Gene

KWMTBOMO07956

Pre Gene Modal

BGIBMGA001156

Annotation

Malate_dehydrogenase_[Operophtera_brumata]

Location

Bomo_Chr13(-):11189387-11190679      View in EpiBrowser

Full name

Malate dehydrogenase      

Location in the cell

PlasmaMembrane   Reliability : 3.059

CDS

ATGGCCCAAAAAATATTTTGTTGTTTATTTGCAACGCAGCTAAAGAAAAACACACTGATCTTACAAAAAAGAAATGTACAAGTATCTGTTATTGGAGCAGCAAGTGATATTGGTTCATATGTGTCTCTCTTTCTGAAGCGAAATTCTAAAGTAAGCAAACTACATTTGTATGACGACGATGATAGAATTAAAGGCACAGAATTGGAACTAAGCAATCTACCAGGTGGGCCTTCAGTTTCTGCTTTTATTGGAGATACTAATTTAGAACAAGCCATCCATTCATCAAATTTGGTTGTAATGGTCTCGCGAATGCCACGTAAGCCTGGTAATACAAGAGAACAAATGCTCGGGGCTAATGCACCATTGATTCAAAGACTTTGCAAAGCCATTGCAGCTCAAAATCAGGAAGCGTTTGTAGCTATATCTACCAACCCCATAAATTATCTGATACCTTTTGCAAGTACTGTAATGTATAAATACGGGTGTTACAATCCGTCCAAAATGTTTGGAATCACGCATATAGACACGTCAAGAAGTCGATCATTTGTTGCTAAAGCGTTGAAAATTAACGCACAAGAGATACAAGTACCGGTAATAGGAGGTCATTCTGACAAGACTATCATACCGCTGTTTTCGAATTTAACTCCTCGAAATTATCGTATTGAACCATGCCAAGCTGATATGTTAACGAGACTGGTGAGGAAAGCCGGCACAGAAGTAGTTATGCACAAACATGGAGCGGAATCTTCGACGCTGGCAATGGCATGGTCTATAAATGAATTTATTGATATTATCTTGGATGCAATACTTGGATATAGAGTGGTAGTCAACTGTTATACTGCAAATTCAAATTTTGGTACTAAATTTTTTGCCGGACCCACTAGTGTTGGACCGCACGGAATCATTCAAGCATGTTGTCACTTTCCTATGAGTGAATTTGAAAGCTACCTGTTAAATCGCTGTATACCAATTTTAAGTCGTGAAGTGCTAGAAGGAGAGAAATACGTAGAATTTATGGAAAATGTTAAAGGTTAA

Protein

MAQKIFCCLFATQLKKNTLILQKRNVQVSVIGAASDIGSYVSLFLKRNSKVSKLHLYDDDDRIKGTELELSNLPGGPSVSAFIGDTNLEQAIHSSNLVVMVSRMPRKPGNTREQMLGANAPLIQRLCKAIAAQNQEAFVAISTNPINYLIPFASTVMYKYGCYNPSKMFGITHIDTSRSRSFVAKALKINAQEIQVPVIGGHSDKTIIPLFSNLTPRNYRIEPCQADMLTRLVRKAGTEVVMHKHGAESSTLAMAWSINEFIDIILDAILGYRVVVNCYTANSNFGTKFFAGPTSVGPHGIIQACCHFPMSEFESYLLNRCIPILSREVLEGEKYVEFMENVKG

Catalytic Activity

(S)-malate + NAD(+) = H(+) + NADH + oxaloacetate

Similarity

Belongs to the LDH/MDH superfamily.

Uniprot

H9IV76   A0A2A4JYT0   A0A0L7LRW3   A0A2H1W6H6   A0A194R9N4   A0A212FA21   + More
A0A194Q8Z5   A0A3B0JTY4   A0A232F4J8   K7J833   A0A3G5BIM4   A0A1B0AIQ6   D2A663   A0A0R3T0T5   A0A1I8PUI8   A0A2A4K4Z0   A0A2I4DBF5   A0A158QBW6   A0A1L8EEK1   A0A1L8EEQ2   E1Z349   G3NRT5   A0A023GIR1   A0A087ZUK9   G3MNZ4   A0A1A9X226   E0W2E5   A0A224Z2B3   A0A131Z2S2   A0A060WNZ4   V9IKY6   R7TSV0   T1PH40   B5G3E4   F4WPA4   B5G3E1   L7M8Y4   A0A068XHN9   A0A0C9S2L6   A0A1Y3AQX6   A0A023FJ07   A6GAW8   A0A2A3E6L2   B5G3E2   A0A154PN63   B5DGS4   D3TLF9   A0A158NR67   A0A1B0AIQ1   B5X5I4   A0A1A9UCL6   B5DGS5   T2MGF7   A0A267EG16   A0A1I8HS03   A0A195E5P6   A0A060XXI1   A0A267H613   H0Z2E6   V5SJ21   A0A151WME8   Q6WJ29   A0A267EQT3   H0Z2F0   H9JU51   I0YQB9   G1PXQ3   A0A195C8W5   A0A023FWQ5   A0A1L8EI00   A0A2I9LP59   B5G3E0   S7NGU8   A0A3P8VIR3   B4MY57   B5XBK0   A0A3P6SGY9   A0A1B0GEC9   A0A2H1V8P8   A0A026WP45   A0A1I8CFH1   Q4PP90   B5G3E5   A0A1B0BFC4   A0A131XGD2   A0A158Q7N8   A0A1I7VM37   A0A218V2K7   W4YS38   B4K7H4   A0A091NB83   A0A1B6CB81   A0A1A9YNS9   A0A3P9A005   A0A2Z5RE49   A0A182DZC4   A0A1B6DH64   A0A2K6WIX3   A0A1A8RQR8   A0A1A8KL87  

