Gene

KWMTBOMO08020

Pre Gene Modal

BGIBMGA001022

Annotation

PREDICTED:_CD9_antigen_[Papilio_machaon]

Location

Bomo_Chr13(+):12785255-12807253      View in EpiBrowser

Full name

Tetraspanin       + More
Tetraspanin-2A      

Location in the cell

PlasmaMembrane   Reliability : 4.962

CDS

ATGGCTGGCGGACAAGGACCCGTGGTCGGGAAACTGGAATCCCAGATTTATTGTATAAAATACACGCTGTTTTGCTTCAACGTCGTTCTCTGGTTGTTTGGCGTATCGGTATTCGCACTATGTCTCTGGATTTGCTTCGAGCCCGGCTTCAATGAATGGATGAGGATCCTAGAACTACAGAAGTACTTCATCGGTATCTACATTATGCTCATTGCCTCTTTGGGCATCATGGTGGTCGCGTTCCTCGGATGCGGGTCGGCACTGATGGAAAACGTAACACTTTTATACGGTTACATTGGGTCACAGTTAGCTTTGTTTGTGTTTGGGCTGATCGGGGCATGCGTGGTGCTTGACTTTTCGACCTATGACTCCAGTATTCAACCCCTCATCAGAAATGTAATTGTGCGGCTGATAAATAACCCTCAACATGACGGCAGCAGGGAGATTCTCAGAATGGTCCAAGAAGGGATCGGTTGCTGCGGTGCAGACGGGCCCATGGACTACATCAATCTGAACAAGCCCCTACCGTCCGAATGCCGTGATTCAGTAACCGGCAACGCATATTTCCACGGCTGCGTCGATGAAATGACTTGGTACTTAGAAGGAAAGACCGGTTGGCTAGCTGGCATTGTGTTGGCATCTTGCATGGTTTCTATAATTAACGCAGTCATGTCTTTAGTCCTTATCCAAGCTGTGAAGAAAGAAGAAGATGAAGCTATAGTATACAAATGA

Protein

MAGGQGPVVGKLESQIYCIKYTLFCFNVVLWLFGVSVFALCLWICFEPGFNEWMRILELQKYFIGIYIMLIASLGIMVVAFLGCGSALMENVTLLYGYIGSQLALFVFGLIGACVVLDFSTYDSSIQPLIRNVIVRLINNPQHDGSREILRMVQEGIGCCGADGPMDYINLNKPLPSECRDSVTGNAYFHGCVDEMTWYLEGKTGWLAGIVLASCMVSIINAVMSLVLIQAVKKEEDEAIVYK

Description

Required for assembly of smooth septate junctions (sSJs), together with Ssk and mesh. Important for barrier function of the midgut epithelium.

Subunit

Forms a complex with Ssk and mesh.

Similarity

Belongs to the tetraspanin (TM4SF) family.

Keywords

Cell junction   Cell membrane   Complete proteome   Membrane   Reference proteome   Transmembrane   Transmembrane helix  

Feature

chain  Tetraspanin-2A

Uniprot

A0A194RBQ4   A0A194Q603   A0A212FNJ7   A0A2H1WCH7   H9IUU2   A0A0L7LKU7   + More
A0A232F1Z7   A0A1L8DJV0   K7J2U1   A0A1B0DGB0   A0A088A8X8   A0A0L7QYE6   E2B773   A0A0M8ZVF9   B4L3W1   A0A026WG38   A0A1I8MD72   A0A158NEQ9   B4M3J8   Q29IZ2   B4GTN1   A0A1A9ZEQ3   A0A0R3P3K0   A0A1I8Q5I5   A0A034WSS2   A0A2A3E4A0   A0A1W4VF34   A0A0K8VM41   B4PXN4   O46101   A0A3B0JW11   B3MRE8   B4NTU2   B4I9C5   A0A1Y1NBM0   A0A0A1WZU1   A0A195CR41   B4JLB1   F4WRN7   A0A0L0CPK3   B4N1T5   A0A195DZP9   A0A1S4EXC3   B3P9G6   A0A182HFP2   A0A1A9VCR9   A0A0M4ESA4   A0A1L8EHY0   W8BUX6   A0A1Q3FUM0   A0A084WI25   A0A1L8DJL3   E2A155   A0A0J7P0M8   E9IA99   A0A195FLR9   A0A336LYH5   A0A195AV52   T1PJ11   A0A1J1HF35   A0A151XIV3   A0A2P8YFI9   A0A1L8E9K8   A0A1A9WCN0   A0A023F7S3   A0A224XRT9   A0A182J4B4   A0A0P4VU49   R4FK66   A0A0A9VZ36   A0A182P8F1   A0A067R289   A0A1B6MVH2   E0VDN9   A0A182Q5J3   R4WKS3   A0A1B6HWJ6   A0A2S2NJZ2   A0A171BBI0   A0A2S2R619   A0A2H8TJY5   A0A336LVI3   X1WIV8   A0A0P5WTI2   A0A0P5V0R9   A0A0P5YUQ0   A0A0P5TWT6   A0A0P5JF36   A0A0P5ERT3  

