Silkworm Genome Informatics Database

Gene

KWMTBOMO07997 Validated by peptides from experiments

Pre Gene Modal

BGIBMGA001011

Annotation

PREDICTED:_ER_degradation-enhancing_alpha-mannosidase-like_protein_2_isoform_X2_[Bombyx_mori]

Location

Bomo_Chr13(+):12093494-12107112 View in EpiBrowser

Full name

alpha-1,2-Mannosidase

Location in the cell

Cytoplasmic Reliability : 1.363 Nuclear Reliability : 1.379 PlasmaMembrane Reliability : 1.301

CDS

ATGGTCAAATTAACCTTCCTGATCAGTATTTCAGTGTTGACTTGTAATTTAATTTTAAGTGTACGAGTATACAAACGTGCAGATATACTTAAACTAAGAGAGGAAGTACGTGAAATGTTTCAACATGCATACGACAGCTATTTAAGATATGCATATCCTTATGACGAATTACGTCCATTGAGCTGCGACGGTGTTGATACCTGGGGCAGTTACTCACTCACCCTCATTGATGCATTGGACACGCTTGCCATTATGGGAAACTATAGTGAATTTAATCGAGTAGTAGATATAGTACTACAGAAAAGACACTTTGATGCAGACATTAACGTTTCAGTGTTTGAGACGAATATTAGAATTGTTGGCGGTTTATTGAGTGCTCATTTACTGTCACATAAAACTGGGATGAAATTAGAACCAGGCTGGCCATGCAATGGTCCTTTACTTCGTTTAGCTGAAGATGTAGCACAGAGACTAATAGCTGCATTTGATACAACTACTGGAATGCCTTATGGAACAATTAACTTGCGATCAGGTGTTCCACCTGGGGAAACTAGTATCACATGCACTGCTGGAGTTGGTACATTTATAATTGAGTTTGGTACTTTGAGTAGACTGACAGGAGATCCATTGTATGAAGAGGTAGCTTATAATGCTTTGAAAGCCTTATACCATCATAGATCACCAATTGGTCTCCTTGGCAACCACATAGATGTGATGACTGGACGCTGGACAGCTCAAGATGCTGGAATTGGTGGTGGAATCGATTCTTATTATGAATATTTGGTTAAAGGTGCCATACTACTAGAGAAGCCAGAGTTAATGTCCATGTTCTTAGAAGCACGTCAATCTATTGAGAAGTACCTGAAAAAAGATGATTGGTTTGTGTGGGCCACTATGTTGCGTGGGCACGTCACCTTACCTGTCTTTCAGTCTCTTGAATCATATTGGCCAGGTCTTTTAAGCCTCATAGGCGAAAGTGACGCAGCGATGCGCATAATTCACAACTACCACAGCGTGTGGCGCCAATATGGATTTACACCTGAAGTGTACAATCTCGGGACGGGTGAGGCGTCTTCGTCACGCGAGAGTTATCCCCTACGACCCGAACTCATAGAGTCAATCATGTATTTGTACCGAGACACCAGAGACCCTATACTGTTGCAAATGGGCGAAGATATTCTGAGGAGCATACAGCATAGTGCCAGGACACCGTGTGGGTATGCAACGATAAAAGATGTTCGTGACCATCGTAAAGAAGATCGCATGGAATCGTTTTTCTTAGCCGAAACCACAAAATACCTGTACCTACTGTTCGATCCGGATAATTTCATTCACAACCCTGGGGTCCGCGGTACTGTCATCGACACACCTAATGGCGAATGCGTGGTCGACCTTGGCGGATACATCTTCAATACAGAAGCACATCCGATTGACCCTAACATGCTGTATTGCTGCCATGAAGCTAGACAAGGTATAAATATCAGCGAGGTTTACAGTATATACCAAATTTTGGAAGAAGAAGATAATATAAAATTTATGACTATGATAGAAGCGAACACCAATGAAACTAAGATCACTCAATCGAACAACAACAATAATGAGAGTGCAATAGAAAATAAAACAATTGACCACACAGAACCGAAGGAAAGATCAGATGAAAACGAGCCTGAACAAAATCAAGTATTGATAAAAACTGAATCGAGAACCGGATACGTCAACCTCGACGGAACGGAAAGGGAGAACGCAAACGAATCAAACCTCAGTGATCTTGTTAAAGAGACGATCAATAAATATTACAACGACACTATAAATGCCGAAACACAAGAAAATGTTAAACATTCAGCCGAAGAACCAACGGCAGGATCGTCGCAAACCGTTGAAGTGGACGACATAATCGTGCCAGAGAAATCGGAGGTGCAACTGCCAAGCGTCACGAAAACGAAAGAAGTAATGAACATGCTGCCAAAAGTTATACAAGACTTTTTGAACAGCGATTGGAAATCGAAACCGAAATGCGAACCGCAGAAGATGTTAGAAAGGATACGTAGAGAACAGAAGTATCCAGATCACCCGGATGTATATAAGTACGAGTTATTATTGACGCCGGCTCCGTCGTTTCTACAAAGAATATCGTTGGCCGGAGAGTTCTTAAATAAGAAGCAACTGGATAAAGAAGATTCACATAAATCAACGCTTGCTTGTAAAATTATTGAAACGGCAAAGGCCCCAAAAGATTTTGTTGTAAAATTTTTGCCACGCGAAATAGATGTGCTCGTGCGCTTGAATCATCCGCATCTGATTCACGTGCATAGCATATTTCAGAGGAAAACAAAATACTATATTTTCATGAGGTACACGGAAAATGGTGATTTACTGAGTTATATACTAAAAAACGGGTGCGTGTCTGAAAATCAAGCTCGCGTCTGGACTCGACAACTTGCATTGGGACTACAATACTTGCACGAGTTAGAAATCGCTCACAGAGACATCAAATGCGAGAACGTACTGTTGACGGCGAATTTTAACGTGAAATTATCTGATTTTGGCTTTTCCCGTTTCTGTGTTGAAAGCGACAATCAGCCTGTCTTAAGCGAAACTTATTGCGGTTCTATGTCATACGCTGCACCAGAAATACTACGCGGAAAACCGTATTGCCCGAAGCCAACGGATTTATGGTCCTTAGGCGTCGTACTATTTGTAATGCTGAACAAATCAATGCCATTTGACGACACGCGTATGAGAAAACTTTATGAACAGCAAATGGGAAAGAAATATCGCTTTAGATCGCGCGTAGCTAGTATACTCTCGCTCGAATGTAAGACTGTTGTAAAGCATTTGTTAGAACCGGATCCAGGACTCCGACATTCCGCTACCAATGTTCTCGACTCTGAATGGATTGCTATGGATAGTAGATTAACCAGTAAGTATAGAAATATATTAAATACTAGCTGA

