Gene

KWMTBOMO07969  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA001152

Annotation

PREDICTED:_NADH-cytochrome_b5_reductase_2_isoform_X1_[Bombyx_mori]

Location

Bomo_Chr13(-):11312941-11328059      View in EpiBrowser

Full name

NADH-cytochrome b5 reductase      

Location in the cell

Cytoplasmic   Reliability : 1.167 Mitochondrial   Reliability : 1.315 Nuclear   Reliability : 1.127

CDS

ATGTTTCAGACTATCAATTCTAAAATTGTACTACCAATAATATTTGGTGTTGGATCAGTGGTAGTCTTAGCAACTATAATAGCCAATTGTCTATGGGGAAAGAAATCTAAAGGATCTAGCAAAAAGTTAATAACATTAGTAGATTCTAACGTAAAATATGCATTACCGCTGATAGAAAGGGAAGAAATCAGTCATGACACCAGGAGATTCAGGCTGGGACTGCCGTCTCCTCAACATGTATTGGGATTACCGATCGGTCAACATATTCATTTGTCTGCAAAAATTAACGACGACCTAGTCATAAGAGCATACACGCCGGTGTCGAGCGATGAGGATAAAGGCTATGTCGATTTGGTTATCAAGGTATACTTTAAGAATGTACATCCGAAGTTTCCCGAGGGAGGGAAGCTGTCTCAGTACTTGAACAATATGAAGATAAATGATACTATAGATGTCCGTGGACCGTCAGGGAGATTGCAGTACACAGGAAACGGAACATTCCTCATTAAGAAATTAAGAAAAGATCCGCCTACAAAAGTTGTCGTCAAGAAATTGAACTTGATTGCAGGCGGTACTGGCATAGCTCCAATGCTTCAGCTGGTCCGACATATATGCACTGACGTCAACGACCGCACCGAACTGAAGCTGCTATTCGCGAACCAAAGCGAAGATGACATTCTACTTAGAGATGAATTAGAAAGATACCAAAGGGAACATCCTTCCCAATTCCAAGTTTGGTACACGATTGATCGGCCAACGGATGGTTGGAAATACAGCTCCGGTTTCATCAACGATGAAATGATCCGCGACCATTTGTTTCCGCCGTCCAACGATGTTCTAGTACTGATGTGCGGTCCACCGCCGATGATCAACTTCGCTTGCAACCCAGCTTTAGATAAATTAGGCTTTAAGCCAGACCAACGCTTTGCTTATTAA

Protein

MFQTINSKIVLPIIFGVGSVVVLATIIANCLWGKKSKGSSKKLITLVDSNVKYALPLIEREEISHDTRRFRLGLPSPQHVLGLPIGQHIHLSAKINDDLVIRAYTPVSSDEDKGYVDLVIKVYFKNVHPKFPEGGKLSQYLNNMKINDTIDVRGPSGRLQYTGNGTFLIKKLRKDPPTKVVVKKLNLIAGGTGIAPMLQLVRHICTDVNDRTELKLLFANQSEDDILLRDELERYQREHPSQFQVWYTIDRPTDGWKYSSGFINDEMIRDHLFPPSNDVLVLMCGPPPMINFACNPALDKLGFKPDQRFAY

Catalytic Activity

2 [Fe(III)-cytochrome b5] + NADH = 2 [Fe(II)-cytochrome b5] + H(+) + NAD(+)

Cofactor

FAD

Similarity

Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.

Uniprot

A0A2A4JIV2   A0A2H1VVY9   S4NZ85   A0A2A4JIP3   A0A3S2L9Y7   A0A2A4JHV5   + More
U3LUX9   F1DI28   F1CZW3   E2JE74   H9IV72   A0A194R4E9   A0A212F7Z1   A0A194Q8Y9   A0A2P8YM95   A0A0T6AU88   D6WD52   A0A1Y1MT45   J3JV27   A0A1W4WGZ8   A0A1W4WST4   A0A1B0D3G2   A0A1L8DZK0   A0A1L8DZK6   A0A1B0CE42   A0A1A9X321   A0A1L8EGY3   A0A0K8U663   A0A0K8WBM4   A0A1L8ECX1   T1P7R9   A0A1I8MJ03   A0A0B4J2S5   B4QQN4   B4J3C2   B4KYV3   A0A0P8XTI8   A0A1I8P2Z9   A0A0J9UJE3   Q4LDP7   A0A0Q9WS49   B3M4K6   A0A0Q9XDL5   B4N403   A0A232F486   B4HEZ7   Q9I7R1   A0A1B6DUJ7   B4LDM4   D3TNG7   A0A0Q9WKV4   A0A0Q9WJ70   A0A1B6DPJ0   A0A026WBP4   A0A1B0A6S3   A0A336K3J3   A0A0A1WX89   A0A154PE53   B4PFQ1   A0A1A9YKT5   A0A1B0AVZ9   A0A3B0JMM3   A0A1A9URW1   A0A3B0JVI0   A0A3R7M6V6   A0A1B6E148   A0A0R1DX47   A0A0K8TTZ8   A0A0C9S327   A0A1B6EA56   A0A1B6LF45   A0A088AB11   A0A1B6LG70   A0A0R8YFP6   A0A034WPM3   A0A1W4W5E6   A0A034WUU1   A0A1W4VTC1   V9IDL9   E2BQ94   A0A2A3EFN3   V9IBB3   A0A0A9WFH4   A0A1B6CCH9   B4H469   Q29DY6   A0A0M4EK44   A0A0R3P6M7   A0A0A9WQT2   A0A0A9WL13   K1R6L5   W8B1X6   W8BDS6   A0A0K8T4I2   A0A0P4X249   A0A0N7ZDQ1   A0A1B6ENX0   A0A1B6GUP1   A0A0L7QTJ5   U5ET56  

