Gene

KWMTBOMO07845  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA000937

Annotation

PREDICTED:_uroporphyrinogen_decarboxylase_[Papilio_machaon]

Location

Bomo_Chr13(+):8240083-8242027      View in EpiBrowser

Full name

Uroporphyrinogen decarboxylase      

Location in the cell

Cytoplasmic   Reliability : 3.582

CDS

ATGGAGTACTCTAACAAGAATTTTCCAGAATTGAAAAATGATAGACTACTTCGAGCAGCTTTAGGAAAAAGTGTTGACAAAGTCCCTGTTTGGGTAATGCGACAAGCTGGAAGATATTTACCAGAATTTCAGGAAGTCCGAGTTAAACACGATTTTTTCACGGTTTGTCGAACTCCAGAATTAGCTTGTGAAGTAACACTGCAGCCGCTCAGAAGGTATGAGCACTTGGATGCATCTATAATATTCAGTGATATTCTTGTGATACCACAAGCACTCGGCATGACTGTTGAAATGCACCCTGGAGTCGGTCCAGTATTTCCTAAACCACTTCAAACCCCATCAGAAATAGATGGTCTCCAACCAGAAGGTGCAGTTTCAAGGTTGGATTATGTTGGAAAGGCTATCACACTGACAAGACATAAAATAGATGGTAAAGTTCCCTTGATTGGCTTTACTGGAGCTCCGTTTACACTATTTGGATACATGCTAGAGGGTGGAGGAAGCAAAACAATGTCTAAAACAAAAGAATGGCTCGAGAAGTATCCTAAAGATGTCCATAGACTCCTTTGTCTTCTTACTAATGTTATAATTGACTATGTGGTGATGCAAGTGGAGAGTGGAGCGCAACTTCTGCAAGTATTTGAATCAAGTGCAGATCACCTCTCAAGAGAACAATTTACTGAGTTTTCTATTCCATATTTGAAAGACATTAGAAGTGGAGTTAGAGCTAAACTTACAGAAAAATCTTTAGAACAGGTTCCTATGACCATATTTGCAAAAGGAGCTGGACATTCCTTAGATATTCAAGCTCAATTAGGTTATGAAACCATTGGACTAGATTGGACAGTGGATCCTACTGAAGCCAGGAAAATTGTAGGTGAAAACATTACTTTGCAAGGAAATCTTGATCCTCAGGATTTATACAAAACTCCTGAAGAAATAAAAACACTTACAACTGAAATGGTGAAAAAGTTTGGAAAACATAGATACATAGCTAATTTGGGTCATGGGATTACACCACAAACCCCACTTGAGAGTATGACTGTTTTTACTGAAACAGTACATGAAGCTATATAA

Protein

MEYSNKNFPELKNDRLLRAALGKSVDKVPVWVMRQAGRYLPEFQEVRVKHDFFTVCRTPELACEVTLQPLRRYEHLDASIIFSDILVIPQALGMTVEMHPGVGPVFPKPLQTPSEIDGLQPEGAVSRLDYVGKAITLTRHKIDGKVPLIGFTGAPFTLFGYMLEGGGSKTMSKTKEWLEKYPKDVHRLLCLLTNVIIDYVVMQVESGAQLLQVFESSADHLSREQFTEFSIPYLKDIRSGVRAKLTEKSLEQVPMTIFAKGAGHSLDIQAQLGYETIGLDWTVDPTEARKIVGENITLQGNLDPQDLYKTPEEIKTLTTEMVKKFGKHRYIANLGHGITPQTPLESMTVFTETVHEAI

Description

Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.

Catalytic Activity

4 H(+) + uroporphyrinogen III = 4 CO2 + coproporphyrinogen III

Subunit

Homodimer.

Similarity

Belongs to the uroporphyrinogen decarboxylase family.

Keywords

Complete proteome   Cytoplasm   Decarboxylase   Heme biosynthesis   Lyase   Porphyrin biosynthesis   Reference proteome  