Protein

MVKLTFLISISVLTCNLILSVRVYKRADILKLREEVREMFQHAYDSYLRYAYPYDELRPLSCDGVDTWGSYSLTLIDALDTLAIMGNYSEFNRVVDIVLQKRHFDADINVSVFETNIRIVGGLLSAHLLSHKTGMKLEPGWPCNGPLLRLAEDVAQRLIAAFDTTTGMPYGTINLRSGVPPGETSITCTAGVGTFIIEFGTLSRLTGDPLYEEVAYNALKALYHHRSPIGLLGNHIDVMTGRWTAQDAGIGGGIDSYYEYLVKGAILLEKPELMSMFLEARQSIEKYLKKDDWFVWATMLRGHVTLPVFQSLESYWPGLLSLIGESDAAMRIIHNYHSVWRQYGFTPEVYNLGTGEASSSRESYPLRPELIESIMYLYRDTRDPILLQMGEDILRSIQHSARTPCGYATIKDVRDHRKEDRMESFFLAETTKYLYLLFDPDNFIHNPGVRGTVIDTPNGECVVDLGGYIFNTEAHPIDPNMLYCCHEARQGINISEVYSIYQILEEEDNIKFMTMIEANTNETKITQSNNNNNESAIENKTIDHTEPKERSDENEPEQNQVLIKTESRTGYVNLDGTERENANESNLSDLVKETINKYYNDTINAETQENVKHSAEEPTAGSSQTVEVDDIIVPEKSEVQLPSVTKTKEVMNMLPKVIQDFLNSDWKSKPKCEPQKMLERIRREQKYPDHPDVYKYELLLTPAPSFLQRISLAGEFLNKKQLDKEDSHKSTLACKIIETAKAPKDFVVKFLPREIDVLVRLNHPHLIHVHSIFQRKTKYYIFMRYTENGDLLSYILKNGCVSENQARVWTRQLALGLQYLHELEIAHRDIKCENVLLTANFNVKLSDFGFSRFCVESDNQPVLSETYCGSMSYAAPEILRGKPYCPKPTDLWSLGVVLFVMLNKSMPFDDTRMRKLYEQQMGKKYRFRSRVASILSLECKTVVKHLLEPDPGLRHSATNVLDSEWIAMDSRLTSKYRNILNTS

