Gene

KWMTBOMO08028

Pre Gene Modal

BGIBMGA001129

Annotation

PREDICTED:_glucosylceramidase-like_[Bombyx_mori]

Location

Bomo_Chr13(-):13089405-13091184      View in EpiBrowser

Full name

Glucosylceramidase       + More
Putative glucosylceramidase 3      

Location in the cell

Extracellular   Reliability : 2.104

CDS

ATGGTTTTACCATTGATACCTTTCTGTTTAAGTCTTGAAGATTTAAACAACTACGTAGTGGGTTGGATCGATTGGAACCTCTGTTTGGATCCCAACGGTGGCCCAAACTGGGCTAGCAACTTCGTAGACTCCCCAATAATTGTATATGAAGATAAAGGAGAATTCGTGAAGCAACCAATGTATTATGCATTGGGGCATTTTTCTAAATTTATTCCAAGAGGCTCAGCGCGTCTCCAAGTAACAACGCTTAGTACAGAAGGCATAGAGAACGTTGCAGTTATAACGCCGAAGGGGAATGTTGTGGTTGTTATGCAAAACAGGAAGCCACATACAGTACCTGTGAAGATATATGTGAGCAGTAGAAAAGCTATAAACATTAATATGGAACCTGAATCAATAAAAACTGTAGAAATTAATTCTGTCTCATGA

Protein

MVLPLIPFCLSLEDLNNYVVGWIDWNLCLDPNGGPNWASNFVDSPIIVYEDKGEFVKQPMYYALGHFSKFIPRGSARLQVTTLSTEGIENVAVITPKGNVVVVMQNRKPHTVPVKIYVSSRKAININMEPESIKTVEINSVS

Catalytic Activity

a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + H2O = an N-acylsphing-4-enine + D-glucose

Similarity

Belongs to the glycosyl hydrolase 30 family.

Keywords

Alternative splicing   Complete proteome   Hydrolase   Lipid metabolism   Reference proteome   Signal   Sphingolipid metabolism  

Feature

chain  Glucosylceramidase
splice variant  In isoform d.

Uniprot

A0A2H1VA54   A0A194Q614   A0A194RBR5   A0A212F349   A0A212EPK9   H9JUB6   + More
A0A2S2P4H2   A0A1W1EGM7   J9L5B0   A0A0N1IF15   A0A0N1INL2   A0A067QM95   A0A2A4K8P8   A0A2P8YXD8   A0A329T258   A0A2J7R6J1   G4ZEC3   A0A368H792   A0A081ANK6   W2JGX1   A0A3R7HCU5   W2NS50   W2JGV9   W2XHH3   W2QGT2   W2ZQX7   W2H8M4   W2H8L5   V9FMS3   A0A0W8D288   W4Z0W5   A0A212F254   G5A8P3   A0A0M3HW45   A0A329T209   A0A329T1T2   H3GW35   A0A1Y3B8N5   H3GW34   G4ZEB8   V9LBE0   A0A225WKD5   W2QN93   A0A329SI21   V9FRQ0   W2XM40   A0A081AVG3   W2LSY8   A0A0W8D122   W2ZX75   H3G7N0   W4YPC5   G4ZEB9   A0A0P5P886   A0A023GIV4   A0A0N7L536   A0A2H1VUS0   A0A182EXL9   A0A261A234   S4RMS8   W5ULT4   A0A2D0R7B2   A0A260ZP45   D0N0V3   G5ECR8-4   H9JUB7   F1L2Y4   A0A0P5L6K4   A0A3P6NZ05   M3VVL7   A0A183CWR4   A0A1I7V4N9   A0A2G9U3J6   A0A337SNL3   A0A225WW95   W2JP47   A0A3F2RCM9   A0A0D6M7G3   A0A0B1TDP7   A0A3R7H2D6   A0A0P5GMD5   A0A2G9U5T9   W2HHH0   A0A0P5BVB7   A0A0P5BV77   A0A2P4WZX2   A0A0C9QXG4   A0A162QRA1   D0P1U3   A0A2H1VG50   A0A0P5E3J3   V4B2P4   U3DTR8   A0A0P5WGR1   F7E7C1  

