Gene

KWMTBOMO08011  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA001136

Annotation

signal_peptidase_complex_subunit_3_[Bombyx_mori]

Location

Bomo_Chr13(-):12252139-12253803      View in EpiBrowser

Full name

Signal peptidase complex subunit 3      

Alternative Name

Microsomal signal peptidase 22 kDa subunit

Location in the cell

Extracellular   Reliability : 2.295

CDS

ATGTATTCCGTGTTAACGAGAGGAAATGCAATACTGACATACACGCTAAGCGTACTAGCATGTCTTACTTTCTTGTGTTTTTTATCAACCCTGACTGTGGACTACAGAACTGGGGCCCAAATGAATACAGTTAAAGTAGTAGTTAAAAACGTACCTGACTACGGAGCATCTAGGGAACGAAATGATCTTGGCTTCTTAACTTTCGATCTTAAAACAGATCTGTCCAACCTCTTTAACTGGAACGTTAAACAGTTGTTCCTATATCTCACTGCCGAATACATTACACCAAGCAATGAATTGAATCAGGTTGTATTGTGGGACAAAATAATATTAAGAGGTGAAAATGCTGTGCTAGACTTCAAGAACATGAACACTAAGTACTATTTCTGGGACGATGGCAACGGCTTAAAAGGTCACAGCAATGTCACATTAACATTATCATGGAATATTATTCCCAATGCTGGCTTGTTACCCAACATCCAGGCTCTTGGTCAACACTCCTTCAAGTTTCCTATAGAATATACTCAAACAAGAGTATGA

Protein

MYSVLTRGNAILTYTLSVLACLTFLCFLSTLTVDYRTGAQMNTVKVVVKNVPDYGASRERNDLGFLTFDLKTDLSNLFNWNVKQLFLYLTAEYITPSNELNQVVLWDKIILRGENAVLDFKNMNTKYYFWDDGNGLKGHSNVTLTLSWNIIPNAGLLPNIQALGQHSFKFPIEYTQTRV

Description

Component of the microsomal signal peptidase complex which removes signal peptides and other N-terminal peptides from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum.

Subunit

Complex of five different proteins: SEC11L1, SEC11L3, Spase12/SPCS1, Spase25/SPCS2 and Spase22-23/SPCS3.

Similarity

Belongs to the SPCS3 family.
Belongs to the enoyl-CoA hydratase/isomerase family.

Keywords

Complete proteome   Endoplasmic reticulum   Glycoprotein   Hydrolase   Membrane   Microsome   Protease   Reference proteome   Signal-anchor   Transmembrane   Transmembrane helix  

Feature

chain  Signal peptidase complex subunit 3

Uniprot

Q1HQ14   A0A2H1V5P2   A0A2A4J9Q2   A0A1E1WS34   I4DK09   A0A3S2M1P9   + More
A0A212FP10   S4PYE5   E0VVU3   A0A1B6K719   A0A1B6FD55   U5EZA3   A0A1B6DLS3   T1E333   B4NAG0   A0A1B6KPJ9   A0A1B0EY93   A0A1L8DV91   Q1HRQ4   B4QT28   A0A182Q241   B4HGK6   A0A1B0CYQ9   A0A1S4HE52   A0A2C9GRH5   A0A182USP7   A0A182U3B1   A0A1Y1JXW5   A0A084VHY9   A0A182YSJ7   A0A182LH70   A0A1Q3FFB9   B0XD98   R4UMY6   A0A182WXF5   B4M5R0   A0A023EIB7   A0A023EIC3   A0A182IRX3   E2B052   A0A2M3Z2Z7   A0A2M4C0U2   A0A182FBY0   B3P770   A0A2M4A7N4   T1DU70   J3JXQ5   A0A0B4K7R1   Q9VCA9   B3M0J8   B4JH35   A0A1S3DMD4   W5JAG0   B4PKZ4   A0A182MRI0   N6UKB3   A0A0K8TQ55   A0A336KDB6   A0A182PSU3   A0A0K8U9T6   A0A0M4EKV4   A0A182S090   A0A194R9G5   A0A3B0JP43   Q298I2   B4G3Z3   A0A194QC05   A0A182N3A6   A0A034W0F5   A0A0C9QGF2   A0A2J7Q682   A0A1W4V479   A0A182W1P2   B4K7G2   A0A0A1WYM2   D1ZZP0   A0A310SIA3   A0A1J1J6U1   A0A1L8EHJ2   A0A0A9WST4   A0A158N9C9   A0A026WJN9   A0A1W4X1I6   A0A0C9RM97   A0A1I8M4T6   A0A1B0BAA7   D3TNN0   A0A1B0FGJ0   A0A1A9VMX2   A0A1B0A2G5   A0A154P0L1   A0A1W7R9K2   A0A1I8PFR4   A0A2R7WLQ1   A0A1A9W4L2   D3TNM9   A0A087ZPW9   T1JM89   A0A0M8ZRA7   A0A151XFY5  

