SGID Silkworm Genome Informatics Database
Gene
KWMTBOMO07912  Validated by peptides from experiments
Pre Gene Modal
BGIBMGA001175
Annotation
PREDICTED:_apoptosis_inhibitor_5_[Bombyx_mori]
Full name
Apoptosis inhibitor 5      
Alternative Name
Antiapoptosis clone 11 protein
Cell migration-inducing gene 8 protein
Fibroblast growth factor 2-interacting factor
Protein XAGL
Location in the cell
Nuclear   Reliability : 3.696
 

Sequence

CDS
ATGGCTGGTGATAATATAGAGAAATTATATAAGAATTACGATATTTTAGCTGCCGCGAAAGATGAAATTTCACAGCACGAGAAAGAGTACTTGGAAATACTCGCAGCCGTAAAGGGATCTGACAAAGAGAAACGTTTGGCATCTCAATTCATTGCGAAGTTTTTTAACAGTTTTCCTACTTTATCCGAACAAGCAATAGAAGCCCAATTTGACTTGTGCGAGGATGACGACGTTGCTATTCGTAAACAAGCCATAAAAGATTTGCCAGTTTTATGCAAAGAGCACAAAGAACACACTCAGAGAATTGCTGATATATTAGCCCAGCTATTGCAATCTGAAGATTCTACAGAGATAAATGTAGTAACAAACTCTCTTGTAACAATTTTGAAAAGTGATCCCAAAGGAGCTTTGTCTGGTATCTTCTCACAAATTCATCAGAACACAGATGGTGAACTAGCAAATGAAATTGTTAGAGAAAGATGTATCAAGTTTTTATCTTCTAAAATTCAACAATTAGGAAGAGAAATAATCAACAAAGAAGCTGAGGAACTCATTATCACAGAATGCAAAAAAATTTTAGAGGATGTTGTTGCTGAAGAATTCGAACATATAATGGAACTGCTTACTTGGTCAAGATTAGGTAAAACACCCCTGGGAAAGAAGGAGTTGGTTCAAATTGTTGCAGCTCTAGCTTTTTCTCCTGATGACTGGCATCCAGAGGATCCTGAATATATAGATAGATTGATACAATGTACACAACATGCTGTCCCTTTGTTTTCACCCCAAGTGGATTCAACACAGTTTATAAACTTTTTCTGTGACCATGTACTACCCAAATGGAAAGACATTGTTGTGGCTGATGGAGCATCTGATTCGAAACTTGAATTACTAAAAATATTTGCTGAAATAACAGAATACTCTGGAGATTTGGAAAATGCTCAACAAAGAATTGATACAGTTTTTGAAGTACTTATGGATTATTTGCCTGAAGCTCCAGTAGAAGATGAAACTCAGAAGACCAAAGAAGATAAAGTTGAGGAAACTAAAACTGCACCATCACTGCAGTTTTCACACGTGGAATGTGCATTGTTTGCATTACATTCACTATGCAGAAAATCACCTAATTCATTAACTAGCGATGCCGCGAAACTTAAGATGCTACGTTTACGTTTACAATATACTGCTCGTCTCACACAAGGCTATATTAAAAAATTAAAGGAAGTGACACAATCTCAAAAAACCGAAGATGAAAATTCCGAAGAAAGTAAATTAAAAGTAGCTGCATTAAAGACTACTTCAAACATTAATACTTTAATTAGAGACATTTTCCGTACCCCACCATCATTTAAAAGCAAAGTTCAGCTTTCATTTAAATCAAAAAAATCTGAGAAAGAGGAAAAACAAACAGCCAGCACTAGTGATGCCACCAAAGATTCGCCCCAAAAACGTCACCGCCCTATTACATTTGACAATGGAGGTGAAAAAGAATCTCCAGAAAAACGGTCCCGTAGCAGTGATAGAAACCTTAAAATGTATACACCACCATCAGGGAAATACAGCTCAAGAATAAACAGTAGCCGGTTCTCTGGTTCAAGTGGGAGGGGTAGAGGTTATGGAAGACGGGACTATAGAAATAATGGGGCATCTTTCAGAAATCGAAGCAACTATTAA
Protein
MAGDNIEKLYKNYDILAAAKDEISQHEKEYLEILAAVKGSDKEKRLASQFIAKFFNSFPTLSEQAIEAQFDLCEDDDVAIRKQAIKDLPVLCKEHKEHTQRIADILAQLLQSEDSTEINVVTNSLVTILKSDPKGALSGIFSQIHQNTDGELANEIVRERCIKFLSSKIQQLGREIINKEAEELIITECKKILEDVVAEEFEHIMELLTWSRLGKTPLGKKELVQIVAALAFSPDDWHPEDPEYIDRLIQCTQHAVPLFSPQVDSTQFINFFCDHVLPKWKDIVVADGASDSKLELLKIFAEITEYSGDLENAQQRIDTVFEVLMDYLPEAPVEDETQKTKEDKVEETKTAPSLQFSHVECALFALHSLCRKSPNSLTSDAAKLKMLRLRLQYTARLTQGYIKKLKEVTQSQKTEDENSEESKLKVAALKTTSNINTLIRDIFRTPPSFKSKVQLSFKSKKSEKEEKQTASTSDATKDSPQKRHRPITFDNGGEKESPEKRSRSSDRNLKMYTPPSGKYSSRINSSRFSGSSGRGRGYGRRDYRNNGASFRNRSNY

