Gene

KWMTBOMO08016  Validated by peptides from experiments

Annotation

cocoonase_precursor_[Bombyx_mori]

Location

Bomo_Chr13(+):12448811-12454520      View in EpiBrowser

Full name

Trypsin 3A1      

Location in the cell

Extracellular   Reliability : 4.027

CDS

ATGGAAAAGTTGTATCTGTTTATTGTTTTTCTTTCATGTGCCTTATTACTGAAAGATGTTACATGTACGGATTCTGAGGCGTTATCCAAAGACGAGGAAAAGATTGTAGGAGGCGAAGAGATTAGCATTAACAAAGTTCCGTACCAAGCGTATCTTTTGCTTCAAAAAGATAACGAATACTTCCAATGCGGAGGTTCGATTATTAGCAAACGTCACATCCTCACGGCGGCACATTGTATCGAAGGTATCTCCAAAGTAACGGTGCGTATCGGAAGCTCAAATTCTAATAAAGGAGGCACCGTTTATACAGCGAAATCAAAGGTGGCTCATCCGAAATACAATTCTAAAACTAAAAACAACGATTTCGCCATTGTCACTGTGAACAAAGACATGGCGATCGATGGAAAAACTACTAAAATCATTACTTTAGCCAAAGAAGGCTCTTCGGTTCCTGACAAAACGAAACTATTGGTTTCCGGGTGGGGAGCTACAAGCGAAGGTGGTTCATCAAGTACAACGCTAAGGGCTGTGCACGTTCAAGCTCATTCTGACGATGAATGCAAGAAATATTTCCGTAGTTTGACATCTAATATGTTCTGCGCTGGGCCCCCCGAAGGCGGAAAGGACTCCTGTCAGGGTGATTCCGGTGGTCCAGCTGTTAAGGGCAATGTCCAACTTGGTGTGGTCTCCTTTGGTGTCGGCTGCGCTCGCAAGAATAACCCTGGTATCTATGCTAAAGTAAGTGCTGCTGCAAAATGGATAAAATCAACGGCGGGCCTATAA

Protein

MEKLYLFIVFLSCALLLKDVTCTDSEALSKDEEKIVGGEEISINKVPYQAYLLLQKDNEYFQCGGSIISKRHILTAAHCIEGISKVTVRIGSSNSNKGGTVYTAKSKVAHPKYNSKTKNNDFAIVTVNKDMAIDGKTTKIITLAKEGSSVPDKTKLLVSGWGATSEGGSSSTTLRAVHVQAHSDDECKKYFRSLTSNMFCAGPPEGGKDSCQGDSGGPAVKGNVQLGVVSFGVGCARKNNPGIYAKVSAAAKWIKSTAGL

Description

Major function may be to aid in digestion of the blood meal.

Catalytic Activity

Preferential cleavage: Arg-|-Xaa, Lys-|-Xaa.

Similarity

Belongs to the peptidase S1 family.

Keywords

Alternative splicing   Complete proteome   Digestion   Disulfide bond   Hydrolase   Protease   Reference proteome   Secreted   Serine protease   Signal   Zymogen  

Feature

propeptide  Activation peptide
chain  Trypsin 3A1
splice variant  In isoform A.

Uniprot

A7TVD3   A7UNZ4   E5RVK3   A2TGR7   Q18NR4   D6QUQ4   + More
A0A3G2LYE2   A0A1B3TP20   A0A1B3TNZ9   A0A1B3TP02   A0A1B3TNW8   A0A1B3TNY5   A0A1B3TP23   A0A3G2LYM8   A0A1B3TNW7   A0A1B3TNY9   A0A1B3TNV7   A0A1B3TP21   A0A194R3X4   A0A3G2LYM4   A0A1B3TNX5   A0A1B3TNW3   A0A1B3TNY2   A0A1B3TNZ8   A0A3S2NEF5   A0A1B3TP00   A0A1B3TNY7   A0A1B3TP08   A0A194Q6G2   A0A1B3TNX6   A0A2A4IV60   A0A1B3TP15   A0A1B3TNZ7   A0A1B3TNV9   A0A1I8Q1B5   A0A1I8MQV4   A0A0J9QZW1   B3N7W6   P29786-2   E3NYI2   G9B5J2   G9B5F5   G9B5E6   G9B5G0   G9B5I6   P29786   G9B5H2   G9B5F7   G9B5F4   G9B5G5   G9B5E8   G9B5H4   G5DGE0   G9B5G4   A0A1L8DQF2   G9B5F2   G9B5J7   Q9VLF5   G9B5G7   G9B5I5   B3DMZ7   A0A1Q3FTA7   U5EZJ4   G9B5F1   B4HYU1   G9B5J8   G9B5E7   A8CW51   G9B5I9   B5AKB2   B8XY09   G9B5H5   G9B5E9   G9B5G8   B4NY05   G9B5I2   G9B5H9   G9B5H8   A0A2H4SAP8   A0A1B0DA37   A0A182GET7   G9B5F6   G9B5G1   G9B5F9   C5IB55   C5IB53   C5IB50   G3JB05   G9B5H1   G9B5J6   C5IB51   C5IB48   C5IB52   G9B5H7   A0A3B3D656   C5IB49   A0A182G8J0   G9B5I7   A0A1I8MB43   Q27J28  