Similarity

Belongs to the glycosyl hydrolase 47 family.

Feature

chain alpha-1,2-Mannosidase

Uniprot

A0A2H1V469 A0A194R4C2 A0A194QA35 A0A212FNY3 A0A1Y1K2H4 A0A1B0CP03 + More
T1HZ06 A0A2A3EU65 A0A087ZNQ5 K7ITY4 A0A151JU09 A0A195ECB0 A0A151WY74 A0A026VUB7 A0A067RCH2 F4WQ38 A0A151IHP3 E9IVZ0 E2ANC9 A0A0M8ZV48 A0A0L7R2G5

EC Number

3.2.1.-

Pubmed

26354079 22118469 28004739 20075255 24508170 30249741 + More
24845553 21719571 21282665 20798317

EMBL

ODYU01000577 SOQ35599.1 KQ460761 KPJ12527.1 KQ459299 KPJ01855.1 + More
AGBW02004200 OWR55452.1 GEZM01099009 JAV53576.1 AJWK01021254 ACPB03022213 KZ288186 PBC34746.1 KQ981799 KYN35691.1 KQ979074 KYN22858.1 KQ982651 KYQ52838.1 KK107921 QOIP01000001 EZA47245.1 RLU26311.1 KK852793 KDR16453.1 GL888262 EGI63661.1 KQ977586 KYN01682.1 GL766449 EFZ15264.1 GL441177 EFN65077.1 KQ435876 KOX70169.1 KQ414666 KOC65029.1

Proteomes

UP000053240 UP000053268 UP000007151 UP000092461 UP000015103 UP000242457 + More
UP000005203 UP000002358 UP000078541 UP000078492 UP000075809 UP000053097 UP000279307 UP000027135 UP000007755 UP000078542 UP000000311 UP000053105 UP000053825

Pfam

PF01532 Glyco_hydro_47

Interpro

IPR012341   6hp_glycosidase-like_sf        + More
IPR036026   Seven-hairpin_glycosidases
IPR001382   Glyco_hydro_47

SUPFAM

SSF48225 SSF48225

Gene 3D

1.50.10.10

ProteinModelPortal

A0A2H1V469 A0A194R4C2 A0A194QA35 A0A212FNY3 A0A1Y1K2H4 A0A1B0CP03 + More
T1HZ06 A0A2A3EU65 A0A087ZNQ5 K7ITY4 A0A151JU09 A0A195ECB0 A0A151WY74 A0A026VUB7 A0A067RCH2 F4WQ38 A0A151IHP3 E9IVZ0 E2ANC9 A0A0M8ZV48 A0A0L7R2G5

PDB

5KKB E-value=8.4166e-57, Score=562

KEGG

101743683 K10085 ER degradation enhancer, mannosidase alpha-like 2 | (RefSeq) ER degradation-enhancing alpha-m

PATHWAY

04141 Protein processing in endoplasmic reticulum - Bombyx mori (domestic silkworm)

GO

GO:0004571 GO:0016020 GO:0008152 GO:0005509 GO:0004672 GO:0006468 GO:0005524 GO:0006412 GO:0016876 GO:0043039 GO:0003824

SignalP

Position: 1 - 20, Likelihood: 0.634926

Length:

983

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

7.36507999999997

Exp number, first 60 AAs:

6.54729

Total prob of N-in:

0.30394

outside

1 - 983

Pi

160.696083

Theta

170.543261

Tajima's D

0

CLR

32.645811

CSRT

0.367381630918454

Interpretation

Uncertain

Sequence

Summary

Ontologies

Topology

Population Genetic Test Statistics

Multiple alignment of Orthologues

Gene Tree