Gene

KWMTBOMO08021

Pre Gene Modal

BGIBMGA001024

Annotation

PREDICTED:_transmembrane_and_TPR_repeat-containing_protein_CG4050_[Plutella_xylostella]

Location

Bomo_Chr13(+):12860805-12998305      View in EpiBrowser

Full name

Protein O-mannosyl-transferase TMTC3      

Alternative Name

Transmembrane and TPR repeat-containing protein CG4050

Location in the cell

PlasmaMembrane   Reliability : 1.668

CDS

ATGTTCCTACCGGAGTTCGCAAGTTTCGTCGCCGCCATCTTGTTCGCCGTGCATCCGATTCACACCGAAGCGGTTACGGGTGTAGTGGGAAGAGCCGAGATGTTGTCATCGCTTTTTTTCCTCGGAGCGCTCCTTTGTTATGCCAAAGCTGCTAATAGGCGAAGAAATACAGATTGGCGCTACGTGGCTGCGTGCACTGCATGCGTGGGCATCGCAATGCTATGCAAGGAACAAGGCATTACTGTTACCGGAGTGTGTGTGGTCTACGAACTATTAGTCGCACAAAAGCGTCGAAGCGCCACCGGCGAAAGCCGCTGGTCGTGGATGGACGCCTGGGGTAAAGGCTCCGGTTGGGGTTGCGCCTGTGGCGAGGCTGCTCGAAGGGTCGCCACAGTTTGTTGCGCTACGTTAGCGTTGCTGGCCGCGAGGTTACACGTTATGGGCGCTCAGCTGCCAGTGTTCACCAGATTCGACAATCCGGCCGGAGCGGCACCTGGTCCGACTAGACACTTGACCTTCGCCTATTTACCGGCGTTGAATGCTTGGCTCTTGGCATTACCCGAAGCCTTATGCTGCGACTGGACCATGGGCACCGTAGCTCTGGTCAAATCGTGGCGAGATCCTCGGAACGTCGCCACGTTGGCGTTAGCTGCAGTTCTCGTTGCCGCGGCTATTCATGCCTTGCGTACAAGATGTTCCGCCTTATCCATGGGTCTGGCTTTGCTAGTCTTACCTTTCTTGCCAGCGTCTAACCTTTTCTTTCCCGTGGGTTTCGTGGTGGCCGAACGAGTTCTTTATATGCCTTCGATGGGTTGGTGCTTGTTGGTCGCACACGGATGGAGAATAGTCGCGCAAAGCCGAGCCAAACTGGCTGCGGCCGCTCTCATATTTCTCCTTCTGGCGTTCAGTGCCAAAACGTACATGAGAAACTGGGATTGGAAGACTGAATATTCCATCTTCGCCTCCGGGTTAAAGGTAAATCGGTTCAATGCCAAATTGTACAACAACGTTGGACACGCTTTGGAAGCCGAAGGTAAATATTCCGAAGCGTTGGACTTCTTCAACACCGCAGTGAGCGTACAACCCGATGACGTAGGGGCCCATATCAACGTGGGCCGAACTTACAACCATTTAGGCAGATACCAGGAAGCCGAAGATGCCTACGTGAAAGCGAAGTCGTTGCTACCGAAAGCGAAACCCGGTGAATCGTACCAAGCCAGGATAGCGCCCAACCATTTGAACGTCTTCCTCAATCTGGCCAACTTAATATCTAAGAACGCAACGAGGCTGGAGGAGGCTGACATGCTGTACCGACAAGCGATCAGCATGAGGGCCGATTACACTCAAGCTTATATAAATCGAGGGGATATTCTGATCAAATTGAACAGGACAAAAGAAGCGCAGGAGGTTTACGAACGCGCCCTATTGTACGACAGCGGAAACCCGGACATTTACTATAACTTGGGAGTTGTCCTTCTAGAACAAGGGAAGGCGTCCCAAGCTCTCGCGTACTTGGACAAGGCATTAGAACTTGAACCGGAACACGAGCAGGCTCTGTTGAATTCCGCCATACTCCTGCAAGAATTGGGAGCTGCTGATCTAAGGCATCTGGCCAGGCAGCGACTGCTGAAACTACTCGATAAGGACGCTACCAACGAACGCGTGCACTTCAATTTGGGCATGGTGTGTATGGACGAGGGCGACGCGGAGTGCGCCGAGCGCTGGTTCCGGGCGGCCGTTCACCTCAAGCCCGACTTCCGGTCGGCGCTATTCAACCTGGCGCTGCTGCTCGCGGACCGCCGCCGCCCCTTGGAGGCCGCCCCGTTTTTGAAACAGCTCGTCCGACACCACCCGGACCACGTGAAGGCGCTCGTACTACTCGGCGACATTTACATCAATTCCGTGAAGGACTTGGACGCGGCCGAGAGCTGCTACCGTCGCATACTGGAGTTAGAGCCGGACAACGTGCAGGCCTTGCACAACCTTTGCGTGGTGGCCGTCGAGCGCGGGAAGCTCGCAGTTGCCGAGGAGTGCCTCACCAGGGCGGCAGCGCTCGCTCCTCACGAACACTACATACAGCGACATCTCGCGGTCGTGAAAGCGAGACGGGCAGCTAACACTTCTGTCCCCTCGAAGTCGGAACCGCCCGCACCCACCGCCACCACTGAGGTGCGAGCGAGATGGAACTACATCCCGCAGCAACCCCCCGATCCACACGAGACTGACGCGTCATAG