EC Number

1.1.1.37

Pubmed

19121390    26227816    26354079    22118469    28648823    20075255    + More
30400621    18362917    19820115    20852019    22216098    20566863    28797301    26830274    24755649    23254933    25315136    17018643    21719571    25576852    26131772    19878547    20353571    21347285    20433749    24065732    26392545    20360741    22630137    21993624    29248469    24487278    17994087    24508170    26829753    28049606    25217238    25069045    26760975    22919073   

EMBL

BABH01000644    NWSH01000379    PCG76838.1    JTDY01000221    KOB78213.1    ODYU01006624    + More
SOQ48633.1    KQ460761    KPJ12561.1    AGBW02009529    OWR50573.1    KQ459299    KPJ01889.1    OUUW01000002    SPP76171.1    NNAY01000986    OXU25605.1    MK075230    AYV99633.1    KQ971346    EFA04972.1    UZAE01000122    VDN96313.1    NWSH01000176    PCG78732.1    UYSG01000081    VDL16944.1    GFDG01001652    JAV17147.1    GFDG01001643    JAV17156.1    GL433835    EFN60110.1    GBBM01001629    GBBM01001628    JAC33789.1    JO843595    AEO35212.1    DS235877    EEB19801.1    GFPF01009557    MAA20703.1    GEDV01002858    JAP85699.1    FR904640    CDQ68732.1    JR049934    AEY61131.1    AMQN01012226    KB309380    ELT94561.1    KA647450    AFP62079.1    DQ216578    ACH45805.1    GL888243    EGI64085.1    DQ216575    DQ216582    ACH45802.1    GACK01005436    JAA59598.1    GBZX01001486    JAG91254.1    MUJZ01063727    OTF70849.1    GBBK01002880    JAC21602.1    ABCS01000054    EDM76953.1    KZ288351    PBC27350.1    DQ216576    ACH45803.1    KQ434960    KZC12660.1    BT043833    ACH70948.1    CCAG010012182    EZ422261    ADD18537.1    ADTU01023767    BT046303    ACI66104.1    BT043834    BT048216    ACH70949.1    ACI68017.1    HAAD01004768    CDG71000.1    NIVC01002149    PAA60473.1    KQ979608    KYN20488.1    FR906351    CDQ84176.1    NIVC01000022    PAA93713.1    ABQF01026201    KF647639    AHB50501.1    KQ982944    KYQ49026.1    AY282738    AAQ18808.1    NIVC01001805    PAA63900.1    BABH01004084    BABH01004085    AGSI01000015    EIE20588.1    AAPE02016712    KQ978081    KYM97140.1    GBBL01001391    JAC25929.1    GFDG01000570    JAV18229.1    GFWZ01000184    MBW20174.1    DQ216574    ACH45801.1    KE164168    EPQ15740.1    CH963894    EDW77046.2    BT048419    ACI68220.1    UYRX01000105    VDK74056.1    CCAG010012184    ODYU01001242    SOQ37186.1    KK107139    EZA57723.1    DQ062223    AAY63978.1    DQ216580    ACH45806.1    JXJN01013365    GEFH01002017    JAP66564.1    JH712099    EFO26441.1    MUZQ01000070    OWK59872.1    AAGJ04135693    CH933806    EDW15318.1    KK844910    KFP86726.1    GEDC01026556    JAS10742.1    FX983743    BAX07242.1    UYRW01000119    VDK63335.1    GEDC01012275    JAS25023.1    CMVM020000250    HAEI01000392    HAEH01018924    SBS08445.1    HAED01003861    HAEE01013112    SBR33162.1   

Proteomes

UP000005204    UP000218220    UP000037510    UP000053240    UP000007151    UP000053268    + More
UP000268350    UP000215335    UP000002358    UP000092445    UP000007266    UP000046398    UP000278807    UP000095300    UP000192220    UP000046397    UP000274504    UP000008141    UP000007635    UP000005203    UP000091820    UP000009046    UP000193380    UP000014760    UP000095301    UP000007755    UP000005801    UP000242457    UP000076502    UP000092444    UP000005205    UP000087266    UP000078200    UP000215902    UP000095280    UP000078492    UP000007754    UP000075809    UP000007264    UP000001074    UP000078542    UP000265120    UP000007798    UP000277928    UP000053097    UP000095286    UP000092460    UP000050640    UP000095285    UP000197619    UP000007110    UP000009192    UP000092443    UP000265140    UP000077448    UP000271087    UP000024404   

