Gene

KWMTBOMO07933  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA001166

Annotation

transient_receptor_potential_cation_channel_protein_painless_[Bombyx_mori]

Location

Bomo_Chr13(-):10437497-10451196      View in EpiBrowser

Full name

Transient receptor potential cation channel protein painless      

Location in the cell

PlasmaMembrane   Reliability : 2.476

CDS

ATGTCACGTGATAATTACGAAATGAAGCCGAAGCAATTATCAAGAAACAGCTCTTTATTTGGAACCGATCCCCAAGAGCTGTTGAACAAGGCCCTTCAGAATAACGACTACGCGAAGTTCAAGAAACTCGTTACCGAAGCTAATGTTGATCTCGAACATGTTTATGAATATCCTGATTACAAAACATGCCTCGAAGTGGCTGTATCCGACAGAAACAAATTAGAATTCGTCAAATTACTATTACAATATCAAGTAGAAGTGAACAAAGTGAACGTTACACATTCTGCCGCACCCATACACTTTGCTGTCGAAAATGGCAACATAGACGCACTTGCGGCCCTTTTAGAAGACGACCGAATTGATGTTAACGTTAAAAGTAGGGGGAACACCGCGATATTGATGGCCGTCAAACAAATTGAAGAACTAGACGATGCCCGTGAACACGAATTAACAATATATGAAGATATGATTGAACTACTTCTAAAAGCTGGATGTAATGCAAATTCACCAGACCTTAAGGGTGTAACTCCTATTTATAGTGCAGCGAAACAAGGCCTAGAAAGAGTTATCACACTAATTATTGACTATGCAAAGCACGCTATTGACATAGACACGTACAAAGATAGAAGGGGTAAAACTGCTCGCGATTATTTAAAAGAAGCTTTCCCGTATCTAGAAGCAAAGTTTGATTCGACTACTCAAGACCCTGAAATTGTAGACTCTGATAAATTATTCTCATATTTAAGCAGACACGAAGAGGACAACTTTATAAGAGATTTTCTAAAACTTGCTAACAAAAACGAACATCGTAAAATATTGCCGGTCAACAATGGTATGAATACTATGTTACAACTAGCAACAGAGAAAGGTTTTGAAAAAGCAGTCAGTACTTTATTAAGATATGGGGCGGATCCTAACGCAACTTGTTCCAGTAATACGAGCAGACCGATTGCGTTGGCGTGTCAAAACGGATATTACAAAATTGTTAAAATGTTCATGGATAATGAGTCGACTTTGTTCGATCCAGTTAATTCGGAATCTCTAGTGCAAATTACTATAAAAGGAAGGCGCTCATCTATAAATATCCCTAATGTTAATTTTGATGAATGTTTGCGACTATTACTCAATCATCCTAAAATGGACATTAATGTTAATCATATGGATATGAAAAATAACACGGCCCTTCACTATGCTGCAAGAAACGGTGATAATAAAACTGTCCTGGAACTACTTAGAAACGGGGCTTGCATAGGATTGCGTAACTCGTTCGACGAACCACCACTCGCAGATATTAATGCTAAAACATTGGAAGCATTCTTGGATGAATGTGTCACAACGAACAACGAAAGACCAAGCAATGACGATTATGAAATACACATGAAATACAGTTTCCTAGTTTATCCAAATAATTCGCTAGAAAACGAACTTTGTAAAGTGCCATTAATCGACAATACTAACAATAACGTTAAAGAGTATGATACTATATTAGCACCCGAAACTGATGCTTTGTTATACATGACACGAAATGAAGAATTACGACCATTGCTAAAACACCCGGTGATAACAAGTTTTCTTTATTTAAAATGGCAAAGAATAAGCTGTCTTTTTTTTGCGAACATAACGTTTTATTCCTTTTTGTGGTTATGTTTAATTCTCTATATTATTTTGGGATACGGCGCTGAAAAGAAGCAACGAGACTCTTTTGAGGCGTTAAACGTTATCACACATGTCGGTGTTATTATTGGTGTGGTTTTGCTATTGATCAGGGAATTATTTCAACTTTTACTATCACCGACAAGATATTTACAGAGCATTGAAAATTGGATGGAAATCGGTCTTATTTTTGTGACGATTTGGATAGTGTTTTCTAAATCGGCTACAGAGTCGACGAAGCAGCAACTTTCAGCGGTTGCAATTTTGTTATCATCAGCCGAATTAGTTCTACTAATTGGACAGTTTCCGACACTGTCAACTAACATCGTCATGTTGAAAACGGTTTCGTGGAATTTCTTCAAATTTTTACTTTGGTATTGCATTCTCATAATAGCTTTTGCGTTAAGTTTCTACACACTATTCAGGCAAGAAAATGAAGAAGATCAGCGAGCACCAGACCCCAACACAGTCGGTAAAGAGGAGGAAGAAGAAGATTTCTTCGAAGATCCTGGTAGATCTTTATTTAAGACCATCGTCATGTTAACTGGAGAATTCGATGCATCTTCCATAAAATTCAGTACATATCCCTTAACGAGTCACATTATATTCATCGTGTTCGTTTTCATGATACCCATTGTGCTTTTTAATTTACTCAACGGTCTTGCGGTTAGTGACACACAAGAAATTAGGGCAGATGCCGAATTAGTAGGGCATATTTCTCGAATTAAACTTATTTCTTATATCGAGAGCGTGCTTATCGGTAGCGCGAAAACCCATTCACGACCATCAAAGTGTTGGTCGTTGCTGCCGTTCAACATTCAAAACTTAAATCTCATCAAACCTAAAACCTTTTTTACGAAATCCTTTGCAAAGAGGATTTGTTTGTTTCCCCATTTCCTGCCGAAATATAAAATACTTGTTAAACCAAATCAAAACAATATAATTGAGATACCGCACGCCGATGACAAAGACCTTGAAAGGAGCGGGGGGTGTTGTTTCGAGCGCTGTCAAAACTATAGGCTGGATCGTAAAATTGTCAAAAACGCAAAGCTAGTGATTAGTAATAAAACAAAGATAACCGAATTCGATGATAAGCTTTCGATGTACGAAAATAAAATTGAGAGTCTCGAGGCAACTCTGAAGAAAGTATTATTAGCCATTGAATCGCAACGCAATTAA