EC Number

3.4.-.-

Pubmed

22651552    22118469    23622113    20566863    24330624    17994087    + More
17204158    17510324    12364791    28004739    24438588    25244985    20966253    24945155    26483478    20798317    22516182    10731132    12537568    12537572    12537573    12537574    16110336    17569856    17569867    12537569    15901661    20920257    23761445    17550304    23537049    26369729    26354079    15632085    25348373    25830018    18362917    19820115    25401762    26823975    21347285    24508170    25315136    20353571   

EMBL

DQ443238    ABF51327.1    ODYU01000577    SOQ35584.1    NWSH01002453    PCG68264.1    + More
GDQN01001201    JAT89853.1    AK401627    BAM18249.1    RSAL01000074    RVE48961.1    AGBW02004200    OWR55467.1    GAIX01003428    JAA89132.1    DS235814    EEB17499.1    GECU01000459    JAT07248.1    GECZ01021876    JAS47893.1    GANO01001154    JAB58717.1    GEDC01010700    JAS26598.1    GALA01000735    JAA94117.1    CH964232    EDW80774.1    GEBQ01026599    JAT13378.1    AJWK01017654    GFDF01003745    JAV10339.1    DQ440040    CH477204    ABF18073.1    EAT47974.1    CM000364    EDX14192.1    AXCN02001118    CH480815    EDW43459.1    AJVK01009300    AAAB01008816    APCN01004488    GEZM01098148    JAV53973.1    ATLV01013250    KE524847    KFB37583.1    GFDL01008814    JAV26231.1    DS233746    DS232746    EDS31438.1    EDS45352.1    KC571981    AGM32480.1    CH940652    EDW58986.1    GAPW01004928    JAC08670.1    JXUM01145177    GAPW01004930    GAPW01004929    GAPW01004927    KQ569935    JAC08671.1    KXJ68481.1    GL444392    EFN60937.1    GGFM01002146    MBW22897.1    GGFJ01009786    MBW58927.1    CH954182    EDV53890.1    GGFK01003431    MBW36752.1    GAMD01000414    JAB01177.1    BT128026    AEE62987.1    AE014297    AFH06597.1    AY070615    CH902617    EDV44245.1    CH916369    EDV92726.1    ADMH02001689    ETN61422.1    CM000160    EDW98979.1    AXCM01001158    APGK01010787    APGK01029690    KB740739    KB738301    KB632179    ENN79112.1    ENN82676.1    ERL89610.1    GDAI01001332    JAI16271.1    UFQS01000290    UFQT01000290    SSX02489.1    SSX22863.1    GDHF01028993    JAI23321.1    CP012526    ALC47177.1    ALC47908.1    KQ460761    KPJ12511.1    OUUW01000007    SPP82683.1    CM000070    EAL27973.1    CH479179    EDW24404.1    KQ459439    KPJ00961.1    GAKP01011317    JAC47635.1    GBYB01002529    JAG72296.1    NEVH01017535    PNF24088.1    CH933806    EDW14286.1    GBXI01010551    JAD03741.1    KQ971338    EFA02397.1    KQ760832    OAD58889.1    CVRI01000074    CRL08104.1    GFDG01000675    JAV18124.1    GBHO01032092    GDHC01007831    JAG11512.1    JAQ10798.1    ADTU01009386    KK107211    EZA55334.1    GBYB01008101    JAG77868.1    JXJN01010888    EZ423032    ADD19308.1    CCAG010006947    KQ434791    KZC05373.1    GFAH01000567    JAV47822.1    KK855052    PTY20542.1    EZ423031    ADD19307.1    JH432064    KQ435966    KOX67929.1    KQ982174    KYQ59299.1   

Proteomes

UP000218220    UP000283053    UP000007151    UP000009046    UP000007798    UP000092461    + More
UP000008820    UP000000304    UP000075886    UP000001292    UP000092462    UP000075840    UP000075903    UP000075902    UP000030765    UP000076408    UP000075882    UP000002320    UP000076407    UP000008792    UP000069940    UP000249989    UP000075880    UP000000311    UP000069272    UP000008711    UP000000803    UP000007801    UP000001070    UP000079169    UP000000673    UP000002282    UP000075883    UP000019118    UP000030742    UP000075885    UP000092553    UP000075900    UP000053240    UP000268350    UP000001819    UP000008744    UP000053268    UP000075884    UP000235965    UP000192221    UP000075920    UP000009192    UP000007266    UP000183832    UP000005205    UP000053097    UP000192223    UP000095301    UP000092460    UP000092444    UP000078200    UP000092445    UP000076502    UP000095300    UP000091820    UP000005203    UP000053105    UP000075809   

