Gene

KWMTBOMO07886  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA001188

Annotation

PREDICTED:_probable_Ufm1-specific_protease_2_[Amyelois_transitella]

Location

Bomo_Chr13(-):9171310-9175889      View in EpiBrowser

Full name

Probable Ufm1-specific protease 2      

Location in the cell

Cytoplasmic   Reliability : 1.372 PlasmaMembrane   Reliability : 1.081

CDS

ATGTCACCACGTCTTAAAATATCAAGTTATGTTATTGAGAGGTTGTCTAAAATCGACACAACAGAGAGTACAGGATGTTTGTATGGGCTGATGTACGATGGTACACTTCTAGTTGTCGGGTTCAGTTTAGAATCGTTTGAAACAGAAACCGAAAAAAATAGCTACAGCCAACTGTTACTTAATTTCCCCGCCGAGATAGAACTTTGCGGCGTCGTGAAGTTTGGGGAAACCTTAACCACTGATTCAACAACAAAAGAGATCTTACAGGATGTAGATATTACAGATAACCCATTAATTATAATAATAAATCGTGAGAAGGATATGAAAGCTCACTTTATTGTTCATGATAAATTTGAAGAAACGAAATATGAGGTTTTCAGTCCTGAAGAGTTGTGGAAACAGTTCCTTCATGTACGTTTGAACACTGTGCTACCCCTGCGATGTGAAGCTACCATTGCTGGAGTTAAAAATTCACTGCAAAATAAGAGGAAAAAGATTGCTTCAGGTCAAGTGTCATTTCATATAGACAGTACACAAGTATATTTGTTTGGAGTAGCGTCAGATGTGGGCTTGACTGGAACAAGCACAGAAGCTACTGTTGGGGAACTTGTTGATTCAATGAGTCCTGAACAGCCATCGAAGAAAAAAAAATACAATATCAATAATGCAGAAATATTACCGGTGAGTTTAATACTAAAAGTGACAAAAGATATCTTGTCTGATAAATTAGTTAAAACAGCAGTAAAAATGATGACAACACAAAGAAAACCTGCTTTTTACATCAGTATGCCTCTCCGAATAGACACCCTGGCTATGATACACCGAAATACTAAATTGCTTGATCTTTATATTGTGTTAGTTGAAGCAGCGTGCAGGTCACTGAGGTTGATGGAGAGTGTGTTGATAGAACAACTTGGTCAAGAAGGTATTGGTGATGGAGGAGGTCTAAGGCTACCTGAAACATTTCATTATCTACCACCAGAAATAGGCCATTTTATTACCAGACTAATACCTAAGGGGAAATCTGAAGATTGTATGCAGAAAGAGAGGCGCACTCTCCACGAACAATTGGGACTGCCACTACACAGGCCTGTGTTCCGTCGAGGTAACGCGTTCATAGACAAAAGTGGAGGATACTTAGTGAATCCACATGAAGCCATGCCGATACAAGCTTCAAAATCTGACGTTACTGTAGCATTAGTCAGAGGACGATACGCATACCATCATTACATGCAAGACAACTTCAATGACGATGGTTGGGGTTGTGCTTATCGCTCAATGCAAACAATTTTCTCTTGGTTTAGATATCAAGGTTACACTGATGTTGAAGTACCCACCCATAAAGAAATTCAACAGTGCCTTGTCAAGATTGGAGATAAACAGTCAACATTCATTGGTTCAAAACAATGGATTGGATCTACAGAAGTCATGTTTTGTTTGGAAACTCTACTGGGTGTCCAATCAAGGATAATTTTTGCAAATACTGGGACTGAATTACAAAGTTATGCCCCAGAATTAGTCCATCATTTTCAAACTCACGGTAGCCCCATAATGATTGGTGGTGGTGTACTGGCACATACTATACTAGGGATTGAATACAACTCTATTACTAACGAAACAAGATATCTCATCTTAGACCCTCACTATACTGGAGCTGAAGATATCACAACTGTTATTAATAAAGGATGGTGCGGTTGGAAGAGTTCAGATTTTTGGAATAAAACTGCTCATTATAATCTTTGTTTGCCACAAACAAGGCCAGCTATTTGA