Protein

MSRDNYEMKPKQLSRNSSLFGTDPQELLNKALQNNDYAKFKKLVTEANVDLEHVYEYPDYKTCLEVAVSDRNKLEFVKLLLQYQVEVNKVNVTHSAAPIHFAVENGNIDALAALLEDDRIDVNVKSRGNTAILMAVKQIEELDDAREHELTIYEDMIELLLKAGCNANSPDLKGVTPIYSAAKQGLERVITLIIDYAKHAIDIDTYKDRRGKTARDYLKEAFPYLEAKFDSTTQDPEIVDSDKLFSYLSRHEEDNFIRDFLKLANKNEHRKILPVNNGMNTMLQLATEKGFEKAVSTLLRYGADPNATCSSNTSRPIALACQNGYYKIVKMFMDNESTLFDPVNSESLVQITIKGRRSSINIPNVNFDECLRLLLNHPKMDINVNHMDMKNNTALHYAARNGDNKTVLELLRNGACIGLRNSFDEPPLADINAKTLEAFLDECVTTNNERPSNDDYEIHMKYSFLVYPNNSLENELCKVPLIDNTNNNVKEYDTILAPETDALLYMTRNEELRPLLKHPVITSFLYLKWQRISCLFFANITFYSFLWLCLILYIILGYGAEKKQRDSFEALNVITHVGVIIGVVLLLIRELFQLLLSPTRYLQSIENWMEIGLIFVTIWIVFSKSATESTKQQLSAVAILLSSAELVLLIGQFPTLSTNIVMLKTVSWNFFKFLLWYCILIIAFALSFYTLFRQENEEDQRAPDPNTVGKEEEEEDFFEDPGRSLFKTIVMLTGEFDASSIKFSTYPLTSHIIFIVFVFMIPIVLFNLLNGLAVSDTQEIRADAELVGHISRIKLISYIESVLIGSAKTHSRPSKCWSLLPFNIQNLNLIKPKTFFTKSFAKRICLFPHFLPKYKILVKPNQNNIIEIPHADDKDLERSGGCCFERCQNYRLDRKIVKNAKLVISNKTKITEFDDKLSMYENKIESLEATLKKVLLAIESQRN

Description

Receptor-activated non-selective cation channel involved in detection of pain sensation due to high temperature. Involved in heat nociception by being activated by noxious temperature of 38 degrees Celsius.