PRIDE

Q1HQ14    Q9VCA9   

Pfam

PF04573   SPC22        + More
PF00378   ECH_1
PF12848   ABC_tran_Xtn
PF00005   ABC_tran

Interpro

IPR007653   SPC3        + More
IPR018376   Enoyl-CoA_hyd/isom_CS       
IPR014748   Enoyl-CoA_hydra_C       
IPR029045   ClpP/crotonase-like_dom_sf       
IPR001753   Enoyl-CoA_hydra/iso       
IPR032781   ABC_tran_Xtn       
IPR003593   AAA+_ATPase       
IPR027417   P-loop_NTPase       
IPR017871   ABC_transporter_CS       
IPR003439   ABC_transporter-like       

SUPFAM

SSF52096   SSF52096        + More
SSF52540   SSF52540       

Gene 3D

1.10.12.10    

ProteinModelPortal

Q1HQ14   A0A2H1V5P2   A0A2A4J9Q2   A0A1E1WS34   I4DK09   A0A3S2M1P9   + More
A0A212FP10   S4PYE5   E0VVU3   A0A1B6K719   A0A1B6FD55   U5EZA3   A0A1B6DLS3   T1E333   B4NAG0   A0A1B6KPJ9   A0A1B0EY93   A0A1L8DV91   Q1HRQ4   B4QT28   A0A182Q241   B4HGK6   A0A1B0CYQ9   A0A1S4HE52   A0A2C9GRH5   A0A182USP7   A0A182U3B1   A0A1Y1JXW5   A0A084VHY9   A0A182YSJ7   A0A182LH70   A0A1Q3FFB9   B0XD98   R4UMY6   A0A182WXF5   B4M5R0   A0A023EIB7   A0A023EIC3   A0A182IRX3   E2B052   A0A2M3Z2Z7   A0A2M4C0U2   A0A182FBY0   B3P770   A0A2M4A7N4   T1DU70   J3JXQ5   A0A0B4K7R1   Q9VCA9   B3M0J8   B4JH35   A0A1S3DMD4   W5JAG0   B4PKZ4   A0A182MRI0   N6UKB3   A0A0K8TQ55   A0A336KDB6   A0A182PSU3   A0A0K8U9T6   A0A0M4EKV4   A0A182S090   A0A194R9G5   A0A3B0JP43   Q298I2   B4G3Z3   A0A194QC05   A0A182N3A6   A0A034W0F5   A0A0C9QGF2   A0A2J7Q682   A0A1W4V479   A0A182W1P2   B4K7G2   A0A0A1WYM2   D1ZZP0   A0A310SIA3   A0A1J1J6U1   A0A1L8EHJ2   A0A0A9WST4   A0A158N9C9   A0A026WJN9   A0A1W4X1I6   A0A0C9RM97   A0A1I8M4T6   A0A1B0BAA7   D3TNN0   A0A1B0FGJ0   A0A1A9VMX2   A0A1B0A2G5   A0A154P0L1   A0A1W7R9K2   A0A1I8PFR4   A0A2R7WLQ1   A0A1A9W4L2   D3TNM9   A0A087ZPW9   T1JM89   A0A0M8ZRA7   A0A151XFY5  

KEGG

778464    K12948 signal peptidase complex subunit 3 [EC:3.4.-.-] | (RefSeq) signal peptidase complex subunit 3

PATHWAY

03060    Protein export - Bombyx mori (domestic silkworm)

GO

GO:0005787   GO:0006465   GO:0008233   GO:0016021   GO:0045047   GO:0005524   GO:0016887   GO:0016020   GO:0006412   GO:0016876   GO:0043039  

PANTHER

PTHR12804  

Subcellular location

Endoplasmic reticulum membrane  
Microsome membrane  

Length:

179

Number of predicted TMHs:

1

Exp number of AAs in TMHs:

22.82217

Exp number, first 60 AAs:

22.54046

Total prob of N-in:

0.08161

POSSIBLE N-term signal

sequence

outside

1  -  9

TMhelix

10  -  32

inside

33  -  179

 

 

Pi

280.950554

Theta

224.452275

Tajima's D

1.01075

CLR

0.192989

CSRT

0.668066596670167

Interpretation

Uncertain