Gene

KWMTBOMO07957

Pre Gene Modal

BGIBMGA000994

Annotation

PREDICTED:_malate_dehydrogenase_1?_mitochondrial-like_[Bombyx_mori]

Location

Bomo_Chr13(+):11192510-11193637      View in EpiBrowser

Full name

Malate dehydrogenase      

Location in the cell

Mitochondrial   Reliability : 1.679 PlasmaMembrane   Reliability : 1.016

CDS

ATGATAGTGAATCGAAGAATAATCTCGTCGTTGTTCACCACAACAAGAAGTTACCAAGTTACGGTAGTTGGCGCAACAAGCGAAGTCGGTCAAGTCCTGAGTCTATTACTGAGATCTTTACCTTTAATAACTAAATTAGTTGTTCACGATAACAAGGAATTTACTCCAGGTGTTACATTAGATTTATCACAAATACCCAGTCCCTCGCGAATATTAGGATTGACTGGCGAAGATACCTTAGAACGAGCTCTTAAAAACTCTGATTTGATCATAGCAGCTGGCGGACTTTCACAACGTCCAGATATAAGTGAAAAAGCTCTGTTGACAGCGAATAGCCAGTTCATTAAGTCTATCATCTCGAAATTGGGAAGATCGTGTCCTATACCTTTTGTAGGAATAGTTACTGAACCTATAAACTATTTAATTCCCATGACTGCTGAAATTATGAGGAATCACGGTGTTTATGATGAAAAAAAGTTATTTGGAATAACCGAAATTGACGCCATACGATCGCAGTGTCTTTACGCCACGGAGAATAATTTGAAAGCAAACGATTGTTATGTACCTGTTATTGGAGGCCATTCAGATAAAACGATTGTCCCATTGTTGTCTCAAGCTAAACCCACTGTGGAAATGAAAGAAAAAGATTTAGAAGAATTTACCATTAAATTGCGAAATTGCGATGGTATGATAACAAAGGCTAAAAGAGGGTGTATTCCTAATTTGTCAGTTGCATATAGTAGTTTTCTTTTCACTAAAAGCATTCTCGACGCTTTAGAAGGCAGCCCTGCAAAAATTCACGCTTTTGTAGATAACAATGACTTTGGTACATCATATTTCTCTAGCCTGGTGAATCTGGATAAAAATGGCGTCAAGGAAATGGTAAGATATTCAGAGTTCTCAAAATTTGAGTGTGATTTAATTGAAAAAAGTTTGCAGCAGTTGCGAAAAGACGTATCTAAAGGAAGGAAAATATTGGAACTGGCGTAA

Protein

MIVNRRIISSLFTTTRSYQVTVVGATSEVGQVLSLLLRSLPLITKLVVHDNKEFTPGVTLDLSQIPSPSRILGLTGEDTLERALKNSDLIIAAGGLSQRPDISEKALLTANSQFIKSIISKLGRSCPIPFVGIVTEPINYLIPMTAEIMRNHGVYDEKKLFGITEIDAIRSQCLYATENNLKANDCYVPVIGGHSDKTIVPLLSQAKPTVEMKEKDLEEFTIKLRNCDGMITKAKRGCIPNLSVAYSSFLFTKSILDALEGSPAKIHAFVDNNDFGTSYFSSLVNLDKNGVKEMVRYSEFSKFECDLIEKSLQQLRKDVSKGRKILELA

Description

Catalyzes the reversible oxidation of malate to oxaloacetate.

Catalytic Activity

(S)-malate + NAD(+) = H(+) + NADH + oxaloacetate

Subunit

Homodimer.

Similarity

Belongs to the LDH/MDH superfamily.
Belongs to the LDH/MDH superfamily. MDH type 1 family.