Summary

Description
Antiapoptotic factor that may have a role in protein assembly. Negatively regulates ACIN1. By binding to ACIN1, it suppresses ACIN1 cleavage from CASP3 and ACIN1-mediated DNA fragmentation. Also known to efficiently suppress E2F1-induced apoptosis. Its depletion enhances the cytotoxic action of the chemotherapeutic drugs.
Antiapoptotic factor that may have a role in protein assembly. Negatively regulates ACIN1. By binding to ACIN1, it suppresses ACIN1 cleavage from CASP3 and ACIN1-mediated DNA fragmentation. Also known to efficiently suppress E2F1-induced apoptosis (By similarity).
Subunit
Monomer. Interacts with FGF2 and ACIN1.
Monomer. Interacts with FGF2 and ACIN1 (By similarity).
Similarity
Belongs to the API5 family.
Keywords
3D-structure   Acetylation   Alternative splicing   Apoptosis   Complete proteome   Cytoplasm   Direct protein sequencing   Methylation   Nucleus   Phosphoprotein   Polymorphism   Reference proteome   Repeat  
Feature
chain  Apoptosis inhibitor 5
splice variant  In isoform 1.
sequence variant  In dbSNP:rs5743240.
EMBL
BABH01000737    BABH01000738    BABH01000739    KZ149944    PZC76828.1    NWSH01000988    + More
PCG73215.1    ODYU01013252    SOQ59954.1    KQ460202    KPJ17198.1    KQ459299    KPJ01932.1    AGBW02013607    OWR43175.1    GDQN01008901    JAT82153.1    JTDY01003524    KOB69409.1    NEVH01027059    PNF14006.1    GEDC01017276    JAS20022.1    GBYB01014252    JAG84019.1    KK107320    QOIP01000009    EZA52774.1    RLU18945.1    LBMM01001422    KMQ96349.1    KQ976413    KYM90367.1    GL448558    EFN84229.1    KQ434820    KZC07012.1    GL437711    EFN70040.1    KZ288325    PBC28047.1    KQ435720    KOX78566.1    KQ414721    KOC62732.1    GECU01001258    JAT06449.1    GECZ01032150    GECZ01002991    JAS37619.1    JAS66778.1    NNAY01001413    OXU24057.1    KQ977642    KYN00911.1    GDAI01002035    JAI15568.1    GL764479    EFZ17582.1    DS235023    EEB10656.1    PYGN01000836    PSN40191.1    KA646773    AFP61402.1    GANO01000407    JAB59464.1    JXUM01046436    KQ561476    KXJ78476.1    AXCN02000651    AAAB01008980    EAA13869.4    DS231888    EDS43559.1    CH477860    EAT35554.1    GGFK01004523    MBW37844.1    GGFK01004517    MBW37838.1    GGFM01001468    MBW22219.1    ATLV01023406    KE525343    KFB49102.1    GGFM01001503    MBW22254.1    ADMH02001884    ETN60634.1    AXCM01001667    GGFJ01003674    MBW52815.1    GGFJ01003555    MBW52696.1    GAMD01000469    JAB01122.1    NEDP02004093    OWF46745.1    CH933807    EDW12901.1    CH902620    EDV30924.1    GFDL01011877    JAV23168.1    CH940649    EDW64850.1    OUUW01000004    SPP80037.1    KU553310    AOR07008.1    JXJN01012632    GFDL01011677    JAV23368.1    GFDL01011743    JAV23302.1    CVRI01000010    CRK88724.1    KPU73126.1    GABZ01005527    JAA47998.1    CCAG010020049    JSUE03012362    NBAG03000291    PNI46824.1    NDHI03003391    PNJ68595.1    AC087276    U83857    Y15906    AF229253    AF229254    AY311389    BT007093    AY265973    AK294724    AK299288    AK304157    CH471064    BC017709    W40304    PNJ68590.1    JU336827    JU471217    JV048520    AFE80580.1    AFH28021.1    AFI38591.1    GABC01005902    GABF01008015    GABD01002024    GABE01007911    JAA05436.1    JAA14130.1    JAA31076.1    JAA36828.1    PNI46819.1    GAMT01006302    GAMS01009454    GAMS01009452    GAMR01001528    GAMQ01000679    GAMP01006226    JAB05559.1    JAB13682.1    JAB32404.1    JAB41172.1    JAB46529.1    CR860652    AQIA01020359    AQIA01020360    AQIA01020361    KB030484    ELK16052.1    CH954179    EDV54841.1    KQS61963.1    AQIB01081974    AQIB01081975    AFYH01004865    AFYH01004866   
Pfam
PF05918   API5
Interpro
IPR016024   ARM-type_fold        + More
IPR008383   API5       
IPR011989   ARM-like       
SUPFAM
SSF48371   SSF48371       
Gene 3D
PDB
3U0R     E-value=2.09641e-109,     Score=1013

Ontologies

Topology

Subcellular location
Nucleus  
Cytoplasm  
Length:
556
Number of predicted TMHs:
0
Exp number of AAs in TMHs:
0.00017
Exp number, first 60 AAs:
0.00015
Total prob of N-in:
0.00167
outside
1  -  556
 
 

Population Genetic Test Statistics

Pi
46.974652
Theta
188.145401
Tajima's D
-0.76119
CLR
0.474305
CSRT
0.186890655467227
Interpretation
Uncertain
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