Pubmed

26354079    22118469    19121390    26227816    28648823    20075255    + More
20798317    17994087    18057021    24508170    30249741    25315136    21347285    15632085    25348373    17550304    10731132    12537572    10731137    26848177    28004739    25830018    21719571    26108605    24495485    24438588    21282665    29403074    25474469    27129103    25401762    26823975    24845553    20566863    23691247   

EMBL

KQ460397    KPJ15268.1    KQ459439    KPJ00968.1    AGBW02005338    OWR55293.1    + More
ODYU01007739    SOQ50781.1    BABH01000495    JTDY01000735    KOB76060.1    NNAY01001280    OXU24509.1    GFDF01007439    JAV06645.1    AJVK01033607    KQ414693    KOC63571.1    GL446149    EFN88434.1    KQ435827    KOX71945.1    CH933810    EDW07239.1    KK107260    QOIP01000001    EZA54004.1    RLU27364.1    ADTU01013611    CH940651    EDW65373.1    CH379063    EAL32511.1    CH479190    EDW25901.1    KRT06101.1    GAKP01000331    JAC58621.1    KZ288379    PBC26557.1    GDHF01012396    JAI39918.1    CM000162    EDX00887.1    AE014298    AL022018    BT014915    AAT47766.1    CAA17687.1    OUUW01000011    SPP86265.1    CH902622    EDV34353.1    CH983330    EDX16361.1    CH480825    EDW43806.1    GEZM01007288    JAV95263.1    GBXI01010121    JAD04171.1    KQ977381    KYN03171.1    CH916370    EDW00364.1    GL888292    EGI63044.1    JRES01000104    KNC34102.1    CH963925    EDW78324.1    KQ979999    KYN18306.1    CH954183    EDV45462.1    APCN01005558    APCN01005559    APCN01005560    CP012528    ALC49152.1    GFDG01000590    JAV18209.1    GAMC01003578    JAC02978.1    GFDL01003859    JAV31186.1    ATLV01023909    KE525347    KFB49869.1    GFDF01007442    JAV06642.1    GL435707    EFN72822.1    LBMM01000509    KMQ98185.1    GL761997    EFZ22499.1    KQ981490    KYN41276.1    UFQT01000227    SSX22061.1    KQ976736    KYM76123.1    KA647903    AFP62532.1    CVRI01000001    CRK86592.1    KQ982080    KYQ60245.1    PYGN01000638    PSN43003.1    GFDG01003500    JAV15299.1    GBBI01001429    JAC17283.1    GFTR01003888    JAW12538.1    GDKW01002254    JAI54341.1    ACPB03015041    GAHY01002003    JAA75507.1    GBHO01042735    GBRD01010932    GDHC01018038    JAG00869.1    JAG54892.1    JAQ00591.1    KK852761    KDR17014.1    GEBQ01000051    JAT39926.1    DS235083    EEB11495.1    AXCN02001046    AK418215    BAN21430.1    GECU01028648    JAS79058.1    GGMR01004858    MBY17477.1    GEMB01000028    JAS03080.1    GGMS01016304    MBY85507.1    GFXV01002486    MBW14291.1    SSX22062.1    ABLF02038439    ABLF02038444    ABLF02038445    ABLF02038448    ABLF02038449    ABLF02038457    ABLF02038458    ABLF02038459    ABLF02038465    ABLF02038469    GDIP01082016    JAM21699.1    GDIP01122459    JAL81255.1    GDIP01053125    JAM50590.1    GDIP01120707    JAL83007.1    GDIQ01203422    JAK48303.1    GDIQ01265399    JAJ86325.1   