Protein

MSPRLKISSYVIERLSKIDTTESTGCLYGLMYDGTLLVVGFSLESFETETEKNSYSQLLLNFPAEIELCGVVKFGETLTTDSTTKEILQDVDITDNPLIIIINREKDMKAHFIVHDKFEETKYEVFSPEELWKQFLHVRLNTVLPLRCEATIAGVKNSLQNKRKKIASGQVSFHIDSTQVYLFGVASDVGLTGTSTEATVGELVDSMSPEQPSKKKKYNINNAEILPVSLILKVTKDILSDKLVKTAVKMMTTQRKPAFYISMPLRIDTLAMIHRNTKLLDLYIVLVEAACRSLRLMESVLIEQLGQEGIGDGGGLRLPETFHYLPPEIGHFITRLIPKGKSEDCMQKERRTLHEQLGLPLHRPVFRRGNAFIDKSGGYLVNPHEAMPIQASKSDVTVALVRGRYAYHHYMQDNFNDDGWGCAYRSMQTIFSWFRYQGYTDVEVPTHKEIQQCLVKIGDKQSTFIGSKQWIGSTEVMFCLETLLGVQSRIIFANTGTELQSYAPELVHHFQTHGSPIMIGGGVLAHTILGIEYNSITNETRYLILDPHYTGAEDITTVINKGWCGWKSSDFWNKTAHYNLCLPQTRPAI

Description

Thiol protease which recognizes and hydrolyzes the peptide bond at the C-terminal Gly of UFM1, a ubiquitin-like modifier protein bound to a number of target proteins. Does not hydrolyze SUMO1 or ISG15 ubiquitin-like proteins.

Similarity

Belongs to the peptidase C78 family.

Keywords

Complete proteome   Hydrolase   Protease   Reference proteome   Thiol protease   Ubl conjugation pathway  

Feature

chain  Probable Ufm1-specific protease 2

Uniprot

H9IVA8   A0A1E1VX63   A0A2W1BQG0   A0A2A4JZR1   A0A2H1X1V6   A0A194Q959   + More
A0A212FHC8   A0A0N1PGK5   A0A0L7LP23   A0A1Q3FAM1   B0WFS8   B0XHZ4   A0A336KAR1   D1ZZB8   Q176I2   A0A0K8TSP7   A0A1Y1KF17   A0A1W4XW74   K7IYX6   A0A232F6K6   A0A067RJ18   A0A026WGZ4   A0A195BNN5   A0A1J1IA36   A0A151ISM3   A0A151XGR0   E2BQA5   F4WRI1   E2AGI2   A0A0K8TZQ5   A0A195F8U7   A0A034VL55   A0A2P8ZAX0   A0A088AI42   U5ENV8   A0A2A3EC39   A0A0C9R9H8   A0A158N9Q4   A0A154PFP5   A0A1I8N7C5   T1PCE0   A0A0N0BHT1   A0A310S5C0   A0A1A9YG32   A0A1W4VML5   B4LH89   A0A0L0CGH0   B3MAD2   A0A1A9Z8Z5   A0A1A9V4D6   A0A1B0AR14   A0A182GRL2   A0A240SWY2   A0A151IC55   W8B8A6   Q9VUR0   A0A0M4EIT3   A0A1A9X336   B4IWU7   B4MLY5   B4ITX5   B3NI42   B4KUJ9   J3JZA0   U4USI2   Q2M1D1   B4QL38   B4HIG6   A0A1I8Q7X1   A0A3B0KAJ6   A0A182Q957   A0A0T6B3M7   A0A1S4H809   A0A182TMC3   A0A182JIU5   T1GAL3   E0VBF5   Q7PZM0   A0A182PVX9   A0A182K082   A0A182VE50   E9J0W0   A0A182SKN7   A0A182YBN4   W5JLM1   A0A182N2Y5   A0A182L5B0   A0A182HHQ5   A0A0A1X056   A0A182W233   A0A0J7P5D7   A0A182XJM4   A0A2M4AL09   A0A2M4BHW0   A0A182M1Q8   A0A2M4BHV0   A0A2M4ALG2   K1QAI2  

EC Number

3.4.22.-

Pubmed

19121390    28756777    26354079    22118469    26227816    18362917    + More
19820115    17510324    26369729    28004739    20075255    28648823    24845553    24508170    30249741    20798317    21719571    25348373    29403074    21347285    25315136    17994087    26108605    26483478    24495485    10731132    12537572    12537569    17550304    22516182    23537049    15632085    22936249    12364791    20566863    21282665    25244985    20920257    23761445    20966253    25830018    22992520   

