Gene

KWMTBOMO07864

Pre Gene Modal

BGIBMGA001198

Annotation

cyclin_D_[Bombyx_mori]

Location

Bomo_Chr13(-):8819327-8833849      View in EpiBrowser

Full name

G1/S-specific cyclin-D2      

Alternative Name

Vin-1 proto-oncogene

Location in the cell

Extracellular   Reliability : 2.161

CDS

ATGGACTTGTCTTGTGGCGAAAATATGGAGAATTCAGGAAACATCAACGAAAGAGCTGGGGACTTGTGCGTGGCCGGGTCCGATCGAGCATTGGATCGCGACCCTCGCGTTCTTCTCAATCTCCTGGCCTTGGAGAGATCACATGCTTTGCACACGGATTACTTTCAAAACGTGCAAATTGATATACAACCTTTTATGCGTAAAGTTGTTACTACTTGGATGCTAGAGGTATGTGAAGAACAACAATGTGAAGAACAGGTGTTTCCTCTGGCGGTGAGCTACATGGACCGGTTCTTGGCACAGCGTGCGATATCTCGTCAGCAGCTGCAGCTTCTGGCTGTCACAACCATGCTGCTAGCCTCAAAGTTTCGTCAGTGTCATCCGCTGTCCGTAGATTTGCTGTGTGCTTACACGGACAATTCTGTTTATCCCCACGAAGTGAGGCAATGGGAGATTATGCTGCTCCAGAGGTTGAATTGGCAGCTTTCAGTGGCAACAGCGTTTGACTTCGTGGAACCATTTTTGGCCAGGGTACCGTGGGGCAGAAGCAATTCGTTAATTCGGACACACGCCCTCACCTTAACTTCTGTCTGTTATACAGAAACGGAATTCCTGCTGGTCCCGCCATCCATGGTTGCGGTGGCTTGCATAACGGCTGCGGCCCGTGGATTGCGCGTGCGAATGTCTGTCAACGAGCTGTGCGCGCTGACGAGAACTCCTGCTGCAGCAGCTGAGCTGGTAGCGCGGCATGTCGAGCGAGTACTCGCCAGGGAGACTCAACCACAAGAACCAAGAACGAGAGTTTCCCAAGCACACAAACAAACCACACCAGAACACACCGAGCTCCCGGATACACCAACAGATGTACAGGACGTACGTTTCTGA

Protein

MDLSCGENMENSGNINERAGDLCVAGSDRALDRDPRVLLNLLALERSHALHTDYFQNVQIDIQPFMRKVVTTWMLEVCEEQQCEEQVFPLAVSYMDRFLAQRAISRQQLQLLAVTTMLLASKFRQCHPLSVDLLCAYTDNSVYPHEVRQWEIMLLQRLNWQLSVATAFDFVEPFLARVPWGRSNSLIRTHALTLTSVCYTETEFLLVPPSMVAVACITAAARGLRVRMSVNELCALTRTPAAAAELVARHVERVLARETQPQEPRTRVSQAHKQTTPEHTELPDTPTDVQDVRF

Description

Regulatory component of the cyclin D2-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity. Component of the ternary complex, cyclin D2/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex (By similarity).

Subunit

Interacts with either CDK4 or CDK6 protein kinase to form a serine/threonine kinase holoenzyme complex. The cyclin subunit imparts substrate specificity to the complex. Component of the ternary complex cyclin D/CDK4/CDKN1B required for nuclear translocation and modulation of CDK4-mediated kinase activity.
Interacts with either CDK4 or CDK6 protein kinase to form a serine/threonine kinase holoenzyme complex. The cyclin subunit imparts substrate specificity to the complex. Component of the ternary complex cyclin D/CDK4/CDKN1B required for nuclear translocation and modulation of CDK4-mediated kinase activity (By similarity).

Similarity

Belongs to the cyclin family.
Belongs to the cyclin family. Cyclin D subfamily.

Keywords

3D-structure   Alternative splicing   Cell cycle   Cell division   Complete proteome   Cyclin   Cytoplasm   Disease mutation   Membrane   Nucleus   Phosphoprotein   Polymorphism   Reference proteome   Ubl conjugation  

Feature

chain  G1/S-specific cyclin-D2
splice variant  In isoform 2.
sequence variant  In dbSNP:rs3217921.