Feature

chain  Malate dehydrogenase

Uniprot

H9IUR4   A0A0L7LSP5   A0A2A4JXU5   A0A2H1W725   A0A194R5Q1   A0A194Q8N5   + More
A0A1I7VM37   A0A069DYP3   A0A158Q7N8   A0A0K0IZA2   A0A0N4TT58   A0A1I8CFH1   A0A0V0G3N9   A0A1L8EI00   A0A0K0EJS9   J9F386   A0A0H5SP26   A0A0N4ZV85   D8RBW3   A0A0L0BXC1   A0A151KTC4   A0A099MAH7   A0A0F2I4B9   A0A087U9C0   A0A1I8B0F3   D8RXR3   A0A0K0F735   A0A0N5B542   A0A3R9EK95   A0A3P6SGY9   A0A023FKC0   A0A1Y0D1C4   U4K8H6   A0A2N0XS07   A0A090LKA7   A0A1Y6IZK4   Q4PP90   A0A2G8L9N0   A0A3B1JQM0   A0A1L8EEQ2   A0A1L8EEK1   A0A3B0KCD1   A0A2P7R8R3   Q9NHX3   A0A0L7ZFB9   D2A663   A0A1S3ZW53   A0A1U7YI28   A0A023FJ07   A0A0C9S2L6   R4G866   A0A329EAC4   U4DXT9   B4K7H4   A0A0C9QFA6   A0A034VDU0   A0A0K8VWB8   A0A023FWQ5   A0A317ZXA6   A0A2N6CU64   A0A3S0Q063   A0A1J6IJL7   V5SJ21   A0A170ZKM6   A0A182DZC4   R7TSV0   A0A1V0I515   B4NG95   A0A026WP45   A0A380NUH3   C9P2S3   A0A2P0XJ03   A0A2K6WIX3   A0A2G5CGV8   A0A2J8GIH2   W8BVV6   A0A1W4U941   D0X9A1   A0A086WHW1   A0A097QN77   B4IB85   Q9VEB1   A0A1S4A9C7   A0A2I4ETB2   D1MBR2   B4PL86   A0A3L6FDC0   B4FRJ1   A0A2Z5RE49   A0A231MX69   K3XJN7   A0A2G9UBR2   Q6BCF2   Q6BCF0   A0A0P7XGH5   A0A3S4Q176   A0A3P8VIR3   A0A1B0AIQ6   B4M0W4  

EC Number

1.1.1.37

Pubmed

19121390    26227816    26354079    25217238    26334808    17885136    + More
26829753    26850696    21551031    26108605    18809916    23739050    27311813    29023486    25329095    10713448    18362917    19820115    24807620    23773524    26131772    17994087    25348373    22919073    23254933    24508170    24495485    19860885    10731132    12537568    12537572    12537573    12537574    16110336    17569856    17569867    26109357    26109356    27145194    17550304    30061735    19936069    26760975    22580951    16598154    30626928    24487278   

