Gene

KWMTBOMO07962

Pre Gene Modal

BGIBMGA000996

Annotation

PREDICTED:_uncharacterized_protein_LOC101746483_isoform_X2_[Bombyx_mori]

Location

Bomo_Chr13(+):11228440-11230056      View in EpiBrowser

Full name

Protein quiver       + More
Multifunctional fusion protein      

Alternative Name

Protein sleepless

Location in the cell

Extracellular   Reliability : 2.458 PlasmaMembrane   Reliability : 1.971

CDS

ATGAAACTCGAAGTATTGTTGACAACTGTGCTAGCGATAAGTTACCTTAAAGTTGAAATCAGCTGTTTAAGTAGGAGATGTATACAGTGTAGATCTCGAGGAGAGCTTGGGTCATGTGGAGACCCTCTACCCTTTAATATAAGTGACCCTGAAGCAGAACATGGTGTGCATATTACTGCTTGTCCATCTGGATGGTGTGCCAAGAGAATTCAGGGAACCACTGGCACATTTAGAACTGATGATTATGGTGCGGTAACAGAAAGGTCCTGTCTTCAACAGCCTCCTAGTGATTATGAAGAAAGATGTGCGTATACCATGTGGAAATATAAAAGGGTATATGTATGTTTCTGTAATGGTGATTTGTGCAATTCAGCTCCAACAATGAAGATGTTTTCTCCTGTATTATTGCTCAGTATTTTTATCTTCATAAAGAATTATATTTATTAA

Protein

MKLEVLLTTVLAISYLKVEISCLSRRCIQCRSRGELGSCGDPLPFNISDPEAEHGVHITACPSGWCAKRIQGTTGTFRTDDYGAVTERSCLQQPPSDYEERCAYTMWKYKRVYVCFCNGDLCNSAPTMKMFSPVLLLSIFIFIKNYIY

Description

Required for homeostatic regulation of sleep under normal conditions and after sleep deprivation. Important regulator of the Sh K(+) channel, acting as a signaling molecule that connects sleep drive to lowered membrane excitability, possibly by enhancing K(+) channel activity and thus reducing neuronal excitability.
Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation.

Catalytic Activity

4 Fe(2+) + 4 H(+) + O2 = 4 Fe(3+) + 2 H2O

Similarity

Belongs to the quiver family.
Belongs to the ferritin family.

Feature

chain  Protein quiver

Uniprot

H9IUR6   A0A194R9M4   S4P4T8   A0A3S2M1C8   A0A1E1WN51   I4DKP0   + More
I4DKN9   A0A2A4JXT4   A0A2H1WLM9   A0A182H2X5   A0A023EDS6   A0A2M4AWN9   A0A2M4CJZ8   A0A2M3Z3A8   A0A2M4AWT0   A0A1S4F1U2   Q17I69   A0A2M4C2T7   B0X179   A0A1I8NDP3   A0A182WR58   A0A182LPP4   Q7Q2Z7   A0A182HNQ1   A0A0M5JDS4   A0A182VJC0   A0A182FJA9   A0A2J7PYC1   A0A067QST0   A0A1L8DP67   A0A2M4C335   A0A182MZT5   B4F5Y8   A0A182G608   B4F5Z0   Q9VZ21   B4IDZ0   B4NUA5   A0A0L0C0B6   A0A2M4AXJ8   A0A182RVP6   B4F5Z6   A0A182YH23   A0A182W5Y2   B4F5Z5   A0A182U521   B4PYE6   B4F5Z3   B3MVY1   A0A1J1ISB0   A0A0C9QQ49   A0A1W4V1L9   A0A182MST6   B4NCI9   A0A1I8PPE1   A0A2R7VU52   A0A224XPJ4   A0A161MT98   A0A182QS10   A0A084VDE1   A0A182K5P4   A0A3B0JWZ6   A0A088AE79   A0A1Y1NPU0   A0A1A9X3A5   T1ICK5   T1GCM6   A0A1W4XEN6   B4K2D2   B4M2N1   B4JJL3   A0A1A9YDD2   A0A1B0B035   Q29HJ3   A0A195FEF0   B4L4H7   A0A1B6INM5   J9ZZN6   A0A1B0G421   A0A1B0A3H8   A0A195BG51   A0A1A9VC03   A0A195CBF6   A0A1B6DF33   A0A336LRB1   A0A1B6FII3   B4GXK7   A0A2P8XRD8   A0A1S3CXZ1   B3NV97   A0A151J979   A0A0A9XAT5   C4WX31   E0VCD4   A0A2A3ERS0   E2BID2   A0A226CXF1   A0A226E6J0   A0A0T6B6S7   A0A0N0BFP8  