EC Number

3.2.1.45

Pubmed

26354079    22118469    19121390    28680679    24845553    29403074    + More
16946064    24402279    22919073    23127152    19741609    9851916    21685128    17975172    28186564    23254933    25243066   

EMBL

ODYU01001475    SOQ37718.1    KQ459439    KPJ00977.1    KQ460397    KPJ15278.1    + More
AGBW02010629    OWR48154.1    AGBW02013448    OWR43423.1    BABH01038539    BABH01038540    BABH01038541    GGMR01011734    MBY24353.1    LT635665    SGZ49395.1    ABLF02008893    KQ461178    KPJ07773.1    KPJ07772.1    KK853153    KDR10552.1    NWSH01000035    PCG80449.1    PYGN01000302    PSN48919.1    MJFZ01000012    RAW42724.1    NEVH01006756    PNF36452.1    JH159154    EGZ17886.1    JOJR01000007    RCN52483.1    ANJA01000988    ETO80467.1    KI671854    ETL45017.1    MAYM02001277    MBDN02000653    RLN21147.1    RLN73856.1    KI678593    KI691839    ETL98166.1    ETM51335.1    KI671855    ETL45007.1    ANIX01001073    ETP21414.1    KI669577    ETN12367.1    ANIY01001102    ETP49406.1    KI685308    ETK91607.1    KI685309    ETK91597.1    ANIZ01000889    ETI51717.1    LNFO01001539    KUF90525.1    AAGJ04103183    AAGJ04103184    AGBW02010783    OWR47828.1    JH159161    EGZ08269.1    RAW42719.1    RAW42721.1    DS566059    MUJZ01033843    OTF77212.1    EGZ17881.1    JW876614    AFP09131.1    NBNE01000628    OWZ18186.1    KI669572    ETN14662.1    MJFZ01000176    RAW35212.1    ANIZ01000561    ETI54139.1    ANIX01000668    ETP23960.1    ANJA01000623    ETO82874.1    KI678010    KI691249    ETM00502.1    ETM53704.1    LNFP01001456    LNFO01001593    KUF86242.1    KUF90004.1    ANIY01000684    ETP51967.1    DS566004    AAGJ04003827    EGZ17882.1    GDIQ01138535    JAL13191.1    GBBM01001526    JAC33892.1    CCYD01000482    CEG40379.1    ODYU01004571    SOQ44585.1    UYRW01012587    VDN00299.1    NMWX01000014    OZF92071.1    JT411533    JT418303    AHH42685.1    NIPN01000376    NIPN01000375    OZF87457.1    OZF87500.1    DS028122    EEY67266.1    BX284604    AL031254    BABH01038531    BABH01038532    BABH01038533    BABH01038534    JI170344    ADY44488.1    GDIQ01199303    JAK52422.1    UYRT01000954    VDK28999.1    AANG04002876    KZ350247    PIO64080.1    NBNE01000176    OWZ21926.1    KI671251    ETL47408.1    MBAD02001844    MBDO02000659    RLN51536.1    RLN53096.1    KE124814    EPB78356.1    KN550413    KHJ94226.1    RLN51535.1    GDIQ01261484    JAJ90240.1    KZ349327    PIO65072.1    KI684753    ETK94015.1    GDIP01179428    JAJ43974.1    GDIP01179427    JAJ43975.1    NCKW01020142    POM58843.1    GBYB01005352    JAG75119.1    LRGB01000311    KZS19887.1    DS028257    EEY55076.1    ODYU01002190    SOQ39362.1    GDIP01147339    JAJ76063.1    KB200701    ESP00722.1    GAMT01003193    GAMS01007908    GAMQ01006239    JAB08668.1    JAB15228.1    JAB35612.1    GDIP01099492    JAM04223.1   

Proteomes

UP000053268    UP000053240    UP000007151    UP000005204    UP000007819    UP000027135    + More
UP000218220    UP000245037    UP000251314    UP000235965    UP000002640    UP000252519    UP000028582    UP000053864    UP000285624    UP000285883    UP000054423    UP000054532    UP000018958    UP000018817    UP000018948    UP000053236    UP000018721    UP000052943    UP000007110    UP000036681    UP000005238    UP000198211    UP000054928    UP000077448    UP000271087    UP000216624    UP000245300    UP000221080    UP000216463    UP000006643    UP000001940    UP000011712    UP000050760    UP000095282    UP000277300    UP000284657    UP000076858    UP000030746    UP000008225   