PRIDE

H9IV76    A0A087ZUK9    G3MNZ4    B5G3E4    B5G3E1    L7M8Y4    + More
B5G3E2    H0Z2E6    H9JU51    B5G3E0    B5G3E5   

Pfam

PF02866   Ldh_1_C        + More
PF00056   Ldh_1_N

Interpro

IPR015955   Lactate_DH/Glyco_Ohase_4_C        + More
IPR001557   L-lactate/malate_DH       
IPR022383   Lactate/malate_DH_C       
IPR036291   NAD(P)-bd_dom_sf       
IPR001236   Lactate/malate_DH_N       
IPR010097   Malate_DH_type1       
IPR001252   Malate_DH_AS       

SUPFAM

SSF56327   SSF56327        + More
SSF51735   SSF51735       

Gene 3D

3.90.110.10    

ProteinModelPortal

H9IV76   A0A2A4JYT0   A0A0L7LRW3   A0A2H1W6H6   A0A194R9N4   A0A212FA21   + More
A0A194Q8Z5   A0A3B0JTY4   A0A232F4J8   K7J833   A0A3G5BIM4   A0A1B0AIQ6   D2A663   A0A0R3T0T5   A0A1I8PUI8   A0A2A4K4Z0   A0A2I4DBF5   A0A158QBW6   A0A1L8EEK1   A0A1L8EEQ2   E1Z349   G3NRT5   A0A023GIR1   A0A087ZUK9   G3MNZ4   A0A1A9X226   E0W2E5   A0A224Z2B3   A0A131Z2S2   A0A060WNZ4   V9IKY6   R7TSV0   T1PH40   B5G3E4   F4WPA4   B5G3E1   L7M8Y4   A0A068XHN9   A0A0C9S2L6   A0A1Y3AQX6   A0A023FJ07   A6GAW8   A0A2A3E6L2   B5G3E2   A0A154PN63   B5DGS4   D3TLF9   A0A158NR67   A0A1B0AIQ1   B5X5I4   A0A1A9UCL6   B5DGS5   T2MGF7   A0A267EG16   A0A1I8HS03   A0A195E5P6   A0A060XXI1   A0A267H613   H0Z2E6   V5SJ21   A0A151WME8   Q6WJ29   A0A267EQT3   H0Z2F0   H9JU51   I0YQB9   G1PXQ3   A0A195C8W5   A0A023FWQ5   A0A1L8EI00   A0A2I9LP59   B5G3E0   S7NGU8   A0A3P8VIR3   B4MY57   B5XBK0   A0A3P6SGY9   A0A1B0GEC9   A0A2H1V8P8   A0A026WP45   A0A1I8CFH1   Q4PP90   B5G3E5   A0A1B0BFC4   A0A131XGD2   A0A158Q7N8   A0A1I7VM37   A0A218V2K7   W4YS38   B4K7H4   A0A091NB83   A0A1B6CB81   A0A1A9YNS9   A0A3P9A005   A0A2Z5RE49   A0A182DZC4   A0A1B6DH64   A0A2K6WIX3   A0A1A8RQR8   A0A1A8KL87  

PDB

4WLV     E-value=9.21772e-50,     Score=496

KEGG

101746906    K00026 malate dehydrogenase [EC:1.1.1.37] | (RefSeq) malate dehydrogenase, mitochondrial

PATHWAY

00020    Citrate cycle (TCA cycle) - Bombyx mori (domestic silkworm)
00270    Cysteine and methionine metabolism - Bombyx mori (domestic silkworm)
00620    Pyruvate metabolism - Bombyx mori (domestic silkworm)
00630    Glyoxylate and dicarboxylate metabolism - Bombyx mori (domestic silkworm)
01100    Metabolic pathways - Bombyx mori (domestic silkworm)
01200    Carbon metabolism - Bombyx mori (domestic silkworm)

GO

GO:0019752   GO:0005975   GO:0016616   GO:0006099   GO:0006108   GO:0030060   GO:0016491   GO:0005739   GO:0005737   GO:0006475   GO:0016020   GO:0006919   GO:0035209   GO:0035096   GO:0035071   GO:0003824   GO:0006427   GO:0006412   GO:0016876   GO:0043039   GO:0055114  

Length:

344

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.63301

Exp number, first 60 AAs:

0.31533

Total prob of N-in:

0.02951

outside

1  -  344

 

 

Pi

277.556567

Theta

226.322874

Tajima's D

0.712877

CLR

0

CSRT

0.578021098945053

Interpretation

Uncertain