Gene

KWMTBOMO07961  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA001154

Annotation

aly_protein_[Bombyx_mori]

Location

Bomo_Chr13(-):11221764-11223909      View in EpiBrowser

Full name

Protein lin-9 homolog      

Alternative Name

TUDOR gene similar 1 protein
Type I interferon receptor beta chain-associated protein

Location in the cell

Nuclear   Reliability : 4.359

CDS

ATGGCGGATAAATCAGAAAGAGAGTATGACGAATTATCAACTCCACCAAGATCACTCCAAAAGGTTAAAGATGAGCCAATGGAAATGGATTTTCCGGAAGAAGAAGAAGAAGAACCTCCAGCATTCGGACCTGCAGCATTGGGCTTGCATAGAGTTGGTACAAAATTGCCGCCAAAACCAGCTCCAAGTGAGCCAGTTCAAAAACTTAATGCAAGGGGAATGCCCGCTAGGATCAGAAAGAAAAATAGGTTCATTTTTGTTGACGATTTTGTGAACACGTCACCTCCACGACAGTCTCCAAAAAAGACTCCAAAAATACTTAACAAAACGCCTAATAAACCACCAAGTGCAAAAAAACAAAAATCTCCAATAAAAGTTCAAAAGGCTACAGAGAGGAATGATAAGGTAGATTCTGTAGGCATCCAAATGCAAGACAATAAATCAGGTCATCGAATTGGCATGCGACTTAGAAATTTATTGAAGCTACCCAAGGCTCACAAGTGGGTGTGTTTTGAATACTTTTATAGTAATATTGATAAAGTATTATTTGATGGTGAAAATGATTTTATGATTTGCTTAAAAGAATCATTTCCACAATTGACCAACAGAAAGTTAACTAGAACACAATGGTCAAAAATCAGAAGAATGATGGGAAAGCCTCGACGATGTTCTCAAGCATTTTTTGATGAGGAGCGGAAAGAATTGGAAAGAAAGAGGAAATTGATTCGATATGTACAACAGCAAAAATCGGCTGATGTGTGTGTCAAAGATTTACCAACCGAAATACCAATGCAATTAGTAGTTGGTACTAAAGTTACTGCTAGACTACGTCGACCACAGGATGGATTGTTCACTGGATGCATCGATGCTGTTGATACATCTAATAACACATATAGGATAACTTTTGAAAGACCTAAATTGGGCACACATTCAGTACCTGATTATGAAGTATTGTCAAATGAACCACCTGATACTATTTGTCTGACAAGTATAACGCAACGTTTTAGACCAAGAAAAGTAATTCAAGATCTACTCAGTTTGTATTCACCAATACAGAAAAATTCGCAAGGAGATCCTTTGATTGGATGTTCTGATCTTGCAAATCAAGCTAATTCTGTAATTGGTAGTTACCCATTCCGGTTTTTAGAACTCATTGTAAAATTAAGAAGATTATTAAATGCTAAAAAGAGCAAGATAAATAAATTAAAAGAATATAACTGTATGGCAGAAAAAAGAAAGTCCTTTGGACAGAGGATGCCTGAAGACTTTGAACGAAAATATGCTGCTGTTGTGATTGAGTTAGAAAGAATGAATATGGATTTACAAGAATATATCAATGAGATTCAACATCATTGTCAACAAATTGCACCAGGGCCATGTTTGGCTGCAATGTTAGCACCATCGCAACTTCGAGACAAATGTCATGAAGAAGCTTCAGTTCTTGTTGAGAAGAATAACAATGGAGTTATTCAAGATCCTTCAGTTTTAGATCTCATAACAGATCTAACTGCACTCATGTTGCAAGTTAGAAGTTTATCTGATTCAGATCAGAATGCCTATGAACTGAGTGTACTTCAAGGTACAATGGATCAGATCAAGATGAAATTAAAACCACAATATCACAGATTGTTTCAAAATAATGTTGAAATACATATGCATAAAATTCAGATGGGATTGGGGCAAATGATTTTTGAATATTCTGCAGGCACATAA