Pubmed

19121390    26354079    23622113    22651552    26483478    24945155    + More
17510324    25315136    20966253    12364791    14747013    17210077    24845553    18477586    19126864    10731132    12537568    12537572    12537573    12537574    16110336    17569856    17569867    26109357    26109356    17994087    26108605    25244985    17550304    24438588    28004739    15632085    18362917    19820115    29403074    25401762    20566863    20798317   

EMBL

BABH01000633    KQ460761    KPJ12556.1    GAIX01007516    JAA85044.1    RSAL01000074    + More
RVE48921.1    GDQN01002595    JAT88459.1    AK401858    KQ459299    BAM18480.1    KPJ01883.1    AK401857    BAM18479.1    NWSH01000379    PCG76831.1    ODYU01009497    SOQ53981.1    JXUM01106183    JXUM01106184    JXUM01106185    KQ565031    KXJ71423.1    GAPW01005860    JAC07738.1    GGFK01011896    MBW45217.1    GGFL01001387    MBW65565.1    GGFM01002256    MBW23007.1    GGFK01011894    MBW45215.1    CH477242    EAT46360.1    GGFJ01010177    MBW59318.1    DS232255    EDS38528.1    AAAB01008966    EAA13014.4    APCN01001962    CP012528    ALC49306.1    NEVH01020850    PNF21312.1    KK853324    KDR08506.1    GFDF01005939    JAV08145.1    GGFJ01010544    MBW59685.1    AM999224    AM999225    AM999227    AM999228    AM999230    FM246342    FM246346    FM246347    FM246348    FM246349    CAQ53586.1    CAQ53587.1    CAQ53589.1    CAQ53590.1    CAQ53592.1    CAR94268.1    CAR94272.1    CAR94273.1    CAR94274.1    CAR94275.1    JXUM01007400    JXUM01007401    KQ560239    KXJ83657.1    AM999226    CAQ53588.1    AE014298    AY061126    KX531353    AM999233    AM999234    AM999235    FM246338    FM246339    FM246340    FM246341    FM246343    FM246344    FM246345    AAF48010.1    AAL28674.1    ANY27163.1    CAQ53595.1    CAQ53596.1    CAQ53597.1    CAR94264.1    CAR94265.1    CAR94266.1    CAR94267.1    CAR94269.1    CAR94270.1    CAR94271.1    CH480830    EDW45798.1    CH983813    EDX16552.1    JRES01001072    KNC25733.1    GGFK01012205    MBW45526.1    AM999232    CAQ53594.1    AM999231    CAQ53593.1    CM000162    EDX02008.1    AM999229    CAQ53591.1    CH902625    EDV35126.1    CVRI01000057    CRL01998.1    GBYB01005799    JAG75566.1    AXCM01011918    CH964239    EDW82548.2    KK854082    PTY10889.1    GFTR01002020    JAW14406.1    GEMB01000256    JAS02859.1    AXCN02001405    ATLV01011272    KE524660    KFB35985.1    OUUW01000011    SPP86574.1    GEZM01000724    JAV98297.1    ACPB03022220    CAQQ02082737    CH918959    EDW04389.1    CH940651    EDW65935.1    CH916370    EDV99765.1    JXJN01006551    CH379064    EAL31765.3    KQ981673    KYN38399.1    CH933810    EDW07455.1    GECU01019178    JAS88528.1    JX470185    KQ971338    AFS64713.1    KYB27965.1    CCAG010020282    KQ976500    KYM83157.1    KQ978068    KYM97536.1    GEDC01012990    JAS24308.1    UFQS01000116    UFQT01000116    SSW99945.1    SSX20325.1    GECZ01019757    JAS50012.1    CH479196    EDW27484.1    PYGN01001493    PSN34474.1    CH954180    EDV46085.1    KQ979433    KYN21571.1    GBHO01027676    GBHO01027675    JAG15928.1    JAG15929.1    ABLF02029452    AK342418    BAH72451.1    DS235053    EEB11040.1    KZ288192    PBC34390.1    GL448504    EFN84520.1    LNIX01000077    OXA36716.1    LNIX01000006    OXA53232.1    LJIG01009450    KRT83055.1    KQ435794    KOX73661.1   

Proteomes

UP000005204    UP000053240    UP000283053    UP000053268    UP000218220    UP000069940    + More
UP000249989    UP000008820    UP000002320    UP000095301    UP000076407    UP000075882    UP000007062    UP000075840    UP000092553    UP000075903    UP000069272    UP000235965    UP000027135    UP000075884    UP000000803    UP000001292    UP000000304    UP000037069    UP000075900    UP000076408    UP000075920    UP000075902    UP000002282    UP000007801    UP000183832    UP000192221    UP000075883    UP000007798    UP000095300    UP000075886    UP000030765    UP000075881    UP000268350    UP000005203    UP000091820    UP000015103    UP000015102    UP000192223    UP000001070    UP000008792    UP000092443    UP000092460    UP000001819    UP000078541    UP000009192    UP000007266    UP000092444    UP000092445    UP000078540    UP000078200    UP000078542    UP000008744    UP000245037    UP000079169    UP000008711    UP000078492    UP000007819    UP000009046    UP000242457    UP000008237    UP000198287    UP000053105   