EC Number

1.6.2.2

Pubmed

23622113    22986333    19121390    26354079    22118469    29403074    + More
18362917    19820115    28004739    22516182    25315136    20075255    17994087    22936249    10731132    12537568    12537572    12537573    12537574    16110336    17569856    17569867    26109357    26109356    28648823    20353571    24508170    30249741    25830018    17550304    26369729    25348373    20798317    25401762    26823975    15632085    22992520    24495485   

EMBL

NWSH01001335    PCG71638.1    ODYU01004755    SOQ44973.1    GAIX01011447    JAA81113.1    + More
PCG71636.1    RSAL01000074    RVE48925.1    PCG71637.1    JX569756    AGL61416.1    HQ852050    ADX95747.1    HQ638220    ADY89570.1    HQ190046    ADO08221.1    BABH01000621    BABH01000622    BABH01000623    BABH01000624    KQ460761    KPJ12552.1    AGBW02009813    OWR49857.1    KQ459299    KPJ01879.1    PYGN01000495    PSN45371.1    LJIG01022837    KRT78459.1    KQ971312    EEZ98339.1    GEZM01023570    JAV88298.1    BT127093    AEE62055.1    AJVK01023535    AJVK01023536    GFDF01002184    JAV11900.1    GFDF01002183    JAV11901.1    AJWK01008544    GFDG01000885    JAV17914.1    GDHF01033099    GDHF01030268    GDHF01023517    GDHF01017061    JAI19215.1    JAI22046.1    JAI28797.1    JAI35253.1    GDHF01015010    GDHF01008964    GDHF01003716    JAI37304.1    JAI43350.1    JAI48598.1    GFDG01002305    JAV16494.1    KA644666    AFP59295.1    CM000363    CM002912    EDX10136.1    KMY99079.1    CH916366    EDV97221.1    CH933809    EDW18845.1    CH902618    KPU78038.1    KMY99080.1    AE014296    BT082110    AAG22320.1    ACQ45348.1    CH964095    KRF99050.1    EDV39405.1    KRG06389.1    EDW79358.1    NNAY01001033    OXU25412.1    CH480815    EDW41166.1    BT001444    AAF50004.1    AAN71199.1    GEDC01007948    GEDC01002055    JAS29350.1    JAS35243.1    CH940647    EDW69985.1    EZ422969    ADD19245.1    KRF84662.1    KRF84664.1    GEDC01009717    JAS27581.1    KK107292    QOIP01000001    EZA53480.1    RLU27130.1    UFQS01000039    UFQT01000039    SSW98128.1    SSX18514.1    GBXI01010830    GBXI01010398    JAD03462.1    JAD03894.1    KQ434886    KZC10156.1    CM000159    EDW94200.1    JXJN01004436    OUUW01000002    SPP76740.1    SPP76741.1    QCYY01002014    ROT73625.1    GEDC01005642    GEDC01003251    GEDC01000942    GEDC01000865    JAS31656.1    JAS34047.1    JAS36356.1    JAS36433.1    KRK01702.1    GDAI01000168    JAI17435.1    GBYB01015306    JAG85073.1    GEDC01002476    JAS34822.1    GEBQ01017793    JAT22184.1    GEBQ01017281    JAT22696.1    KP083296    ALA55993.1    GAKP01001401    JAC57551.1    GAKP01001407    GAKP01001404    GAKP01001403    GAKP01001402    JAC57548.1    JR038814    AEY58424.1    GL449698    EFN82148.1    KZ288267    PBC30092.1    JR038813    AEY58423.1    GBHO01036407    GDHC01019867    JAG07197.1    JAP98761.1    GEDC01026179    GEDC01020141    GEDC01012611    GEDC01012575    GEDC01006298    JAS11119.1    JAS17157.1    JAS24687.1    JAS24723.1    JAS31000.1    CH479208    EDW31184.1    CH379070    EAL30277.1    CP012525    ALC44476.1    KRT08785.1    GBHO01036405    GBHO01036404    JAG07199.1    JAG07200.1    GBHO01036406    GDHC01021650    GDHC01020694    JAG07198.1    JAP96978.1    JAP97934.1    JH819194    EKC29576.1    GAMC01011415    JAB95140.1    GAMC01011417    GAMC01011414    JAB95138.1    GBRD01005379    JAG60442.1    GDRN01012467    JAI67871.1    GDRN01012466    JAI67872.1    GECZ01030196    JAS39573.1    GECZ01003611    JAS66158.1    KQ414742    KOC61945.1    GANO01002930    JAB56941.1   