Protein

MADKSEREYDELSTPPRSLQKVKDEPMEMDFPEEEEEEPPAFGPAALGLHRVGTKLPPKPAPSEPVQKLNARGMPARIRKKNRFIFVDDFVNTSPPRQSPKKTPKILNKTPNKPPSAKKQKSPIKVQKATERNDKVDSVGIQMQDNKSGHRIGMRLRNLLKLPKAHKWVCFEYFYSNIDKVLFDGENDFMICLKESFPQLTNRKLTRTQWSKIRRMMGKPRRCSQAFFDEERKELERKRKLIRYVQQQKSADVCVKDLPTEIPMQLVVGTKVTARLRRPQDGLFTGCIDAVDTSNNTYRITFERPKLGTHSVPDYEVLSNEPPDTICLTSITQRFRPRKVIQDLLSLYSPIQKNSQGDPLIGCSDLANQANSVIGSYPFRFLELIVKLRRLLNAKKSKINKLKEYNCMAEKRKSFGQRMPEDFERKYAAVVIELERMNMDLQEYINEIQHHCQQIAPGPCLAAMLAPSQLRDKCHEEASVLVEKNNNGVIQDPSVLDLITDLTALMLQVRSLSDSDQNAYELSVLQGTMDQIKMKLKPQYHRLFQNNVEIHMHKIQMGLGQMIFEYSAGT

Description

Acts as a tumor suppressor. Inhibits DNA synthesis. Its ability to inhibit oncogenic transformation is mediated through its association with RB1. Plays a role in the expression of genes required for the G1/S transition (By similarity).

Subunit

Component of the DREAM complex (also named LINC complex) at least composed of E2F4, E2F5, LIN9, LIN37, LIN52, LIN54, MYBL1, MYBL2, RBL1, RBL2, RBBP4, TFDP1 and TFDP2. The complex exists in quiescent cells where it represses cell cycle-dependent genes. It dissociates in S phase when LIN9, LIN37, LIN52 and LIN54 form a subcomplex that binds to MYBL2. Interacts with RB1 (By similarity).

Similarity

Belongs to the lin-9 family.

Keywords

Acetylation   Alternative splicing   Cell cycle   Coiled coil   Complete proteome   DNA synthesis   Isopeptide bond   Nucleus   Phosphoprotein   Reference proteome   Tumor suppressor   Ubl conjugation  

Feature

chain  Protein lin-9 homolog
splice variant  In isoform 3.

Uniprot

H9IV74   D0V0M8   A0A2A4JZL1   A0A1E1WKP7   A0A2H1V6N8   A0A212ETP1   + More
S4PYF9   A0A194R4F4   A0A194QA65   A0A3S2NED6   A0A0L7LS56   A0A2J7R2K7   A0A2J7R2K0   A0A195BG63   A0A158NBV4   A0A067R349   A0A195FDE3   A0A151X9T1   E2BID1   A0A151J9K1   A0A195C9J4   A0A154P6H5   A0A1Y1LYI4   F4X8D9   E2ABC7   A0A1Y1LZH8   A0A1W4X561   A0A1Y1LTP9   A0A1W4XFT6   A0A3L8DVH9   E9J8J6   A0A0J7NSZ6   D1ZZX2   A0A2A3ETL9   K7IZB0   A0A0L7R224   A0A088AEB7   A0A0N0BFQ1   A0A232EXQ1   A0A026X131   A0A1B6FUC5   U4UDA0   N6TXS0   A0A1B6MGU0   A0A1B6D2M1   E0W435   A0A2R7VW22   A0A2R7VVH1   A0A1B0CRA5   N6UK17   T1IXW4   A0A3R7QWA5   A0A0P4WF63   A0A023F175   A0A0A9YXA9   A0A1L8DXB6   A0A1L8DWX9   A0A0A9YMA3   A0A069DVS6   Q0IFF2   A0A1S4FB31   A0A182GFR3   A0A0K2UPL5   A0A0K2UNH6   A0A182GWM1   A0A1S3K263   A0A210QWB4   B0X055   A0A226E786   V4ALJ9   K1QPE0   T1HYZ9   A0A336LMI7   C3Y680   A0A1D2MWD7   A0A146LAC4   A0A2T7PJE4   A0A3B5AY24   A0A286XYS0   A0A2D4MSX5   A0A2D4FNQ9   H0VTU6   A0A091H8T7   A0A091IE25   A0A0B6YU57   R4GCS8   A0A286XM72   K7GDQ0   A0A093IMJ2   A0A091HH70   A0A0A6YWD3   Q8C735   G1KF29   A0A093GV25   A0A2Y9JSM0   A0A3P4KT75   A0A2Y9QX57   G3SQF4   A0A0A6YVZ7  