Similarity

Belongs to the transient receptor (TC 1.A.4) family.

Keywords

ANK repeat   Complete proteome   Ion channel   Ion transport   Membrane   Reference proteome   Repeat   Sensory transduction   Transmembrane   Transmembrane helix   Transport  

Feature

chain  Transient receptor potential cation channel protein painless

Uniprot

H9IV86   W8VLJ7   A0A0L7KV58   A0A194Q921   A0A0N1IB44   A0A2W1BPE4   + More
A0A2A4J6X8   A0A212FGX5   A0A2H1V5D0   A0A1B6CGD6   A0A384TDJ9   A0A1B6KZ14   A0A1B6JWY2   A0A1B6F0M2   A0A2P8Z590   A0A2J7QDV1   A0A2J7QDV3   A0A067R3X9   A0A2H8TFV4   A0A1Y1M4Y6   A0A1Y1M7K7   A0A2S2PRU0   A0A2S2R3K0   J9K079   A0A1W4XWE3   T1H8V5   A0A0A9YSC7   A0A0K8SLJ5   A0A023F0T9   A0A0C9RIG0   E2BX95   A0A348G651   A0A067QX85   A0A2R7VY74   A0A2P8YT24   A0A3L8DGE4   A0A2J7PS48   D2A388   A0A0J7L592   A0A026WVC4   A0A195FXH2   A0A1B0D8H9   A0A195ED38   A0A151XBZ5   F4WNM4   A0A195B8E2   E2AFM2   A0A151IHW4   A0A154PSN7   A0A088A461   A0A310SML5   A0A0M9A5P8   A0A0L7R634   A0A232EUY7   U5EX02   A0A0K2TXL7   Q174M7   A0A1W7R6N9   B3NR12   A0A0M4EUM6   A0A1S4FES5   A0A0P5J7P1   W8AWL1   A0A067R6H8   A0A034WER2   A0A0K8VZT7   A0A0L0BPE1   B4PBX3   B4QCM3   A0A0P6IL64   Q9W0Y6   E9G8Q1   B4MJW8   A0A0K2U030   B4J8W6   B3MC48   A0A182J552   B4IHA7   B4MEC5   A0A3B0J123   B4GD22   B0WK88   B5DZ25   A0A0P4W7B1   A0A0P6GNN0   A0A336N1Y4   A0A336LPG2   A0A1W4UZ98   A0A0N8AAY9   A0A164QBG9   A0A0A1XPF7   A0A0N8BX55   A0A182WZG9   Q174M6   A0A1A9WP89   A0A0P5LSY8   F5HIU3   A0A182HZL5  

Pubmed

19121390    24639527    26227816    26354079    28756777    22118469    + More
29403074    24845553    28004739    25401762    26823975    25474469    20798317    30249741    18362917    19820115    24508170    21719571    28648823    17510324    17994087    24495485    25348373    26108605    17550304    22936249    12705873    10731132    12537572    21292972    15632085    25830018    12364791    14747013    17210077   