EMBL

BABH01000812    GDQN01011736    GDQN01004942    JAT79318.1    JAT86112.1    KZ149978    + More
PZC75864.1    NWSH01000371    PCG76900.1    ODYU01012731    SOQ59186.1    KQ459299    KPJ01954.1    AGBW02008504    OWR53145.1    KQ460462    KPJ14631.1    JTDY01000434    KOB77192.1    GFDL01010483    JAV24562.1    DS231920    EDS26422.1    DS233231    EDS28840.1    UFQS01000147    UFQT01000147    SSX00515.1    SSX20895.1    KQ971338    EFA01874.1    CH477386    EAT42101.1    GDAI01000455    JAI17148.1    GEZM01085252    JAV60039.1    NNAY01000791    OXU26484.1    KK852444    KDR23802.1    KK107211    QOIP01000005    EZA55337.1    RLU22691.1    KQ976428    KYM87839.1    CVRI01000044    CRK96594.1    KQ981064    KYN09872.1    KQ982169    KYQ59547.1    GL449698    EFN82159.1    GL888287    EGI63198.1    GL439316    EFN67439.1    GDHF01032340    JAI19974.1    KQ981727    KYN36637.1    GAKP01014901    JAC44051.1    PYGN01000121    PSN53636.1    GANO01000428    JAB59443.1    KZ288293    PBC29044.1    GBYB01004780    JAG74547.1    ADTU01009733    KQ434886    KZC10138.1    KA646426    AFP61055.1    KQ435742    KOX76662.1    KQ770716    OAD52627.1    CH940647    EDW70602.1    JRES01000502    KNC30594.1    CH902618    EDV40183.1    JXJN01002206    JXUM01016365    JXUM01016366    JXUM01016367    KQ560456    KXJ82331.1    CCAG010006155    KQ978067    KYM97653.1    GAMC01009120    JAB97435.1    AE014296    BT001409    CP012525    ALC44715.1    CH916366    EDV97348.1    CH963847    EDW73196.1    CH891736    CH891737    EDW99838.1    KRK05253.1    CH954178    EDV52128.1    CH933809    EDW18227.1    BT128581    AEE63538.1    KB632345    ERL93060.1    CH379069    CM000363    CM002912    EDX10563.1    KMY99777.1    CH480815    EDW41596.1    OUUW01000027    SPP89742.1    AXCN02001144    LJIG01015966    KRT82016.1    AAAB01008986    CAQQ02018421    CAQQ02018422    DS235030    EEB10711.1    EAA00315.4    GL767538    EFZ13588.1    ADMH02001207    ETN63674.1    GBXI01009805    JAD04487.1    LBMM01000061    KMR05119.1    GGFK01008149    MBW41470.1    GGFJ01003505    MBW52646.1    AXCM01000173    GGFJ01003495    MBW52636.1    GGFK01008315    MBW41636.1    JH817568    EKC33677.1   

Proteomes

UP000005204    UP000218220    UP000053268    UP000007151    UP000053240    UP000037510    + More
UP000002320    UP000007266    UP000008820    UP000192223    UP000002358    UP000215335    UP000027135    UP000053097    UP000279307    UP000078540    UP000183832    UP000078492    UP000075809    UP000008237    UP000007755    UP000000311    UP000078541    UP000245037    UP000005203    UP000242457    UP000005205    UP000076502    UP000095301    UP000053105    UP000092443    UP000192221    UP000008792    UP000037069    UP000007801    UP000092445    UP000078200    UP000092460    UP000069940    UP000249989    UP000092444    UP000078542    UP000000803    UP000092553    UP000091820    UP000001070    UP000007798    UP000002282    UP000008711    UP000009192    UP000030742    UP000001819    UP000000304    UP000001292    UP000095300    UP000268350    UP000075886    UP000075902    UP000075880    UP000015102    UP000009046    UP000007062    UP000075885    UP000075881    UP000075903    UP000075901    UP000076408    UP000000673    UP000075884    UP000075882    UP000075920    UP000036403    UP000076407    UP000075883    UP000005408   

PRIDE

H9IVA8    Q9VUR0   

Pfam

PF01138   RNase_PH        + More
PF07910   Peptidase_C78
PF00084   Sushi
PF00629   MAM
PF01607   CBM_14
PF01033   Somatomedin_B
PF00035   dsrm
PF00704   Glyco_hydro_18
PF05158   RNA_pol_Rpc34