EMBL

BABH01000643    JTDY01000221    KOB78221.1    NWSH01000379    PCG76837.1    ODYU01006624    + More
SOQ48632.1    KQ460761    KPJ12560.1    KQ459299    KPJ01888.1    JH712099    EFO26441.1    GBGD01002040    JAC86849.1    UZAD01013255    VDN93060.1    GECL01003432    JAP02692.1    GFDG01000570    JAV18229.1    ADBV01000013    UYWW01000109    EJW88983.1    VDM07303.1    LN857006    CRZ25392.1    GL377575    EFJ30575.1    JRES01001197    KNC24655.1    LOBR01000109    KYN81875.1    JMCG01000001    KGK10254.1    JZAM01000168    KJR31831.1    KK118832    KFM73959.1    GL377594    EFJ22957.1    RSFA01000010    RSD32391.1    UYRX01000105    VDK74056.1    GBBK01002903    JAC21579.1    CP021376    ART80905.1    FO203526    CCO58964.1    PIZL01000019    PKF78653.1    LN609529    CEF67990.1    FXXI01000010    SMS02451.1    DQ062223    AAY63978.1    MRZV01000159    PIK56961.1    GFDG01001643    JAV17156.1    GFDG01001652    JAV17147.1    OUUW01000008    SPP83849.1    PXYG01000002    PSJ46605.1    AF218064    AAF27650.1    LFWL01000049    KOE88878.1    KQ971346    EFA04972.1    GBBK01002880    JAC21602.1    GBZX01001486    JAG91254.1    ACPB03000504    GAHY01001507    JAA76003.1    QLTR01000009    RAS64464.1    CANW01000002    CCN39022.1    CH933806    EDW15318.1    GBYB01013203    JAG82970.1    GAKP01018685    GAKP01018684    JAC40267.1    GDHF01009138    JAI43176.1    GBBL01001391    JAC25929.1    QHMB01000011    PXA69912.1    PKUN01000023    PLX60668.1    RXZH01000009    RTZ14337.1    MJEQ01037190    OIS99074.1    KF647639    AHB50501.1    GEMB01002082    JAS01097.1    UYRW01000119    VDK63335.1    AMQN01012226    KB309380    ELT94561.1    CP020453    ARC91281.1    CH964251    EDW83312.1    KK107139    EZA57723.1    UHIS01000006    SUP51126.1    ACZO01000006    EEX37971.1    KY661311    AVA17398.1    CMVM020000250    KZ305072    PIA30524.1    POSH01000020    PNH85793.1    GAMC01003193    JAC03363.1    ACZC01000015    EEZ88439.1    JPQB01000033    KFI09361.1    NRHY01000021    NRQO01000019    PAU35767.1    PAW01028.1    CH480827    EDW44643.1    AE014297    AY119152    BT029274    AAF55516.1    AAM51012.1    ABK30911.1    GU130143    ACZ13336.1    CM000160    EDW95868.1    NCVQ01000004    PWZ31152.1    BT039729    CM007649    ACF84734.1    ONM39824.1    FX983743    BAX07242.1    CP012621    NMUO01000056    ATG75149.1    OXS14784.1    AGNK02003222    CM003532    RCV26435.1    KZ347463    PIO67669.1    AB185122    BAD30065.1    AB185123    BAD30066.1    LIHO01000011    KPQ02561.1    QPKB01000013    RWR97473.1    CH940650    EDW68423.1   

Proteomes

UP000005204    UP000037510    UP000218220    UP000053240    UP000053268    UP000095285    + More
UP000050640    UP000006672    UP000038020    UP000278627    UP000095286    UP000035681    UP000004810    UP000093561    UP000270924    UP000038045    UP000001514    UP000037069    UP000075346    UP000029994    UP000033477    UP000054359    UP000095281    UP000035680    UP000046392    UP000269041    UP000277928    UP000243793    UP000016895    UP000233580    UP000035682    UP000196125    UP000230750    UP000018467    UP000268350    UP000240243    UP000037536    UP000007266    UP000084051    UP000189701    UP000015103    UP000248729    UP000018247    UP000009192    UP000246709    UP000235015    UP000268973    UP000187609    UP000077448    UP000271087    UP000014760    UP000007798    UP000053097    UP000254349    UP000005604    UP000024404    UP000230069    UP000236330    UP000192221    UP000004396    UP000029061    UP000217861    UP000218364    UP000001292    UP000000803    UP000235220    UP000002282    UP000251960    UP000007305    UP000215233    UP000217763    UP000004995    UP000053932    UP000283530    UP000265120    UP000092445    UP000008792   

PRIDE

H9IUR4    Q9VEB1    B4FRJ1   

Pfam

PF00056   Ldh_1_N        + More
PF02866   Ldh_1_C

Interpro

IPR001236   Lactate/malate_DH_N        + More
IPR036291   NAD(P)-bd_dom_sf       
IPR022383   Lactate/malate_DH_C       
IPR001557   L-lactate/malate_DH       
IPR015955   Lactate_DH/Glyco_Ohase_4_C       
IPR010097   Malate_DH_type1       
IPR001252   Malate_DH_AS       
IPR023958   Malate_DH_type1_bac       