EMBL

BABH01000690    AB264789    BAO53208.1    JTDY01005527    KOB66914.1    KQ459299    + More
KPJ01914.1    KQ460202    KPJ17180.1    KZ149944    PZC76848.1    NWSH01002968    PCG67200.1    AGBW02008583    OWR52996.1    ODYU01000763    SOQ36037.1    GEDC01024817    JAS12481.1    KX249693    AOR81470.1    GEBQ01023332    JAT16645.1    GECU01004017    JAT03690.1    GECZ01026128    JAS43641.1    PYGN01000189    PSN51663.1    NEVH01015683    PNF26761.1    PNF26762.1    KK852775    KDR16796.1    GFXV01000797    MBW12602.1    GEZM01041195    JAV80581.1    GEZM01041196    JAV80580.1    GGMR01019429    MBY32048.1    GGMS01015137    MBY84340.1    ABLF02020407    ACPB03006508    KU356754    GBHO01008520    GDHC01018488    APB88050.1    JAG35084.1    JAQ00141.1    GBRD01012159    JAG53665.1    GBBI01004091    JAC14621.1    GBYB01013010    GBYB01013011    GBYB01013012    JAG82777.1    JAG82778.1    JAG82779.1    GL451230    EFN79678.1    FX985591    BBF97924.1    KK852854    KDR14974.1    KK854155    PTY12279.1    PYGN01000377    PSN47403.1    QOIP01000008    RLU19517.1    NEVH01021939    PNF19162.1    KQ971338    EFA02836.1    LBMM01000695    KMQ97718.1    KK107109    EZA59059.1    KQ981215    KYN44544.1    AJVK01027446    KQ979074    KYN22759.1    KQ982316    KYQ57818.1    GL888237    EGI64217.1    KQ976565    KYM80512.1    GL439118    EFN67773.1    KQ977545    KYN02029.1    KQ435066    KZC14334.1    KU532290    ANT80565.1    KQ762962    OAD55186.1    KQ435728    KOX77755.1    KQ414648    KOC66313.1    NNAY01002072    OXU22161.1    GANO01000313    JAB59558.1    HACA01013224    CDW30585.1    CH477408    EAT41530.1    GEHC01000819    JAV46826.1    CH954179    EDV57095.1    CP012524    ALC41437.1    GDIQ01202002    JAK49723.1    GAMC01016088    JAB90467.1    KDR14973.1    GAKP01004881    JAC54071.1    GDHF01008199    JAI44115.1    JRES01001578    KNC21853.1    CM000158    EDW92627.1    CM000362    CM002911    EDX08639.1    KMY96473.1    GDIQ01029808    JAN64929.1    AY268106    AE013599    BT011483    GL732535    EFX84229.1    CH963846    EDW72407.1    HACA01014079    CDW31440.1    CH916367    EDW02406.1    CH902619    EDV37235.1    CH480838    EDW49283.1    CH940662    EDW58890.2    OUUW01000001    SPP74495.1    CH479181    EDW31560.1    DS231968    EDS29662.1    CM000071    EDY68761.1    GDRN01085983    JAI61269.1    GDIQ01031001    JAN63736.1    UFQT01002005    SSX32378.1    UFQT01000040    SSX18573.1    GDIP01165225    JAJ58177.1    LRGB01002451    KZS07610.1    GBXI01001396    JAD12896.1    GDIQ01136219    JAL15507.1    EAT41531.1    GDIQ01165709    JAK86016.1    AAAB01008799    EGK96204.1    APCN01001985   

Proteomes

UP000005204    UP000037510    UP000053268    UP000053240    UP000218220    UP000007151    + More
UP000245037    UP000235965    UP000027135    UP000007819    UP000192223    UP000015103    UP000008237    UP000279307    UP000007266    UP000036403    UP000053097    UP000078541    UP000092462    UP000078492    UP000075809    UP000007755    UP000078540    UP000000311    UP000078542    UP000076502    UP000005203    UP000053105    UP000053825    UP000215335    UP000008820    UP000008711    UP000092553    UP000037069    UP000002282    UP000000304    UP000000803    UP000000305    UP000007798    UP000001070    UP000007801    UP000075880    UP000001292    UP000008792    UP000268350    UP000008744    UP000002320    UP000001819    UP000192221    UP000076858    UP000076407    UP000091820    UP000007062    UP000075840   

PRIDE

H9IV86    W8VLJ7    Q9W0Y6   

Pfam

PF00520   Ion_trans        + More
PF12796   Ank_2
PF00023   Ank
PF13606   Ank_3

Interpro

IPR036770   Ankyrin_rpt-contain_sf        + More
IPR020683   Ankyrin_rpt-contain_dom       
IPR005821   Ion_trans_dom       
IPR002110   Ankyrin_rpt       