EC Number

3.4.21.4

Pubmed

29298934    27553646    26354079    25315136    22936249    17994087    + More
9087545    17510324    22727120    10731132    12537568    12537572    12537573    12537574    16110336    17569856    17569867    26109357    26109356    18194529    17550304    29178836    26483478    19204376    22112802    29451363   

EMBL

EF428980    EU095343    ABR14241.1    ABU49588.1    EU095344    ABU49589.1    + More
AB604648    BAJ46146.1    EF199627    ABM88498.1    AB257565    BAE96354.1    HM011050    ADG26770.1    MG774893    AYN79048.1    KU925765    AOG75390.1    KU925753    AOG75378.1    KU925749    AOG75374.1    KU925716    AOG75341.1    KU925736    AOG75361.1    KU925769    AOG75394.1    MG774892    AYN79047.1    KU925725    AOG75350.1    KU925739    AOG75364.1    KU925715    AOG75340.1    KU925766    AOG75391.1    KQ460761    KPJ12508.1    MG774891    AYN79046.1    KU925724    AOG75349.1    KU925713    AOG75338.1    KU925737    AOG75362.1    KU925751    AOG75376.1    RSAL01000074    RVE48965.1    KU925750    AOG75375.1    KU925738    AOG75363.1    KU925754    AOG75379.1    KQ459439    KPJ00964.1    KU925726    AOG75351.1    NWSH01005899    PCG63857.1    KU925768    AOG75393.1    KU925752    AOG75377.1    KU925714    AOG75339.1    CM002910    KMY89204.1    CH954177    EDV58327.1    AF487426    AF508783    X64362    CH477469    EF672103    ABW17548.1    HM480752    AEI58598.1    HM480715    AEI58561.1    HM480706    AEI58552.1    HM480720    AEI58566.1    HM480743    HM480746    AEI58592.1    HM480732    AEI58578.1    HM480717    AEI58563.1    HM480714    HM480722    HM480723    HM480726    AEI58560.1    HM480725    AEI58571.1    HM480708    HM480729    AEI58554.1    HM480734    AEI58580.1    JN662341    AEQ55298.1    HM480724    AEI58570.1    GFDF01005376    JAV08708.1    HM480712    AEI58558.1    HM480757    AEI58603.1    AE014134    AAF52738.1    AHN54286.1    HM480727    AEI58573.1    HM480745    AEI58591.1    BT032785    BT032800    ACD81799.1    ACD81814.1    GFDL01004392    JAV30653.1    GANO01000688    JAB59183.1    HM480711    AEI58557.1    CH480818    EDW52221.1    HM480758    AEI58604.1    HM480707    AEI58553.1    AJWK01004381    AJWK01004382    EU124582    ABV60300.1    HM480749    AEI58595.1    EU855138    ACF72874.2    FJ458410    ACL37992.1    HM480735    AEI58581.1    HM480709    AEI58555.1    HM480728    AEI58574.1    CM000157    EDW88607.2    HM480736    HM480742    AEI58588.1    HM480739    AEI58585.1    HM480738    AEI58584.1    CP023323    ATY60163.1    AJVK01028773    JXUM01058532    KQ562007    KXJ76927.1    HM480716    AEI58562.1    HM480721    AEI58567.1    HM480719    AEI58565.1    FJ839170    ACR61226.1    FJ839168    ACR61224.1    FJ839165    ACR61221.1    JH126400    EGX95217.1    HM480731    AEI58577.1    HM480756    AEI58602.1    FJ839166    ACR61222.1    FJ839163    ACR61219.1    FJ839167    ACR61223.1    HM480737    AEI58583.1    FJ839164    FJ839169    FJ839172    ACR61220.1    ACR61225.1    ACR61228.1    JXUM01047815    KQ561534    KXJ78237.1    HM480747    AEI58593.1    DQ396618    ABD57312.1   