Protein

MFLPEFASFVAAILFAVHPIHTEAVTGVVGRAEMLSSLFFLGALLCYAKAANRRRNTDWRYVAACTACVGIAMLCKEQGITVTGVCVVYELLVAQKRRSATGESRWSWMDAWGKGSGWGCACGEAARRVATVCCATLALLAARLHVMGAQLPVFTRFDNPAGAAPGPTRHLTFAYLPALNAWLLALPEALCCDWTMGTVALVKSWRDPRNVATLALAAVLVAAAIHALRTRCSALSMGLALLVLPFLPASNLFFPVGFVVAERVLYMPSMGWCLLVAHGWRIVAQSRAKLAAAALIFLLLAFSAKTYMRNWDWKTEYSIFASGLKVNRFNAKLYNNVGHALEAEGKYSEALDFFNTAVSVQPDDVGAHINVGRTYNHLGRYQEAEDAYVKAKSLLPKAKPGESYQARIAPNHLNVFLNLANLISKNATRLEEADMLYRQAISMRADYTQAYINRGDILIKLNRTKEAQEVYERALLYDSGNPDIYYNLGVVLLEQGKASQALAYLDKALELEPEHEQALLNSAILLQELGAADLRHLARQRLLKLLDKDATNERVHFNLGMVCMDEGDAECAERWFRAAVHLKPDFRSALFNLALLLADRRRPLEAAPFLKQLVRHHPDHVKALVLLGDIYINSVKDLDAAESCYRRILELEPDNVQALHNLCVVAVERGKLAVAEECLTRAAALAPHEHYIQRHLAVVKARRAANTSVPSKSEPPAPTATTEVRARWNYIPQQPPDPHETDAS

Description

Transfers mannosyl residues to the hydroxyl group of serine or threonine residues.

Catalytic Activity

dolichyl beta-D-mannosyl phosphate + L-seryl-[protein] = 3-O-(alpha-D-mannosyl)-L-seryl-[protein] + dolichyl phosphate + H(+)
dolichyl beta-D-mannosyl phosphate + L-threonyl-[protein] = 3-O-(alpha-D-mannosyl)-L-threonyl-[protein] + dolichyl phosphate + H(+)

Similarity

Belongs to the TMTC family.