Proteomes

UP000053240    UP000053268    UP000007151    UP000005204    UP000037510    UP000215335    + More
UP000002358    UP000092462    UP000005203    UP000053825    UP000008237    UP000053105    UP000009192    UP000053097    UP000279307    UP000095301    UP000005205    UP000008792    UP000001819    UP000008744    UP000092445    UP000095300    UP000242457    UP000192221    UP000002282    UP000000803    UP000268350    UP000007801    UP000000304    UP000001292    UP000078542    UP000001070    UP000007755    UP000037069    UP000007798    UP000078492    UP000008711    UP000075840    UP000078200    UP000092553    UP000030765    UP000000311    UP000036403    UP000078541    UP000078540    UP000183832    UP000075809    UP000245037    UP000091820    UP000075880    UP000015103    UP000075885    UP000027135    UP000009046    UP000075886    UP000007819   

PRIDE

H9IUU2    O46101   

Pfam

PF00335   Tetraspanin

Interpro

IPR008952   Tetraspanin_EC2_sf        + More
IPR018499   Tetraspanin/Peripherin       
IPR000301   Tetraspanin       
IPR036408   PSI_PsaA/B_sf       
IPR018503   Tetraspanin_CS       

SUPFAM

SSF48652   SSF48652        + More
SSF81558   SSF81558       

Gene 3D

1.10.1450.10    

ProteinModelPortal

A0A194RBQ4   A0A194Q603   A0A212FNJ7   A0A2H1WCH7   H9IUU2   A0A0L7LKU7   + More
A0A232F1Z7   A0A1L8DJV0   K7J2U1   A0A1B0DGB0   A0A088A8X8   A0A0L7QYE6   E2B773   A0A0M8ZVF9   B4L3W1   A0A026WG38   A0A1I8MD72   A0A158NEQ9   B4M3J8   Q29IZ2   B4GTN1   A0A1A9ZEQ3   A0A0R3P3K0   A0A1I8Q5I5   A0A034WSS2   A0A2A3E4A0   A0A1W4VF34   A0A0K8VM41   B4PXN4   O46101   A0A3B0JW11   B3MRE8   B4NTU2   B4I9C5   A0A1Y1NBM0   A0A0A1WZU1   A0A195CR41   B4JLB1   F4WRN7   A0A0L0CPK3   B4N1T5   A0A195DZP9   A0A1S4EXC3   B3P9G6   A0A182HFP2   A0A1A9VCR9   A0A0M4ESA4   A0A1L8EHY0   W8BUX6   A0A1Q3FUM0   A0A084WI25   A0A1L8DJL3   E2A155   A0A0J7P0M8   E9IA99   A0A195FLR9   A0A336LYH5   A0A195AV52   T1PJ11   A0A1J1HF35   A0A151XIV3   A0A2P8YFI9   A0A1L8E9K8   A0A1A9WCN0   A0A023F7S3   A0A224XRT9   A0A182J4B4   A0A0P4VU49   R4FK66   A0A0A9VZ36   A0A182P8F1   A0A067R289   A0A1B6MVH2   E0VDN9   A0A182Q5J3   R4WKS3   A0A1B6HWJ6   A0A2S2NJZ2   A0A171BBI0   A0A2S2R619   A0A2H8TJY5   A0A336LVI3   X1WIV8   A0A0P5WTI2   A0A0P5V0R9   A0A0P5YUQ0   A0A0P5TWT6   A0A0P5JF36   A0A0P5ERT3  

PDB

5TCX     E-value=2.7942e-09,     Score=145

KEGG

101741490    no KO assigned | (RefSeq) CD9 antigen

GO

GO:0016021   GO:0090557   GO:0090528   GO:0005920   GO:0016327   GO:0061028   GO:0006508   GO:0008233   GO:0016020   GO:0005524   GO:0006412   GO:0016876   GO:0043039  

Subcellular location

Membrane  
Apicolateral cell membrane  
Cell junction  
Septate junction  

Length:

243

Number of predicted TMHs:

4

Exp number of AAs in TMHs:

91.0195000000001

Exp number, first 60 AAs:

22.93755

Total prob of N-in:

0.86110

POSSIBLE N-term signal

sequence

inside

1  -  20

TMhelix

21  -  43

outside

44  -  62

TMhelix

63  -  85

inside

86  -  93

TMhelix

94  -  116

outside

117  -  205

TMhelix

206  -  228

inside

229  -  243

 

 

Pi

23.72907

Theta

21.353501

Tajima's D

0.485609

CLR

0.849275

CSRT

0.516774161291935

Interpretation

Uncertain