Gene

KWMTBOMO07913

Pre Gene Modal

BGIBMGA000974

Annotation

PREDICTED:_tyrosine-protein_kinase_Btk29A_[Bombyx_mori]

Location

Bomo_Chr13(+):9979630-10008003      View in EpiBrowser

Full name

Tyrosine-protein kinase      

Location in the cell

Cytoplasmic   Reliability : 1.217 Mitochondrial   Reliability : 1.623 Nuclear   Reliability : 1.292

CDS

ATGGCAGGAAAAGACAATGAAGTTCTGCTGCAGGCATTTATGGTGAAGAGGTCACAAAATAAGAATTTATTTACACCAGTAAATTTCAAGGAGCGCTGGGTGGTCCTTACTCCTCGGTCTCTAATTTATTATGATTCTGACAGTGAAAAGCGTAAAGAAAGGGGCCGTATAGCAACAGAGACTATACATACTGTCGAAACTGCACAGTTGGGAGAACTAAGTAAGCAAATACCTGACAGCGACGGAGAAAAACGACCCACGTACAGGTATCCATTTCAGGTGGGGTACTCAGAGCAGAATTCAGACTATACGCTATATCTAATAGCTGGCGACCACACTGAGCGCTTACGTTGGATTCACACCCTTAGATCAGTTTGTGTATGTAATTCTCGTCGGAGTCAATATCACCCGGCCGTGAGGTCTGCTCGGAGGTGGCCGTGCTGTGACGCCGAACGTCGCTCTGCACCGGGGTGCGCCCTAACCGCCGTTTGGCCGTTACCAGAGCCCGAACTAGATTTAATACAGGAAGAAAGCGACAAACTCTCCGAGAACGCTACACCTGTCACAGCAGCGGTCACAATGCCCGGGGGAGGAGGAGGACCACCAGGCACTCCATCCGCTAAGCCCAAGGAGAAACCTAGAACGAAAATTGTCGTCGCGCTGTATCCATTTAAAGCAATCGAAAGTGGAGATCTGTCCTTGGAAAAGGGAGCCGAATATGAAGTCATAGACGACTCGCAAGATCACTGGTGGAAAGTCAAAGATGAGAACGGTTCTGTCGGCTACATACCGAGCAATTACGTAAAAGAGAAAGAAACGATCGGGTTGCAGAAATATGAATGGTTTGTGGGCGAAATGTCCCGCCAAAGAGCGGAATCTTTGCTCAAACGTGAAGATAAGGAGGGGTGCTTCGTCGTACGGAACTCGTCAACGAAGGGAATGTATACGTTGTCATTGTATACTAAAGTGAATCATCAACAGACGAAGCACTATCACATAAAACAGAACAGTCGCGGCGAGTTTTATTTGTCGGACAAGCATTGCTGCGCGAGTATACCGGAGCTGATCAACTATCACAAGCACAATAGCGGCGGTCTGTGCTCTCGTCTAAAGGCGACGCCCTGCGACCGCCCCGCGCCCCCCACCGCCGGACTCTCGCACGACAAGTGGGAGATCGATCCATCGGAGCTGGTCCTGATGGAGGTGCTGGGCGCGGGACAGTTCGGCGTGGTGCGGCGCGGCGTCTGGCGCGGACGGATCGACACGGCCGTCAAGATGATGAAGGAGGGCACCATGTCCGAGGACGACTTCATCGACGAAGCTAAAGTTATGACTAAACTTCAGCACCAGAACCTGGTGCAGCTGTACGGCGTGTGCTCCAAGCACCGGCCCATCTACATCGTGACGGAGTTCATGCGCCACGGCTCGCTGTTCAACTACCTGCGCCGCACGTCGCCCGACCAGCTCGGCCACGCCGTCCTCCTCGACATGTGCATACAGGTTTGCAGAGGGATGGCGTACCTAGAAAGGCATAACTACATTCACCGAGATCTGGCTGCGAGAAATTGTTTGGTAGGCGATGAGAACGTTGTGAAGGTAGCCGATTTCGGTCTAGCGCGGTACGTTCTGGACGACCAGTACACGAGCTCCGGAGGCACCAAGTTCCCAATAAAGTGGGCGCCGCCCGAAGTGCTCAACTTCACCAGGTTCTCATCGAAATCCGACGTTTGGGCTTTTGGAGTGCTGATGTGGGAGGTGTTCACGTGCGGGAAGGTACCGTACGGTCGACTCACTAACTCGGAGGTCGTGGATAAAGTACAACGGGGACAAGTGCTAGAAAAACCTAAAGGTTGCATCAACGAAATATACAATGTGATGCGCGCGTGCTGGGGCCACACGCCGGAGGAGCGGCCGTCGTTCCGCGTCCTCAAGGAGCAGCTGGCCGTCATCTCGCAGAGCGTGCTGGCCGATTGA