Keywords

Complete proteome   Endoplasmic reticulum   Glycoprotein   Membrane   Reference proteome   Repeat   TPR repeat   Transferase   Transmembrane   Transmembrane helix  

Feature

chain  Protein O-mannosyl-transferase TMTC3

Uniprot

H9IUU4   A0A194Q7J7   A0A194RH60   A0A2H1VP12   A0A212F329   A0A1W4X7D0   + More
A0A0T6B9B0   A0A1Y1MZA3   D1ZZM8   A0A087ZXM0   A0A1Y1MZA5   A0A151IJE7   A0A195ECP6   E2BZ92   A0A158NY64   K7IYU1   A0A195EV02   A0A195AZT2   E2AXX3   A0A026WJF4   A0A1B6CC38   A0A1B6L999   A0A0L7R8N4   A0A0C9RE72   A0A1B6F0B4   A0A1B6JSP7   A0A0V0G6Y8   T1HMF2   A0A224XJU4   E9J0P2   E0VDN7   A0A0N1IU94   A0A146L2T0   A0A0A9XE34   A0A232ESA3   A0A2A3EC51   U4UDB0   A0A1J1HF50   J9JZ49   A0A2H8TF53   A0A2S2R6V2   A0A310SKP5   A0A1Y9GLF6   A0A164PQ75   A0A2R5LEI4   A0A0N8AEJ6   V9IB44   A0A0J7NZC1   A0A2P2HX23   A0A0N8AGA7   A0A0P5ISW0   A0A0N8BLU3   A0A1D2N4K5   A0A034VHM9   A0A0P5UL86   A0A0P6IJU7   A0A147BMG7   A0A0M3QUR2   A0A224Z242   A0A0P5WAK1   B4LMR8   T1J5F2   A0A0A1WKU4   A0A3B0J1P0   A0A0J9RJ04   Q28X17   B3MDU2   B4QFM3   B3NJY1   E2QCJ5   B4P9H7   Q7K4B6   B4MKC8   B4I7K0   A0A336KWY0   A0A182QTG0   B4KNB0   W8BJJ3   A0A1A9UVB9   A0A1W4VI06   A0A1B0ACW3   A0A1B0FAZ2   A0A1A9YBE8   A0A1B0B2G1   A0A182IMN2   B4J6R6   A0A0K2TUB6   A0A084WI12   E9H3D7   A0A0K8W6E4   A0A0P5VCQ0   A0A0K8VW81   T1ITR6   A0A2M4DSF7   C3Y7I3   N6TXE2   N6UID8   A0A1S3KH78   B4H4W9  

EC Number

2.4.1.109

Pubmed

19121390    26354079    22118469    28004739    18362917    19820115    + More
20798317    21347285    20075255    24508170    30249741    21282665    20566863    26823975    25401762    28648823    23537049    27289101    25348373    29652888    28797301    17994087    25830018    22936249    15632085    23185243    10731132    12537568    12537572    12537573    12537574    16110336    17569856    17569867    17550304    12537569    18057021    24495485    24438588    21292972    18563158   