Interpro

IPR001247   ExoRNase_PH_dom1        + More
IPR027408   PNPase/RNase_PH_dom_sf       
IPR033196   Rrp43       
IPR020568   Ribosomal_S5_D2-typ_fold       
IPR038765   Papain-like_cys_pep_sf       
IPR036345   ExoRNase_PH_dom2_sf       
IPR012462   Peptidase_C78_UfSP1/2       
IPR001190   SRCR       
IPR036508   Chitin-bd_dom_sf       
IPR017853   Glycoside_hydrolase_SF       
IPR013320   ConA-like_dom_sf       
IPR035976   Sushi/SCR/CCP_sf       
IPR002557   Chitin-bd_dom       
IPR036024   Somatomedin_B-like_dom_sf       
IPR000998   MAM_dom       
IPR000436   Sushi_SCR_CCP_dom       
IPR001212   Somatomedin_B_dom       
IPR040375   DGCR8       
IPR014720   dsRBD_dom       
IPR001223   Glyco_hydro18_cat       
IPR029070   Chitinase_insertion_sf       
IPR036390   WH_DNA-bd_sf       
IPR036388   WH-like_DNA-bd_sf       
IPR007832   RNA_pol_Rpc34       
IPR016049   RNA_pol_Rpc34-like       

SUPFAM

SSF54211   SSF54211        + More
SSF55666   SSF55666       
SSF54001   SSF54001       
SSF49899   SSF49899       
SSF57625   SSF57625       
SSF51445   SSF51445       
SSF57535   SSF57535       
SSF90188   SSF90188       
SSF46785   SSF46785       

Gene 3D

3.30.230.70     3.10.50.10     1.10.10.10    

CDD

cd00033  CCP
cd06263  MAM
cd00048  DSRM

ProteinModelPortal

H9IVA8   A0A1E1VX63   A0A2W1BQG0   A0A2A4JZR1   A0A2H1X1V6   A0A194Q959   + More
A0A212FHC8   A0A0N1PGK5   A0A0L7LP23   A0A1Q3FAM1   B0WFS8   B0XHZ4   A0A336KAR1   D1ZZB8   Q176I2   A0A0K8TSP7   A0A1Y1KF17   A0A1W4XW74   K7IYX6   A0A232F6K6   A0A067RJ18   A0A026WGZ4   A0A195BNN5   A0A1J1IA36   A0A151ISM3   A0A151XGR0   E2BQA5   F4WRI1   E2AGI2   A0A0K8TZQ5   A0A195F8U7   A0A034VL55   A0A2P8ZAX0   A0A088AI42   U5ENV8   A0A2A3EC39   A0A0C9R9H8   A0A158N9Q4   A0A154PFP5   A0A1I8N7C5   T1PCE0   A0A0N0BHT1   A0A310S5C0   A0A1A9YG32   A0A1W4VML5   B4LH89   A0A0L0CGH0   B3MAD2   A0A1A9Z8Z5   A0A1A9V4D6   A0A1B0AR14   A0A182GRL2   A0A240SWY2   A0A151IC55   W8B8A6   Q9VUR0   A0A0M4EIT3   A0A1A9X336   B4IWU7   B4MLY5   B4ITX5   B3NI42   B4KUJ9   J3JZA0   U4USI2   Q2M1D1   B4QL38   B4HIG6   A0A1I8Q7X1   A0A3B0KAJ6   A0A182Q957   A0A0T6B3M7   A0A1S4H809   A0A182TMC3   A0A182JIU5   T1GAL3   E0VBF5   Q7PZM0   A0A182PVX9   A0A182K082   A0A182VE50   E9J0W0   A0A182SKN7   A0A182YBN4   W5JLM1   A0A182N2Y5   A0A182L5B0   A0A182HHQ5   A0A0A1X056   A0A182W233   A0A0J7P5D7   A0A182XJM4   A0A2M4AL09   A0A2M4BHW0   A0A182M1Q8   A0A2M4BHV0   A0A2M4ALG2   K1QAI2  

PDB

3OQC     E-value=2.31871e-92,     Score=866

KEGG

101738483    K01376 UFM1-specific protease 2 [EC:3.4.22.-] | (RefSeq) probable Ufm1-specific protease 2

GO

GO:0008233   GO:0006955   GO:0006030   GO:0030247   GO:0005576   GO:0016020   GO:0005044   GO:0008061   GO:0012505   GO:0071567   GO:0016790   GO:0006508   GO:0016021   GO:0031053   GO:0020037   GO:0070877   GO:0003723   GO:0042802   GO:0005975   GO:0006383   GO:0005666  

PANTHER

PTHR11097:SF9   PTHR13482   PTHR12780  

Length:

589

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.635730000000001

Exp number, first 60 AAs:

0.20312

Total prob of N-in:

0.01067

outside

1  -  589

 

 

Pi

179.272825

Theta

164.665628

Tajima's D

0.043586

CLR

264.928043

CSRT

0.386880655967202

Interpretation

Uncertain