Proteomes

UP000218220    UP000283053    UP000005204    UP000053240    UP000007151    UP000053268    + More
UP000245037    UP000007266    UP000192223    UP000092462    UP000092461    UP000091820    UP000095301    UP000002358    UP000000304    UP000001070    UP000009192    UP000007801    UP000095300    UP000000803    UP000007798    UP000215335    UP000001292    UP000008792    UP000053097    UP000279307    UP000092445    UP000076502    UP000002282    UP000092443    UP000092460    UP000268350    UP000078200    UP000283509    UP000005203    UP000192221    UP000008237    UP000242457    UP000008744    UP000001819    UP000092553    UP000005408    UP000053825   

PRIDE

H9IV72    Q4LDP7    Q9I7R1   

Pfam

PF00970   FAD_binding_6        + More
PF00175   NAD_binding_1
PF01490   Aa_trans

Interpro

IPR017938   Riboflavin_synthase-like_b-brl        + More
IPR001834   CBR-like       
IPR017927   FAD-bd_FR_type       
IPR001433   OxRdtase_FAD/NAD-bd       
IPR008333   Cbr1-like_FAD-bd_dom       
IPR039261   FNR_nucleotide-bd       
IPR001709   Flavoprot_Pyr_Nucl_cyt_Rdtase       
IPR013057   AA_transpt_TM       

SUPFAM

SSF52343   SSF52343        + More
SSF63380   SSF63380       

Gene 3D

3.40.50.80    

ProteinModelPortal

A0A2A4JIV2   A0A2H1VVY9   S4NZ85   A0A2A4JIP3   A0A3S2L9Y7   A0A2A4JHV5   + More
U3LUX9   F1DI28   F1CZW3   E2JE74   H9IV72   A0A194R4E9   A0A212F7Z1   A0A194Q8Y9   A0A2P8YM95   A0A0T6AU88   D6WD52   A0A1Y1MT45   J3JV27   A0A1W4WGZ8   A0A1W4WST4   A0A1B0D3G2   A0A1L8DZK0   A0A1L8DZK6   A0A1B0CE42   A0A1A9X321   A0A1L8EGY3   A0A0K8U663   A0A0K8WBM4   A0A1L8ECX1   T1P7R9   A0A1I8MJ03   A0A0B4J2S5   B4QQN4   B4J3C2   B4KYV3   A0A0P8XTI8   A0A1I8P2Z9   A0A0J9UJE3   Q4LDP7   A0A0Q9WS49   B3M4K6   A0A0Q9XDL5   B4N403   A0A232F486   B4HEZ7   Q9I7R1   A0A1B6DUJ7   B4LDM4   D3TNG7   A0A0Q9WKV4   A0A0Q9WJ70   A0A1B6DPJ0   A0A026WBP4   A0A1B0A6S3   A0A336K3J3   A0A0A1WX89   A0A154PE53   B4PFQ1   A0A1A9YKT5   A0A1B0AVZ9   A0A3B0JMM3   A0A1A9URW1   A0A3B0JVI0   A0A3R7M6V6   A0A1B6E148   A0A0R1DX47   A0A0K8TTZ8   A0A0C9S327   A0A1B6EA56   A0A1B6LF45   A0A088AB11   A0A1B6LG70   A0A0R8YFP6   A0A034WPM3   A0A1W4W5E6   A0A034WUU1   A0A1W4VTC1   V9IDL9   E2BQ94   A0A2A3EFN3   V9IBB3   A0A0A9WFH4   A0A1B6CCH9   B4H469   Q29DY6   A0A0M4EK44   A0A0R3P6M7   A0A0A9WQT2   A0A0A9WL13   K1R6L5   W8B1X6   W8BDS6   A0A0K8T4I2   A0A0P4X249   A0A0N7ZDQ1   A0A1B6ENX0   A0A1B6GUP1   A0A0L7QTJ5   U5ET56  

PDB

1IB0     E-value=7.21634e-97,     Score=902

KEGG

101746108    K00326 cytochrome-b5 reductase [EC:1.6.2.2] | (RefSeq) NADH-cytochrome b5 reductase 2

PATHWAY

00520    Amino sugar and nucleotide sugar metabolism - Bombyx mori (domestic silkworm)

GO

GO:0004128   GO:0016021   GO:0016491   GO:0071949   GO:0012505   GO:0006890   GO:0010883   GO:0030126   GO:0005643   GO:0016616   GO:0019752   GO:0006427   GO:0016020   GO:0006412   GO:0016876   GO:0043039   GO:0055114  

Length:

311

Number of predicted TMHs:

1

Exp number of AAs in TMHs:

23.48841

Exp number, first 60 AAs:

22.60846

Total prob of N-in:

0.22930

POSSIBLE N-term signal

sequence

outside

1  -  9

TMhelix

10  -  32

inside

33  -  311

 

 

Pi

215.874659

Theta

197.007735

Tajima's D

-1.574005

CLR

16.951684

CSRT

0.0510474476276186

Interpretation

Uncertain