EMBL

BABH01000476    KQ459439    KPJ00970.1    KQ460397    KPJ15271.1    ODYU01003599    + More
SOQ42570.1    AGBW02010629    OWR48148.1    LJIG01009021    KRT83914.1    GEZM01016973    JAV91001.1    KQ971338    EFA01829.1    GEZM01016975    GEZM01016974    GEZM01016972    JAV91002.1    KQ977355    KYN03315.1    KQ979074    KYN22995.1    GL451577    EFN78998.1    ADTU01003242    ADTU01003243    KQ981958    KYN31981.1    KQ976692    KYM77748.1    GL443736    EFN61737.1    KK107168    QOIP01000001    EZA56172.1    RLU26770.1    GEDC01026349    GEDC01018947    JAS10949.1    JAS18351.1    GEBQ01019695    JAT20282.1    KQ414631    KOC67242.1    GBYB01011447    JAG81214.1    GECZ01026070    JAS43699.1    GECU01005482    GECU01003515    JAT02225.1    JAT04192.1    GECL01003037    JAP03087.1    ACPB03002866    ACPB03002867    GFTR01008125    JAW08301.1    GL767538    EFZ13549.1    DS235083    EEB11493.1    KQ435689    KOX81252.1    GDHC01015931    JAQ02698.1    GBHO01024632    JAG18972.1    NNAY01002462    OXU21234.1    KZ288288    PBC29315.1    KB632308    ERL91949.1    CVRI01000001    CRK86591.1    ABLF02028572    ABLF02028580    ABLF02028583    ABLF02028584    GFXV01000113    MBW11918.1    GGMS01016227    MBY85430.1    KQ763581    OAD54935.1    APCN01005549    APCN01005550    APCN01005551    APCN01005552    LRGB01002580    KZS07045.1    GGLE01003780    MBY07906.1    GDIP01155169    JAJ68233.1    JR037029    JR037030    AEY57539.1    AEY57540.1    LBMM01000691    KMQ97745.1    IACF01000567    LAB66333.1    GDIP01150281    JAJ73121.1    GDIQ01209439    JAK42286.1    GDIQ01165115    JAK86610.1    LJIJ01000224    ODN00207.1    GAKP01017692    JAC41260.1    GDIP01113643    JAL90071.1    GDIQ01005234    JAN89503.1    GEGO01003417    JAR91987.1    CP012524    ALC41109.1    GFPF01012772    MAA23918.1    GDIP01088835    JAM14880.1    CH940648    EDW61009.1    JH431861    GBXI01015428    GBXI01015152    JAC98863.1    JAC99139.1    OUUW01000001    SPP74875.1    CM002911    KMY95444.1    KMY95445.1    CM000071    EAL26499.2    KRT03142.1    CH902619    EDV36477.2    CM000362    EDX08015.1    CH954179    EDV55409.1    AE013599    AAM70854.1    CM000158    EDW91297.1    KRJ99775.1    AY052013    X92653    CH963846    EDW72567.1    CH480824    EDW56575.1    UFQS01001151    UFQT01001151    SSX09254.1    SSX29156.1    AXCN02001045    CH933808    EDW09963.1    KRG05011.1    GAMC01016771    GAMC01016770    JAB89784.1    CCAG010012974    JXJN01007633    CH916367    EDW00969.1    HACA01012272    CDW29633.1    ATLV01023902    KE525347    KFB49856.1    GL732588    EFX73796.1    GDHF01022013    GDHF01005618    JAI30301.1    JAI46696.1    GDIP01101580    JAM02135.1    GDHF01009180    GDHF01002154    JAI43134.1    JAI50160.1    JH431494    GGFL01016281    MBW80459.1    GG666489    EEN63811.1    APGK01010396    APGK01010397    APGK01010398    APGK01010399    APGK01010400    APGK01010401    KB738183    ENN82738.1    APGK01022962    APGK01022963    APGK01022964    APGK01022965    APGK01022966    APGK01022967    APGK01024417    APGK01024418    APGK01024419    APGK01024420    APGK01024421    APGK01024422    APGK01030142    APGK01030143    APGK01030144    APGK01030145    APGK01030146    KB740760    KB740545    KB740455    ENN79047.1    ENN80406.1    ENN80625.1    CH479210    EDW32805.1   

Proteomes

UP000005204    UP000053268    UP000053240    UP000007151    UP000192223    UP000007266    + More
UP000005203    UP000078542    UP000078492    UP000008237    UP000005205    UP000002358    UP000078541    UP000078540    UP000000311    UP000053097    UP000279307    UP000053825    UP000015103    UP000009046    UP000053105    UP000215335    UP000242457    UP000030742    UP000183832    UP000007819    UP000075840    UP000076858    UP000036403    UP000094527    UP000092553    UP000008792    UP000268350    UP000001819    UP000007801    UP000000304    UP000008711    UP000000803    UP000002282    UP000007798    UP000001292    UP000075886    UP000009192    UP000078200    UP000192221    UP000092445    UP000092444    UP000092443    UP000092460    UP000075880    UP000001070    UP000030765    UP000000305    UP000001554    UP000019118    UP000085678    UP000008744   