Protein

MAGKDNEVLLQAFMVKRSQNKNLFTPVNFKERWVVLTPRSLIYYDSDSEKRKERGRIATETIHTVETAQLGELSKQIPDSDGEKRPTYRYPFQVGYSEQNSDYTLYLIAGDHTERLRWIHTLRSVCVCNSRRSQYHPAVRSARRWPCCDAERRSAPGCALTAVWPLPEPELDLIQEESDKLSENATPVTAAVTMPGGGGGPPGTPSAKPKEKPRTKIVVALYPFKAIESGDLSLEKGAEYEVIDDSQDHWWKVKDENGSVGYIPSNYVKEKETIGLQKYEWFVGEMSRQRAESLLKREDKEGCFVVRNSSTKGMYTLSLYTKVNHQQTKHYHIKQNSRGEFYLSDKHCCASIPELINYHKHNSGGLCSRLKATPCDRPAPPTAGLSHDKWEIDPSELVLMEVLGAGQFGVVRRGVWRGRIDTAVKMMKEGTMSEDDFIDEAKVMTKLQHQNLVQLYGVCSKHRPIYIVTEFMRHGSLFNYLRRTSPDQLGHAVLLDMCIQVCRGMAYLERHNYIHRDLAARNCLVGDENVVKVADFGLARYVLDDQYTSSGGTKFPIKWAPPEVLNFTRFSSKSDVWAFGVLMWEVFTCGKVPYGRLTNSEVVDKVQRGQVLEKPKGCINEIYNVMRACWGHTPEERPSFRVLKEQLAVISQSVLAD

Catalytic Activity

ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein]

Similarity

Belongs to the protein kinase superfamily. Tyr protein kinase family.

Feature

chain  Tyrosine-protein kinase

Uniprot

A0A2A4JME8   A0A2A4JN65   A0A212ENW7   A0A3S2M2I9   A0A2W1BVL1   A0A1B6GJN3   + More
A0A1B6DKH6   A0A2S2Q5S5   J9K931   A0A195DQM7   A0A069DW57   A0A3L8DEZ3   A0A195CJM0   A0A067R294   A0A023F5H0   A0A0A9WY19   A0A0A9X9A5   A0A158NAL4   A0A1Y1MCK9   D2A292   E0VDK7   A0A2H1V415   U4UI89   A0A0K8WHK2   A0A034WB84   A0A151I5L4   A0A224X9S0   A0A1I8PPF4   W8AU04   A0A1I8MKV1   T1I9M4   A0A194QAA5   A0A0Q5WKH8   A0A0R1DKU6   A0A195EWJ8   A0A0V0GAA2  

EC Number

2.7.10.2

Pubmed

22118469    28756777    26334808    30249741    24845553    25474469    + More
25401762    21347285    28004739    18362917    19820115    20566863    23537049    25348373    24495485    25315136    26354079    17994087    17550304   

