Gene

KWMTBOMO08003  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA001138

Annotation

PREDICTED:_putative_neutral_sphingomyelinase_isoform_X1_[Bombyx_mori]

Location

Bomo_Chr13(-):12176108-12180023      View in EpiBrowser

Location in the cell

PlasmaMembrane   Reliability : 1.363

CDS

ATGGGTTATAGAGTATTTACTGAGCATTTAACATTTAATATACATCTTAAATTTTATTTAAAAACAAGTCGTCATCTAACTAAATTAAGTTTCTTTAGAAACCACATATACATACTTCAAAGGGGTATACCAGTGGTGTCTAAGAATAAGAAAGAAAGATATGAAGCTATATCTACATACTTATTAAAAAGCGAACATAATATAGTATGTTTGCAAGAAGTTTGGAGTGAAAAAGATTACCTATATTTAAAGGAGAACCTAAAGAATGTACTCCCATATTCTTACTACTTTTACAGTGGAGTTCTAGGTTCAGGTCTCTGTGTATTTTCTAAATGGGTAATCCAAGATGTCTTCTTCCATCAGTGGCCCTTGAATGGGTACATACACAAAATACATCATGGTGACTGGTTTGGAGGAAAAGGTGTGGGTCTCTGTCGGATCAAGTTTGGGGAGAGACTCATCAATGTCTATTGCACACATCTTCACGCAGAATACCACGAAGACGACATGTATCTAGCTCATCGTGTGCTTCAGGCATACTCAACAGCAGAGTTCGTCAAATTAACATCATCACCAGCTGATGTTTCTATACTAGCTGGAGATTTAAATACTGCACCCGGGGATTTGTCTTATAAGATAATATCCCAACTGCCATCTCTTCTTGATCCATATAACATGAAGTTTGAAGGGACCAATCCTTTAATAGCTAAAGCATCTGGTACAAGTGATAACCTCAACAATAGCTATTCGGATCCTAAACAAGTAAAGGCATATCCTGAAGGGAAACGTATAGATCATATATTATTCCATACTAACCATTCTTGGGAGGCCCGTGTCGTGAATTTCGGTAATCCGTTACCAGATAGAGTTCCAGAACAACAGTTTTCTTACTCTGATCACAATGCAGTCTCGCTTGAGTTACACCTAAAACCTTGTGAACAAAAATTAAACCAGAGACAAGAGAGTGTAGACAGTGCATTTCAAGAAACTATCACTCAAGCGATCAAAGTTTGCAGGGATGCCACAACAAATTTATCGAAATCAAAAAAGCTGTATTTACTCAGCGGCGGTTTAATATTCATGTTTTTGTTAGGTTCAGTAGGTTTCTGGCCTAACTTTCTTATTTATGATGTACTGAAACTTCTTATTACAGCCTTATGCTTCTACAATTTAGTAATGGGATCTCTATGGAATCAAATTGAAATGAACAGTTTGAAAGCTGGTCTGAATGCCTTAGAGAATTTCATTCAAACAAGAAATGATACAAAACCCGAAGACATCAATAAAGAGGATGTTAAAAACAAATGA

Protein

MGYRVFTEHLTFNIHLKFYLKTSRHLTKLSFFRNHIYILQRGIPVVSKNKKERYEAISTYLLKSEHNIVCLQEVWSEKDYLYLKENLKNVLPYSYYFYSGVLGSGLCVFSKWVIQDVFFHQWPLNGYIHKIHHGDWFGGKGVGLCRIKFGERLINVYCTHLHAEYHEDDMYLAHRVLQAYSTAEFVKLTSSPADVSILAGDLNTAPGDLSYKIISQLPSLLDPYNMKFEGTNPLIAKASGTSDNLNNSYSDPKQVKAYPEGKRIDHILFHTNHSWEARVVNFGNPLPDRVPEQQFSYSDHNAVSLELHLKPCEQKLNQRQESVDSAFQETITQAIKVCRDATTNLSKSKKLYLLSGGLIFMFLLGSVGFWPNFLIYDVLKLLITALCFYNLVMGSLWNQIEMNSLKAGLNALENFIQTRNDTKPEDINKEDVKNK