Feature

chain  Uroporphyrinogen decarboxylase

Uniprot

S4NU11   A0A194RGG8   A0A194Q8Z8   A0A212ELX1   A0A2A4JTY4   A0A2H1VGW4   + More
H9IUK7   A0A0L0BNU8   A0A034WEE3   A0A034WDV8   W8BTP8   W8C6W6   A0A0K8UKT5   A0A0K8W3N4   A0A0A1XH86   T1P8S8   A0A1I8Q209   A0A1I8NGW0   B4MS54   A0A1B0GK24   A0A0L7KTY6   A0A0M3QUK2   A0A1B0GN91   A0A1J1HXU0   A0A1A9WSG4   A0A1L8DZQ7   B3ME52   U5EW78   B3N789   A0A0Q9XB76   A0A3B0JSE8   B4HT11   A0A0Q5WA11   B4QHA7   A0A0J9RA25   B4KTW4   B5RJ76   A0A084WIM9   Q9V595   B4NWH7   A0A1W4UZF6   Q8MRV9   A0A0R1DMG8   Q175D6   A0A0Q9W337   A0A336LVK0   A0A1S4FEA2   Q175D5   A0A1S4FED4   B4LJ20   A0A182INS2   Q28Y18   A0A2M3ZHM0   B4JVW3   A0A182H9M2   A0A1B0FBT4   D3TL10   A0A2M3Z6S6   A0A182FB53   A0A2M4AB95   A0A2M4BSB1   A0A2M4AB94   A0A2M4ABK9   A0A182PP13   A0A182M156   A0A2M4BS46   A0A182Y9F6   A0A182K8L4   A0A2M4ABB3   A0A182RS03   A0A1A9ZFS8   A0A182WDY4   Q7PVA3   A0A182TH76   A0A1S4H7R9   A0A182HHJ0   W5JUC0   A0A1A9YMR3   B4GGF6   A0A182L511   A0A1B0BZ25   A0A182VKH0   A0A182XJU4   A0A182N2V5   A0A182Q098   A0A0K8TMY4   O18601   A0A1A9V2K7   B0WTV7   A0A1Q3FCZ2   A0A1Q3FCW0   A0A1Q3FCY1   A0A1Q3FCQ0   Q175D4   A0A1W4WLW6   A0A1B6L574   A0A1B6GFS6   A0A1B6MUC0   A0A195BR80   A0A158P1S2  

EC Number

4.1.1.37

Pubmed

23622113    26354079    22118469    19121390    26108605    25348373    + More
24495485    25830018    25315136    17994087    26227816    22936249    24438588    10731132    12537572    17550304    17510324    15632085    26483478    20353571    25244985    12364791    20920257    23761445    20966253    26369729    21347285   

EMBL

GAIX01012001    JAA80559.1    KQ460205    KPJ16913.1    KQ459299    KPJ01997.1    + More
AGBW02013971    OWR42485.1    NWSH01000642    PCG75084.1    ODYU01002495    SOQ40047.1    BABH01000896    JRES01001589    KNC21643.1    GAKP01006437    GAKP01006436    JAC52515.1    GAKP01006435    JAC52517.1    GAMC01003998    GAMC01003997    JAC02558.1    GAMC01003999    JAC02557.1    GDHF01025022    JAI27292.1    GDHF01016629    GDHF01006642    JAI35685.1    JAI45672.1    GBXI01004424    JAD09868.1    KA645089    AFP59718.1    CH963850    EDW74943.1    AJWK01022514    JTDY01005830    KOB66570.1    CP012524    ALC40773.1    AJVK01013080    CVRI01000020    CRK90969.1    GFDF01002200    JAV11884.1    CH902619    EDV35447.1    GANO01001551    JAB58320.1    CH954177    EDV58240.1    CH933808    KRG05429.1    OUUW01000001    SPP74018.1    CH480816    EDW47121.1    KQS70333.1    CM000362    CM002911    EDX06361.1    KMY92538.1    KMY92539.1    EDW10690.1    BT044350    ACH92415.1    ATLV01023941    KE525347    KFB50073.1    AE013599    CM000157    EDW89522.1    AY119238    AAM51098.1    KRJ98517.1    CH477402    EAT41685.1    CH940648    KRF79432.1    UFQT01000117    SSX20357.1    EAT41687.1    EDW60470.1    CM000071    EAL26148.2    GGFM01007271    MBW28022.1    CH916375    EDV98101.1    JXUM01121119    KQ566463    KXJ70116.1    CCAG010003604    EZ422101    ADD18305.1    GGFM01003460    MBW24211.1    GGFK01004742    MBW38063.1    GGFJ01006799    MBW55940.1    GGFK01004736    MBW38057.1    GGFK01004781    MBW38102.1    AXCM01000907    GGFJ01006764    MBW55905.1    GGFK01004755    MBW38076.1    AAAB01008986    EAA00166.4    APCN01002417    ADMH02000120    ETN67741.1    CH479183    EDW35576.1    JXJN01022958    AXCN02001090    GDAI01002318    JAI15285.1    U93213    DS232092    EDS34648.1    GFDL01009673    JAV25372.1    GFDL01009703    JAV25342.1    GFDL01009676    JAV25369.1    GFDL01009699    JAV25346.1    EAT41686.1    GEBQ01021119    JAT18858.1    GECZ01031233    GECZ01008482    JAS38536.1    JAS61287.1    GEBQ01000433    JAT39544.1    KQ976419    KYM89361.1    ADTU01006777   

