A0A2M4CVI4   A0A1B6GKI7   A0A2M3ZGK2   A0A182FJN6   A0A182HGL4   A0A2M4A745   A0A2M4A734   A0A2M4A7M8   A0A182QEF3   A0A2M4A9C0   W8BCP9   M1V8P8   A0A182JBP5   U5ETI6   A0A034W2Z3   W8ANL6   A0A0K8UCT2   A0A0A1WRN1   A0A1I8MIZ1   T1DQ03   A0A0Q9X3Z9   A0A1W4VFR6   A0A1I8MJ00   B4IKD9   E1JJ99   A0A3B0JZI8   Q058U0   A0A1W4V3E8   A0A0Q9WTQ5   A0A0Q9X389   A0A2M4AHM3   A0A1W4VF78   A8JUY5   A0A0Q9WCZ8   A0A0Q9WMY7   A8JUY9   P30052   F3YDC4   A0A0Q9WMV6   A0A1S3W8Y7   F1NIL6   B4M2R1   B4L4E3   A0A0R3NVF1   C8KHR2   A0A0Q9WCX7   A0A0R3P0D1   Q8IR25   A0A0Q9WYG0   A0A0F7R2P5   A0A1W5A554   A0A3B1JJG7   A0A0R3NVC7   A0A2K5TT96   A0A2I3MK68   A0A2K6P3K4   A0A2K5I3U0   A0A2K5R0Y3   A0A2J8TAT2   A0A384D8H3   A0A286ZNY3   Q15561-3   A0A0A0MRF3   A0A2K6TE98   G1QR68   A0A0R3NVU9   F1MED8   A0A2K6MCE9   X2JFL9   A0A2I3LPP6   A0A2K6DL87   A0A2I3SFQ9   A0A2R8MSV9   A0A286XDD8  

PDB

3KYS     E-value=8.28804e-99,     Score=920

KEGG

101741252    K09448 transcriptional enhancer factor | (RefSeq) transcriptional enhancer factor TEF-3

PATHWAY

04391    Hippo signaling pathway - fly - Bombyx mori (domestic silkworm)
04392    Hippo signaling pathway - multiple species - Bombyx mori (domestic silkworm)

GO

GO:0005634   GO:0003677   GO:0003700   GO:0035329   GO:0005667   GO:0045944   GO:0001085   GO:0044212   GO:0043565   GO:0046872   GO:0005654   GO:0055013   GO:0000981   GO:0007049   GO:0001745   GO:0007423   GO:0035220   GO:0007476   GO:2000826   GO:0001223   GO:0045892   GO:0007525   GO:0019904   GO:0000980   GO:0008134   GO:0007480   GO:0072089   GO:0007406   GO:0007517   GO:0006357   GO:0006367   GO:0001501   GO:0006355   GO:0005975   GO:0016021   GO:0016020   GO:0005524   GO:0006412   GO:0016876   GO:0043039  

Subcellular location

Nucleus  

Length:

407

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.0534000000000001

Exp number, first 60 AAs:

0.05305

Total prob of N-in:

0.01024

outside

1  -  407

 

 

Pi

23.479146

Theta

22.24584

Tajima's D

0.12225

CLR

0.667165

CSRT

0.408629568521574

Interpretation

Uncertain