Uniprot

H9IV58   A0A194R4T0   A0A194Q7I2   A0A2A4JA21   A0A1E1WTB4   S4P819   + More
A0A0L7LAW8   A0A195BUS2   A0A158NEL9   F4WRU1   A0A195CQW9   A0A195FMQ1   A0A195EMZ9   E9IJD8   A0A026WUF7   E2AEJ5   A0A151XJ16   A0A067QJ62   K7J2F3   A0A154PE23   A0A232EY38   D1ZZU9   A0A087ZRR4   A0A0M9A5E9   A0A2A3EQG7   A0A0L7R5L5   A0A1W4X3U6   A0A0C9QFV7   U4U6L4   N6U1V5   A0A2U6TC85   A0A182Y030   A0A182LZ60   B0W7J5   A7UUQ6   A0A182NU79   Q17JK7   A0A182TGU1   A0A1S4GXT5   A0A182HUV9   A0A182L1P3   B0XLI7   A0A182V8B4   A0A182GNG4   A0A2M4AND1   A0A182WU92   A0A182P4W5   A0A182RC91   A0A182QW34   A0A182W797   A0A336KTK6   A0A182GXD5   A0A226E771   A0A0K8TSH4   A0A336KQA9   W5JLV8   A0A182KDE3   A0A1B6DDU6   A0A1B6E4I2   A0A1B6IHQ4   A0A1Q3FAF3   A0A182J841   A0A182F6D9   A0A310SHV1   U5EWI2   A0A1Y1K207   A0A084VNC4   A0A2J7RG53   A0A0P5KZZ5   A0A0P5G7K4   A0A1D2MWX7   A0A0P5PDD6   A0A0P5E581   A0A0P6JEK1   A0A1L8DJX7   A0A0P5PP10   E9GIK1   A0A1L8DJZ2   A0A0P5HVW5   A0A0K8T9T5   A0A1J1HZR6   A0A1B0DRC6   A0A0A9XVL4   A0A0P5KGP8   A0A0M4EC29   A0A0P5LTP6   A0A0L0CEY0   A0A0Q9XLV1   A0A1D2N153   A0A0A1WKI1   W8BLR8   A0A069DZ32  

Pubmed

19121390    26354079    23622113    26227816    21347285    21719571    + More
21282665    24508170    30249741    20798317    24845553    20075255    28648823    18362917    19820115    23537049    25244985    12364791    17510324    20966253    26483478    26369729    20920257    23761445    28004739    24438588    27289101    21292972    25401762    26823975    26108605    17994087    25830018    24495485    26334808   