Pubmed

19121390    22118469    23622113    26354079    26227816    21347285    + More
24845553    20798317    28004739    21719571    30249741    21282665    18362917    19820115    20075255    28648823    24508170    23537049    20566863    25474469    25401762    26334808    17510324    26483478    28812685    23254933    22992520    18563158    27289101    26823975    21993624    17381049    19468303    21183079    16141072    16730350   

EMBL

BABH01000635    GQ999610    ACY24884.1    NWSH01000379    PCG76832.1    GDQN01003623    + More
JAT87431.1    ODYU01000707    SOQ35924.1    AGBW02012542    OWR44860.1    GAIX01003358    JAA89202.1    KQ460761    KPJ12557.1    KQ459299    KPJ01885.1    RSAL01000074    RVE48919.1    JTDY01000221    KOB78214.1    NEVH01007828    PNF35052.1    PNF35051.1    KQ976500    KYM83155.1    ADTU01011330    ADTU01011331    KK852744    KDR17349.1    KQ981673    KYN38401.1    KQ982373    KYQ57048.1    GL448504    EFN84519.1    KQ979433    KYN21569.1    KQ978068    KYM97534.1    KQ434827    KZC07462.1    GEZM01046567    JAV77075.1    GL888932    EGI57154.1    GL438237    EFN69248.1    GEZM01046566    JAV77076.1    GEZM01046568    JAV77074.1    QOIP01000004    RLU23758.1    GL769034    EFZ10847.1    LBMM01001917    KMQ95545.1    KQ971338    EFA02434.1    KZ288192    PBC34391.1    KQ414666    KOC64889.1    KQ435794    KOX73662.1    NNAY01001719    OXU23133.1    KK107036    EZA62010.1    GECZ01016020    JAS53749.1    KB632308    ERL91939.1    APGK01009034    APGK01029131    KB740725    KB737836    ENN79342.1    ENN82898.1    GEBQ01004876    JAT35101.1    GEDC01017483    JAS19815.1    DS235886    EEB20391.1    KK854082    PTY10890.1    PTY10891.1    AJWK01024544    APGK01030256    KB740764    ENN79027.1    JH431663    QCYY01001102    ROT80589.1    GDRN01061470    JAI65204.1    GBBI01003968    JAC14744.1    GBHO01039528    GBHO01009414    JAG04076.1    JAG34190.1    GFDF01003189    JAV10895.1    GFDF01003190    JAV10894.1    GBHO01039526    GBHO01009432    JAG04078.1    JAG34172.1    GBGD01001087    JAC87802.1    CH477351    EAT42873.1    JXUM01062663    KQ562210    KXJ76404.1    HACA01022451    CDW39812.1    HACA01022452    CDW39813.1    JXUM01093639    KQ564070    KXJ72837.1    NEDP02001544    OWF53011.1    DS232229    EDS37930.1    LNIX01000006    OXA52456.1    KB199650    ESP05059.1    JH818449    EKC30705.1    ACPB03022219    UFQS01000062    UFQT01000062    SSW98810.1    SSX19196.1    GG666487    EEN64477.1    LJIJ01000459    ODM97251.1    GDHC01014562    JAQ04067.1    PZQS01000003    PVD33549.1    AAKN02053936    IACM01117717    IACM01117720    LAB35863.1    IACJ01084300    LAA49115.1    KL448315    KFO82657.1    KL218535    KFP06512.1    HACG01012130    CEK58995.1    AGCU01051922    KL216060    KFV67921.1    KL537238    KFO94809.1    AC167020    AK042357    AK052618    AF190325    KL205761    KFV74158.1    CYRY02000988    VCW54932.1   