SUPFAM

SSF48403   SSF48403       

Gene 3D

1.25.40.20    

CDD

cd00204  ANK

ProteinModelPortal

H9IV86   W8VLJ7   A0A0L7KV58   A0A194Q921   A0A0N1IB44   A0A2W1BPE4   + More
A0A2A4J6X8   A0A212FGX5   A0A2H1V5D0   A0A1B6CGD6   A0A384TDJ9   A0A1B6KZ14   A0A1B6JWY2   A0A1B6F0M2   A0A2P8Z590   A0A2J7QDV1   A0A2J7QDV3   A0A067R3X9   A0A2H8TFV4   A0A1Y1M4Y6   A0A1Y1M7K7   A0A2S2PRU0   A0A2S2R3K0   J9K079   A0A1W4XWE3   T1H8V5   A0A0A9YSC7   A0A0K8SLJ5   A0A023F0T9   A0A0C9RIG0   E2BX95   A0A348G651   A0A067QX85   A0A2R7VY74   A0A2P8YT24   A0A3L8DGE4   A0A2J7PS48   D2A388   A0A0J7L592   A0A026WVC4   A0A195FXH2   A0A1B0D8H9   A0A195ED38   A0A151XBZ5   F4WNM4   A0A195B8E2   E2AFM2   A0A151IHW4   A0A154PSN7   A0A088A461   A0A310SML5   A0A0M9A5P8   A0A0L7R634   A0A232EUY7   U5EX02   A0A0K2TXL7   Q174M7   A0A1W7R6N9   B3NR12   A0A0M4EUM6   A0A1S4FES5   A0A0P5J7P1   W8AWL1   A0A067R6H8   A0A034WER2   A0A0K8VZT7   A0A0L0BPE1   B4PBX3   B4QCM3   A0A0P6IL64   Q9W0Y6   E9G8Q1   B4MJW8   A0A0K2U030   B4J8W6   B3MC48   A0A182J552   B4IHA7   B4MEC5   A0A3B0J123   B4GD22   B0WK88   B5DZ25   A0A0P4W7B1   A0A0P6GNN0   A0A336N1Y4   A0A336LPG2   A0A1W4UZ98   A0A0N8AAY9   A0A164QBG9   A0A0A1XPF7   A0A0N8BX55   A0A182WZG9   Q174M6   A0A1A9WP89   A0A0P5LSY8   F5HIU3   A0A182HZL5  

PDB

6MOL     E-value=1.45762e-13,     Score=189

KEGG

101736668    no KO assigned | (RefSeq) painless; transient receptor potential cation channel protein painless

GO

GO:0005216   GO:0016021   GO:0006811   GO:0050960   GO:0019233   GO:0042048   GO:0070588   GO:0005227   GO:0048060   GO:0045924   GO:0008016   GO:0007620   GO:0007638   GO:0050974   GO:0034704   GO:0008049   GO:0050966   GO:0050965   GO:0007631   GO:0009408   GO:0009612   GO:0035179   GO:0048266   GO:0005262   GO:0005886   GO:0006816   GO:0005515   GO:0016020   GO:0043015   GO:0007169   GO:0006412   GO:0016876   GO:0043039   GO:0055085  

Subcellular location

Membrane  

Length:

943

Number of predicted TMHs:

6

Exp number of AAs in TMHs:

126.78375

Exp number, first 60 AAs:

0

Total prob of N-in:

0.00729

outside

1  -  534

TMhelix

535  -  557

inside

558  -  569

TMhelix

570  -  589

outside

590  -  603

TMhelix

604  -  623

inside

624  -  635

TMhelix

636  -  658

outside

659  -  672

TMhelix

673  -  692

inside

693  -  751

TMhelix

752  -  774

outside

775  -  943

 

 

Pi

160.017589

Theta

163.085172

Tajima's D

-0.463291

CLR

1.042381

CSRT

0.247987600619969

Interpretation

Uncertain