EMBL

BABH01000557    KQ460761    KPJ12519.1    KQ459439    KPJ00955.1    NWSH01002453    + More
PCG68272.1    GDQN01000877    JAT90177.1    GAIX01004344    JAA88216.1    JTDY01001914    KOB72550.1    KQ976401    KYM92369.1    ADTU01013497    GL888292    EGI63098.1    KQ977381    KYN03101.1    KQ981490    KYN41214.1    KQ978625    KYN29578.1    GL763764    EFZ19335.1    KK107119    QOIP01000009    EZA58744.1    RLU18828.1    GL438862    EFN68152.1    KQ982080    KYQ60305.1    KK853449    KDR07562.1    KQ434886    KZC10093.1    NNAY01001687    OXU23225.1    KQ971338    EFA01795.1    KQ435740    KOX76826.1    KZ288202    PBC33512.1    KQ414648    KOC66175.1    GBYB01013403    JAG83170.1    KB631724    ERL85595.1    APGK01045762    APGK01045763    KB741038    ENN74581.1    KX013771    AND65757.1    AXCM01004940    DS231854    EDS38030.1    AAAB01008964    EDO63591.1    CH477232    EAT46833.1    APCN01002480    DS234497    EDS34220.1    JXUM01076253    KQ562934    KXJ74809.1    GGFK01008970    MBW42291.1    AXCN02000772    UFQS01000880    UFQT01000880    SSX07472.1    SSX27812.1    JXUM01021513    KQ560603    KXJ81668.1    LNIX01000006    OXA52817.1    GDAI01000718    JAI16885.1    UFQS01000798    UFQT01000798    SSX06986.1    SSX27330.1    ADMH02001153    ETN63880.1    GEDC01013421    JAS23877.1    GEDC01004509    JAS32789.1    GECU01021257    JAS86449.1    GFDL01010481    JAV24564.1    KQ759874    OAD62358.1    GANO01001404    JAB58467.1    GEZM01096908    GEZM01096903    GEZM01096896    JAV54488.1    ATLV01014737    KE524984    KFB39468.1    NEVH01004406    PNF39814.1    GDIQ01202513    GDIQ01202512    JAK49213.1    GDIQ01245157    GDIQ01222308    GDIQ01222307    GDIQ01164188    GDIQ01158177    GDIQ01149133    GDIQ01137433    GDIQ01125701    GDIQ01116549    GDIQ01109050    GDIQ01076353    GDIQ01071310    JAK06568.1    LJIJ01000465    ODM97185.1    GDIQ01130240    JAL21486.1    GDIP01147901    LRGB01000568    JAJ75501.1    KZS18109.1    GDIQ01008621    JAN86116.1    GFDF01007338    JAV06746.1    GDIQ01131497    JAL20229.1    GL732546    EFX80740.1    GFDF01007318    JAV06766.1    GDIQ01227111    JAK24614.1    GBRD01003514    JAG62307.1    CVRI01000037    CRK93599.1    AJVK01019877    GBHO01020179    GBHO01020178    GDHC01008207    JAG23425.1    JAG23426.1    JAQ10422.1    GDIQ01191158    JAK60567.1    CP012525    ALC42908.1    GDIQ01165780    JAK85945.1    JRES01000493    KNC30805.1    CH933809    KRG06130.1    LJIJ01000303    ODM99023.1    GBXI01015252    GBXI01011982    JAC99039.1    JAD02310.1    GAMC01006793    JAB99762.1    GBGD01001345    JAC87544.1   

Proteomes

UP000005204    UP000053240    UP000053268    UP000218220    UP000037510    UP000078540    + More
UP000005205    UP000007755    UP000078542    UP000078541    UP000078492    UP000053097    UP000279307    UP000000311    UP000075809    UP000027135    UP000002358    UP000076502    UP000215335    UP000007266    UP000005203    UP000053105    UP000242457    UP000053825    UP000192223    UP000030742    UP000019118    UP000076408    UP000075883    UP000002320    UP000007062    UP000075884    UP000008820    UP000075902    UP000075840    UP000075882    UP000075903    UP000069940    UP000249989    UP000076407    UP000075885    UP000075900    UP000075886    UP000075920    UP000198287    UP000000673    UP000075881    UP000075880    UP000069272    UP000030765    UP000235965    UP000094527    UP000076858    UP000000305    UP000183832    UP000092462    UP000092553    UP000037069    UP000009192   

PRIDE

H9IV58   

Pfam

PF03372   Exo_endo_phos        + More
PF00096   zf-C2H2
PF03392   OS-D
PF01433   Peptidase_M1
PF11838   ERAP1_C

Interpro

IPR036691   Endo/exonu/phosph_ase_sf        + More
IPR005135   Endo/exonuclease/phosphatase       
IPR038772   SMPD2-like       
IPR036236   Znf_C2H2_sf       
IPR013087   Znf_C2H2_type       
IPR036682   OS_D_A10/PebIII_sf       
IPR005055   A10/PebIII       
IPR034016   M1_APN-typ       
IPR001930   Peptidase_M1       
IPR014782   Peptidase_M1_dom       
IPR024571   ERAP1-like_C_dom       
IPR042097   Aminopeptidase_N-like_N       