PRIDE

H9JUB6    H9JUB7   

Pfam

PF17189   Glyco_hydro_30C        + More
PF02055   Glyco_hydro_30

Interpro

IPR017853   Glycoside_hydrolase_SF        + More
IPR033453   Glyco_hydro_30_TIM-barrel       
IPR033452   GH30_C       
IPR013780   Glyco_hydro_b       
IPR001139   Glyco_hydro_30       

SUPFAM

SSF51445   SSF51445       

Gene 3D

2.60.40.1180    

ProteinModelPortal

A0A2H1VA54   A0A194Q614   A0A194RBR5   A0A212F349   A0A212EPK9   H9JUB6   + More
A0A2S2P4H2   A0A1W1EGM7   J9L5B0   A0A0N1IF15   A0A0N1INL2   A0A067QM95   A0A2A4K8P8   A0A2P8YXD8   A0A329T258   A0A2J7R6J1   G4ZEC3   A0A368H792   A0A081ANK6   W2JGX1   A0A3R7HCU5   W2NS50   W2JGV9   W2XHH3   W2QGT2   W2ZQX7   W2H8M4   W2H8L5   V9FMS3   A0A0W8D288   W4Z0W5   A0A212F254   G5A8P3   A0A0M3HW45   A0A329T209   A0A329T1T2   H3GW35   A0A1Y3B8N5   H3GW34   G4ZEB8   V9LBE0   A0A225WKD5   W2QN93   A0A329SI21   V9FRQ0   W2XM40   A0A081AVG3   W2LSY8   A0A0W8D122   W2ZX75   H3G7N0   W4YPC5   G4ZEB9   A0A0P5P886   A0A023GIV4   A0A0N7L536   A0A2H1VUS0   A0A182EXL9   A0A261A234   S4RMS8   W5ULT4   A0A2D0R7B2   A0A260ZP45   D0N0V3   G5ECR8-4   H9JUB7   F1L2Y4   A0A0P5L6K4   A0A3P6NZ05   M3VVL7   A0A183CWR4   A0A1I7V4N9   A0A2G9U3J6   A0A337SNL3   A0A225WW95   W2JP47   A0A3F2RCM9   A0A0D6M7G3   A0A0B1TDP7   A0A3R7H2D6   A0A0P5GMD5   A0A2G9U5T9   W2HHH0   A0A0P5BVB7   A0A0P5BV77   A0A2P4WZX2   A0A0C9QXG4   A0A162QRA1   D0P1U3   A0A2H1VG50   A0A0P5E3J3   V4B2P4   U3DTR8   A0A0P5WGR1   F7E7C1  

PDB

2XWE     E-value=5.35445e-28,     Score=303

KEGG

101741392    K01201 glucosylceramidase [EC:3.2.1.45] | (RefSeq) glucosylceramidase-like

GO

GO:0006665   GO:0004348   GO:0016787   GO:0006680   GO:0016021   GO:0036268   GO:0030278   GO:0070050   GO:0005623   GO:0032436   GO:0032715   GO:0005615   GO:0009267   GO:0043202   GO:0030259   GO:0071356   GO:0005124   GO:1904457   GO:0046513   GO:1904925   GO:0008203   GO:0050295   GO:0005783   GO:0046512   GO:0032463   GO:0007040   GO:0043243   GO:0005765   GO:1905037   GO:1903061   GO:0023021   GO:0005802   GO:0046527   GO:0035307   GO:0032006   GO:0043407   GO:1901215   GO:0005975   GO:0008236   GO:0016020   GO:0005524   GO:0006412   GO:0016876   GO:0043039  

PANTHER

PTHR11069  

Length:

142

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.00205

Exp number, first 60 AAs:

0.00065

Total prob of N-in:

0.00864

outside

1  -  142

 

 

Pi

17.762122

Theta

17.727465

Tajima's D

0.007775

CLR

0.006249

CSRT

0.384180790960452

Interpretation

Uncertain