Proteomes

UP000053240    UP000283053    UP000053268    UP000218220    UP000095300    UP000095301    + More
UP000008711    UP000008820    UP000000803    UP000001292    UP000092461    UP000002282    UP000092462    UP000069940    UP000249989    UP000001610    UP000261560   

PRIDE

A7TVD3    E5RVK3    A2TGR7    Q18NR4    P29786    Q9VLF5    + More

Pfam

PF00089   Trypsin

Interpro

IPR018114   TRYPSIN_HIS        + More
IPR001254   Trypsin_dom       
IPR009003   Peptidase_S1_PA       
IPR001314   Peptidase_S1A       
IPR033116   TRYPSIN_SER       
IPR012224   Pept_S1A_FX       

SUPFAM

SSF50494   SSF50494       

CDD

cd00190  Tryp_SPc

ProteinModelPortal

A7TVD3   A7UNZ4   E5RVK3   A2TGR7   Q18NR4   D6QUQ4   + More
A0A3G2LYE2   A0A1B3TP20   A0A1B3TNZ9   A0A1B3TP02   A0A1B3TNW8   A0A1B3TNY5   A0A1B3TP23   A0A3G2LYM8   A0A1B3TNW7   A0A1B3TNY9   A0A1B3TNV7   A0A1B3TP21   A0A194R3X4   A0A3G2LYM4   A0A1B3TNX5   A0A1B3TNW3   A0A1B3TNY2   A0A1B3TNZ8   A0A3S2NEF5   A0A1B3TP00   A0A1B3TNY7   A0A1B3TP08   A0A194Q6G2   A0A1B3TNX6   A0A2A4IV60   A0A1B3TP15   A0A1B3TNZ7   A0A1B3TNV9   A0A1I8Q1B5   A0A1I8MQV4   A0A0J9QZW1   B3N7W6   P29786-2   E3NYI2   G9B5J2   G9B5F5   G9B5E6   G9B5G0   G9B5I6   P29786   G9B5H2   G9B5F7   G9B5F4   G9B5G5   G9B5E8   G9B5H4   G5DGE0   G9B5G4   A0A1L8DQF2   G9B5F2   G9B5J7   Q9VLF5   G9B5G7   G9B5I5   B3DMZ7   A0A1Q3FTA7   U5EZJ4   G9B5F1   B4HYU1   G9B5J8   G9B5E7   A8CW51   G9B5I9   B5AKB2   B8XY09   G9B5H5   G9B5E9   G9B5G8   B4NY05   G9B5I2   G9B5H9   G9B5H8   A0A2H4SAP8   A0A1B0DA37   A0A182GET7   G9B5F6   G9B5G1   G9B5F9   C5IB55   C5IB53   C5IB50   G3JB05   G9B5H1   G9B5J6   C5IB51   C5IB48   C5IB52   G9B5H7   A0A3B3D656   C5IB49   A0A182G8J0   G9B5I7   A0A1I8MB43   Q27J28  

PDB

2BYA     E-value=2.71279e-34,     Score=361

KEGG

733072    K01312 trypsin [EC:3.4.21.4] | (RefSeq) Coc, Coc-AP, QH-Coc, cap-hq; cocoonase

PATHWAY

04080    Neuroactive ligand-receptor interaction - Bombyx mori (domestic silkworm)

GO

GO:0004252   GO:0016021   GO:0005509   GO:0007596   GO:0005615   GO:0007586   GO:0006508   GO:0008233   GO:0016020   GO:0005524   GO:0006412   GO:0016876   GO:0043039  

Subcellular location

  

SignalP

Position:   1 - 22,         Likelihood:  0.996385

 

 

Length:

260

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.02456

Exp number, first 60 AAs:

0.02382

Total prob of N-in:

0.00842

outside

1  -  260

 

 

Pi

20.445042

Theta

23.662266

Tajima's D

-0.521817

CLR

0.315301

CSRT

0.23908804559772

Interpretation

Uncertain