SUPFAM

SSF56219   SSF56219        + More
SSF57667   SSF57667       
SSF100910   SSF100910       

Gene 3D

3.60.10.10     1.10.2080.10     2.60.40.1730    

CDD

cd09601  M1_APN_2

ProteinModelPortal

H9IV58   A0A194R4T0   A0A194Q7I2   A0A2A4JA21   A0A1E1WTB4   S4P819   + More
A0A0L7LAW8   A0A195BUS2   A0A158NEL9   F4WRU1   A0A195CQW9   A0A195FMQ1   A0A195EMZ9   E9IJD8   A0A026WUF7   E2AEJ5   A0A151XJ16   A0A067QJ62   K7J2F3   A0A154PE23   A0A232EY38   D1ZZU9   A0A087ZRR4   A0A0M9A5E9   A0A2A3EQG7   A0A0L7R5L5   A0A1W4X3U6   A0A0C9QFV7   U4U6L4   N6U1V5   A0A2U6TC85   A0A182Y030   A0A182LZ60   B0W7J5   A7UUQ6   A0A182NU79   Q17JK7   A0A182TGU1   A0A1S4GXT5   A0A182HUV9   A0A182L1P3   B0XLI7   A0A182V8B4   A0A182GNG4   A0A2M4AND1   A0A182WU92   A0A182P4W5   A0A182RC91   A0A182QW34   A0A182W797   A0A336KTK6   A0A182GXD5   A0A226E771   A0A0K8TSH4   A0A336KQA9   W5JLV8   A0A182KDE3   A0A1B6DDU6   A0A1B6E4I2   A0A1B6IHQ4   A0A1Q3FAF3   A0A182J841   A0A182F6D9   A0A310SHV1   U5EWI2   A0A1Y1K207   A0A084VNC4   A0A2J7RG53   A0A0P5KZZ5   A0A0P5G7K4   A0A1D2MWX7   A0A0P5PDD6   A0A0P5E581   A0A0P6JEK1   A0A1L8DJX7   A0A0P5PP10   E9GIK1   A0A1L8DJZ2   A0A0P5HVW5   A0A0K8T9T5   A0A1J1HZR6   A0A1B0DRC6   A0A0A9XVL4   A0A0P5KGP8   A0A0M4EC29   A0A0P5LTP6   A0A0L0CEY0   A0A0Q9XLV1   A0A1D2N153   A0A0A1WKI1   W8BLR8   A0A069DZ32  

PDB

5UVG     E-value=9.0922e-05,     Score=109

KEGG

101743119    K12351 sphingomyelin phosphodiesterase 2 [EC:3.1.4.12] | (RefSeq) putative neutral sphingomyelinase

PATHWAY

00600    Sphingolipid metabolism - Bombyx mori (domestic silkworm)
01100    Metabolic pathways - Bombyx mori (domestic silkworm)

GO

GO:0016021   GO:0003676   GO:0006302   GO:0005737   GO:0003697   GO:0016605   GO:0005654   GO:0070260   GO:0004767   GO:0005901   GO:0006684   GO:0008270   GO:0008237  

PANTHER

PTHR12393:SF7  

Length:

435

Number of predicted TMHs:

2

Exp number of AAs in TMHs:

55.22693

Exp number, first 60 AAs:

0.02916

Total prob of N-in:

0.24366

inside

1  -  350

TMhelix

351  -  370

outside

371  -  374

TMhelix

375  -  397

inside

398  -  435

 

 

Pi

231.311543

Theta

195.06987

Tajima's D

0.844802

CLR

0.308066

CSRT

0.614569271536423

Interpretation

Uncertain