Proteomes

UP000053240    UP000053268    UP000007151    UP000218220    UP000005204    UP000037069    + More
UP000095301    UP000095300    UP000007798    UP000092461    UP000037510    UP000092553    UP000092462    UP000183832    UP000091820    UP000007801    UP000008711    UP000009192    UP000268350    UP000001292    UP000000304    UP000030765    UP000000803    UP000002282    UP000192221    UP000008820    UP000008792    UP000075880    UP000001819    UP000001070    UP000069940    UP000249989    UP000092444    UP000069272    UP000075885    UP000075883    UP000076408    UP000075881    UP000075900    UP000092445    UP000075920    UP000007062    UP000075902    UP000075840    UP000000673    UP000092443    UP000008744    UP000075882    UP000092460    UP000075903    UP000076407    UP000075884    UP000075886    UP000078200    UP000002320    UP000192223    UP000078540    UP000005205   

PRIDE

H9IUK7    B5RJ76    Q9V595    Q8MRV9    O18601   

Pfam

PF01208   URO-D        + More
PF01198   Ribosomal_L31e

Interpro

IPR038071   UROD/MetE-like_sf        + More
IPR006361   Uroporphyrinogen_deCO2ase_HemE       
IPR000257   Uroporphyrinogen_deCOase       
IPR023621   Ribosomal_L31e_dom_sf       
IPR020052   Ribosomal_L31e_CS       
IPR000054   Ribosomal_L31e       

SUPFAM

SSF51726   SSF51726        + More
SSF54575   SSF54575       

Gene 3D

3.20.20.210     3.10.440.10    

CDD

cd00717  URO-D
cd00463  Ribosomal_L31e

ProteinModelPortal

S4NU11   A0A194RGG8   A0A194Q8Z8   A0A212ELX1   A0A2A4JTY4   A0A2H1VGW4   + More
H9IUK7   A0A0L0BNU8   A0A034WEE3   A0A034WDV8   W8BTP8   W8C6W6   A0A0K8UKT5   A0A0K8W3N4   A0A0A1XH86   T1P8S8   A0A1I8Q209   A0A1I8NGW0   B4MS54   A0A1B0GK24   A0A0L7KTY6   A0A0M3QUK2   A0A1B0GN91   A0A1J1HXU0   A0A1A9WSG4   A0A1L8DZQ7   B3ME52   U5EW78   B3N789   A0A0Q9XB76   A0A3B0JSE8   B4HT11   A0A0Q5WA11   B4QHA7   A0A0J9RA25   B4KTW4   B5RJ76   A0A084WIM9   Q9V595   B4NWH7   A0A1W4UZF6   Q8MRV9   A0A0R1DMG8   Q175D6   A0A0Q9W337   A0A336LVK0   A0A1S4FEA2   Q175D5   A0A1S4FED4   B4LJ20   A0A182INS2   Q28Y18   A0A2M3ZHM0   B4JVW3   A0A182H9M2   A0A1B0FBT4   D3TL10   A0A2M3Z6S6   A0A182FB53   A0A2M4AB95   A0A2M4BSB1   A0A2M4AB94   A0A2M4ABK9   A0A182PP13   A0A182M156   A0A2M4BS46   A0A182Y9F6   A0A182K8L4   A0A2M4ABB3   A0A182RS03   A0A1A9ZFS8   A0A182WDY4   Q7PVA3   A0A182TH76   A0A1S4H7R9   A0A182HHJ0   W5JUC0   A0A1A9YMR3   B4GGF6   A0A182L511   A0A1B0BZ25   A0A182VKH0   A0A182XJU4   A0A182N2V5   A0A182Q098   A0A0K8TMY4   O18601   A0A1A9V2K7   B0WTV7   A0A1Q3FCZ2   A0A1Q3FCW0   A0A1Q3FCY1   A0A1Q3FCQ0   Q175D4   A0A1W4WLW6   A0A1B6L574   A0A1B6GFS6   A0A1B6MUC0   A0A195BR80   A0A158P1S2  

PDB

3GW0     E-value=5.17217e-113,     Score=1042

KEGG

101742739    K01599 uroporphyrinogen decarboxylase [EC:4.1.1.37] | (RefSeq) uroporphyrinogen decarboxylase

PATHWAY

00860    Porphyrin and chlorophyll metabolism - Bombyx mori (domestic silkworm)
01100    Metabolic pathways - Bombyx mori (domestic silkworm)

GO

GO:0006782   GO:0004853   GO:0006779   GO:0005840   GO:0003735   GO:0006412   GO:0016021   GO:0005737   GO:0006783   GO:0005829   GO:0043565   GO:0005506   GO:0030145   GO:0050906   GO:0005515   GO:0016818   GO:0003707   GO:0051537  

Subcellular location

Cytoplasm  

Length:

358

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

3.30176

Exp number, first 60 AAs:

0.00038

Total prob of N-in:

0.12994

outside

1  -  358

 

 

Pi

312.001202

Theta

236.354396

Tajima's D

0.954386

CLR

0

CSRT

0.646367681615919

Interpretation

Uncertain