PRIDE

H9IUU4    E2QCJ5    Q7K4B6   

Pfam

PF08409   DUF1736        + More
PF13181   TPR_8
PF13231   PMT_2
PF13174   TPR_6
PF00515   TPR_1
PF07719   TPR_2

Interpro

IPR013026   TPR-contain_dom        + More
IPR019734   TPR_repeat       
IPR011990   TPR-like_helical_dom_sf       
IPR013618   DUF1736       
IPR038731   RgtA/B/C-like       
IPR001440   TPR_1       
IPR013105   TPR_2       

SUPFAM

SSF48452   SSF48452       

Gene 3D

1.25.40.10    

ProteinModelPortal

H9IUU4   A0A194Q7J7   A0A194RH60   A0A2H1VP12   A0A212F329   A0A1W4X7D0   + More
A0A0T6B9B0   A0A1Y1MZA3   D1ZZM8   A0A087ZXM0   A0A1Y1MZA5   A0A151IJE7   A0A195ECP6   E2BZ92   A0A158NY64   K7IYU1   A0A195EV02   A0A195AZT2   E2AXX3   A0A026WJF4   A0A1B6CC38   A0A1B6L999   A0A0L7R8N4   A0A0C9RE72   A0A1B6F0B4   A0A1B6JSP7   A0A0V0G6Y8   T1HMF2   A0A224XJU4   E9J0P2   E0VDN7   A0A0N1IU94   A0A146L2T0   A0A0A9XE34   A0A232ESA3   A0A2A3EC51   U4UDB0   A0A1J1HF50   J9JZ49   A0A2H8TF53   A0A2S2R6V2   A0A310SKP5   A0A1Y9GLF6   A0A164PQ75   A0A2R5LEI4   A0A0N8AEJ6   V9IB44   A0A0J7NZC1   A0A2P2HX23   A0A0N8AGA7   A0A0P5ISW0   A0A0N8BLU3   A0A1D2N4K5   A0A034VHM9   A0A0P5UL86   A0A0P6IJU7   A0A147BMG7   A0A0M3QUR2   A0A224Z242   A0A0P5WAK1   B4LMR8   T1J5F2   A0A0A1WKU4   A0A3B0J1P0   A0A0J9RJ04   Q28X17   B3MDU2   B4QFM3   B3NJY1   E2QCJ5   B4P9H7   Q7K4B6   B4MKC8   B4I7K0   A0A336KWY0   A0A182QTG0   B4KNB0   W8BJJ3   A0A1A9UVB9   A0A1W4VI06   A0A1B0ACW3   A0A1B0FAZ2   A0A1A9YBE8   A0A1B0B2G1   A0A182IMN2   B4J6R6   A0A0K2TUB6   A0A084WI12   E9H3D7   A0A0K8W6E4   A0A0P5VCQ0   A0A0K8VW81   T1ITR6   A0A2M4DSF7   C3Y7I3   N6TXE2   N6UID8   A0A1S3KH78   B4H4W9  

PDB

1W3B     E-value=1.10694e-15,     Score=206

KEGG

101741533    K23424 protein O-mannosyl-transferase [EC:2.4.1.-] | (RefSeq) transmembrane and TPR repeat-containin

GO

GO:0016021   GO:0016740   GO:0005783   GO:0000030   GO:0035269   GO:0004169   GO:0005515   GO:0006508   GO:0008233   GO:0016020   GO:0005524   GO:0006412   GO:0016876   GO:0043039  

Subcellular location

Membrane  
Endoplasmic reticulum  

SignalP

Position:   1 - 24,         Likelihood:  0.533350

 

 

Length:

744

Number of predicted TMHs:

5

Exp number of AAs in TMHs:

117.54205

Exp number, first 60 AAs:

29.52608

Total prob of N-in:

0.47130

POSSIBLE N-term signal

sequence

inside

1  -  6

TMhelix

7  -  29

outside

30  -  33

TMhelix

34  -  51

inside

52  -  210

TMhelix

211  -  228

outside

229  -  237

TMhelix

238  -  260

inside

261  -  289

TMhelix

290  -  307

outside

308  -  744

 

 

Pi

24.047772

Theta

21.243985

Tajima's D

0.273501

CLR

0.781551

CSRT

0.459127043647818

Interpretation

Uncertain