Uniprot

F8WT27   H9IVB8   A0A2A4JCL4   A0A0L7LAZ7   S4P5G4   A0A3S2NF83   + More
A0A2H1W223   A0A194Q8X5   A0A194RGI9   A0A212F4E6   A0A336LTH5   A0A1B0CE04   A0A1W4X331   U5EPH7   Q5TN60   A0A2C9GPI8   A0A1Y1KV61   A0A182GIB9   A0A1S3DIR1   Q16PG7   A0A2M4AWL6   A0A139WJW6   A0A1Q3EV77   A0A1B6CVJ1   B0WNJ3   W5JIZ6   A0A1B6JW06   A0A2S2PZM8   G3R223   A0A2R9BB92   H2Q584   P30279   Q53ER2   A0A1B6LW36   L5ME17   S7Q0U1   A0A2K6BTL8   A0A2K6A1Z8   A0A0D9RFF8   A0A096NFY6   A0A2K5MLV5   A0A2K5JGR3   A0A2J8TAW1   A0A2K5E5F8   A0A2K5RK75   A0A2K6STD2   F7I947   G1PW49   A0A2K6Q182   A0A2S2NQQ4   A0A218UEB0   G7PJL4   G7N5K1   J9JZI5   A0A2H8TYE8   A0A250YES4   L8XZ25   H0WRJ4   T1JB92   A0A2K6ETN7   K9IRC4   A0A3M0JKI9   A0A3Q2E9F5   G3V8M9   Q04827   A0A0K8RW79   I3MV82   A0A091EEC5   A0A341AH14   A0A340Y8P9   A0A2Y9NG81   A0A3B3IT44   A0A383Z531   W5PKX9   B2MVY2   Q0P5D3   A0A2Y9DU87   I3QUJ2   A0A2Y9F9Z9   H3BER4   M3YD44   Q4FK45   A0A384D7P3   D2HEK1   A0A3Q7MKN8   A0A2Y9H3J1   M3VU57   A0A2Y9L386   A0A3Q7S5M7   A0A2U3X1S4   M1ELS8   A0A3Q7WA78   P30280   G1MB63   H0W1V6   G3GUJ9  

Pubmed

19121390    26227816    23622113    26354079    22118469    12364791    + More
28004739    26483478    17510324    18362917    19820115    20920257    23761445    22398555    22722832    16136131    1386336    8455931    14702039    16541075    15489334    1386335    18827403    17873913    22323446    23186163    24705253    8125298    9373149    25243066    21993624    25362486    22002653    17431167    25319552    28087693    23385571    15057822    15632090    22673903    8502486    7926809    25727380    20809919    23473789    9215903    10349636    11042159    11076861    11217851    12466851    12040188    16141073    21183079    24813606    20010809    17975172    23236062    1372445    1827757    21804562    29704459   

