Gene

KWMTBOMO07846  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA001209

Annotation

PREDICTED:_COP9_signalosome_complex_subunit_3_[Papilio_machaon]

Location

Bomo_Chr13(-):8242042-8248932      View in EpiBrowser

Full name

COP9 signalosome complex subunit 3      

Alternative Name

JAB1-containing signalosome subunit 3

Location in the cell

Cytoplasmic   Reliability : 1.61 Extracellular   Reliability : 1.275

CDS

ATGGCTTCTCCTTTAGAACAATTTGTCAACAATGTGAGGACAATGTCGGCATCAGGTAATTTTCGCGATTTATATGAGATTATTGCAAAATCAGATGAAGTGTTGCAGAGGAATAGCTTCCACCTCAATACAGTACTTGAAACTCTTGATATCCAACAGCATTCATTGGGTGTTTTAGCAGTCCTGGTGGCCAAATTTTCCTTGCCTCCGGGCAATCCAGAAGTTGATAGGTCAACTATGTATCAACAGTTTCATGATTTTATCAATAACTGCAATGGTGAACAAGTTCGATTTGCAACTGATTTATATGCAGATTTGTGTCATCTACTCACAAATCATTTGGTAGAAATCAAACAACCAATAAGGGGCCTGGAAATATTAAAAAAGGCTATAAGAAAGATACAATTGTTTGATTCACAGCTGACCTCAATTCATGCTGATCTTTGCCAGCTCTGTTTGCTCTCAAAATGTATGAAGCCAGCTCTTGAGTTTTTGGACACTGACGTCACTGGGATTGGCAATGAGCTTGGCGGTATTAATGATTCCAAACATTTTCTACTATATTATTACTATGGGGGCATGATTTATACAGCAATGAAAAACTATGATAGAGCTTTGTATTTCTTTGAAGTTGTAGTGACTGTTCCGGCAATGGTTGTATCCCACATCATGTTGGAAGCATACAAGAAATATATTTTAGTGTCTCTTATACTTCATGGAAAGGTTTTGCCAATGCCGAAATACACATCTCAAGTGGTTTGTCGGTTTTTGAAACCGTTGTCAGCGCCATATCATGATTTAGTGGCATCCCAACATGCTGCAAGCAAACACCGCGAGATATTTGTCAGAGACAAGAATATGGGACTAGTTAATCAGGTTTTAAATTCAATGTATAAGAAGAATATTCAGAGATTGACAAAAACATTTTTAACGCTTTCGTTGAGCGATGTCGCTTCTCGCGTGGAATTATCTGGGCCTCTTCAAGCGGAAACATACATACTTAATATGATTGAAGAAGGCGAAATATATGCAATGATTAACCAAAAAGATGGTATGGTGGTGTTTCTAGATAGTCCAGAAAAATATGCATCACCGGAAACATTGTGTGTCTTAGAACAGCAAATGGCTGCTTGTACTAAACTTCACCAGTACATACAGGAAATGGATGTTCAGATACAAGTCAATCCACAGTATGTGAAGAAATCAGTTGGAAGTCACGATGAAGATATGCCCGGCACAAGTCAAAATACGAAGACAACATACACAATGTAA

Protein

MASPLEQFVNNVRTMSASGNFRDLYEIIAKSDEVLQRNSFHLNTVLETLDIQQHSLGVLAVLVAKFSLPPGNPEVDRSTMYQQFHDFINNCNGEQVRFATDLYADLCHLLTNHLVEIKQPIRGLEILKKAIRKIQLFDSQLTSIHADLCQLCLLSKCMKPALEFLDTDVTGIGNELGGINDSKHFLLYYYYGGMIYTAMKNYDRALYFFEVVVTVPAMVVSHIMLEAYKKYILVSLILHGKVLPMPKYTSQVVCRFLKPLSAPYHDLVASQHAASKHREIFVRDKNMGLVNQVLNSMYKKNIQRLTKTFLTLSLSDVASRVELSGPLQAETYILNMIEEGEIYAMINQKDGMVVFLDSPEKYASPETLCVLEQQMAACTKLHQYIQEMDVQIQVNPQYVKKSVGSHDEDMPGTSQNTKTTYTM

Description

Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of E3 ligase complexes, leading to modify the Ubl ligase activity (By similarity).
Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Essential to maintain the survival of epiblast cells and thus the development of the postimplantation embryo.