SUPFAM

SSF56327   SSF56327        + More
SSF51735   SSF51735       

Gene 3D

3.90.110.10    

ProteinModelPortal

H9IUR4   A0A0L7LSP5   A0A2A4JXU5   A0A2H1W725   A0A194R5Q1   A0A194Q8N5   + More
A0A1I7VM37   A0A069DYP3   A0A158Q7N8   A0A0K0IZA2   A0A0N4TT58   A0A1I8CFH1   A0A0V0G3N9   A0A1L8EI00   A0A0K0EJS9   J9F386   A0A0H5SP26   A0A0N4ZV85   D8RBW3   A0A0L0BXC1   A0A151KTC4   A0A099MAH7   A0A0F2I4B9   A0A087U9C0   A0A1I8B0F3   D8RXR3   A0A0K0F735   A0A0N5B542   A0A3R9EK95   A0A3P6SGY9   A0A023FKC0   A0A1Y0D1C4   U4K8H6   A0A2N0XS07   A0A090LKA7   A0A1Y6IZK4   Q4PP90   A0A2G8L9N0   A0A3B1JQM0   A0A1L8EEQ2   A0A1L8EEK1   A0A3B0KCD1   A0A2P7R8R3   Q9NHX3   A0A0L7ZFB9   D2A663   A0A1S3ZW53   A0A1U7YI28   A0A023FJ07   A0A0C9S2L6   R4G866   A0A329EAC4   U4DXT9   B4K7H4   A0A0C9QFA6   A0A034VDU0   A0A0K8VWB8   A0A023FWQ5   A0A317ZXA6   A0A2N6CU64   A0A3S0Q063   A0A1J6IJL7   V5SJ21   A0A170ZKM6   A0A182DZC4   R7TSV0   A0A1V0I515   B4NG95   A0A026WP45   A0A380NUH3   C9P2S3   A0A2P0XJ03   A0A2K6WIX3   A0A2G5CGV8   A0A2J8GIH2   W8BVV6   A0A1W4U941   D0X9A1   A0A086WHW1   A0A097QN77   B4IB85   Q9VEB1   A0A1S4A9C7   A0A2I4ETB2   D1MBR2   B4PL86   A0A3L6FDC0   B4FRJ1   A0A2Z5RE49   A0A231MX69   K3XJN7   A0A2G9UBR2   Q6BCF2   Q6BCF0   A0A0P7XGH5   A0A3S4Q176   A0A3P8VIR3   A0A1B0AIQ6   B4M0W4  

PDB

4E0B     E-value=3.97633e-46,     Score=465

KEGG

101746766    K00026 malate dehydrogenase [EC:1.1.1.37] | (RefSeq) malate dehydrogenase 1, mitochondrial-like

PATHWAY

00020    Citrate cycle (TCA cycle) - Bombyx mori (domestic silkworm)
00270    Cysteine and methionine metabolism - Bombyx mori (domestic silkworm)
00620    Pyruvate metabolism - Bombyx mori (domestic silkworm)
00630    Glyoxylate and dicarboxylate metabolism - Bombyx mori (domestic silkworm)
01100    Metabolic pathways - Bombyx mori (domestic silkworm)
01200    Carbon metabolism - Bombyx mori (domestic silkworm)

GO

GO:0005975   GO:0016616   GO:0019752   GO:0006108   GO:0006099   GO:0030060   GO:0005739   GO:0005737   GO:0006919   GO:0035209   GO:0035096   GO:0035071   GO:0043068   GO:0016615   GO:0043067   GO:0005759   GO:0055114   GO:0035070   GO:0005886   GO:0009505   GO:0003824   GO:0016491   GO:0006427   GO:0016020   GO:0006412   GO:0016876   GO:0043039  

PANTHER

PTHR11540:SF22  

Length:

329

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.864849999999999

Exp number, first 60 AAs:

0.75494

Total prob of N-in:

0.08407

outside

1  -  329

 

 

Pi

52.409584

Theta

124.699184

Tajima's D

-0.460984

CLR

5.878747

CSRT

0.247287635618219

Interpretation

Uncertain