EMBL

AB649262    BAK53864.1    BABH01000844    NWSH01001911    PCG69701.1    JTDY01001901    + More
KOB72579.1    GAIX01005559    JAA87001.1    RSAL01000144    RVE45983.1    ODYU01005831    SOQ47108.1    KQ459299    KPJ01977.1    KQ460205    KPJ16933.1    AGBW02010374    OWR48618.1    UFQT01000187    SSX21346.1    AJWK01008458    AJWK01008459    AJWK01008460    GANO01003718    JAB56153.1    AAAB01008986    EAL38702.3    APCN01003290    GEZM01075587    JAV64050.1    JXUM01065602    JXUM01065603    KQ562356    KXJ76079.1    CH477783    EAT36255.1    GGFK01011875    MBW45196.1    KQ971338    KYB28107.1    GFDL01015831    JAV19214.1    GEDC01019860    JAS17438.1    DS232012    EDS31820.1    ADMH02001044    ETN64347.1    GECU01004603    JAT03104.1    GGMS01001773    MBY70976.1    CABD030082460    CABD030082461    AJFE02069577    AACZ04028145    GABC01006789    GABF01002402    GABD01005787    GABE01007120    NBAG03000351    JAA04549.1    JAA19743.1    JAA27313.1    JAA37619.1    PNI36098.1    M90813    X68452    D13639    BT019847    AF518005    AK291146    AC006122    CH471116    BC010958    BC089384    M88083    M88080    M88081    M88082    AI146555    AK223577    BAD97297.1    GEBQ01012071    JAT27906.1    KB101165    ELK36874.1    KE163933    EPQ14412.1    AQIB01143812    AHZZ02001569    AHZZ02001570    AHZZ02001571    ABGA01082218    ABGA01082219    ABGA01082220    NDHI03003510    PNJ30151.1    PNJ30152.1    GAMT01002825    GAMS01011061    GAMR01005447    GAMR01005446    GAMP01010579    JAB09036.1    JAB12075.1    JAB28485.1    JAB42176.1    AAPE02031484    AAPE02031485    GGMR01006910    MBY19529.1    MUZQ01000400    OWK51752.1    AQIA01009775    AQIA01009776    AQIA01009777    CM001286    EHH65999.1    JSUE03005990    JSUE03005991    JU321222    JU477698    JV043469    JV043470    CM001263    AFE64978.1    AFH34502.1    AFI33540.1    EHH20399.1    ABLF02039333    GFXV01007528    MBW19333.1    GFFW01002734    JAV42054.1    KB371075    ELV09167.1    AAQR03128076    AAQR03128077    JH432010    GABZ01002322    JAA51203.1    QRBI01000149    RMB99209.1    AC103292    CH473964    EDM01813.1    L09752    D16308    GBKC01001380    JAG44690.1    AGTP01074541    KK718210    KFO55017.1    AC008012    AMGL01083704    AMGL01083705    AMGL01083706    EU626221    ACC93616.1    BC120199    JQ700064    AFK15626.1    AFYH01018218    AFYH01018219    AEYP01093889    AK147345    AK160751    AK168954    CT010207    CH466523    BAE27858.1    BAE35987.1    BAE40760.1    CAJ18415.1    EDK99856.1    GL192757    EFB28704.1    AANG04001873    JP007145    AER95742.1    M83749    M86182    BC049086    ACTA01097990    ACTA01105990    ACTA01113990    AAKN02051648    JH000031    RAZU01000250    EGV98497.1    RLQ62302.1   

Proteomes

UP000005204    UP000218220    UP000037510    UP000283053    UP000053268    UP000053240    + More
UP000007151    UP000092461    UP000192223    UP000007062    UP000075840    UP000069940    UP000249989    UP000079169    UP000008820    UP000007266    UP000002320    UP000000673    UP000001519    UP000240080    UP000002277    UP000005640    UP000233120    UP000233140    UP000029965    UP000028761    UP000233060    UP000233080    UP000001595    UP000233020    UP000233040    UP000233220    UP000008225    UP000001074    UP000233200    UP000197619    UP000009130    UP000233100    UP000006718    UP000007819    UP000011518    UP000005225    UP000233160    UP000269221    UP000265020    UP000002494    UP000005215    UP000052976    UP000252040    UP000265300    UP000248483    UP000261681    UP000002356    UP000009136    UP000248480    UP000248484    UP000008672    UP000000715    UP000261680    UP000291021    UP000286641    UP000248481    UP000011712    UP000248482    UP000286640    UP000245340    UP000286642    UP000000589    UP000008912    UP000005447    UP000001075    UP000273346   

PRIDE

F8WT27    H9IVB8    P30279    G3V8M9    Q04827    Q0P5D3    + More
P30280    G3GUJ9   

Pfam

PF00134   Cyclin_N        + More
PF02984   Cyclin_C

Interpro

IPR036915   Cyclin-like_sf        + More
IPR013763   Cyclin-like       
IPR006671   Cyclin_N       
IPR039361   Cyclin       
IPR004367   Cyclin_C-dom       
IPR015451   Cyclin_D       