EMBL

NWSH01000988    PCG73227.1    PCG73226.1    AGBW02013607    OWR43174.1    RSAL01000063    + More
RVE49506.1    KZ149944    PZC76830.1    GECZ01007159    JAS62610.1    GEDC01011104    JAS26194.1    GGMS01003861    MBY73064.1    ABLF02040355    KQ980612    KYN15151.1    GBGD01000813    JAC88076.1    QOIP01000009    RLU19017.1    KQ977642    KYN00913.1    KK852761    KDR17019.1    GBBI01002308    JAC16404.1    GBHO01033869    JAG09735.1    GBHO01026287    JAG17317.1    ADTU01010372    ADTU01010373    ADTU01010374    ADTU01010375    ADTU01010376    GEZM01034874    GEZM01034873    JAV83572.1    KQ971338    EFA02156.1    DS235078    EEB11463.1    ODYU01000364    SOQ35024.1    KB632179    ERL89605.1    GDHF01019961    GDHF01001742    JAI32353.1    JAI50572.1    GAKP01007907    GAKP01007904    JAC51048.1    KQ976413    KYM90370.1    GFTR01007319    JAW09107.1    GAMC01014230    JAB92325.1    ACPB03016963    KQ459299    KPJ01930.1    CH954177    KQS70766.1    CM000157    KRJ97868.1    KQ981954    KYN32259.1    GECL01001066    JAP05058.1   

Proteomes

UP000218220    UP000007151    UP000283053    UP000007819    UP000078492    UP000279307    + More
UP000078542    UP000027135    UP000005205    UP000007266    UP000009046    UP000030742    UP000078540    UP000095300    UP000095301    UP000015103    UP000053268    UP000008711    UP000002282    UP000078541   

Pfam

PF07714   Pkinase_Tyr        + More
PF00018   SH3_1
PF00779   BTK
PF00169   PH
PF00017   SH2

Interpro

IPR011993   PH-like_dom_sf        + More
IPR017441   Protein_kinase_ATP_BS       
IPR001562   Znf_Btk_motif       
IPR001245   Ser-Thr/Tyr_kinase_cat_dom       
IPR001849   PH_domain       
IPR036028   SH3-like_dom_sf       
IPR011009   Kinase-like_dom_sf       
IPR001452   SH3_domain       
IPR000719   Prot_kinase_dom       
IPR000980   SH2       
IPR008266   Tyr_kinase_AS       
IPR036860   SH2_dom_sf       
IPR020635   Tyr_kinase_cat_dom       
IPR000489   Pterin-binding_dom       

SUPFAM

SSF56112   SSF56112        + More
SSF50044   SSF50044       
SSF55550   SSF55550       

Gene 3D

2.30.29.30     3.30.505.10    

ProteinModelPortal

A0A2A4JME8   A0A2A4JN65   A0A212ENW7   A0A3S2M2I9   A0A2W1BVL1   A0A1B6GJN3   + More
A0A1B6DKH6   A0A2S2Q5S5   J9K931   A0A195DQM7   A0A069DW57   A0A3L8DEZ3   A0A195CJM0   A0A067R294   A0A023F5H0   A0A0A9WY19   A0A0A9X9A5   A0A158NAL4   A0A1Y1MCK9   D2A292   E0VDK7   A0A2H1V415   U4UI89   A0A0K8WHK2   A0A034WB84   A0A151I5L4   A0A224X9S0   A0A1I8PPF4   W8AU04   A0A1I8MKV1   T1I9M4   A0A194QAA5   A0A0Q5WKH8   A0A0R1DKU6   A0A195EWJ8   A0A0V0GAA2  

PDB

4XI2     E-value=5.50133e-132,     Score=1208

KEGG

101745569    K07364 tyrosine-protein kinase Tec [EC:2.7.10.2] | (RefSeq) tyrosine-protein kinase Btk29A

PATHWAY

04013    MAPK signaling pathway - fly - Bombyx mori (domestic silkworm)

GO

GO:0005524   GO:0035556   GO:0004715   GO:0038083   GO:0042558   GO:0005515   GO:0004672   GO:0006468   GO:0004713   GO:0007169   GO:0016020   GO:0006412   GO:0016876   GO:0043039  

Length:

657

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.0596

Exp number, first 60 AAs:

0

Total prob of N-in:

0.00017

outside

1  -  657

 

 

Pi

3.094252

Theta

183.017694

Tajima's D

-1.425097

CLR

2036.042265

CSRT

0.0736963151842408

Interpretation

Uncertain