PRIDE

H9IUR6    Q9VZ21   

Pfam

PF17064   QVR        + More
PF00096   zf-C2H2
PF00210   Ferritin
PF00047   ig

Interpro

IPR031424   QVR        + More
IPR036236   Znf_C2H2_sf       
IPR013087   Znf_C2H2_type       
IPR014034   Ferritin_CS       
IPR009040   Ferritin-like_diiron       
IPR008331   Ferritin_DPS_dom       
IPR009078   Ferritin-like_SF       
IPR012347   Ferritin-like       
IPR001519   Ferritin       
IPR038905   ARMC2       
IPR036179   Ig-like_dom_sf       
IPR013151   Immunoglobulin       
IPR013783   Ig-like_fold       
IPR039311   FAM187A/B       
IPR007110   Ig-like_dom       

SUPFAM

SSF57667   SSF57667        + More
SSF47240   SSF47240       
SSF48726   SSF48726       

Gene 3D

1.20.1260.10     2.60.40.10    

ProteinModelPortal

H9IUR6   A0A194R9M4   S4P4T8   A0A3S2M1C8   A0A1E1WN51   I4DKP0   + More
I4DKN9   A0A2A4JXT4   A0A2H1WLM9   A0A182H2X5   A0A023EDS6   A0A2M4AWN9   A0A2M4CJZ8   A0A2M3Z3A8   A0A2M4AWT0   A0A1S4F1U2   Q17I69   A0A2M4C2T7   B0X179   A0A1I8NDP3   A0A182WR58   A0A182LPP4   Q7Q2Z7   A0A182HNQ1   A0A0M5JDS4   A0A182VJC0   A0A182FJA9   A0A2J7PYC1   A0A067QST0   A0A1L8DP67   A0A2M4C335   A0A182MZT5   B4F5Y8   A0A182G608   B4F5Z0   Q9VZ21   B4IDZ0   B4NUA5   A0A0L0C0B6   A0A2M4AXJ8   A0A182RVP6   B4F5Z6   A0A182YH23   A0A182W5Y2   B4F5Z5   A0A182U521   B4PYE6   B4F5Z3   B3MVY1   A0A1J1ISB0   A0A0C9QQ49   A0A1W4V1L9   A0A182MST6   B4NCI9   A0A1I8PPE1   A0A2R7VU52   A0A224XPJ4   A0A161MT98   A0A182QS10   A0A084VDE1   A0A182K5P4   A0A3B0JWZ6   A0A088AE79   A0A1Y1NPU0   A0A1A9X3A5   T1ICK5   T1GCM6   A0A1W4XEN6   B4K2D2   B4M2N1   B4JJL3   A0A1A9YDD2   A0A1B0B035   Q29HJ3   A0A195FEF0   B4L4H7   A0A1B6INM5   J9ZZN6   A0A1B0G421   A0A1B0A3H8   A0A195BG51   A0A1A9VC03   A0A195CBF6   A0A1B6DF33   A0A336LRB1   A0A1B6FII3   B4GXK7   A0A2P8XRD8   A0A1S3CXZ1   B3NV97   A0A151J979   A0A0A9XAT5   C4WX31   E0VCD4   A0A2A3ERS0   E2BID2   A0A226CXF1   A0A226E6J0   A0A0T6B6S7   A0A0N0BFP8  

KEGG

101746483    no KO assigned | (RefSeq) uncharacterized LOC101746483

GO

GO:0032222   GO:0031225   GO:0030431   GO:1903818   GO:0005886   GO:0048511   GO:0034235   GO:0045187   GO:0016021   GO:0003676   GO:0035158   GO:0035152   GO:0008362   GO:0007424   GO:0006031   GO:0006826   GO:0004322   GO:0008199   GO:0006879  

PANTHER

PTHR11431   PTHR21356   PTHR32178  

Subcellular location

Cell membrane  

SignalP

Position:   1 - 24,         Likelihood:  0.881532

 

 

Length:

148

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

11.769

Exp number, first 60 AAs:

2.48665

Total prob of N-in:

0.16561

outside

1  -  148

 

 

Pi

251.665132

Theta

221.366019

Tajima's D

0.467326

CLR

0

CSRT

0.508174591270437

Interpretation

Uncertain