Proteomes

UP000005204    UP000218220    UP000007151    UP000053240    UP000053268    UP000283053    + More
UP000037510    UP000235965    UP000078540    UP000005205    UP000027135    UP000078541    UP000075809    UP000008237    UP000078492    UP000078542    UP000076502    UP000007755    UP000000311    UP000192223    UP000279307    UP000036403    UP000007266    UP000242457    UP000002358    UP000053825    UP000005203    UP000053105    UP000215335    UP000053097    UP000030742    UP000019118    UP000009046    UP000092461    UP000283509    UP000008820    UP000069940    UP000249989    UP000085678    UP000242188    UP000002320    UP000198287    UP000030746    UP000005408    UP000015103    UP000001554    UP000094527    UP000245119    UP000261400    UP000005447    UP000053760    UP000054308    UP000001646    UP000007267    UP000053875    UP000000589    UP000053584    UP000248482    UP000248480    UP000007646   

PRIDE

H9IV74    D0V0M8    K1QPE0    Q8C735    A0A0A6YVZ7   

Pfam

PF06584   DIRP

Interpro

IPR033471   DIRP        + More
IPR010561   LIN-9/ALY1       

ProteinModelPortal

H9IV74   D0V0M8   A0A2A4JZL1   A0A1E1WKP7   A0A2H1V6N8   A0A212ETP1   + More
S4PYF9   A0A194R4F4   A0A194QA65   A0A3S2NED6   A0A0L7LS56   A0A2J7R2K7   A0A2J7R2K0   A0A195BG63   A0A158NBV4   A0A067R349   A0A195FDE3   A0A151X9T1   E2BID1   A0A151J9K1   A0A195C9J4   A0A154P6H5   A0A1Y1LYI4   F4X8D9   E2ABC7   A0A1Y1LZH8   A0A1W4X561   A0A1Y1LTP9   A0A1W4XFT6   A0A3L8DVH9   E9J8J6   A0A0J7NSZ6   D1ZZX2   A0A2A3ETL9   K7IZB0   A0A0L7R224   A0A088AEB7   A0A0N0BFQ1   A0A232EXQ1   A0A026X131   A0A1B6FUC5   U4UDA0   N6TXS0   A0A1B6MGU0   A0A1B6D2M1   E0W435   A0A2R7VW22   A0A2R7VVH1   A0A1B0CRA5   N6UK17   T1IXW4   A0A3R7QWA5   A0A0P4WF63   A0A023F175   A0A0A9YXA9   A0A1L8DXB6   A0A1L8DWX9   A0A0A9YMA3   A0A069DVS6   Q0IFF2   A0A1S4FB31   A0A182GFR3   A0A0K2UPL5   A0A0K2UNH6   A0A182GWM1   A0A1S3K263   A0A210QWB4   B0X055   A0A226E786   V4ALJ9   K1QPE0   T1HYZ9   A0A336LMI7   C3Y680   A0A1D2MWD7   A0A146LAC4   A0A2T7PJE4   A0A3B5AY24   A0A286XYS0   A0A2D4MSX5   A0A2D4FNQ9   H0VTU6   A0A091H8T7   A0A091IE25   A0A0B6YU57   R4GCS8   A0A286XM72   K7GDQ0   A0A093IMJ2   A0A091HH70   A0A0A6YWD3   Q8C735   G1KF29   A0A093GV25   A0A2Y9JSM0   A0A3P4KT75   A0A2Y9QX57   G3SQF4   A0A0A6YVZ7  

PDB

6C48     E-value=1.87821e-16,     Score=211

KEGG

100313490    K21773 protein lin-9 | (RefSeq) Aly; aly protein

GO

GO:0017053   GO:0006351   GO:0000003   GO:0051726   GO:0003677   GO:0005654   GO:0016021   GO:0007049   GO:0071897  

PANTHER

PTHR21689  

Subcellular location

   Found in perinucleolar structures. Associated with chromatin.   With evidence from 2 publications.

Length:

570

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.000620000000000001

Exp number, first 60 AAs:

0

Total prob of N-in:

0.00307

outside

1  -  570

 

 

Pi

5.159964

Theta

5.430406

Tajima's D

-0.138441

CLR

0.763971

CSRT

0.351932403379831

Interpretation

Uncertain