Subunit

Component of the CSN complex, probably composed of cops1, cops2, cops3, cops4, cops5, cops6, cops7, cops8 and cops9.
Component of the CSN complex, composed of COPS1/GPS1, COPS2, COPS3, COPS4, COPS5, COPS6, COPS7 (COPS7A or COPS7B), COPS8 and COPS9 (PubMed:9707402). In the complex, it probably interacts directly with COPS1, COPS4, COPS8 and COPS9. Interacts with CK2 and PKD. Interacts with the translation initiation factor EIF3S6 and IKBKG (By similarity).

Similarity

Belongs to the CSN3 family.

Keywords

Complete proteome   Cytoplasm   Nucleus   Reference proteome   Signalosome   Acetylation   Phosphoprotein  

Feature

chain  COP9 signalosome complex subunit 3

Uniprot

H9IVC9   A0A3S2NEW8   S4P2Q8   A0A2A4JUC9   A0A2H1VGU3   A0A194RHJ8   + More
A0A212ELY1   A0A194QEV3   A0A2A4JUK7   E2BPK5   A0A151X550   A0A195DQE1   A0A195EVE0   F4X259   A0A158NAJ0   A0A026WXI7   A0A0L7QN33   A0A1W4XU92   A0A067QS27   A0A2J7RAV1   A0A195CK47   A0A2A3ESB6   C3YWE6   A0A2R5LBI0   A0A1S3KEP4   A0A310SE83   A0A131XNX0   E0VSQ7   A0A1B6IIE3   K1QYH6   A0A154PNP6   A0A087UWZ5   A0A1B6H1Y0   M3ZJW5   G3NPQ9   W5M1F6   H3ANJ4   A0A3Q2ZTV0   A0A2R7WLN2   Q6P2U9   A0A3Q2E8K3   W5KBN9   B2GTE8   A0A0S7KKQ0   A0A3Q3IFH9   A0A3B3XQH8   A0A087YJ13   A0A3B3TL63   A0A3P9QD43   A0A3B4CUZ0   A0A3Q2PPM2   A0A3Q2X869   A0A3Q0SNM9   I3KUD0   A0A3P8QPA8   A0A3Q3KGS2   A0A146KXE6   A0A3P8WYG2   A0A3B3BU21   A0A3P8TWL2   A0A2D0SAL5   A0A2I4CBH4   A0A3B4YGE1   A0A3Q1GAV8   A0A3B4ZRR5   A0A3Q1H0L1   A0A3Q1CVU4   A0A3B4U783   A0A1W4ZB82   A0A060X8M2   B5X4W9   A0A1A7YZ90   A0A1Y1K187   A0A131X9K8   A0A0K8RCJ8   A0A2U9CL19   C1BKN9   A0A3B3QWV8   A0A3P8XLB8   A0A1B6L0M0   A0A060XH69   A0A1A8DII7   A0A1A8MR52   A0A3P9HM57   L7M8S2   A0A1A8G9P5   A0A224YQL2   A0A131Z2A0   Q3UQL2   O88543   A0A1A8CIZ2   A0A1A8HVR1   A0A1A8K9G8   A0A1A8GS95   A0A1A8RRL4   E2RD70   A0A3Q7TJE0   M3X663   A0A1A8ACH3   A0A1A8UPF1  