SUPFAM

SSF47954   SSF47954       

CDD

cd00043  CYCLIN

ProteinModelPortal

F8WT27   H9IVB8   A0A2A4JCL4   A0A0L7LAZ7   S4P5G4   A0A3S2NF83   + More
A0A2H1W223   A0A194Q8X5   A0A194RGI9   A0A212F4E6   A0A336LTH5   A0A1B0CE04   A0A1W4X331   U5EPH7   Q5TN60   A0A2C9GPI8   A0A1Y1KV61   A0A182GIB9   A0A1S3DIR1   Q16PG7   A0A2M4AWL6   A0A139WJW6   A0A1Q3EV77   A0A1B6CVJ1   B0WNJ3   W5JIZ6   A0A1B6JW06   A0A2S2PZM8   G3R223   A0A2R9BB92   H2Q584   P30279   Q53ER2   A0A1B6LW36   L5ME17   S7Q0U1   A0A2K6BTL8   A0A2K6A1Z8   A0A0D9RFF8   A0A096NFY6   A0A2K5MLV5   A0A2K5JGR3   A0A2J8TAW1   A0A2K5E5F8   A0A2K5RK75   A0A2K6STD2   F7I947   G1PW49   A0A2K6Q182   A0A2S2NQQ4   A0A218UEB0   G7PJL4   G7N5K1   J9JZI5   A0A2H8TYE8   A0A250YES4   L8XZ25   H0WRJ4   T1JB92   A0A2K6ETN7   K9IRC4   A0A3M0JKI9   A0A3Q2E9F5   G3V8M9   Q04827   A0A0K8RW79   I3MV82   A0A091EEC5   A0A341AH14   A0A340Y8P9   A0A2Y9NG81   A0A3B3IT44   A0A383Z531   W5PKX9   B2MVY2   Q0P5D3   A0A2Y9DU87   I3QUJ2   A0A2Y9F9Z9   H3BER4   M3YD44   Q4FK45   A0A384D7P3   D2HEK1   A0A3Q7MKN8   A0A2Y9H3J1   M3VU57   A0A2Y9L386   A0A3Q7S5M7   A0A2U3X1S4   M1ELS8   A0A3Q7WA78   P30280   G1MB63   H0W1V6   G3GUJ9  

PDB

3G33     E-value=1.52837e-40,     Score=416

KEGG

100862781    K10151 G1/S-specific cyclin-D2 | (RefSeq) cycD; cyclin D

PATHWAY

04068    FoxO signaling pathway - Bombyx mori (domestic silkworm)
04310    Wnt signaling pathway - Bombyx mori (domestic silkworm)

GO

GO:0005634   GO:0006468   GO:0000307   GO:0000079   GO:1900087   GO:0005737   GO:0019901   GO:0016538   GO:0044772   GO:0071481   GO:0007616   GO:0097129   GO:0008344   GO:0051726   GO:0045737   GO:0001934   GO:0051301   GO:0000785   GO:0031965   GO:0005730   GO:0008284   GO:0005654   GO:0005829   GO:0043066   GO:0046626   GO:0007165   GO:0000122   GO:0042127   GO:0042098   GO:0004693   GO:0043434   GO:0007283   GO:0032355   GO:0016020   GO:0032869   GO:0045664   GO:0033574   GO:0014070   GO:0051591   GO:0000082   GO:0050679   GO:0045471   GO:0001541   GO:0001889   GO:0006355   GO:0043565   GO:0005506   GO:0030145   GO:0050906   GO:0005515   GO:0016818   GO:0003707   GO:0051537  

PANTHER

PTHR10177   PTHR10177:SF66   PTHR10177:SF65  

Subcellular location

Nucleus   Cyclin D-CDK4 complexes accumulate at the nuclear membrane and are then translocated into the nucleus through interaction with KIP/CIP family members.   With evidence from 2 publications.
Cytoplasm   Cyclin D-CDK4 complexes accumulate at the nuclear membrane and are then translocated into the nucleus through interaction with KIP/CIP family members.   With evidence from 2 publications.
Membrane   Cyclin D-CDK4 complexes accumulate at the nuclear membrane and are then translocated into the nucleus through interaction with KIP/CIP family members.   With evidence from 2 publications.

Length:

294

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.675969999999999

Exp number, first 60 AAs:

0

Total prob of N-in:

0.02461

outside

1  -  294

 

 

Pi

190.943391

Theta

172.433368

Tajima's D

0.278137

CLR

110.732113

CSRT

0.449177541122944

Interpretation

Uncertain