Pubmed

19121390    23622113    26354079    22118469    20798317    21719571    + More
21347285    24508170    30249741    24845553    18563158    20566863    22992520    23542700    9215903    25329095    25186727    26823975    24487278    29451363    24755649    20433749    28004739    28049606    29240929    25069045    17554307    25576852    28797301    26830274    10349636    11042159    11076861    11217851    12466851    16141073    21183079    9707402    15489334    12972600    16341006    17975172   

EMBL

BABH01000896    RSAL01000152    RVE45712.1    GAIX01009887    JAA82673.1    NWSH01000642    + More
PCG75083.1    ODYU01002495    SOQ40046.1    KQ460205    KPJ16914.1    AGBW02013971    OWR42486.1    KQ459299    KPJ01996.1    PCG75082.1    GL449633    EFN82409.1    KQ982519    KYQ55545.1    KQ980612    KYN15125.1    KQ981954    KYN32230.1    GL888565    EGI59475.1    ADTU01010338    KK107077    QOIP01000010    EZA60538.1    RLU17349.1    KQ414860    KOC60062.1    KK852999    KDR12669.1    NEVH01006564    PNF37957.1    KQ977642    KYN01096.1    KZ288193    PBC34019.1    GG666561    EEN55190.1    GGLE01002758    MBY06884.1    KQ770827    OAD52585.1    GEFM01006672    JAP69124.1    AAZO01005171    DS235755    EEB16413.1    GECU01025059    GECU01021014    JAS82647.1    JAS86692.1    JH818444    EKC42032.1    KQ435007    KZC13479.1    KK122078    KFM81884.1    GECZ01001121    JAS68648.1    AHAT01031987    AFYH01167875    AFYH01167876    AFYH01167877    KK855050    PTY20523.1    BC045415    BC064288    BC165863    AAI65863.1    GBYX01208248    JAO77163.1    AYCK01000799    AERX01002154    GDHC01019209    JAP99419.1    FR904885    CDQ73180.1    BT046088    ACI34350.1    HADW01001214    HADX01013209    SBP35441.1    GEZM01097366    JAV54248.1    GEFH01004938    JAP63643.1    GADI01005007    JAA68801.1    CP026260    AWP17304.1    BT075168    ACO09592.1    GEBQ01022767    JAT17210.1    FR905370    CDQ78776.1    HAEA01005387    SBQ33867.1    HAEF01017780    HAEG01015354    SBR58939.1    GACK01004772    JAA60262.1    HAEB01021266    SBQ67793.1    GFPF01006903    MAA18049.1    GEDV01003499    JAP85058.1    AK142318    BAE25027.1    AF071313    BC068179    HADZ01014790    SBP78731.1    HAED01002635    SBQ88483.1    HAEE01008933    SBR28983.1    HAEC01005769    SBQ73846.1    HAEI01009758    SBS08676.1    AAEX03003732    AANG04000740    HADY01013450    SBP51935.1    HAEJ01009029    SBS49486.1   

Proteomes

UP000005204    UP000283053    UP000218220    UP000053240    UP000007151    UP000053268    + More
UP000008237    UP000075809    UP000078492    UP000078541    UP000007755    UP000005205    UP000053097    UP000279307    UP000053825    UP000192223    UP000027135    UP000235965    UP000078542    UP000242457    UP000001554    UP000085678    UP000009046    UP000005408    UP000076502    UP000054359    UP000002852    UP000007635    UP000018468    UP000008672    UP000264800    UP000000437    UP000265020    UP000018467    UP000261600    UP000261480    UP000028760    UP000261500    UP000242638    UP000261440    UP000265000    UP000264840    UP000261340    UP000005207    UP000265100    UP000261640    UP000265120    UP000261560    UP000265080    UP000221080    UP000192220    UP000261360    UP000257200    UP000261400    UP000265040    UP000257160    UP000261420    UP000192224    UP000193380    UP000087266    UP000246464    UP000261540    UP000265140    UP000265200    UP000000589    UP000002254    UP000286640    UP000011712   

PRIDE

H9IVC9    L7M8S2    Q3UQL2    O88543    E2RD70   

Pfam

PF01399   PCI

Interpro

IPR037753   CSN3        + More
IPR000717   PCI_dom       
IPR036390   WH_DNA-bd_sf       
IPR011990   TPR-like_helical_dom_sf       
IPR036388   WH-like_DNA-bd_sf       

SUPFAM

SSF46785   SSF46785        + More
SSF48452   SSF48452       

Gene 3D

1.10.10.10    

ProteinModelPortal

H9IVC9   A0A3S2NEW8   S4P2Q8   A0A2A4JUC9   A0A2H1VGU3   A0A194RHJ8   + More
A0A212ELY1   A0A194QEV3   A0A2A4JUK7   E2BPK5   A0A151X550   A0A195DQE1   A0A195EVE0   F4X259   A0A158NAJ0   A0A026WXI7   A0A0L7QN33   A0A1W4XU92   A0A067QS27   A0A2J7RAV1   A0A195CK47   A0A2A3ESB6   C3YWE6   A0A2R5LBI0   A0A1S3KEP4   A0A310SE83   A0A131XNX0   E0VSQ7   A0A1B6IIE3   K1QYH6   A0A154PNP6   A0A087UWZ5   A0A1B6H1Y0   M3ZJW5   G3NPQ9   W5M1F6   H3ANJ4   A0A3Q2ZTV0   A0A2R7WLN2   Q6P2U9   A0A3Q2E8K3   W5KBN9   B2GTE8   A0A0S7KKQ0   A0A3Q3IFH9   A0A3B3XQH8   A0A087YJ13   A0A3B3TL63   A0A3P9QD43   A0A3B4CUZ0   A0A3Q2PPM2   A0A3Q2X869   A0A3Q0SNM9   I3KUD0   A0A3P8QPA8   A0A3Q3KGS2   A0A146KXE6   A0A3P8WYG2   A0A3B3BU21   A0A3P8TWL2   A0A2D0SAL5   A0A2I4CBH4   A0A3B4YGE1   A0A3Q1GAV8   A0A3B4ZRR5   A0A3Q1H0L1   A0A3Q1CVU4   A0A3B4U783   A0A1W4ZB82   A0A060X8M2   B5X4W9   A0A1A7YZ90   A0A1Y1K187   A0A131X9K8   A0A0K8RCJ8   A0A2U9CL19   C1BKN9   A0A3B3QWV8   A0A3P8XLB8   A0A1B6L0M0   A0A060XH69   A0A1A8DII7   A0A1A8MR52   A0A3P9HM57   L7M8S2   A0A1A8G9P5   A0A224YQL2   A0A131Z2A0   Q3UQL2   O88543   A0A1A8CIZ2   A0A1A8HVR1   A0A1A8K9G8   A0A1A8GS95   A0A1A8RRL4   E2RD70   A0A3Q7TJE0   M3X663   A0A1A8ACH3   A0A1A8UPF1  

PDB

4WSN     E-value=1.92375e-138,     Score=1262

KEGG

101742891    K12177 COP9 signalosome complex subunit 3 | (RefSeq) COP9 signalosome complex subunit 3

GO

GO:0005737   GO:0008180   GO:0016021   GO:0006511   GO:0000502   GO:0000338   GO:0005654   GO:0005829   GO:0001701   GO:0005634   GO:0005515   GO:0006779   GO:0043565   GO:0005506   GO:0030145   GO:0050906   GO:0016818   GO:0003707   GO:0051537  

PANTHER

PTHR10758:SF1  

Subcellular location

Cytoplasm  
Nucleus  

Length:

423

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

14.51395

Exp number, first 60 AAs:

0.04591

Total prob of N-in:

0.52922

outside

1  -  423

 

 

Pi

169.288052

Theta

132.20133

Tajima's D

0.892649

CLR

0.00399

CSRT

0.628168591570421

Interpretation

Uncertain